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| 1 | Transforming growth factor-β in stem cells and tissue homeostasis显示文摘TGF-β 1–3 are unique multi-functional growth factors that are only expressed in mammals, and mainly secreted and stored as a latent complex in the extracellular matrix(ECM). The biological functions of TGF-β in adults can only be delivered after ligand activation, mostly in response to environmental perturbations. Although involved in multiple biological and pathological processes of the human body, the exact roles of TGF-β in maintaining stem cells and tissue homeostasis have not been well-documented until recent advances, which delineate their functions in a given context. Our recent findings, along with data reported by others, have clearly shown that temporal and spatial activation of TGF-β is involved in the recruitment of stem/progenitor cell participation in tissue regeneration/remodeling process, whereas sustained abnormalities in TGF-β ligand activation, regardless of genetic or environmental origin, will inevitably disrupt the normal physiology and lead to pathobiology of major diseases. Modulation of TGF-β signaling with different approaches has proven effective pre-clinically in the treatment of multiple pathologies such as sclerosis/fibrosis, tumor metastasis, osteoarthritis, and immune disorders. Thus, further elucidation of the mechanisms by which TGF-β is activated in different tissues/organs and how targeted cells respond in a context-dependent way can likely be translated with clinical benefits in the management of a broad range of diseases with the involvement of TGF-β. | Xin Xu Liwei Zheng Quan Yuan Gehua Zhen Janet L.Crane Xuedong Zhou Xu Cao | 2018 | Bone Research2018，6，1： | 22 |
| 2 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 3 | Aberrant activation of latent transforming growth factor-β initiates the onset of temporomandibular joint osteoarthritis显示文摘There is currently no effective medical treatment for temporomandibular joint osteoarthritis(TMJ-OA) due to a limited understanding of its pathogenesis. This study was undertaken to investigate the key role of transforming growth factor-β(TGF-β)signalling in the cartilage and subchondral bone of the TMJ using a temporomandibular joint disorder(TMD) rat model, an ageing mouse model and a Camurati–Engelmann disease(CED) mouse model. In the three animal models, the subchondral bone phenotypes in the mandibular condyles were evaluated by μCT, and changes in TMJ condyles were examined by TRAP staining and immunohistochemical analysis of Osterix and p-Smad2/3. Condyle degradation was confirmed by Safranin O staining, the Mankin and OARSI scoring systems and type X collagen(Col X), p-Smad2/3 a and Osterix immunohistochemical analyses. We found apparent histological phenotypes of TMJ-OA in the TMD, ageing and CED animal models, with abnormal activation of TGF-βsignalling in the condylar cartilage and subchondral bone. Moreover, inhibition of TGF-β receptor I attenuated TMJ-OA progression in the TMD models. Therefore, aberrant activation of TGF-β signalling could be a key player in TMJ-OA development. | Liwei Zheng Caixia Pi Jun Zhang Yi Fan Chen Cui Yang Zhou Jianxun Sun Quan Yuan Xin Xu Ling Ye Xu Cao Xuedong Zhou | 2018 | Bone Research2018，6，4： | 13 |
| 4 | Enrichment of putative human epidermal stem cells based on cell size and collagen type IV adhesiveness显示文摘人的表皮的干细胞(EpSCs ) 的丰富和鉴定具有为基本研究和临床的申请的首要的重要性。尽管为 EpSCs 的丰富的几条途径被建立了,充实可行 EpSCs 的一张纯人口仍然是一项挑战性的任务。一条改进途径值得发展提高 EpSCs 的纯净和生存能力。这里,我们报导那种房间尺寸与骨胶原类型 IV 粘着性结合了能在一条改进途径被使用充实纯、可行的人的 EpSCs。我们分开了很快支持者 keratinocytes 进从 5-7 microm (人口 A )在尺寸 的三张人口到 7-9 microm (人口 B ),到>或在直径的 =9 microm (人口 C ),并且发现人的通常认为的 EpSCs 能进一步与最小的尺寸在人口 A 被充实。在三张人口之中,人口 A 显示了 beta1-integrin 受体的最高的密度,在 G0/G1 阶段包含了房间的最高的百分比,显示出最高的原子核到细胞质比率,并且拥有了最高的殖民地形成效率(CFE ) 。当注入了鼠科的胚囊时,这些房间参予了多织物形成。与根据 beta1-integrin 抗体染色排序通常认为的 EpSCs 的一条以前的途径相比,更显著地, EpSCs 的生存能力由改进途径充实显著地被提高。我们的结果为人的 EpSCs 的丰富提供通常认为的策略,并且在干细胞生物学鼓励进一步的学习进房间尺寸的角色。 | Juxue Li Chenglin Miao Welxiang Guo Liwei Jia Jiaxi Zhou Baohua Ma Sha Peng Shuang Liu Yujing Cao Enkui Duan | 2008 | Cell Research2008，18，3： | 8 |
| 5 | Up-regulation of miR-139-5p protects diabetic mice from liver tissue damage and oxidative stress through inhibiting Notch signaling pathway显示文摘The occurrence and development of diabetes seriously threaten the health of patients.Therefore,the mechanism exploration of diabetes is of great significance for more effective control of this disease.In this study,we aimed to investigate the regulatory mechanism of miR-139-5p and Notch signaling pathway on liver damage and oxidative stress in diabetic mice.The mouse model of diabetes was established,and the mice were divided into normal group,model group,negative control(NC)group,miR-139-5p mimic group,miR-139-5p inhibitor group,DAPT group,and miR-139-5p inhibitor+DAPT group.The mRNA expressions of miR-139-5p,Notchl,Jaggedl,and NICD1,and the protein expressions of Notchl,Jaggedl,and NICD1 were detected.In addition,HepG2 cells were cultured for high glucose induction,and cell cycle distribution and apoptosis were detected by flow cytometry.The results showed that the body weights of mice in the model,NC,miR-139-5p mimic,miR-139-5p inhibitor,DAPT,and miR-139-5p inhibitor+DAPT groups were all lower than that in the normal group.Co-localization of miR-139-5p and Notchl was observed in the fluorescence in situ hybridization assay,and miR-139-5p was found to negatively regulate Notch!Furthermore,reduced blood glucose level and inhibited liver oxidative stress were observed in mice with miR-139-5p overexpression or DAPT treatment.DAPT treatment reversed the increase of blood glucose level and oxidative stress injury caused by miR-139-5p silencing.In conclusion,upregulation of miR-139-5p expression can protect liver tissue from oxidative stress injury in diabetic mice,and its mechanism may be related to the inhibition of Notch signaling pathway. | Hua Wei Liwei Huang Fenghua Wei Guangzhi Li Bin Huang Jun Li Cong Cao | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 3 |
| 6 | Facile preparation of organometallic perovskite films and high-efficiency solar cells using solid-state chemistry显示文摘有机金属的基于 perovskite 的太阳能电池的力量变换效率在最近的年里暴涨。集中的努力被作了准备定制到各种各样的设备配置的高质量的 perovskite 电影。平面异质接面设备完成了记录效率;然而,为平面连接设备的 perovskite 电影的准备要求昂贵的真空设备的使用或试验性的条件的好控制。这里,我们表明 perovskite 电影的灵巧的准备用固态化学。固态先锋 CH 的薄电影 < 潜水艇 class= “ a-plus-plus ” > 3 NH < 潜水艇 class= “ a-plus-plus ” > 3 我和 PbI < 潜水艇 class= “ a-plus-plus ” > 2 被带进与对方的接触并且允许经由热地加速的散开反应。产生 perovskite 电影显示好光吸收和光滑的形态学。基于这些,电影显示出的太阳能电池 8.7% 的平均效率和 10% 的最大的效率。固态有机金属的 perovskite 的合成能也在灵活塑料底层上被执行。与 3.2% 的效率用 PET/ITO 底层上的这个方法生产设备。不同于为有机金属的 perovskite 电影的存在合成方法,固态反应方法不要求直角的溶剂或反应条件的小心的调整的使用,并且以后因此为大量生产显示出好潜力。 | Lei Chen Feng Tang Yixin Wang Shan Gao Weiguo Cao Jinhua Cai Liwei Chen | 2015 | Nano Research2015，8，1： | 2 |
| 7 | Leptin induces CD40 expression through the activation of AKT in mumne dendritic cells显示文摘 | Queenie Lai Kwan Lam Liwei Lu Bo-Jian Zheng Dong-Yan Jin Xuetao Cao | 2007 | The Journal of Biological Chemistry2007，，： | 1 |
| 8 | Fluid simulation of internal leakage for continuous rotary electro-hydraulic servo motor显示文摘The internal leakage has important influence on low speed performance of continuous rotary electro-hydraulic motors,and research on internal leakage is of important significance to improve the motor low speed performance. UG software is adopted to establish a flow field inside a motor,which ignores the gap between the blade and the blade groove,and a motor fluid model in different working conditions is established. Using ICEM-CFD to generate high-quality O-Net mesh for meeting the computing requirements,the flow field inside the motor is simulated using fluid simulation software CFX. Applying reasonable boundary conditions and then solving it,pressure field distribution and the variation rule of internal leakage with different pressure difference in the flow field are obtained when the clearance value of the motor key components is 0.01 mm. At the same time the motor's leakage experiment has also been done to verify the validity of the simulation results,which lays a foundation for the study of motor internal leakage effect on the low speed performance. | 王晓晶 Zhang Mengjian Man Guojia Cao Jian Xiu Liwei | 2016 | High Technology Letters2016，22，4： | 1 |
| 9 | Influence of crack surface friction on crack initiation and propagation: A numerical investigation based on extended finite element method显示文摘 | Yousheng Xie Ping Cao Jie Liu Liwei Dong | 2015 | Computers and Geotechnics2015，，： | 1 |
| 10 | 8-Phenyl-(4-oxy-acetic acid N-hydroxysuccinimidyl ester)-d, 4- difluoro-1 ,3,5,7-tetramethyl-44-bora-3a, 4a-diaza-s-indacence as a new highly fluorescent-derivatizing reagent for aliphatic amines in disease-related samples with high-performance liquid chromatography显示文摘 | JINSHU LI HONG WANG LIWEI CAO | 2006 | Talanta2006，69，5： | 1 |
| 11 | Tetrahedral framework nucleic acids promote the biological functions and related mechanism of synovium-derived mesenchymal stem cells and show improved articular cartilage regeneration activity in situ显示文摘Many recent studies have shown that joint-resident mesenchymal stem cells(MSCs)play a vital role in articular cartilage(AC)in situ regeneration.Specifically,synovium-derived MSCs(SMSCs),which have strong chondrogenic differentiation potential,may be the main driver of cartilage repair.However,both the insufficient number of MSCs and the lack of an ideal regenerative microenvironment in the defect area will seriously affect the regeneration of AC.Tetrahedral framework nucleic acids(tFNAs),notable novel nanomaterials,are considered prospective biological regulators in biomedical engineering.Here,we aimed to explore whether tFNAs have positive effects on AC in situ regeneration and to investigate the related mechanism.The results of in vitro experiments showed that the proliferation and migration of SMSCs were significantly enhanced by tFNAs.In addition,tFNAs,which were added to chondrogenic induction medium,were shown to promote the chondrogenic capacity of SMSCs by increasing the phosphorylation of Smad2/3.In animal models,the injection of tFNAs improved the therapeutic outcome of cartilage defects compared with that of the control treatments without tFNAs.In conclusion,this is the first report to demonstrate that tFNAs can promote the chondrogenic differentiation of SMSCs in vitro and enhance AC regeneration in vivo,indicating that tFNAs may become a promising therapeutic for AC regeneration. | Liwei Fu Pinxue Li Junyao Zhu Zhiyao Liao Cangjian Gao Hao Li Zhen Yang Tianyuan Zhao Wei Chen Yu Peng Fuyang Cao Chao Ning Xiang Sui Quanyi Guo Yunfeng Lin Shuyun Liu | 2022 | Bioactive Materials2022，7，3： | 1 |
| 12 | Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-κB pathways显示文摘 | Qiuyan Liu Taoyong Chen Guoyou Chen Xiaoli Shu Anna Sun Pengcheng Ma Liwei Lu Xuetao Cao | 2006 | Molecular Immunology2006，，10： | 1 |
| 13 | Gas Sensitivity of In0.3Ga0.7As Surface QDs Coupled to Multilayer Buried QDs显示文摘A detailed analysis of the electrical response of In0.3Ga0.7As surface quantum dots(SQDs)coupled to 5-layer buried quantum dots(BQDs)is carried out as a function of ethanol and acetone concentration while temperature-dependent photoluminescence(PL)spectra are also analyzed.The coupling structure is grown by solid source molecular beam epitaxy.Carrier transport from BQDs to SQDs is confirmed by the temperature-dependent PL spectra.The importance of the surface states for the sensing application is once more highlighted.The results show that not only the exposure to the target gas but also the illumination affect the electrical response of the coupling sample strongly.In the ethanol atmosphere and under the illumination,the sheet resistance of the coupling structure decays by 50%while it remains nearly constant for the reference structure with only the 5-layer BQDs but not the SQDs.The strong dependence of the electrical response on the gas concentration makes SQDs very suitable for the development of integrated micrometer-sized gas sensor devices. | Guodong WANG Zengguang LIU Junjun WANG Yingli YANG Xiaolian LIU Xinran ZHANG Liwei ZHANG Guohua CAO | 2020 | Photonic Sensors2020，10，3： | 1 |
| 14 | Selective induction heating for MEMS packaging and fabrication显示文摘 | Andrew Cao Liwei Lin | 2001 | Proceedings of 2001 ASME2001，，： | 1 |
| 15 | Ni2P Nanosheets:A High Catalytic Activity Platform for Electrochemical Detection of Acetaminophen显示文摘Main observation and conclusion Accurate determination of acetaminophen concentration is essential for studying the metabolic status of acetaminophen in clinical practice.In this study,nickel phosphide was used for electrochemical detection of acetaminophen for the first time. | Ming Wei Wenbo Lu Guoqin Liu Yimin Jiang Xuebo Liu Liwei Bai Xiaowei Cao Jianfeng Jia Haishun Wu | 2021 | Chinese Journal of Chemistry2021，39，7： | 1 |
| 16 | 8-Phenyl-( 4-oxy-acetic acid N-hydroxysuccinimidyl ester )-4,4-difluoro-1, 3 , 5 , 7-tetramethyl-4-4-bora-3a, 4a-diaza-s-indacence as a new highly fluorescent-derivatizing reagent foraliphatic amines in disease-related samples with high-performance liquid chromatography 显示文摘 | JINSHU LI HONG WANG LIWEI CAO | 2006 | Talanta2006，69，5： | 1 |
| 17 | Fault-Tolerant Routing Algorithm for Network-on-Chip Based on Dynamic XY Routing显示文摘In order to ensure the reliability of network-on-chip(NoC) under faulty circumstance,a dynamic fault tolerant routing algorithm is proposed.This algorithm can implement detour routing when there are both static and dynamic permanent faults in the network.That means the packet is able to move around the faults to the destination with a non-minimum path.In addition,the multilevel congestion control mechanism gives the algorithm the ability to distribute the load over the whole network and to avoid hotspots around the faults.Simulation results demonstrate the advantage of the proposed routing algorithm in terms of average packet latency and packet loss rate compared with negative-first routing algorithm and DyAD routing algorithm in the presence of permanent faults.For the proposed algorithm,it can get much less average packet latency and lead to less than 20% packet loss rate. | LI Xiaohui CAO Yang WANG Liwei CAI Tian | 2009 | Wuhan University Journal of Natural Sciences2009，14，4： | 1 |
| 18 | Simultaneous Enhancement of Open‐Circuit Voltage, Short‐Circuit Current Density, and Fill Factor in Polymer Solar Cells显示文摘 | Zhicai He Chengmei Zhong Xun Huang Wai‐Yeung Wong Hongbin Wu Liwei Chen Shijian Su Yong Cao | 2011 | Adv Mater2011，，40： | 1 |
| 19 | Deep learning model improves radiologists'performance in detection and classification of breast lesions显示文摘Objective:Computer-aided diagnosis using deep learning algorithms has been initially applied in the field of mammography,but there is no large-scale clinical application.Methods:This study proposed to develop and verify an artificial intelligence model based on mammography.Firstly,mammograms retrospectively collected from six centers were randomized to a training dataset and a validation dataset for establishing the model.Secondly,the model was tested by comparing 12 radiologists’performance with and without it.Finally,prospectively enrolled women with mammograms from six centers were diagnosed by radiologists with the model.The detection and diagnostic capabilities were evaluated using the freeresponse receiver operating characteristic(FROC)curve and ROC curve.Results:The sensitivity of model for detecting lesions after matching was 0.908 for false positive rate of 0.25 in unilateral images.The area under ROC curve(AUC)to distinguish the benign lesions from malignant lesions was0.855[95%confidence interval(95%CI):0.830,0.880].The performance of 12 radiologists with the model was higher than that of radiologists alone(AUC:0.852 vs.0.805,P=0.005).The mean reading time of with the model was shorter than that of reading alone(80.18 s vs.62.28 s,P=0.032).In prospective application,the sensitivity of detection reached 0.887 at false positive rate of 0.25;the AUC of radiologists with the model was 0.983(95%CI:0.978,0.988),with sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of94.36%,98.07%,87.76%,and 99.09%,respectively.Conclusions:The artificial intelligence model exhibits high accuracy for detecting and diagnosing breast lesions,improves diagnostic accuracy and saves time. | Yingshi Sun Yuhong Qu Dong Wang Yi Li Lin Ye Jingbo Du Bing Xu Baoqing Li Xiaoting Li Kexin Zhang Yanjie Shi Ruijia Sun Yichuan Wang Rong Long Dengbo Chen Haijiao Li Liwei Wang Min Cao | 2021 | Chinese Journal of Cancer Research2021，33，6： | 1 |
| 20 | Suppression of LjBAK1-mediated immunity by SymRK promotes rhizobial infection in Lotus japonicus.显示文摘An important question in biology is how organisms can associate with different microbes that pose no threat (commensals), pose a severe threat (pathogens) and those that are beneficial (symbionts). The root nodule symbiosis serves as important model system to address such questions in the context of plant-microbe interactions. It is now generally accepted that rhizobia have the abilities to actively suppress host immune responses during the infection process, analogous to the way in which plant pathogens can evade immune recognition. However, much remains to be elucidated with regard to the mechanisms by which the host recognizes the rhizobia as pathogens and how, subsequently, these pathways are suppressed to allow establishment of the nitrogen fixing symbiosis. In this study, we found that SymRK (Symbiosis Receptor-like Kinase) is required for rhizobial suppression of plant innate immunity in Lotus japonicus. SymRK associates with LjBAK1 (BRASSINOSTEROID INSENSITIVE 1-Associated receptor Kinase 1), a well characterized, positive regulator of plant innate immunity, and directly inhibits LjBAK1 kinase activity. Rhizobial inoculation enhances the association between SymRK and LjBAK1 in planta. LjBAK1 is required to regulate plant innate immunity and plays a negative role in mediating rhizobial infection in L. japonicus. The data indicate that the protein complex of SymRK-LjBAK1 serves as an intersection point between rhizobial symbiotic signaling pathways and innate immunity pathways, which provides an evidence that rhizobia might actively suppress the host's ability to mount a defense response in the legume-rhizobium symbiosis. | Yong Feng Ping Wu Chao Liu Liwei Peng Tao Wang Chao Wang Qian Tan Bixuan Li Yajuan Ou Hui Zhu Songli Yuan Renliang Huang Gary Stacey Zhongming Zhang Yangrong Cao | 2021 | Molecular Plant2021，14，11： | 0 |
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