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| 1 | Mechanically induced Ca^(2+) oscillations in osteocytes release extracellular vesicles and enhance bone formation显示文摘The vast osteocytic network is believed to orchestrate bone metabolic activity in response to mechanical stimuli through production of sclerostin, RANKL, and osteoprotegerin(OPG). However, the mechanisms of osteocyte mechanotransduction remain poorly understood. We've previously shown that osteocyte mechanosensitivity is encoded through unique intracellular calcium (Ca^(2+) ) dynamics. Here, by simultaneously monitoring Ca^(2+) and actin dynamics in single cells exposed to fluid shear flow, we detected actin network contractions immediately upon onset of flow-induced Ca^(2+) transients, which were facilitated by smooth muscle myosin and further confirmed in native osteocytes ex vivo. Actomyosin contractions have been linked to the secretion of extracellular vesicles(EVs), and our studies demonstrate that mechanical stimulation upregulates EV production in osteocytes through immunostaining for the secretory vesicle marker Lysosomal-associated membrane protein 1(LAMP1) and quantifying EV release in conditioned medium, both of which are blunted when Ca^(2+) signaling was inhibited by neomycin. Axial tibia compression was used to induce anabolic bone formation responses in mice, revealing upregulated LAMP1 and expected downregulation of sclerostin in vivo. This load-related increase in LAMP1 expression was inhibited in neomycin-injected mice compared to vehicle.Micro-computed tomography revealed significant load-related increases in both trabecular bone volume fraction and cortical thickness after two weeks of loading, which were blunted by neomycin treatment. In summary, we found mechanical stimulation of osteocytes activates Ca^(2+) -dependent contractions and enhances the production and release of EVs containing bone regulatory proteins. Further, blocking Ca^(2+) signaling significantly attenuates adaptation to mechanical loading in vivo, suggesting a critical role for Ca^(2+) -mediated signaling in bone adaptation. | Andrea E.Morrell Genevieve N.Brown Samuel T.Robinson Rachel L.Sattler Andrew D.Baik Gehua Zhen Xu Cao Lynda F.Bonewald Weiyang Jin Lance C.Kam X.Edward Guo | 2018 | Bone Research2018，6，1： | 13 |
| 2 | Current Status and Future Challenges of Weather Radar Polarimetry: Bridging the Gap between Radar Meteorology/Hydrology/Engineering and Numerical Weather Prediction显示文摘After decades of research and development, the WSR-88 D(NEXRAD) network in the United States was upgraded with dual-polarization capability, providing polarimetric radar data(PRD) that have the potential to improve weather observations,quantification, forecasting, and warnings. The weather radar networks in China and other countries are also being upgraded with dual-polarization capability. Now, with radar polarimetry technology having matured, and PRD available both nationally and globally, it is important to understand the current status and future challenges and opportunities. The potential impact of PRD has been limited by their oftentimes subjective and empirical use. More importantly, the community has not begun to regularly derive from PRD the state parameters, such as water mixing ratios and number concentrations, used in numerical weather prediction(NWP) models.In this review, we summarize the current status of weather radar polarimetry, discuss the issues and limitations of PRD usage, and explore potential approaches to more efficiently use PRD for quantitative precipitation estimation and forecasting based on statistical retrieval with physical constraints where prior information is used and observation error is included. This approach aligns the observation-based retrievals favored by the radar meteorology community with the model-based analysis of the NWP community. We also examine the challenges and opportunities of polarimetric phased array radar research and development for future weather observation. | Guifu ZHANG Vivek N.MAHALE Bryan J.PUTNAM Youcun QI Qing CAO ANDrew D.BYRD Petar BUKOVCIC Dusan S.ZRNIC Jidong GAO Ming XUE Youngsun JUNG Heather D.REEVES Pamela L.HEINSELMAN AlexANDer RYZHKOV Robert D.PALMER Pengfei ZHANG Mark WEBER Greg M.MCFARQUHAR Berrien MOORE III Yan ZHANG Jian ZHANG J.VIVEKANANDAN Yasser AL-RASHID Richard L.ICE Daniel S.BERKOWITZ Chong-chi TONG Caleb FULTON Richard J.DOVIAK | 2019 | Advances in Atmospheric Sciences2019，36，6： | 9 |
| 3 | Initiation of Parkinson’s disease from gut to brain byδ-secretase显示文摘Lewy pathology,composed ofα-Synuclein(α-Syn)inclusions,a hallmark of Parkinson’s disease(PD),progressively spreads from the enteric nervous system(ENS)to the central nervous system(CNS).However,it remains unclear how this process is regulated at a molecular level.Here we show thatδ-secretase(asparagine endopeptidase,AEP)cleaves bothα-Syn at N103 and Tau at N368,and mediates their fibrillization and retrograde propagation from the gut to the brain,triggering nigra dopaminergic neuronal loss associated with Lewy bodies and motor dysfunction.α-Syn N103 and Tau N368 robustly interact with each other and are highly elevated in PD patients’gut and brain.Chronic oral administration of the neurotoxin rotenone induces AEP activation andα-Syn N103/Tau N368 complex formation in the gut,eliciting constipation and dopaminergic neuronal death in an AEP-dependent manner.Preformed fibrils(PFFs)ofα-Syn N103/Tau N368 are more neurotoxic and compact,and aggregate more quickly along the vagus nerve than their FL/FL counterparts or the individual fragments’fibrils.Colonic injection of PFFs induces PD pathologies,motor dysfunctions,and cognitive impairments.Thus,δ-secretase plays a crucial role in initiating PD pathology progression from the ENS to the CNS. | Eun Hee Ahn Seong Su Kang Xia Liu Guiqin Chen Zhentao Zhang Bindu Chandrasekharan Ashfaqul M.Alam Andrew S.Neish Xuebing Cao Keqiang Ye | 2020 | Cell Research2020，30，1： | 9 |
| 4 | Fructus Broussonetae extract improves cognitive function and endoplasmic reticulum stress in Alzheimer's disease models显示文摘This study investigated the effects and possible targets of Fructus Broussonetiae extract,a traditional Chinese medicinal herb,on a model of Alzheimer's disease induced by beta-amyloid peptide 25-35 and D-galactose.The results revealed that intragastric administration of Fructus Broussonetiae significantly increased the expression of immunoglobulin-binding protein,a key factor in the endoplasmic reticulum stress-signaling pathway in rat hippocampus.In contrast,the treatment significantly decreased expression levels of PKR-like endoplasmic reticulum kinase and C/EBP homologous protein,and substantially improved learning,memory and spatial recognition dysfunction in rats.This evidence indicates that Fructus Broussonetiae extract improves spatial learning and memory abilities in rats by affecting the regulation of hippocampal endoplasmic reticulum stress and activation of the apoptosis pathway. | Yinghong Li Li Hu Zhengzhi Wu Zhiling Yu Meiqun Cao Kehuan Sun Yu Jin Anmin Wu Andrew CJ Huang | 2011 | Neural Regeneration Research2011，6，30： | 7 |
| 5 | Therapeutic Advances in Pancreatic Cancer显示文摘 | Andrew Scott Paulson Hop S. Tran Cao Margaret A. Tempero Andrew M. Lowy | 2013 | Gastroenterology2013，，6： | 4 |
| 6 | Mobility in China,2020:a tale of four phases显示文摘2020 was an unprecedented year;with rapid and drastic changes in human mobility due to the COVID-19 pandemic.To understand the variation in commuting patterns among the Chinese population across stable and unstable periods,we used nationwide mobility data from 318 million mobile phone users in China to examine the extreme fluctuations of population movements in 2020,ranging from the Lunar New Year travel season(chunyun),to the exceptional calm of COVID-19 lockdown,and then to the recovery period.We observed that cross-city movements;which increased substantially in chunyun and then dropped sharply during the lockdown,are primarily dependent on travel distance and the socio-economic development of cities.Following the Lunar New Year holiday,national mobility remained low until mid-February,and COVID-19 interventions delayed more than 72.89 million people returning to large cities.Mobility network analysis revealed clusters of highly connected cities,conforming to the social-economic division of urban agglomerations in China.While the mass migration back to large cities was delayed,smaller cities connected more densely to form new clusters.During the recovery period after travel restrictions were lifted,the netflows of over 55%city pairs reversed in direction compared to before the lockdown.These findings offer the most comprehensive picture of Chinese mobility at fine resolution across various scenarios in China and are of critical importance for decision making regarding future public-health-emergency response,transportation planning and regional economic development,among others. | Suoyi Tan Shengjie Lai Fan Fang Ziqiang Cao Bin Sai Bing Song Bitao Dai Shuhui Guo Chuchu Liu Mengsi Cai Tong Wang Mengning Wang Jiaxu Li Saran Chen Shuo Qin Jessica R.Floyd Zhidong Cao Jing Tan Xin Sun Tao Zhou Wei Zhang Andrew J.Tatem Petter Holme Xiaohong Chen Xin Lu | 2021 | National Science Review2021，8，11： | 3 |
| 7 | Ecology of industrial pollution in China显示文摘Industrial development has brought China both opportunities and challenges since the reform and opening up in 1978.Spatial and temporal analysis showed that rapid industrialization has made eastern China under a more serious pollution stress.The most serious effects of industrial pollution were reflected in aquatic and soil ecosystem degradation,and damage can be observed from species,population,and community to ecosystem level.Public consciousness about contaminated sites rose from 2004 leading to greater efforts in ecological remediation,monitoring,and risk governance.Considerable efforts are still needed in expanding the extent and breadth of monitoring to explore where the greatest ecological risks lie and how to control them.Ecology of industrial pollution has become a popular discipline in China and will be further developed to help achieve the Sustainable Development Goals.Future research for a better ecological risk management should be focused on multi-media transfer and effects of mixed pollutants,mechanisms for clean energy and material flow,and integration of ecological risk with human health risk. | Jingjing Yuan Yonglong Lu Chenchen Wang Xianghui Cao Chunci Chen Haotian Cui Meng Zhang Cong Wang Xiaoqian Li Andrew C.Johnson Andrew J.Sweetman Di Du | 2020 | Ecosystem Health and Sustainability2020，6，1： | 2 |
| 8 | L-cysteineassisted synthesis and optical properties of Ag2S nanospheres 显示文摘 | XIANG Junhua CAO Huaqiang ANDREW A R W | 2008 | J Plays Chem C2008，112，： | 1 |
| 9 | Degradation kinetics and N-Nitrosodimethylamine formation during monochloramination of chlortoluron显示文摘 | Bin Xu Cao Qin Chen-Yan Hu Yi-Li Lin Sheng-Ji Xia Qian Xu Seleli Andrew Mwakagenda Xiang-yu Bi Nai-Yun Gao | 2011 | Science of the Total Environment2011，，： | 1 |
| 10 | Cooperative Mobile Robotics: Antecedents and Directions显示文摘 | Y. Uny Cao Alex S. Fukunaga Andrew Kahng | 1997 | Autonomous Robots1997，，1： | 1 |
| 11 | Sulfur (S)-induced enhancement of iron plaque formation in the rhizosphere reduces arsenic accumulation in rice ( Oryza sativa L.) seedlings显示文摘 | Zheng-Yi Hu Yong-Guan Zhu Min Li Li-Gan Zhang Zhi-Hong Cao F. Andrew Smith | 2006 | Environmental Pollution2006，，2： | 1 |
| 12 | Stability of Cohen-Grossbery neural network via nonsmooth analysis显示文摘 | Huang T W Andrew Chan Y Huang J D Cao | 2007 | Neural networks2007，，20： | 1 |
| 13 | Finite element formulation of slender structures with shear deformation based on the Cosserat theory显示文摘 | Dongsheng Liu D.Q. Cao Richard Rosing Charles H.-T. Wang Andrew Richardson | 2007 | International Journal of Solids and Structures2007，，24： | 1 |
| 14 | Optimal Utilization of Donor Grafts With Extended Criteria: A Single-Center Experience in Over 1000 Liver Transplants显示文摘 | Andrew M. Cameron R Mark Ghobrial Hasan Yersiz Douglas G. Farmer Gerald S. Lipshutz Sherilyn A. Gordon Michael Zimmerman Johnny Hong Thomas E. Collins Jeffery Gornbein Farin Amersi Michael Weaver Carlos Cao Tony Chen Jonathan R. Hiatt Ronald W. Busuttil | 2006 | Annals of Surgery2006，，6： | 1 |
| 15 | USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma显示文摘 | Samuel A. Williams Heather L. Maecker Dorothy M. French Jinfeng Liu Andrew Gregg Leah B. Silverstein Tim C. Cao Richard A.D. Carano Vishva M. Dixit | 2011 | Cell2011，，6： | 1 |
| 16 | Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome显示文摘 | Koup R A Safrit J A Cao y Andrews C A McLeod G Borkowsky W Farthing C Ho D D | 1994 | J virol1994，68，： | 1 |
| 17 | Removal of heavy metals from aqueous solution by biochars derived from anaerobically digested biomass显示文摘 | Mandu Inyang Bin Gao Ying Yao Yingwen Xue Andrew R. Zimmerman Pratap Pullammanappallil Xinde Cao | 2012 | Bioresource Technology2012，，： | 1 |
| 18 | Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project显示文摘 | Bimey E Stamatoyannopoulos J.A Dutta A Guig6 R Gingeras T.R Margulies E.H Weng Z Snyder M Dermitzakis E.T Thurman R.E Kuehn M.S Taylor C.M Neph S Koch C.M Asthana S Malhotra A Adzhubei I Greenbaum J.A Andrews R.M Flicek P Boyle P.J Cao H Carter N.P Clella | | 0，，： | 1 |
| 19 | Carbon nanotube toughened aluminium oxide nanocomposite显示文摘 | Iftikhar Ahmad Hongzhi Cao Huahui Chen Huiyou Zhao Andrew Kennedy Yan Qiu Zhu | 2009 | Journal of the European Ceramic Society2009，，4： | 1 |
| 20 | Stability of Cohen-Grossbery neural network vianonsmooth analysis 显示文摘 | Huang T W Andrew Chan Huang Y Cao J D | 2007 | Neural Networks2007，，20： | 1 |
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