|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nicotinamide overload may play a role in the development of type 2 diabetes显示文摘AIM: To investigate whether nicotinamide overload plays a role in type 2 diabetes. METHODS: Nicotinamide metabolic patterns of 14diabetic and 14 non-diabetic subjects were compared using HPLC. Cumulative effects of nicotinamide and N1-methylnicotinamide on glucose metabolism, plasma H2O2 levels and tissue nicotinamide adenine dinucleotide (NAD) contents of adult Sprague-Dawley rats were observed. The role of human sweat glands and rat skin in nicotinamide metabolism was investigated using sauna and burn injury, respectively. RESULTS: Diabetic subjects had significantly higher plasma N 1-methylnicotinamide levels 5 h after a 100-mg nicotinamide load than the non-diabetic subjects (0.89 ± 0.13 μmol/L vs 0.6 ± 0.13 μmol/L, P < 0.001). Cumulative doses of nicotinamide (2 g/kg) significantly increased rat plasma N 1-methy lnico-tinamide concentrations associated with severe insulin resistance, which was mimicked by N1-methy-lnicotinamide. Moreover, cumulative exposure to N1-methylnicotinamide (2 g/kg) markedly reduced rat muscle and liver NAD contents and erythrocyte NAD/NADH ratio, and increased plasma H2O2 levels. Decrease in NAD/NADH ratio and increase in H2O2 generation were also observed in human erythrocytes after exposure to N1-methylnicotinamide in vitro. Sweating eliminated excessive nicotinamide (5.3-fold increase in sweat nicotinamide concentration 1 h after a 100-mg nicotinamide load). Skin damage or aldehyde oxidase inhibition with tamoxifen or olanzapine, both being notorious for impairing glucose tolerance, delayed N1-methylnicotinamide clearance. CONCLUSION: These f indings suggest that nicotinamide overload, which induced an increase in plasma N 1-methylnicotinamide, associated with oxidative stress and insulin resistance, plays a role in type 2 diabetes. | Shi-Sheng Zhou Da Li Wu-Ping Sun Ming Guo Yong-Zhi Lun Yi-Ming Zhou Fu-Cheng Xiao Li-Xin Jing Shen-Xia Sun Li-Bin Zhang Ning Luo Fu-Ning Bian Wei Zou Lai-Bin Dong Zhi-Gang Zhao Sheng-Fan Li Xiao-Jie Gong Zeng-Guo Yu Chang-Bin Sun Cong-Long Zheng Dong-Ju Jiang Zheng-Ning Li | 2009 | World Journal of Gastroenterology2009，15，45： | 8 |
| 2 | Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii显示文摘作为在所有生活有机体通用的一台不可缺少的分子的机器,核糖体被是许多抗菌素和小分子的禁止者的自然目标的进化选择了。病原体核糖体的高分辨率的结构为在引起疾病的微生物理解翻译控制的一般、唯一的方面是关键的。与 cryo 电子显微镜学技术,我们从二个人的寄生虫, Trichomonas vaginalis 和 Toxoplasma gondii 决定了 cytosolic 核糖体的结构,在 3.2-3.4 的分辨率 ? 。尽管从两病原体的 ribosomal 蛋白质是真核细胞的家庭的典型成员,与在某些种类特定的插入 / 扩展和扩大分割的附近的 ribosomal RNA (rRNA ) 之间的一个合作进化模式,他们的 rRNAs 的尺寸是严厉地不同的。很有趣地, T 的 rRNAs。vaginalis 在比得上原核生物的对应物的尺寸,与将近优核质特定的 rRNA 扩大分割失踪的所有。这些结构为 ribosomal 蛋白质和 RNA 便于进化路径的解剖,并且可以帮助新奇翻译禁止者的设计。 | Zhifei Li Qiang Guo Lvqin Zheng Yongsheng Ji Yi-Ting Xie De-Hua Lai Zhao-Rong Lun Xun Suo Ning Gao | 2017 | Cell Research2017，27，10： | 2 |
| 3 | Measurement of the neutron total cross section of carbon at the Back-n white neutron beam of CSNS显示文摘To verify the performance of the neutron total cross-sectional spectrometer, the neutron total cross section of carbon is initially measured in the energy range of 1 eV to 20 MeV using the time-of-flight method. The measurement is performed at the Back-n white neutron source with a 76-m time-of-flight path using the China Spallation Neutron Source. A multilayer fast fission chamber with 235U and 238U is employed as the neutron detector. The diameter and thickness of the natural graphite sample are 70 mm and 40 mm, respectively. Signal waveforms are collected using a data acquisition system. Off-line data processing was used to obtain the neutron time-of-flight spectra and transmissions. The uncertainty of the counting statistics is generally approximately 3% for each bin in the energy range of 1–20 MeV. It is determined that the results for the neutron total cross section of carbon obtained using ^235U cells are in good agreement with the results obtained using 238U cells within limits of statistical uncertainty. Moreover, the measured total cross sections show good agreement with the broadening evaluated data. | Xing-Yan Liu Yi-Wei Yang Rong Liu Jie Wen Zhong-Wei Wen Zi-Jie Han Zhi-Zhou Ren Qi An Huai-Yong Bai Jie Bao Ping Cao Qi-Ping Chen Yong-Hao Chen Pin-Jing Cheng Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Min-Hao Gu Feng-Qin Guo Chang-Cai Han Guo-Zhu He Yong-Cheng He Yue-Feng He Han-Xiong Huang Wei-Ling Huang Xi-Ru Huang Xiao-Lu Ji Xu-Yang Ji Hao-Yu Jiang Wei Jiang Han-Tao Jing Ling Kang Ming-Tao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Shu-Bin Liu Guang-Yuan Luan Ying-Lin Ma Chang-Jun Ning Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Hong Sun Xiao-Yang Sun Zhi-Jia Sun Zhi-Xin Tan Hong-Qing Tang Jing-Yu Tang Peng-Cheng Wang Qi Wang Tao-Feng Wang Yan-Feng Wang Zhao-Hui Wang Zheng Wang Qing-Biao Wu Xiao-Guang Wu Xuan Wu Li-Kun Xie Han Yi Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Jing Zhang Lin-Hao Zhang Li-Ying Zhang Qing-Min Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Ying-Tan Zhao Liang Zhou Zu-Ying Zhou Dan-Yang Zhu Ke-Jun Zhu Peng Zhu | 2019 | Nuclear Science and Techniques2019，30，9： | 2 |
| 4 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 5 | Preparation and photocatalysis of TiO2 nanoparticles Co-doped with nitrogen and lanthanum显示文摘 | Wei Huiying Wu Youshi Lun Ning | 2004 | J Mater Sei2004，39，4： | 1 |
| 6 | Porous graphene networks as high performance anode materials for lithium ion batteries显示文摘 | FAN Zhuangjun YAN lun NING Guoqing | 2013 | Carbon2013，，60： | 1 |
| 7 | HRTEM microstructures of PAN precursorfibers显示文摘 | Bai Yujun Wang Chengguo Lun Ning | 2006 | Carbon2006，44，9： | 1 |
| 8 | HRTEM microstructures of PAN precursor fibers显示文摘 | Yu-Jun Bai Cheng-Guo Wang Ning Lun Yan-Xiang Wang Mei-Jie Yu Bo Zhu | 2006 | Carbon2006，，9： | 1 |
| 9 | Identification of a novel bioflocculant from a newly isolated Corynebacterium glutamicum显示文摘 | Ning He Yin Li Jian Chen Shi-Yi Lun | 2002 | Biochemical Engineering Journal2002，11，： | 1 |
| 10 | HRTEM microstructures of PAN precursor fibers显示文摘 | Bai Yujun Wang Chengguo Lun Ning | 2006 | Carbon2006，44，9： | 1 |
| 11 | Hydrothermal synthesis and characterization of ZnO nanorods显示文摘 | WEI Hui-ying WU You-shi LUN Ning | 2005 | Materrials Science and Engineering2005，393，： | 1 |
| 12 | 显示文摘 | Wu Youshi Lun Ning | 2004 | Journal of Materials Science2004，39，4： | 1 |
| 13 | Microbial community coexisting with harmful alga Karenia mikimotoi and microbial control of algal bloom in laboratory显示文摘Algicidal bacteria have been frequently isolated from algal blooming areas.However,knowledge regarding the microbial communities coexisting with microalgae and their potential application in preventing harmful algal blooms(HABs)is limited.In this study,we investigated the composition of the microbial community coexisting with harmful alga Karenia mikimotoi and its responses to algal control via nutrient stimulation or by adding algicidal strain in microcosms.The microorganisms inhabiting the K.mikimotoi culture consisted of 24 identifi ed phyla,including dominant Proteobacteria(relative abundance 76.24%±7.28%)and Bacteroidetes(22.67%±8.32%).Rhodobacteraceae,Phaeodactylibacter,and Maritimibacter predominated during the algal cultivation.Both the added nutrient and fermentation broth of algicidal strain Pseudoalteromonas QF1 caused a massive death of K.mikimotoi and substantial changes in the coexisting microbial community,in which Rhodobacteraceae and Phaeodactylibacter signifi cantly decreased,while Halomonas and Alteromonas increased.Core operational taxonomic units(OTUs)analysis indicated that 13 OTUs belonging to Rhodobacteraceae,Maritimibacter,Marivita,Nisaea,Phaeodactylibacter,Citreicella,Halomonas,Alteromonas,Marinobacter,Muricauda,and Pseudoalteromonas dominated the changes of the microbial communities observed in the K.mikimotoi culture with or without treatments.Collectively,this study indicated that microbial community inhabiting K.mikimotoi culture includes potential algicidal bacteria,and improves our knowledge about microbial community succession during biocontrol of K.mikimotoi via nutrient stimulation or by adding isolated algicidal strains. | Li SUN Peike GAO Yu LI Chao WANG Ning DING Junfeng CHEN Yuhao SONG Chunchen LIU Lun SONG Renjun WANG | 2022 | Journal of Oceanology and Limnology2022，40，3： | 1 |
| 14 | Preparation and photocatalysis of TiO2 nanoparticles co-doped with nitrogen and lanthanum显示文摘 | Huiying Wei Youshi Wu Ning Lun Fang Zhao | 2004 | Journal of Materials Science2004，，4： | 1 |
| 15 | HRTEM micro-structures of PAN precursor fibers 显示文摘 | Yu-Jun Bai Cheng-Guo WANG Ning Lun | 2006 | Carbon2006，44，： | 1 |
| 16 | Identification of a novel bioflocculant from a newly isolated Corynebacterium glutamicum显示文摘 | Li Yin Chen Jian Lun Shiyi | 2002 | Biochemical Engineering Journal2002，11，23： | 1 |
| 17 | Formation of gold nanoparticles supported on carbon nanotubes by using an electroless plating method 显示文摘 | Ma Xicheng Lun Ning Wen Shulin | 2005 | Diamond & Related Materials2005，14，： | 1 |
| 18 | Preparation and photocatalysis of TiO2 nanoparticles co-doped with nitrogen and lanthanum 显示文摘 | Wei Huiying Wu Youshi Lun Ning Zhao Fang | 2004 | Journal of Materials Science2004，39，4： | 1 |
| 19 | Grain refinement mechanism analysis and experimental investigation of equal channel angular pressing for producing pure aluminum ultra-fine grained materials显示文摘 | ZHAO Guo-qun XU Shu-bo LUAN Yi-guo GUAN Yan-jin LUN Ning REN Xu-fang | | 0，，02： | 1 |
| 20 | HRTEM microstructures of PAN precursor fibers显示文摘 | Yu-Jun Bai Cheng-Guo Wang Ning Lun Yan-Xiang Wang Mei-Jie Yu Bo Zhu | 2006 | Carbon2006，，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员