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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Adsorption, concentration, and recovery of aqueous heavy metal ions with the root powder of Eichhornia crassipes显示文摘 | Xiaosen Li Songlin Liu Zhongyuan Na Diannan Lu Zheng Liu | 2013 | Ecological Engineering2013，，： | 1 |
| 3 | Dextran-grafted-PNIPAAm as an artificial chaperone for protein refolding显示文摘 | Diannan Lu Zhixia Liu Minlian Zhang Xiaogong Wang Zheng Liu | 2005 | Biochemical Engineering Journal2005，，3： | 1 |
| 4 | The mechanism of PNIPAAm-assisted refolding of lysozyme denatured by urea 显示文摘 | Lu Diannan Liu Zhixia Zhang Minlian | 2005 | Bichemical Engineering Journal2005，24，： | 1 |
| 5 | Pathways for Degrading TNT by Thu-Z: a Pantoea sp. Strain显示文摘 | Liangdong Zou Diannan Lu Zheng Liu | 2012 | Applied Biochemistry and Biotechnology2012，，7： | 1 |
| 6 | Lipase nanogel catalyzed transesterification in anhydrous dimethyl sulfoxide显示文摘 | GE Jun LU Diannan WANG /un | 2009 | Biomacrornolecules2009，10，6： | 1 |
| 7 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 8 | Italicized carbon nanotube facilitating water transport:a molecular dynamics simulation显示文摘While the preferential movement of water inside carbon nanotube is appealing for water purification,our understanding of the water transport mechanism through carbon nanotube(CNT)-based membrane is far from adequate. Here we conducted molecular dynamics simulations to study how the alignment of the CNTs in the membrane affects the water transport through the CNT membrane. It was shown that compared to the conventional CNT membrane where the alignment of CNTs was vertical to membrane surface, the ‘‘italicized CNT membrane'' in which the contact angel between membrane surface and the CNT alignment is not 90° offered a higher transmembrane flux of water. The expanded exposure of more carbon atoms to water molecules reduced the energy barrier near the entrance of this italicized CNT membrane, compared to the vertical one. For water flows through the italicized CNT membrane, the Lennard-Jones interaction between water and nanotube as function of central path of the CNT changes from ‘‘U'' to ‘‘V'' pattern, which significantly lowers energy barrier for filling water into the CNT,favoring the water transport inside carbon nanotube. Above simulation indicates new opportunities for applying CNT in water purification or related fields in which water transport matters. | Jipeng Li Xian Kong Diannan Lu Zheng Liu | 2015 | Science Bulletin2015，60，18： | 1 |
| 9 | Computational screening and design of nanoporous membranes for efficient carbon isotope separation显示文摘Stable isotopes have been routinely used in chemical sciences,medical treatment and agricultural research.Conventional technologies to produce high-purity isotopes entail lengthy separation processes that often suffer from low selectivity and poor energy efficiency.Recent advances in nanoporous materials open up new opportunities for more efficient isotope enrichment and separation as the pore size and local chemical environment of such materials can be engineered with atomic precision.In this work,we demonstrate the unique capability of nanoporous membranes for the separation of stable carbon isotopes by computational screening a materials database consisting of 12,478 computation-ready,experimental metal-organic frameworks(MOFs).Nanoporous materials with the highest selectivity and membrane performance scores have been identified for separation of^(12)CH_4/^(13)CH_4 at the ambient condition(300 K).Analyzing the structural features and metal sites of the promising MOF candidates offers useful insights into membrane design to further improve the performance.An upper limit of the efficiency has been identified for the separation of^(12)CH_4/^(13)CH_4 with the existing MOFs and those variations by replacement of the metal sites. | Jingqi Wang Musen Zhou Diannan Lu Weiyang Fei Jianzhong Wu | 2020 | Green Energy & Environment2020，5，3： | 1 |
| 10 | Theoretical insights on the hydration of quinones as catholytes in aqueous redox flow batteries显示文摘Quinones have been widely studied as a potential catholyte in water-based redox flow batteries(RFBs)due to their ability to carry both electrons and protons in aqueous solutions.The wide variety of quinones and derivatives offers exciting opportunities to optimize the device performance while poses theoretical challenges to quantify their electrochemical behavior as required for molecular design.Computational screening of target quinones with high performance is far from satisfactory.While solvation of quinones affects their potential application in RFBs in terms of both electrochemical windows,stability,and charge transport,experimental data for the solvation structure and solvation free energies are rarely available if not incomplete.Besides,conventional thermodynamic models are mostly unreliable to estimate the properties of direct interest for electrochemical applications.Here,we analyze the hydration free energies of more than 1,400 quinones by combining the first-principles calculations and the classical density functional theory.In order to attain chemical insights and possible trends,special attention is placed on the effects of'backbones'and functional groups on the solvation behavior.The theoretical results provide a thermodynamic basis for the design,synthesis,and screening of high-performance catholytes for electrical energy storage. | Jipeng Li Huan Xu Jingqi Wang Yujun Wang Diannan Lu Jichang Liu Jianzhong Wu | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 0 |
| 11 | Intensification of chemical separation engineering by nanostructured channels and nanofluidics: From theories to applications显示文摘With the development of manufacturing technology on the nanoscale, the precision of nano-devices is rapidly increasing with lower cost. Different from macroscale or microscale fluids, many specific phenomena and advantages are observed in nanofluidics. Devices and process involving and utilizing these phenomena play an important role in many fields in chemical engineering including separation, chemical analysis and transmission.In this article, we summarize the state-of-the-art progress in theoretical studies and manufacturing technologies on nanofluidics. Then we discuss practical applications of nanofluidics in many chemical engineering fields,especially in separation and encountering problems. Finally, we are looking forward to the future of nanofluidics and believe it will be more important in the separation process and the modern chemical industry. | Xiaoyu Hu Diannan Lu | 2019 | Chinese Journal of Chemical Engineering2019，27，6： | 0 |
| 12 | Designing artificial ion channels with strict K^(+)/Na^(+)selectivity toward next-generation electric-eel-mimetic ionic power generation显示文摘A biological potassium channel is>1000 times more permeable to K^(+)than to Na^(+)and exhibits a giant permeation rate of~10^(8)ions/s.It is a great challenge to construct artificial potassium channels with such high sele ctivity and ion conduction rate.Herein,we unveil a long-overlo oked structural feature that underpins the ultra-high K^(+)/Na^(+)selectivity.By carrying out massive molecular dynamics simulation for ion transport through carbonyl-oxygen-modified bi-layer graphene nanopores,we find that the twisted carbonyl rings enable strict potassium selectivity with a dynamic K^(+)/Na^(+)selectivity ratio of 1295 and a K^(+)conduction rate of 3.5×10^(7)ions/s,approaching those of the biological counterparts.Intriguingly,atomic trajectories of K^(+)permeation events suggest a dual-ion transport mode,i.e.two like-charged potassium ions are successively captured by the nanopores in the graphene bi-layer and are interconnected by sharing one or two interlayer water molecules.The dual-ion behavior allows rapid release of the exiting potassium ion via a soft knock-on mechanism,which has previously been found only in biological ion channels.As a proof-of-concept utilization of this discovery,we propose a novel way for ionic power generation by mixing KCl and NaCl solutions through the bi-layer graphene nanopores,termed potassium-permselectivity enabled osmotic power generation(PoPee-OP G).Theoretically,the biomimetic device achieves a very high power density of>1000 W/m^(2)with graphene sheets of<1%porosity.This study provides a blueprint for artificial potassium channels and thus paves the way toward next-generation electric-eel-mimetic ionic power generation. | Jipeng Li Linhan Du Xian Kong Jianzhong Wu Diannan Lu Lei Jiang Wei Guo | 2023 | National Science Review2023，10，12： | 0 |
| 13 | Recent progress in enzymatic functionalization of carbon-hydrogen bonds for the green synthesis of chemicals显示文摘Enzymatic reactions take place with high chemo-, regio-, and stereo-selectivity, appealing for the direct functionalization of abundant and inexpensive compounds with C-H bonds to make fine chemicals such as high-value intermediates and pharmaceuticals. This review summarizes recent progress in the enzymatic functionalization of C-H bonds with an emphasis on heme enzymes such as cytochrome P450 s, chloroperoxidase and unspecific peroxygenases. Specific examples are discussed to elucidate the applications of the molecular and process engineering approaches to overcome the challenges hindering enzymatic C-H functionalization. Also discussed is the recent development of the chemo-enzymatic cascade as an effective way to integrate the power of metal catalysis and enzymatic catalysis for C-H functionalization. | Zheyu Wang Yupei Jian Yilei Han Zhongwang Fu Diannan Lu Jianzhong Wu Zheng Liu | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 0 |
| 14 | Molecular dynamics for the charging behavior of nanostructured electric double layer capacitors containing room temperature ionic liquids显示文摘电的双层(EDL ) 的收费动力学仔细与许多 nanostructured 设备的表演有关正在包括 supercapacitors,电镀物品致动器,和电解质门晶体管。当离子的液体(RTIL ) 经常是的房间温度在这些新应用用作费用搬运人时,理论分析主要基于对在水的答案的宏观的电气化学的现象合适的常规 electrokinetic 理论。在这个工作,我们用一个纹理粗糙的分子的模型和经常潜力的分子的动力学(MD ) 学习 RTIL-EDLs 的收费行为模拟。在到常规理论的预言的鲜明对比, MD 结果响应在电极之间的分离显示出离子的分布和电气化学的性质的摆动的变化。EDL 收费的率展出在监禁下面在 RTIL 揭示强壮的静电的关联的非单调的行为。 | Xian Kong Diannan Lu Zheng Liu Jianzhong Wu | 2015 | Nano Research2015，8，3： | 0 |
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