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| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 2 | Heat-induced Internal Strain Relaxation and its Effect on the Microstructure of Polyacrylonitrile-based Carbon Fiber显示文摘The transformation of the internal strain and its effect on the microstructure of polyacrylonitrile-based carbon fiber during the high-temperature graphitization were investigated.The internal compressive strain within the carbon turbostratic structure was confirmed through a careful analysis by wide-angle X-ray diffraction and Raman spectroscopy.Heat-induced strain/stress relaxation along the fiber axis was observed and was found to have a profound effect on the structure of both the crystallites and microvoids.The results indicated that,the relaxation of residual strain changed the graphite layers from a wrinkled and distorted morphology to a straight and smooth one,and consequently led the crystallites to stack closely and orderly with increasing stack height.The strain relaxation also changed the morphology of crystallites and microvoids,resulting in an anisotropic growth for the latters. | Denghua Li Chunxiang Lu Gangping Wu Yu Yang Zhihai Feng Xiutao Li Feng An Baoping Zhang | 2014 | Journal of Materials Science & Technology2014，30，10： | 5 |
| 3 | A multi-center study on Molecular Epidemiology of Human Respiratory Syncytial Virus from Children with Acute Lower Respiratory Tract Infections in the Mainland of China between 2015 and 2019显示文摘Human respiratory syncytial virus(RSV) is a major pathogen of acute lower respiratory tract infection among young children. To investigate the prevalence and genetic characteristics of RSV in China, we performed a molecular epidemiological study during 2015–2019. A total of 964 RSV-positive specimens were identified from 5529 enrolled patients during a multi-center study. RSV subgroup A(RSV-A) was the predominant subgroup during this research period except in2016. Totally, 535 sequences of the second hypervariable region(HVR-2) of the G gene were obtained. Combined with182 Chinese sequences from GenBank, phylogenetic trees showed that 521 RSV-A sequences fell in genotypes ON1(512),NA1(6) and GA5(3), respectively;while 196 RSV-B sequences fell in BA9(193) and SAB4(3). ON1 and BA9 were the only genotypes after December 2015. Genotypes ON1 and BA9 can be separated into 10 and 7 lineages, respectively. The HVR-2 of genotype ON1 had six amino acid changes with a frequency more than 10%, while two substitutions H258 Q and H266 L were co-occurrences. The HVR-2 of genotype BA9 had nine amino acid substitutions with a frequency more than10%, while the sequences with T290 I and T312 I were all from 2018 to 2019. One N-glycosylation site at 237 was identified among ON1 sequences, while two N-glycosylation sites(296 and 310) were identified in the 60-nucleotide duplication region of BA9. To conclusion, ON1 and BA9 were the predominant genotypes in China during 2015–2019. For the genotypes ON1 and BA9, the G gene exhibited relatively high diversity and evolved continuously. | Xiangpeng Chen Yun Zhu Wei Wang Changchong Li Shuhua An Gen Lu Rong Jin Baoping Xu Yunlian Zhou Aihuan Chen Lei Li Meng Zhang Zhengde Xie | 2021 | Virologica Sinica2021，36，6： | 2 |
| 4 | A method of monitoring gas saturation in carbon dioxide injection heavy oil reservoirs by pulsed neutron logging technology显示文摘A method is proposed to characterize the fast neutron scattering cross-section ( s f) quantitatively by the combina-tion of inelastic gamma rays and captured gamma rays, so as to realize the gas saturation evaluation of CO_(2)-injected heavy oilreservoirs based on the three-de tector pulsed neutron logging technology. Factors influencing of the evaluation effect of thismethod are analyzed and the effectiveness of this method is verified by a simulation example. By using the Monte Carlo simu-lation method and the physical model of bulk-volume rock, the relationship between s f and CO_(2) saturation is studied, and thesaturation interpretation model is established. The influences of formation temperature and pressure, heavy oil density, bore-hole fluid and reservoir methane content on the evaluation results of CO_(2) saturation are analyzed. The results show that thecharacterization of s f by the combination of secondary gamma information can eliminate the influence of formation lithology,borehole fluid and methane content are the main factors affecting the quantitative monitoring of CO_(2) saturation, and the ef-fects of formation temperature and pressure and heavy oil density are negligible. The simulation example verified the feasibilityof the method for evaluating the CO_(2) saturation of CO_(2)-injected heavy oil reservoirs. | FAN Jilin ZHANG Feng TIAN Lili LIANG Qixuan ZHANG Xiaoyang FANG Qunwei LU Baoping LI Xianghui | 2021 | Petroleum Exploration and Development2021，48，6： | 1 |
| 5 | A simple hydro- thermal synthesis of nickel hydroxide-ordered mesoporous carbons nanocomposites and its electrocatalytic application 显示文摘 | Lu Baoping Bai Jing Bo Xiangjie | 2010 | Eleetrochim Acta2010，55，28： | 1 |
| 6 | Flow injection solid-phase extraction using multi-walled carbon nanotubes packed micro-column for the determination of polycyclic aromatic hydrocarbons in water by gas chromatography–mass spectrometry显示文摘 | Hong Wu Xuecui Wang Bing Liu Jie Lu Baixiang Du Luxin Zhang Jingjing Ji Qiaoyu Yue Baoping Han | 2010 | Journal of Chromatography A2010，，17： | 1 |
| 7 | Outbreaks of the brown planthopper Nilaparvata lugens (Stl) in the Yangtze River Delta:immigration or local reproduction? 显示文摘 | Hu Gao Lu Fang Zhai Baoping | 2014 | PLoS One2014，9，88： | 1 |
| 8 | Electrosynthesis and efficientelectrocatalytic performance of poly(neutral red)/ordered mesoporous carbon composite 显示文摘 | Lu Baoping Bai Jing Bo Xiangjie etc | 2010 | Electrochimica Acta2010，55，15： | 1 |
| 9 | Reversible detection of vancomycin using peptide-functionalized cantilever array sensor显示文摘 | Xiaojing Bai Baoping Lu Xuejuan Chen Bailin Zhang Jilin Tang | 2014 | Biosensors and Bioelectronics2014，，： | 1 |
| 10 | Content of herbs in their preparations Longdan aristolochic acid A and class flavin so determined by RP-HPLC显示文摘 | Yuan Zhifang Tian Baoping Lu Xinghong | 2013 | Intemational Journal of Pharmaceutical Raw Materials Analysis2013，23，3： | 1 |
| 11 | Reviews on Well-known Evaluation Norms of Web-based Courses显示文摘 | Yan Dong Lu Zhang Baoping Li | 2010 | 通讯和计算机(中英文版)2010，7，4： | 0 |
| 12 | Epidemiological characteristics and clinical manifestations of pediatric patients with COVID-19 in China: A multicenter retrospective study显示文摘Importance:The Coronavirus disease 2019(COVID-19)global pandemic poses a considerable challenge for pediatricians.Objective:This study aimed to identify the epidemiological characteristics and clinical features of pediatric patients with COVID-19 in China.Methods:This multicenter retrospective study included pediatric patients from 46 hospitals in China,covering 12 provinces and two municipalities.Epidemiological,demographic,clinical,laboratory,treatment,and outcome data were analyzed.Results:In total,211 pediatric patients with COVID-19 were included in this study.The median age was 7.0 years(range:22 days to 18 years).Approximately 16.3%of the patients exhibited asymptomatic infections,23.0%had upper respiratory tract infections,and 60.7%had pneumonia,including two with severe pneumonia and one with critical illness.Approximately 78.7%of the pediatric patients occurred in familial clusters.The most three common symptoms or signs at onset in children with COVID-19 were fever(54.5%),cough(49.3%),and pharyngeal congestion(20.8%).Only 17.6%of the patients presented with decreased lymphocyte count,whereas 13.6%had increased lymphocyte count.Among the patients with pneumonia who exhibited abnormal chest computed tomography findings,18.2%(23/127)of the patients had no other symptoms.Generally,the chest radiographs showed abnormalities that affected both lungs(49.6%);ground-glass opacity(47.2%)was the most common manifestation.The cure and improvement rates were 86.7%(183/211)and 13.3%(28/211),respectively.Only one patient with an underlying condition received invasive mechanical ventilation;none of the patients died.Interpretation:Similar to adults,children of all age groups are susceptible to COVID-19.Fortunately,most pediatric patients have mild symptoms or remain asymptomatic,despite the high incidence of pneumonia.Decreased proportions of white blood cells and lymphocytes are less frequent in children than in adults. | Yan Bai Liwei Gao Xianfeng Wang Lili Zhong Jingfeng Li Shenggang Ding Yuejie Zheng Jun Liu Yuxia Cui Lina Wang Mingfeng Han Jun Liu Xinping Jiang Min Jiang Junhua Li Ning Chen Yunxiao Shang Hourong Zhou Yi Xu Gen Lu Xing Chen Jizhi Xu Qihong Fan Yu Tang Jiang Wu Cen Li Xiaoxiang Yang Chunxi Chen Yonghong Yang Gary Wing-Kin Wong Adong Shen Tianyou Wang Runming Jin Baoping Xu Kunling Shen | 2021 | Pediatric Investigation2021，5，3： | 0 |
| 13 | CO2-Li-Sr Rich Therapeutic Groundwater in Gounan Village, Yantai, Shandong Province显示文摘Objective The Jiaodong area in Shandong Province of eastern China hosts abundant high-quality groundwater.Most of the mineral water sources in this area,including those in the Laoshan and Kunyu Mountains,occur in Mesozoic granites.The groundwater and mineral waters contain metasilicic acid and strontium but the latter is potable. | SONG Yingxin LU Baoping SONG Mingchun YANG Dongming YAO Chunmei | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 0 |
| 14 | Reproduction does not impede the stopover departure to ensure a potent migration in Cnaphalocrocis medinalis moths显示文摘Despite the importance of reproduction in insects,its relation with multi-stop flight remains poorly understood in migratory species.To clarify whether reproductive maturation commences during the multi-stop flight or after the completion of migration,we conducted physiological and behavioral assays in the rice leaf roller Cnaphalocrocis medinalis with laboratory-simulated conditions and field-captured populations.We found that the ovarian development was significantly promoted by tethered flight treatment for 1-2 nights when compared to the unflown group,while the flight muscle development was not impaired.There was no significant difference in flight duration,flight distance and flight velocity between mated and virgin female moths,indicating that mated moths remained competent for the subsequent flights as did the virgins.Using an integrated field assay,we identified that over 60%of the female moths in the migrating populations cap-tured by high-altitude searchlights in the Immigration period of a season had completed the ovarian development and mating.Sexually mature and mated moths collected in the rice field in the Emigration period were found capable of engaging in migratory take-off,as observed using an indoor monitoring platform.Overall,our findings point out that C.med-inalis managed to complete reproductive maturation to a large extent during the multi-stop migratory flight without compromising the migration performance.Such a cost-effective strategy ensures a successful migration for the moths.These findings advance our under-standing of the relationship between reproduction and migration,thus shedding light on the development of novel control measures for the outbreak of migratory insect pests. | Jiawen Guo Fan Yang Haiyan Zhang Peijiong Lin Baoping Zhai Zhongxian Lu Gao Hu Pengcheng Liu | 2022 | Insect Science2022，29，6： | 0 |
| 15 | Ethanol extract of Cyathulae Radix inhibits osteoclast differentiation and bone loss显示文摘Cyathulae Radix,a traditional Chinese medicine and a common vegetable,boasts a history spanning millennia.It enhances bone density,boosts metabolism,and effectively alleviates osteoporosis-induced pain.Despite its historical use,the molecular mechanisms behind Cyathulae Radix’s impact on osteoporosis remain unexplored.In this study,we investigated the effects and mechanisms of Cyathulae Radix ethanol extract(CEE)in inhibiting osteoporosis and osteoclastogenesis.Eight-week-old female mice underwent ovariectomy and were treated with CEE for eight weeks.Micro-computed tomography(micro-CT)assessed histomorphometric parameters,bone tissue staining observed distal femur histomorphology,and three-point bending tests evaluated tibia mechanical properties.Enzyme-linked immunosorbent assay(ELISA)measured serum estradiol(E2),receptor activator for nuclear factor B ligand(RANKL),and osteoprotegerin(OPG)levels.Osteoclastogenesis-related markers were analyzed via Western blotting(WB)and quantitative real-time polymerase chain reaction(qRT-PCR).Additionally,CEE effects on RANKL-induced osteoclast formation and bone resorption were investigated in vitro using tartrate-resistant acid phosphatase(TRAP)staining,qRT-PCR,and WB assay.Compared with the ovariectomy(OVX)group,CEE treatment enhanced trabecular bone density,maximal load-bearing capacity,and various histomorphometric parameters.Serum E2 and OPG levels significantly increased,while Receptor activator of nuclear factor-κB(RANK)decreased in the CEE group.CEE downregulated matrix metallopeptidase 9(MMP-9),Cathepsin K(CTSK),and TRAP gene and protein expression.In bone marrow macrophages(BMMs),CEE reduced mature osteoclasts,bone resorption pit areas,and MMP-9,CTSK,and TRAP expression during osteoclast differentiation.Compared with DMSO treatment,CEE markedly inhibited RANK,TNF receptor associated factor 6(TRAF6),Proto-oncogene c-Fos(c-Fos),Nuclear factor of activated T-cells cytoplasmic 1(NFATc1)expressions,and Extracellular regulated protein kinases(ERK),c-Jun N-terminal kinase(JNK),NF-kappa B-p65(p65)phosphorylation in osteoclasts.In conclusion,CEE significantly inhibits OVX-induced osteoporosis and RANKL-induced osteoclastogenesis,potentially through modulating the Estrogen Receptor(ER)/RANK/NFATc1 signaling pathway. | SHI Liying REN Liuyi LI Jinping LIU Xin LU Jingjing JIA Lujuan XIE Baoping TANG Siyuan LIU Wei ZHANG Jie | 2024 | Chinese Journal of Natural Medicines2024，22，3： | 0 |
| 16 | The Relationship between Golgi Protein 73, Alpha-Fetoprotein, Liver Function Indicators, and Traditional Chinese Medicine Syndrome Types of Primary Liver Cancer显示文摘Objective Our objective was to analyze the correlation between Golgi protein 73(GP73),alpha-fetoprotein(AFP),liver function indicators,and traditional Chinese medicine(TCM)syndrome types of primary liver cancer(hereinafter referred to as'liver cancer').Methods In total,156 liver cancer patients(liver cancer group)and 52 healthy individuals(health group)were selected as the research subjects to detect their GP73,AFP expression,and liver function-related indicators.The obtained data were statistically analyzed using SPSS 21.0 software.Results(1)The positive expression rate of GP73 in the liver cancer group was 50%;the positive expression rates of qi stagnation and blood stasis syndrome,heat tgxin in liver and galader yndroeand yndefceny flieran kidney yndg1i,%54.3,and 59.6%,respectively.There was no statistically significant difference betwgep the groups(p>0.05),The positive expreion rate of AFP was 50%.he positiy 32.8 expression rates of qi stagnation and blood stasis syndrome,heat-toxin in liyer ane gallbladder syndrome,and yin deficiency of liver and kidney syndrome were 41.7,54.3 an59.6%,respectively.There was a statistically significant difference between the groups(p<0.05).(2)The GP73 levels of patients with different syndrome types in the liver cancer group were ranked from high to low as yin deficiency of liver and ki41.3 syndrome,heat toxin in liver and gallbladder syndrome,and qi stagnation and brooa stasis syndrome.The differences between the groups were statistically significant(p<0.05).The AFP levels of patients with different syndrome types in the liver cancer group were ranked from high to low as heat toxin in liver and gallbladder syndrome,yin deficiency of liver and kidney syndrome,and qi stagnation and blood stasis syndrome.There was no statistically significant difference between the groups(p>0.05).(3)Analysis of liver function indicators in the liver cancer group:the alanine transaminase s(ALT)levels of patients with different syndrome types were in descending order from high to low,including yin deficiency of liver and kidney syndrome,heat toxin in liver and gallbladder syndrome,and qi stagnation and blood stasis syndrome.The differences between groups were statistically significant(p<0.05).The aspartate aminotransferase(AST)levels of patients with different syndrome types were ranked from high to low as follows:heat toxin in liver and gallbladder syndrome,yin deficiency of liver and kidney syndrome,and qi stagnation and blood stasis syndrome.The difference between groups was statistically significant(p<0.05).The levels of albumin(ALB)in patients with different syndrome types were ranked from high to low,including heat toxin in liver and gallbladder syndrome,qi stagnation and blood stasis syndrome,and yin deficiency of liver and kidney syndrome.The differences between groups were statistically significant(p<0.05).Conclusion GP73 and indicators such as ALT,AST,and ALB are of great significance in the diagnosis of TCM syndrome differentiation and classification of liver cancer patients. | Baoping Lu Jinxia Rong Huaimin Liu | 2023 | Chinese Medicine and Natural Products2023，3，4： | 0 |
| 17 | Effect of grain refinement on cutting force of difficult-to-cut metals in ultra-precision machining显示文摘The nickel-based superalloy Inconel 718 is treated with Coupled Ultrasonic and Electric Pulse Treatment(CUEPT),and the surface grain is refined from the average size of 9550.0 nm to287.9,216.3,150.5,126.3,25.8 nm by different effective treatment currents,respectively.The ultraprecision turning experiments are carried out on the processed workpiece after CUEPT.The experimental results show that the average cutting force increases with the decrease of surface grain size.Moreover,a mathematical model that can describe the relationship between grain size and cutting force is established,and the calculated results match the experimental results well.The calculated results also indicate that the variation of cutting force caused by the same variation of grain size decreases as the degree of grain refinement increases.Finally,the influence mechanism of grain refinement on cutting force is analyzed.The improvement of stability of grain boundaries and the increase of number of grain boundaries cause the increase of cutting force after grain refinement. | Renjie JI Qian ZHENG Yonghong LIU Hui JIN Fan ZHANG Shenggui LIU Baokun WANG Shuaichen LU Baoping CAI Xiaopeng LI | 2022 | Chinese Journal of Aeronautics2022，35，3： | 0 |
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