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| 1 | Evaluation on the human settlements environment suitability in the Three Gorges Reservoir Area of Chongqing based on RS and GIS显示文摘为了在量的特征和人的解决的空间模式探索地理差别,在三的环境适用性( HSES )塞满水库区域( TGRA ),地面,气候,水文学,植被和另外的天赋因素被选择造过得去的环境评估,并且定量分析通过遥感( RS )和地理参考系统( GIS )被进行揭示地理特征和 HSES 的空间模式。结果如下被获得:(1 ) 重庆的 TGRA 的居民与中等高 HSES 在区域被集中,它是在 48% 学习区域散布的 78% 全部的人口;(2 ) HSES 是仔细与地面有关,并且它形成一个弧乐队空间继任模式:在东北和东南相对低当时在西方和南方比较地高;(3 ) 大量人与低适用性在区域被散布(与更高的人口密度比西方的中国的一般水准) ,但是在这些区域的经济发展水平是相当低的。而且,这些区域是生态的敏感、易碎,许多种 eco 环境的问题被人的活动引起了。因此,人口移植和布局是为这些区域的发展的合理选择。 | LI Yuechen | 2011 | Journal of Geographical Sciences2011，21，2： | 12 |
| 2 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 3 | Interactions between water vapor and atmospheric aerosols have key roles in air quality and climate change显示文摘INTRODUCTION Atmospheric aerosols,which are ubiquitous in the planetary boundary layer, have received much attention due to their effects on visibility,climate and human health.Water,a semi-volatile species,is ubiquitous in the atmosphere as well.The interaction between water vapor and aerosols plays a key role in determining the aerosol properties in the atmosphere and therefore has great effects on both air quality (Fig.la and b)and climate change (Fig.lc),which is depicted in Fig.1 as a function of atmospheric relative humidity (RH)and temperature. | Zhijun Wu Jie Chen Yu Wang Yishu Zhu Yuechen Liu Bai Yao Yuanhang Zhang Min Hu | 2018 | National Science Review2018，5，4： | 4 |
| 4 | Short-term intermittent administration of CXCR4 antagonist AMD3100 facilitates myocardial repair in experimental myocardial infarction显示文摘stromal 的绑定导出房间的 factor-1 (SDF-1 ) 到半胱氨酸(C)-X-C 主题 chemokine 受体(CXCR4 ) 4 从骨头髓为茎和祖先房间 trafficking 作为一个关键信号出现了到发行量。我们的目的是在心肌的梗塞(MI ) 以后在愈合的过程期间调查 AMD3100 (一个特定的可逆 CXCR4 受体对手) 的每日的断断续续的管理的角色。Wistar 老鼠受到 MI, AMD3100 在外科以后 intraperitoneally 被注射。SDF-1 mRNA 表示被即时聚合酶链反应测量。组织学变化与 immunofluorescence 被分析,马森的三色的染色,并且小麦细菌凝集素。在外部血的白血球的数字被完全的血房间计数分析测量。矩阵 metalloproteinase-2/9 (MMP-2/9 ) 的活动被明胶 zymography 决定。在 infarcted 织物的 SDF-1 mRNA 的表示水平很快被提高(6 h ) ,在 24 h 达到顶点,然后在 7 天 post-MI 衰退了到正常水平。AMD3100 进一步在梗塞区域提高了 SDF-1 的增加。增加的白血球在对待 AMD3100 的组被观察。c-kit+ 干细胞和提高的 neovascularization 的动员被 AMD3100 扩充。另外, AMD3100 改进了室的改变,它被梗塞尺寸的减少揭示,可行 cardiomyocyte 代表性的区域和左室(LV ) LV 免费的墙厚度的扩大索引,和增加。MMP-2/9 的活动由 AMD3100 是起来调整的。在结论, AMD3100 的短期的断断续续的管理能在试验性的 MI 加速弯屈的愈合的过程并且是为 MI 的处理的潜在的治疗。 | Yuechen Luo Xiaoning Zhao Xin Zhou Wenjie Ji Ling Zhang Tao Luo Hongmei Liu Tigang Huang Tiemin Jiang Yuming Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，7： | 3 |
| 5 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 6 | Estimation of the PM_(2.5) effective hygroscopic parameter and water content based on particle chemical composition: Methodology and case study显示文摘Particle hygroscopicity plays a key role in understanding the mechanisms of haze formation and particle optical properties. The present study developed a method for predicting the effective hygroscopic parameter k and the water content of PM_(2.5) on the basis of the k-K?hler theory and bulk chemical components of PM_(2.5). Our study demonstrated that the effective hygroscopic parameter can be estimated using the PM_(2.5) mass concentration, water-soluble ions, and total water-soluble carbon. By combining the estimated k and ambient relative humidity, the water content of PM_(2.5) can be further estimated. As an example, the k and water content of PM_(2.5) in Beijing were estimated utilizing the method proposed in this study. The annual average value of k of PM_(2.5) in Beijing was 0.25±0.09, the maximum k value 0.26±0.08 appeared in summer, and the seasonal variation is insignificant. The PM_(2.5) water content was determined by both the PM_(2.5) hygroscopicity and the ambient relative humidity(RH). The annual average mass ratio of water content and PM_(2.5) was 0.18±0.20, and the maximum value 0.31±0.25 appeared in summer. Based on the estimated water content of PM_(2.5) in Beijing, the relationship between the PM_(2.5) water content and RH was parameterized as: m(%)=0.03+(5.73×10^(-8)) ×RH^(3.72).This parametric formula helps to characterize the relationship between the PM_(2.5) mass concentration and atmospheric visibility. | LIU YueChen WU ZhiJun TAN TianYi WANG YuJue QIN YanHong ZHENG Jing LI MengRen HU Min | 2016 | Science China Earth Sciences2016，59，8： | 1 |
| 7 | Ultrafast growth of wafer-scale fold-free bilayer graphene显示文摘Bilayer graphene provides a versatile platform for exploring a variety of intriguing phenomena and shows much promise for applications in electronics,optoelectronics,etc.Controlled growth of large-area bilayer graphene is therefore highly desired yet still suffers from a slow growth rate and poor layer uniformity.Meanwhile,graphene wrinkles,including folds and ripples,form during cooling due to the thermal contraction mismatch between graphene and the metal substrates,and have been far from suppressed or eliminated,especially in bilayer graphene,which would greatly degrade the extraordinary properties of graphene.Here we report the ultrafast growth of wafer-scale fold-free bilayer graphene by chemical vapor deposition.Through well-tuning the alloy thickness and strain regulation of the single-crystal CuNi(111)/sapphire,the full coverage of a 2-inch fold-free bilayer graphene wafer via mainly isothermal segregation has been achieved as fast as 30 s.The tensile-strained CuNi(111)film reduces the thermal contraction mismatch and suppresses the formation of graphene folds during cooling,which is directly observed through in situ optical microscopy.The ultraflat bilayer graphene exhibits wafer-scale uniformity in electrical performance and enhanced mechanical property comparable to the exfoliated ones.Our results offer a promising route for largescale production of bilayer graphene and enable its various applications. | Jilin Tang Yuechen Wang Yuwei Ma Xiaoyin Gao Xin Gao Ning Li Yani Wang Shishu Zhang Liming Zheng Bing Deng Rui Yan Yisen Cao Ronghua Zhang Lianming Tong Jin Zhang Peng Gao Zhongfan Liu Xiaoding Wei Hongtao Liu Hailin Peng | 2023 | Nano Research2023，16，7： | 0 |
| 8 | Effects of nitrogen fertilizer on root-shoot characteristics,grain yield and nitrogen use efficiency of different maize varieties in North China Plain显示文摘Excessive nitrogen(N)fertilizer application in crop production has resulted in a series of environmental issues in North China Plain(NCP).Breeding N-efficient maize varieties is one of the effective strategies to improve the N use efficiency of maize and reduce environmental pollution.This study designed an experiment for two maize varieties(‘Xian-Yu 335’[XY335]and‘Hua-Nong 138’[HN138])with three N-level treatments(0 kg/hm^(2),180 kg/hm^(2),300 kg/hm^(2),i.e.N0,N180,N300).The aim of the study was to determine the response characteristics of maize canopy structure,root morphology,and anatomical structure,as well as N uptake and utilization of N fertilizer.Results showed that grain yield,N use efficiency,and N harvest index of XY335 were higher 5.20%-13.68%,11.86%-19.11%,and 6.07%-3.33%than those of HN138,respectively.Compared with HN138,XY335 had a higher leaf area index and photosynthetic nitrogen-use efficiency.The root length,root length density,root absorption area,root absorption area,and root active absorption area of XY335 in each period were higher than that of HN138.The proportion of RCA of XY335 was significantly higher than that of HN138,which was 14.64%higher on average.In the future breeding process,the high N and low N double-high-efficiency varieties should pay more attention to the improvement of root cortex aeration tissue. | Xiangling Li Liu Pan Rui Wang Yiping Zuo Jian Wang Jinling Han Yuechen Zhang Baozhong Yin | 2022 | International Journal of Agricultural and Biological Engineering2022，15，5： | 0 |
| 9 | Developing Prototype Simulants for Surface Materials and Morphology of Near Earth Asteroid 2016 HO3显示文摘There are a variety of applications for asteroid simulants in asteroid studies for science advances as well as technology maturation.For specific purpose,it usually requires purpose-specialized simulant.In this study,we designed and developed a set of prototype simulants as S-type asteroid surface materials analogue based on H,L,and LL ordinary chondrites’mineralogy and terrestrial observations of near-earth asteroid 2016 HO3,which is the Chinese sample return mission target.These simulants are able to simulate morphology and reflectance characteristics of asteroid(469219)2016 HO3 and,thus,to be used for engineering evaluation of the optical navigation system and the sampling device of the spacecraft during the mission phase.Meanwhile,these prototype simulants are easily to modify to reflect new findings on the asteroid surface when the spacecraft makes proximate observations. | Xiaojing Zhang Yuechen Luo Yuan Xiao Deyun Liu Fan Guo Qian Guo | 2021 | Space(Science & Technology)2021，，1： | 0 |
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