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| 1 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 2 | Petrogenesis and tectonic setting of the Queershan composite granitic pluton, eastern Tibetan Plateau: Constraints from geochronology, geochemistry and Hf isotope data显示文摘The Queershan composite granitic pluton is located in the north of the late Paleozoic Yidun arc collision-orogenic belt, eastern Tibetan Plateau. The main rock types are coarse-grained porphyritic alkalic-monzonite granite with minor fine-grained porphyritic monzogranite and granodiorite distributed in the eastern and southwestern regions. Here we report their zircon U-Pb ages and geo- chemical data. The intrusive contact relations indicate that granodiorite was formed earlier than the alkalic-monzonite granite(105.9±1.3 Ma) and monzogranite(102.6±1.1 Ma). These suggest that the Queershan composite granitic pluton was formed through three-stage magmatic events. The alkalic-monzonite granite(105.9±1.3 Ma) and monzogranite(102.6±1.1 Ma) are characterized by high SiO2(73.5%–77.7%), K2O+Na2O(6.9%–8.5%), Ga/Al ratios(2.6–3.4) and low Al2O3(11.8%–14.5%), CaO(0.25%–1.5%), MgO(0.18%–0.69%), negative Ba, Sr and Eu anomalies, showing A-type granite affinities. The granodiorite exhibits lower SiO2, P2O5 and K2O+Na2O contents, but higher Al2O3, CaO and MgO contents than alkalic-monzonite granite and monzogranite, showing I-type granite affinity. 176Hf/177 Hf ratios of the alkalic-monzonite granite and the monzogranite are 0.282692–0.282749 and 0.282685–0.282765, respectively, and with similar ?Hf(t) values(?0.56 to 1.43 and ?0.87 to 1.90 respectively). They also present similar TDM2 model ages(1.04–1.22 and 1.07–1.2 Ga respectively), indicating they may be sourced from a similar rock source, mostly like Kangding Complex. The homogeneity of the Hf isotopic compositions and the absence of the MMEs demonstrate that little depleted mantle materials have contributed to the source. We propose that the Mesoproterozoic crust materials of the Yangtze Craton exist beneath the Yidun arc terrane and support it was a dismembered part of the Yangtze Craton. The A-type granites of Queershan composite granitic pluton are most probably related to the closure of the Bangong-Nujiang Tethys ocean. | WU Tao XIAO Long GAO Rui YANG HaiJun YANG Gang | 2014 | Science China Earth Sciences2014，57，11： | 5 |
| 3 | Patients with SARS-CoV-2 and HBV coinfection are at risk of greater liver injury显示文摘To date,it remains unclear if severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)co-infection exacerbates liver injury in patients with chronic hepatitis B virus(HBV)infection.In this study,we present a retrospective study of 133 hospitalized confirmed mild coronavirus disease 2019(COVID-19)cases,including 116 patients with COVID-19 with negative serum hepatitis B antigen and 17 HBV inactive carriers with COVID-19.We found that there were no significant differences for the discharge rate or duration of hospitalization be-tween the two groups.However,inactive HBV carriers with SARS-CoV-2 co-infection are at a higher risk of abnormal liver function tests.The enhanced liver injury induced by SARS-CoV-2 and HBV co-infection was identified as the hepatocyte type rather than the cholangiocyte type.Moreover,the inflammatory response,including abnormal lactate dehydrogenase,D-dimer and interleukin-6 production,may contribute to this injury following SARS-CoV-2 co-infection.Collectively,SARS-CoV-2 and HBV co-infection exacerbates liver function of the pa-tients with COVID-19. | Yong Lin Jun Yuan Quanxin Long Jieli Hu Haijun Deng Zhenyu Zhao Juan Chen Mengji Lu Ailong Huang | 2021 | Genes & Diseases2021，8，4： | 5 |
| 4 | Effects of octacosanol extracted from rice bran on blood hormone levels and gene expressions of glucose transporter protein-4 and adenosine monophosphate protein kinase in weaning piglets显示文摘The object of this study was to explore the regulatory mechanism of octacosanol to the body of animals and the effects of octacosanol on blood hormone levels and gene expressions of glucose transporter protein(GLUT-4) and adenosine monophosphate protein kinase(AMPK) in liver and muscle tissue of weaning piglets. A total of 105 crossbred piglets([Yorkshire x Landrace] x Duroc) with an initial BW of5.70 ± 1.41 kg(21 d of age) were used in a 6-wk trial to evaluate the effects of octacosanol and tiamulin supplementation on contents of triiodothyronine(T3),thyroxine(T4),growth hormone(GH),glucagon(GU) and adrenaline(AD) in blood and gene expressions of GLUT-4 and AMPK in liver and muscle. Piglets were randomly distributed into 3 dietary treatments on the basis of BW and sex. Each treatment had 7 replicate pens with 5 piglets per pen. Treatments were as followed: control group, tiamulin group and octacosanol group. The results showed that compared with control group and tiamulin group, octacosanol greatly promoted the secretion of T3, GH, GU and AD(P < 0.01) and significantly up-regulated the gene expressions of GLUT-4 and AMPK in muscle and liver tissues(P < 0.05). There was no significant difference between the control group and tiamulin group in T3, T4, GH,GU or AD(P> 0.05), Results of the present study has confirmed that octacosanol affects energy metabolism of body by regulating secretion of blood hormones and related gene expression in tissue of weaning piglets, which can reduce stress response and has an impact on performance. | Lei Long Shugeng Wu Jing Sun Jing Wang Haijun Zhang Guanghai Qi | 2015 | Animal Nutrition2015，，4： | 5 |
| 5 | Can the“10-year fishing ban”rescue biodiversity of the Yangtze River?显示文摘Rivers and their lakes are among the world’smost important ecosystems supporting high biodiversity and providing various services through connections with vast landscapes.Reconciling exploitation with sustainability remains one of the world’s greatest challenges tomaintain and/or recover the health of river ecosystems and hence their biodiversity and ecosystem services.1 As one of the major national initiatives toward building“ecological civilization”and an extensive protection of the Yangtze River in China,a“10-year fishing ban”plan(TYFB)was launched from January 2021. | Haijun Wang Puze Wang Chi Xu Yanfeng Sun Lei Shi Long Zhou Erik Jeppesen Jun Chen Ping Xie | 2022 | The Innovation2022，3，3： | 1 |
| 6 | A multiphase sodium vanadium phosphate cathode material for high-rate sodium-ion batteries显示文摘The unsatisfactory rate capability and poor cycling stability at high rate of sodium-ion batteries(SIBs) have impeded their practical applications. Herein, a Na_(3)V_(2)(PO_(4))_(3)/Na_(3)V_(3)(PO_(4))_(4) multiphase cathode materials for high-rate and long cycling SIBs was successfully synthesized by regulation the stoichiometric ratio of raw materials. The combined experiment and simulation results show that the multiphase materials consisted of NASICON structural phase Na3V2(PO4)3 and layered structure phase Na_(3)V_(3)(PO_(4))_(4), possess abundant phase boundaries. Electrochemical experiments demonstrate that the multiphase materials maintain a remarkable reversible capacity of 69.0 mA h g^(-1) even at an ultrahigh current density of 100 C with a high capacity retention of 81.25 % even after 10,000 cycles. Na_(3)V_(2)(PO_(4))_(3)/Na_(3)V_(3)(PO_(4))_(4) electrode exhibits a higher working voltage, superior rate capability and better cycling stability than Na_(3)V_(2)(PO_(4))_(3) electrode, which indicates that the introduction of second phase can be an effective strategy for the development of novel cathode materials for SIBs. | Chuan Wang Hai Long Lijiao Zhou Chao Shen Wei Tang Xiaodong Wang Bingbing Tian Le Shao Zhanyuan Tian Haijun Su Keyu Xie | 2021 | Journal of Materials Science & Technology2021，，7： | 1 |
| 7 | Design of Landscape Ecological Restoration for “Five Mining Areas” of the Laoqing Mountain in the Dianchi Lake Basin显示文摘Through analyzing basic conditions of the 'five mining areas' in the Laoqing Mountain of the Dianchi Lake Basin, in Kunming City, South China, the ecological restoration design of 'integrating engineering protection and biological restoration, building the landscape ecological security pattern of the Laoqing Mountain' was proposed. Considering the different ecological functional areas, varying engineering measures, greening patterns, and irrigation means were selected for the ecological restoration, including site management, vegetation restoration, management and utilization etc.. These ecological restoration measures will produce favorable ecological benefits, and also take landscape effect and sustainable development into consideration, which will contribute to the ecological restoration of the 'five mining areas', and provide a scientific and feasible reference for the ecological restoration in China. | ZHU Guofei HU Yeqing LONG Haijun CAI Fang SHE Lihua | 2019 | Journal of Landscape Research2019，11，2： | 1 |
| 8 | Omicron adopts a different strategy from Delta and other variants to adapt to host显示文摘Dear Editor,With the ongoing of Corona Virus Disease 2019(COVID-19)epidemic,new strains of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)are continuously emerging.After Delta(B.1.617.2)identified in India,Lambda(C.37),Mu(B.1.621),and Omicron(B.1.1.529)were successively found in Peru,Colombia,and Botswana/South Africa,and subsequently defined as variant of interest(VOI)or variant of concern(VOC). | Xiaohong Du Haijun Tang Long Gao Zhao Wu Fang Meng Ruhong Yan Shigang Qiao Jianzhong An Chen Wang F.Xiao-Feng Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 9 | Influence of Biochar on Nitrogen Use Efficiency and Root Morphology of Rice-Seedling in Two Contrasting Paddy Soils显示文摘Biochar may affect the root morphology and nitrogen(N)use efficiency(NUE)of rice at seedling stage,which has not been clearly verified until now.To clarify it,we conducted a pot experiment regarding to two soil types(Hydragric Anthrosol and Haplic Acrisol),two biochar application rates(0.5 wt%and 1.5 wt%)and two rice varieties(common rice var.Xiushui134 and hybrid super rice var.Zhongkejiayou12-6)meanwhile.Seedling NUE of common rice Xiuhui134 was significantly increased(p<0.05)by 78.2%in Hydragric Anthrosol and by 91.4%in Haplic Acrisol following biochar addition with 1.5 wt%.However,biochar addition exerted no influence on seedling NUE of super rice Zhongkejiayou12-6 in both soils.Overall,0.09–0.10 units higher soil pH and 105–116%higher soil NH_(4)^(+)-N were observed in Xiushui134 growing two soils with 1.5 wt%biochar.In addition,improved root morphology(including longer root length,larger root surface area,bigger root volume,and more root tips)contributed to the higher seedling NUE of Xiushui134 in two soils.The soil pH and NH_(4)^(+)-N content,also the root morphology were influenced by biochar,which though could not thoroughly explained the NUE of Zhongkejiayou12-6.In conclusion,biochar application to paddy soil changed soil pH and NH_(4)^(+)-N content,root growth,and the consequent seedling NUE of rice,which effects are relative with rice cultivar,biochar addition rate,and soil type. | Lei Chu Yu Zhang Long Qian Dandan Zhu Haijun Sun | 2020 | Phyton-International Journal of Experimental Botany2020，89，4： | 1 |
| 10 | Molten salt synthesis,morphology modulation,and lithiation mechanism of high entropy oxide for robust lithium storage显示文摘High entropy oxides(HEOs)with ideal element tunability and enticing entropy-driven stability have exhibited unprecedented application potential in electrochemical lithium storage.However,the general control of dimension and morphology remains a major challenge.Here,scalable HEO morphology modulation is implemented through a salt-assisted strategy,which is achieved by regulating the solubility of reactants and the selective adsorption of salt ions on specific crystal planes.The electrochemical properties,lithiation mechanism,and structure evolution of composition-and morphology-dependent HEO anode are examined in detail.More importantly,the potential advantages of HEOs as electrode materials are evaluated from both theoretical and experimental aspects.Benefiting from the high oxygen vacancy concentration,narrow band gap,and structure durability induced by the multi-element synergy,HEO anode delivers desirable reversible capacity and reaction kinetics.In particular,Mg is evidenced to serve as a structural sustainer that significantly inhibits the volume expansion and retains the rock salt lattice.These new perspectives are expected to open a window of opportunity to compositionally/morphologi cally engineer high-performance HEO electrodes. | Xuefeng Liu Honghong Wang Long Dong Kezhuo Li Haijun Zhang Quanli Jia Shaowei Zhang Wen Lei | 2023 | Journal of Energy Chemistry2023，，11： | 0 |
| 11 | Simulation on control of beam halo-chaos by power function in the hackle periodic-focusing channel显示文摘The K-V beam through a hackle periodic-focusing magnetic field is studied using the particle-core model. The beam halo-chaos is found, and a power function controller is proposed based on mechanism of halo formation and strategy of controlling halo-chaos. Multiparticle simulation was performed to control the halo by using the power function control method. The results show that the halo-chaos and its regeneration can be eliminated effectively. We also find that the radial particle density evolvement is of uniformity at the beam’s centre as long as appropriate parameters are chosen. | YU Haijun WENG Jiaqiang BAI Long | 2008 | Nuclear Science and Techniques2008，19，6： | 0 |
| 12 | Durability of Hepatitis B surface antigen seroclearance in patients experienced nucleoside analogs or interferon monotherapy: A real-world data from Electronic Health Record显示文摘Little is known about the difference in durability of HBsAg seroclearance induced by nucleoside analogs (NAs) or by interferon (IFN). A real-world, retrospective cohort study was conducted. Patients were assigned into two groups: NAs monotherapy-induced HBsAg seroclearance subjects and IFN monotherapy induced-HBsAg seroclearance subjects. A total of 198 subjects, comprised by 168 NAs monotherapy-induced and 30 IFN monotherapy-induced, who achieved HBsAg seroclearance were included in this study. The one-year probabilities of confirmed HBsAg seroclearance were significantly different in patients with NAs monotherapy and IFN monotherapy (0.960 (with 95% CI 0.922–0.999) vs. 0.691 (with 95% CI 0.523–0.913), log-rank-P = 4.04e-4). 73.3% (11 of 15) HBsAg recurrence occurred within one year after HBsAg seroclearance. The one-year probabilities of confirmed HBsAg seroclearance were higher in IFN monotherapy patients with anti-HBs than in IFN monotherapy patients without anti-HBs (0.839 (with 95% CI 0.657–1.000) vs. 0.489 (with 95% CI 0.251–0.953), log-rank test, P = 0.024). Our study thus provided novel insights into the durability of HBsAg seroclearance induced by NAs or IFN monotherapy. In particular, the HBsAg seroreversion rate was relatively high in IFN monotherapy subjects. The presence of anti-HBs was significantly correlated with a longer durability of functional cure induced by IFN treatment. And one-year follow-up in HBsAg seroclearance achieved individuals is proper for averting HBsAg seroreversion and other liver disease. | Zongqi Shi Huizhi Zheng Miaomiao Han Jieli Hu Yuan Hu Xiaosong Li Wenyan Zhu Xinjun He Haijun Deng Quanxin Long Ailong Huang | 2023 | Genes & Diseases2023，10，3： | 0 |
| 13 | Ultra Dense Satellite-Enabled 6G Networks:Resource Optimization and Interference Management显示文摘With the evolution of the sixth generation(6G)mobile communication technology,ample attention has gone to the integrated terrestrial-satellite networks.This paper notes that four typical application scenarios of integrated terrestrial-satellite networks are integrated into ultra dense satellite-enabled 6G networks architecture.Then the subchannel and power allocation schemes for the downlink of the ultra dense satellite-enabled 6G heterogeneous networks are introduced.Satellite mobile edge computing(SMEC)with edge caching in three-layer heterogeneous networks serves to reduce the link traffic of networks.Furthermore,a scheme for interference management is presented,involving quality-of-service(QoS)and co-tier/cross-tier interference constraints.The simulation results show that the proposed schemes can significantly increase the total capacity of ultra dense satellite-enabled 6G heterogeneous networks. | Xiangnan Liu Haijun Zhang Min Sheng Wei Li Saba Al-Rubaye Keping Long | 2023 | China Communications2023，20，10： | 0 |
| 14 | Structure and surface modification of MXene for efficient Li/K-ion storage显示文摘In this paper,three-dimensional(3D)hollow Ti_(3)C_(2)T_(x)MXene tubes(HTCTs)with more–O terminal groups and fewer–F groups are successfully prepared via the template-oriented electrostatic self-assembly and the subsequent annealing treatment.The obtained 3D hollow structure with large specific surface area,unique porous structure,and enlarged interlayer spacing could prevent the re-stacking of twodimensional(2D)sheets and shorten the diffusion pathway of ions.Furthermore,density functional theory(DFT)calculations and electrochemical tests reveal that Ti_(3)C_(2)O_(2)MXene possesses higher adsorption ability and lower diffusion barrier for K^(+)and Li^(+)compared to Ti_(3)C_(2)MXene dominated by–F terminal groups.Benefiting from the synergistic effect of the structural design and surface modification,the asprepared 3D HTCTs exhibit excellent electrochemical performance as anodes for K^(+)and Li^(+)storage compared with 2D Ti_(3)C_(2)T_(x)sheets(TCSs). | Keke Guan Long Dong Yingying Xing Xuke Li Jin Luo Quanli Jia Haijun Zhang Shaowei Zhang Wen Lei | 2022 | Journal of Energy Chemistry2022，，12： | 0 |
| 15 | Single-cell and spatial heterogeneity landscapes of mature epicardial cells显示文摘Tbx18,Wt1,and Tcf21 have been identified as epicardial markers during the early embryonic stage.However,the gene markers of mature epicardial cells remain unclear.Single-cell transcriptomic analysis was performed with the Seurat,Monocle,and CellphoneDB packages in R software with standard procedures.Spatial transcriptomics was performed on chilled Visium Tissue Optimization Slides(10x Genomics)and Visium Spatial Gene Expression Slides(10x Genomics).Spatial transcriptomics analysis was performed with Space Ranger software and R software.Immunofluorescence,whole-mount RNA in situ hybridization and X-gal staining were performed to validate the analysis results.Spatial transcriptomics analysis revealed distinct transcriptional profiles and functions between epicardial tissue and non-epicardial tissue.Several gene markers specific to postnatal epicardial tissue were identified,including Msln,C3,Efemp1,and Upk3b.Single-cell transcriptomic analysis revealed that cardiac cells from wildtype mouse hearts(from embryonic day 9.5 to postnatal day 9)could be categorized into six major cell types,which included epicardial cells.Throughout epicardial development,Wt1,Tbx18,and Upk3b were consistently expressed,whereas genes including Msln,C3,and Efemp1 exhibited increased expression during the mature stages of development.Pseudotime analysis further revealed two epicardial cell fates during maturation.Moreover,Upk3b,Msln,Efemp1,and C3 positive epicardial cells were enriched in extracellular matrix signaling.Our results suggested Upk3b,Efemp1,Msln,C3,and other genes were mature epicardium markers.Extracellular matrix signaling was found to play a critical role in the mature epicardium,thus suggesting potential therapeutic targets for heart regeneration in future clinical practice. | Jianlin Du Xin Yuan Haijun Deng Rongzhong Huang Bin Liu Tianhua Xiong Xianglin Long Ling Zhang Yingrui Li Qiang She | 2023 | Journal of Pharmaceutical Analysis2023，13，8： | 0 |
| 16 | 全基因组关联研究发现中国人群前列腺癌两个新易感位点9q31.2和19q13.4显示文摘0前言在全球范围内,前列腺癌的发病率和病死率存在着巨大差异。该病在西方发达国家发病率最高,在非裔美国人群病死率最高,而在亚洲人群中发病率及病死率均为全球最低,提示不同人种在前列腺癌的遗传方面存在异质性。在欧美和日本人群中,全基因组关联研究(GWAS)技术已经被用于检测前列腺癌的遗传易感性位点,但至今尚无关于GWAS检测中国人群前列腺癌易感位点的报道。 | Jianfeng Xu Zengnan Mo Dingwei Ye Meilin Wang Fang Liu Guangfu Jin Chuanliang Xu Xiang Wang Qiang Shao Zhiwen Chen Zhihua Tao Jun Qi Fangjian Zhou Zhong Wang Yaowen Fu Dalin He Qiang Wei Jianming Guo Denglong Wu Xin Gao Jianlin Yuan Gongxian Wang Yong Xu Guozeng Wang Haijun Yao Pei Dong Yang Jiao Mo Shen Jin Yang Jun Ou-Yang Haowen Jiang Yao Zhu Shancheng Ren Zhengdong Zhang Changjun Yin Xu Gao Bo Dai Zhibin Hu Yajun Yang Qijun Wu Hongyan Chen Peng Peng Ying Zheng Xiaodong Zheng Yongbing Xiang Jirong Long Jian Gong Rong Na Xiaoling Lin Hongjie Yu Sha Tao Junjie Feng Jishan Sun Wennuan Liu Ann Hsing Jianyu Rao Qiang Ding Fredirik Wiklund Henrik Gronberg Xiao-Ou Shu Wei Zheng Hongbing Shen Li Jin Rong Shi Daru Lu Xuejun Zhang Jielin Sun S Lilly Zheng Yinghao Sun | 2013 | 第二军医大学学报2013，34，4： | 0 |
| 17 | Hydrogen peroxide-activatable iodoBodipy-phthalhydrazid conjugate nanoparticles for cancer therapy显示文摘The dependence on outer light source strongly hinders clinical applications of photodynamic therapy(PDT)to the deep-seated tumor.However,the majority of documented PDT systems that function without the external light source rely on either the chemiluminescence resonance energy transfer(CRET)or fluorescence resonance energy transfer(FRET)mechanism,which decreases the energy transfer efficiency and reproducibility of PDT.Herein,we developed a novel single-molecule triplet photosensitizer(iodoBodipy(IBDP)-L)that can be chemiexcited to triplet excited state to generate reactive oxygen species instead of outer light irradiation.The direct bonding of phthalhydrazid moiety to iodoBodipy fluorophore evoked valid intramolecular energy transfer(IET),and once phthalhydrazid part is activated by hydrogen peroxide,the released reaction energy could excite the iodoBodipy-phthalhydrazid conjugate as a whole.Reaction product IBDP-L-COOH showed high triplet state quantum yield(ΦT=65%)and large spin-orbit coupling.A large amount of reactive oxygen species(ROS)was produced in MCF-7 cells,thus inhibiting the cell growth both in vitro and in vivo after IBDP-L was formulated into nanoparticles(NPs)via nanoprecipitation.We believe that the synthesized IodoBodipy-phthalhydrazid conjugate based on the IET mechanism will open a new door in the molecular design of efficient triplet photosensitizers for treating deeply seated tumors in the future. | Haijun Ning Yuxin Yang Chengyuan Lv Danhong Zhou Saran Long Wen Sun Jianjun Du Jiangli Fan Xiaojun Peng | 2023 | Nano Research2023，16，10： | 0 |
| 18 | Thermoelectric properties of polycrystalline(SnSe)_(1-x)(AgSnSe2)_(x/2) alloys显示文摘SnSe is considered as a thermoelectric material with great potential and advantages due to the record of high thermoelectric figure of merit(ZT)of 2.6 at 923 K in single crystals.However,it is difficult to use single crystal SnSe in practice due to its poor mechanical properties and high manufacturing costs.Meanwhile,the polycrystalline SnSe also is also not suitable for applications due to its much lower thermoelectric performance compared with single crystal SnSe.Therefore,improving the thermoelectric properties of polycrystalline SnSe has become a hot research topic.In this paper,AgSnSe_(2) doped into SnSe to increase the carrier density of the system and thus improve its thermoelectric properties.It is found that the addition of AgSnSe_(2) can effectively improve the thermoelectric performance of polycrystalline SnSe.A peak ZT of 0.81 was obtained at 713 K for(SnSe)_(0.95)(AgSnSe_(2))_(0.025),which is 305%higher than that of the undoped one.This reveals that AgSnSe_(2)-doped SnSe alloy may become a thermoelectric material system with great application potential and significance. | Long Jiang Weiwei Liu Lihong Han Hao Sun Yu Wang Yihua Zhang Haijun Wu | 2022 | Progress in Natural Science:Materials International2022，32，2： | 0 |
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