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| 1 | Predictive clinical features of cardioembolic infarction in patients aged 85 years and older显示文摘Objective To assess predictive clinical factors of cardioembolic infarction in very old patients(85 years of age and older).Methods Prospective hospital-based stroke registry('The Sagrat Cor Hospital of Barcelona Stroke Registry')is an acute-care teaching hospital in Barcelona,Catalonia,Spain.From 956 first-ever cardioembolic stroke patients included in the stroke registry over a 24-year period,639 were younger than 85 years of age and 317 were 85 years or older(mean age:88.9 years).Demographics,clinical characteristics,risk factors and early outcome were compared.Predictors of cardioembolic infarction in the oldest age group were assessed by multivariate analyses.Results In a logistic regression model based on demographics,risk factors,clinical features and complications,female gender(odds ratio[OR]=1.74,95%confidence interval[CI]:1.27–2.39),heart failure(OR=2.27,95%CI:1.46–3.56),altered consciousness(OR=1.76,95%CI:1.28–2.42),and infectious complications(OR=2.01,95%CI:1.39–2.91)were predictors of cardioembolic stroke in the oldest age group.By contrast,heavy smoking,heart valve disease,hypertension,headache,early seizures,sensory deficit,and involvement of the posterior cerebral artery were independently associated with cardioembolic stroke in the younger group.Conclusions Identification of a differential clinical profile of cardioembolic stroke between patients aged 85 years or more and those younger than 85 years helps clinicians to the optimal management of ischemic infarction in the oldest segment of the population. | Ana Maria Carbajo-García Jonatan Cortés AdriàArboix Joan Massons Laura Díez Enric Vergés Jordi Arboix-Alió Luís García-Eroles | 2019 | Journal of Geriatric Cardiology2019，16，11： | 3 |
| 2 | 基于Pi-演算的工作流模式描述显示文摘工作流模式包含了业务流程的基本特征和共性,其实现依赖于具体的流程建模语言或方法。Pi-演算是一种进程代数,可以应用于业务流程的形式化建模。本文使用Pi-演算作为业务流程形式化的工具,对存在多种BPMN表示的工作流模式进行形式化建模,以探究工作流模式Pi-演算的描述,检验Pi-演算对业务流程行为特征的表现能力。 | 薛岗 姚绍文 Joan Lu | 2008 | 计算机科学2008，35，7： | 2 |
| 3 | A New Join-less Approach for Co-location Pattern Mining显示文摘 | Wang Lizhen Bao Yuzhen Lu Joan | 2008 | IEEE2008，，： | 1 |
| 4 | An Order-clique-based Approach for Mining Maximal Co-locations显示文摘 | Wang Lizhen Zhou Lihua Lu Joan | 2009 | Information Sciences2009，179，： | 1 |
| 5 | Potassium chloride supplementation diminishes platelet reactivity in humans 显示文摘 | Masayuki Kimura Xiaobin Lu Joan Skurnick | 2004 | Hypertension2004，44，： | 1 |
| 6 | VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors显示文摘 | Xin Lu Euphemia Mu Yong Wei Sabine Riethdorf Qifeng Yang Min Yuan Jun Yan Yuling Hua Benjamin J. Tiede Xuemin Lu Bruce G. Haffty Klaus Pantel Joan Massagué Yibin Kang | 2011 | Cancer Cell2011，，6： | 1 |
| 7 | An order-clique-based approach for mining maximal co-locations显示文摘 | Lizhen Wang Lihua Zhou Joan Lu Jim Yip | 2009 | Information Sciences2009，，19： | 1 |
| 8 | An order-clique-based approach for mining maximal co-locations显示文摘 | Wang Lizhen Zhou Lihua Lu Joan | 2009 | Information Sciences2009，179，19： | 1 |
| 9 | Human Mesenchymal Stem Cells as a Gene Delivery System to Create Cardiac Pacemakers显示文摘 | Irina Potapova Alexei Plotnikov Zhongju Lu Peter Danilo Virginijus Valiunas Jihong Qu Sergey Doronin Joan Zuckerman Iryna N. Shlapakova Junyuan Gao Zongming Pan Alan J. Herron Richard B. Robinson Peter R. Brink Michael R. Rosen Ira S. Cohen | 2004 | Circulation Research: Journal of the American Heart Association2004，，7： | 1 |
| 10 | Prospective assessment of levetiracetam pharmacokinetics during dose escalation in 4- to 12-year-old children with partial-onset seizures on concomitant carbamazepine or valproate显示文摘 | Nathan B. Fountain Joan A. Conry Ildefonso Rodríguez-Leyva Juvenal Gutierrez-Moctezuma Edubijes Salas René Coupez Armel Stockis Zhihong (Sarah) Lu | 2007 | Epilepsy Research2007，，1： | 1 |
| 11 | An order-clique-based approach for mining maximal eo-loeation显示文摘 | WANG Li-zhen ZHOU Li-hua LU Joan | 2009 | Infor- mation Sciences2009，179，19： | 1 |
| 12 | An order-cliquebased approach for mining maximal co-locations显示文摘 | Wang Lizhen Zhou Lihua Lu Joan | 2009 | Information Sciences2009，179，： | 1 |
| 13 | Biofuel production and kinetics analysis for microwave pyrolysis of Douglas fir sawdust pellet显示文摘 | Shoujie Ren Hanwu Lei Lu Wang Quan Bu Shulin Chen Joan Wu James Julson Roger Ruan | 2011 | Journal of Analytical and Applied Pyrolysis2011，，： | 1 |
| 14 | An order- clique-based approach for mining maximal co-locations 显示文摘 | Wang Lizhen Zhou Lihua Lu Joan | 2009 | Information Sciences2009，179，19： | 1 |
| 15 | An order-clique-based approach for mining maximal co-locations显示文摘 | WANG LIZHEN ZHOU LIHUA LU JOAN | 2009 | Information Sciences2009，179，19： | 1 |
| 16 | Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized Controlled Trials Worldwide显示文摘Objective.The strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).Methods.From October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 RCTs.These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults.Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies.Results.In the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting glucose.Compared with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,p<0:05;z=2:20,p=0:028)per one copy of the TCF7L2 T risk allele.Furthermore,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist circumference.However,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk allele.Conclusions.Our findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults. | Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup Dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner Joan Sabaté Dolores Corella J.Alfredo Martinez Lu Qi | 2021 | Health Data Science2021，，1： | 0 |
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