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| 1 | Genome analysis of Taraxacum kok-saghyz Rodin provides new insights into rubber biosynthesis显示文摘The Russian dandelion Taraxacum kok-saghyz Rodin(TKS), a member of the Composite family and a potential alternative source of natural rubber(NR) and inulin, is an ideal model system for studying rubber biosynthesis. Here we present the draft genome of TKS, the first assembled NR-producing weed plant. The draft TKS genome assembly has a length of 1.29 Gb, containing 46 731 predicted protein-coding genes and68.56% repeats, in which the LTR-RT elements predominantly contribute to the genome enlargement. We analyzed the heterozygous regions/genes, suggesting its possible involvement in inbreeding depression.Through comparative studies between rubber-producing and non-rubber-producing plants, we found that enzymes of the mevalonate(MVA) pathway and rubber elongation might be critical for rubber biosynthesis, and several key isoforms have been isolated and shown to be predominantly expressed in the latex, indicating their crucial functions in rubber biosynthesis. Moreover, for two important families in rubber elongation, the CPT/CPTL and REF/SRPP families, diverse evolutionary tracks have been revealed. These results provide valuable resources and new insights into the mechanism of NR biosynthesis,and facilitate the development of alternative NR-producing crops. | Tao Lin Xia Xu Jue Ruan Shizhong Liu Shigang Wu Xiujuan Shao Xiaobo Wang Lin Gan Bi Qin Yushuang Yang Zhukuan Cheng Suhua Yang Zhonghua Zhang Guosheng Xiong Sanwen Huang Hong Yu Jiayang Li | 2018 | National Science Review2018，5，1： | 22 |
| 2 | Co3O4 nanocage derived from metal-organic frameworks: An excellent cathode catalyst for rechargeable Li-O2 battery显示文摘Rechargeable non-aqueous Li-O2 battery is regarded as one of the most promising energy-storage technologies on account of its high energy density.It is believed that the rational design of three-dimensional (3D) architecture for catalyst is a key factor for the remarkable performance.Metal-organic frameworks (MOFs) derived materials possess excellent architecture,which is beneficial for Li-O2 batteries.In this work,ZIF-67 is used as precursor template and calcinated under different temperature to produce Co3O4 crystals.When the anneal treatment is under 350℃,the derived Co3O4 nanocage holds the most complete skeleton,which provides better charge transfer ability as well as O2 and Li^+ diffusion.Meanwhile,the Co3O4 nanocage owns more oxygen vacancies,offering more active sites.With the synergistic effect of nanocage structure and active sites,the Co3O4 nanocage stably delivers a large specific capacity of 15,500 mAh·g^-1 as well as a long cycle-life of 132 cycles at limited discharge capacity of 1,000 mAh·g^-1 under discharge/charge current density of 0.5 A·g^-1. | Zhuoliang Jiang Hui Sun Wenke Shi Tianhang Zhou Jianyong Hu Jingyang Cheng Pengfei Hu Shigang Sun | 2019 | Nano Research2019，12，7： | 5 |
| 3 | Tracing of dye molecules in living plants through NaGdF_4:Yb^(3+),Er^(3+)fluorescent nanoprobes显示文摘In this paper, we demonstrated trace of dye molecules in living plants. The NaGdF4:Yb^(3+),Er^(3+) nanoparticles probe was used to detect the rhodamine B(RhB) in bean sprout. It is found that the fluorescencedye can be efficiently imbibed during the growing process and the absorbance presented a position dependence effect, which was supported by the upconversion spectra and the fluorescent image characterization. In addition, the concentration of the residual RhB in bean sprout can be efficiently traced by the synthesized probe based on the fluorescent resonant energy transfer. Finally, the relation between the excitation power, concentration and the ratio of yellow to green emission are discussed in detail. These results can be helpful in understanding the RhB dye molecules absorbance process in vegetable growth and provide an efficient way to trace the residual dyes in vivo plant. | Xiaofeng Wu Ya'nan Zhang Shiping Zhan Jin Li Guozheng Nie Shigang Hu Cong Yan Shaobing Wu Shengbin Cheng Junshan Hu Lichun Shi Yunxin Liu | 2019 | Journal of Rare Earths2019，37，3： | 3 |
| 4 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 5 | C1orf106, an innate immunity activator, is amplified in breast cancer and is required for basal-like/luminal progenitor fate decision显示文摘Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes.However,genes that specifically promote basal-like breast cancer development remain largely unknown.Here,we report that a novel gene C1orf106 plays an important role in maintaining the feature of basal-like/luminal progenitors.C1orf106 is frequently amplified and overexpressed in basal-like breast cancer and is associated with a poor outcome in patients.In human TCGA database,C1orf106 expression was correlated with upregulation of ELF5 and downregulation of GATA3,two transcription factors that regulate mammary gland stem cell fate.Enhanced expression of C1orf106 promotes tumor progression and expression of basal-like/luminal progenitor marker ELF5;depletion of C1orf106 suppresses tumorigenesis and expression of basal-like/luminal progenitor marker GATA3.These findings suggest that C1orf106 maintains the basal-like/luminal progenitor character through balancing the expression of ELF5 and GATA3.Taken together,we demonstrated that C1orf106 is an important regulator for basal-like/luminal progenitors and targeting C1orf106 is of therapeutic value for breast cancer. | Ji Ma Cheng Liu Decao Yang Jiagui Song Jing Zhang Tianzhuo Wang Mengyuan Wang Weizhi Xu Xueying Li Shigang Ding Jun Zhan Hongquan Zhang | 2019 | Science China(Life Sciences)2019，62，9： | 2 |
| 6 | An Overview of Quality of Service Routing for Next Generation High_Speed Networks:Problems and Solutions显示文摘 | | 1998 | IEEE Network1998，6479，： | 1 |
| 7 | Review on mechanics of ultra-high-temperature materials显示文摘Ultra-high-temperature materials have applications in aerospace and nuclear industry.They are usually subjected to complex thermal environments during service.The mechanical properties of materials in ultra-high-temperature environments have been attracted increasing attentions.However,the characterization and evaluation of ultra-high-temperature mechanical properties of materials are still challenging work.This article presents a review on the mechanical properties of materials at elevated temperatures.The experimental results and techniques on the ultra-high-temperature mechanical properties of materials are reviewed.The constitutive models of materials at elevated temperatures are discussed.The recent research progress on the quantitative theoretical characterization models for the temperature-dependent fracture strength of advanced ceramics and their composites is also given,and the emphasis is placed on the applications of the force-heat equivalence energy density principle.The thermal–mechanical-oxygen coupled computational mechanics of materials are discussed.Furthermore,the outlook and concluding remarks are highlighted. | Daining Fang Weiguo Li Tianbao Cheng Zhaoliang Qu Yanfei Chen Ruzhuan Wang Shigang Ai | 2021 | Acta Mechanica Sinica2021，37，9： | 1 |
| 8 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 9 | On topology optimization of damping layer in shell structures under harmonic excitations显示文摘 | Zhan Kang Xiaopeng Zhang Shigang Jiang Gengdong Cheng | 2012 | Structural and Multidisciplinary Optimization2012，，1： | 1 |
| 10 | On topology optimization of damping layer in shell structures under harmonic excitations显示文摘 | Zhan Kang Xiaopeng Zhang Shigang Jiang Gengdong Cheng | 2012 | Structural and Multidisciplinary Optimization2012，，1： | 1 |
| 11 | Can Hybrid Synapse be Formed between Rat Spinal Motor Neurons and Major Pelvic Ganglion Neurons in vitro?显示文摘The purpose of this study is to determine whether synapses can be formed between spinal motor neurons(SMNs)and major pelvic ganglion(MPG)neurons of a rat in vitro.The green fluorescent protein(GFP)-labelled MPG cells were cultured together with SMNs in a specific medium.The synaptic-like contacts established between SMNs and MPG neurons were studied in co-cultures using morphologic and immunocytochemistry approaches.Phase-contrast observation of co-cultures showed apparent SMNs-MPG neurons contacts as early as three or four days in vitro.We demonstrate some evidence of synaptic contacts between SMNs and MPG neurons in vitro by immunostaining with antibody directed against postsynaptic density protein 95(PSD-95).We describe the development process of a defined SMNs-MPG neurons co-culture system.The results suggest that the hybrid synapse formation that may occur between SMNs and MPG neurons in vitro played an essential role in the mechanisms of a regenerated bladder with an artificial somatic-autonomic reflex arc. | CHENG Shigang XIANG Xuan LV Zemin MAO Xiaowen YANG Xinghai | 2021 | Wuhan University Journal of Natural Sciences2021，26，6： | 0 |
| 12 | Construction and identification of recombinant lentivirus-mediated gene transfer system for rat transducer of regulated CREB activity 1显示文摘Objective:To construct a recombinant lentivirus vector which carries SD rat transducer of regulated CREB activity-1(TORC1) gene and examine its ability to express the TORC1 gene in vitro.Methods:The coding sequence of SD rat TORC1 gene was amplified using PCR and cloned into pGC-FU vector.293T cells were transfected using Lipofectamine 2000 and packaged for the recombinant lentivirus particles.When the cloned sequence was identified to be right,the recombinant lentivirus particles were amplified in a large quantity.The titer of virus was determined by real-time PCR and the level of TORC1 expression was examined by Western blot. Results:The recombinant lentivirus vector carrying TORC1 was constructed successfully and could express TORC1 at a high level in 293T cells in vitro,and the titer determined by real-time PCR was 2×108 TU/ml.Conclusion:The recombinant lentivirus vector could express TORC1 gene at a high level,and was very helpful in the study of exploring the effect of TORC1 on spinal cord injury. | Ying Shi Shigang Cheng Xu Chen Chuanguo Xiao | 2008 | Journal of Nanjing Medical University2008，22，5： | 0 |
| 13 | Positive direction of polarization-induced electric field improves formic acid electrooxidation on Pd显示文摘Adjusting the adsorption energy of adsorbates on catalyst can directly regulate the catalytic performance and reaction pathways of heterogeneous catalysis.Herein,we report a novel strategy,introducing polarization-induced electric field(PIEF)with different directions,to manipulate the adsorption energy of intermediates and reaction pathway of formic acid electrooxidation on Pd.Tourmaline nanoparticles are applied as the PIEF provider,of which the direction is successfully controlled via aligning the dipoles in tourmaline in a strong external electric field.Experimental and theoretical results systematically reveal that positive PIEF leads to an electron-deficient state of Pd,reduced adsorption energy of COad,enhanced adsorption energy of*HCOOH and*OH,and promoted formate pathway of formic acid electrooxidation.Pd/TNP+/FTO,with the aid of positive PIEF,shows three-fold enhancement in the formic acid electrooxidation(4.74 mA·cm^(−2))with high durability and anti-poisoning ability compared with pristine Pd.This study leads a new route to design formic acid electrocatalysts and provides an understanding on how to control the adsorption energy of adsorbates on electrocatalysts by an internal electric field. | Shuozhen Hu Yunyun Cheng Guoming Luo Kai Huang Cheng Shi Jie Xu Cheng Lian Shigang Sun Xinsheng Zhang | 2023 | Nano Research2023，16，8： | 0 |
| 14 | Epigenetic regulations in immune evasion of the deadliest malaria parasite Plasmodium falciparum显示文摘Both eukaryotic and prokaryotic pathogens infect the host stably via an immune evasion mechanism termed mutually exclusive expression.Nowadays,little is known about this epigenetic mechanism,largely limiting the understanding of pathogenesis of many bacterial,fungal and protozoan pathogens and therefore the development of novel drugs and vaccines.In the most severe malaria parasite,Plasmodium falciparum,there is a major virulence gene family termed var,by which the variant antigen PfEMP1 is encoded and expressed on the surface of parasite-infected erythrocytes.Each parasite carries about 60 antigenically various var genes,however,only one of which is expressed at a given time during infection.P.falciparum expresses PfEMP1 s in this clonally variant manner to bind to different human endothelial receptors,allowing the infected erythrocytes to sequester in tissues to escape the host's immune response including spleen killing and humoral immunity.At present,the mechanism of mutually exclusive expression of the var gene family remains largely unknown,even though there is increasing evidence suggesting important roles of the epigenetic regulation involved in var gene expression.In addition,epigenetic factors were also found in association with transcriptional regulation of other antigenic variant gene families in P.falciparum.In this paper,we review the current understanding of epigenetic regulations of P.falciparum virulence genes with particular views toward the design of novel vaccines,drugs,and diagnosis to malaria. | YIN ShiGang CHENG Xiu ZHANG Xu JIANG LuBin | 2014 | Science Foundation in China2014，22，1： | 0 |
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