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| 1 | p53 gene in treatment of hepatic carcinoma:Status quo显示文摘Hepatocellular carcinoma (HCC) is one of the 10 most common cancers worldwide. There is no ideal treatment for HCC yet and many researchers are trying to improve the effects of treatment by changing therapeutic strategies. As the majority of human cancers seem to exhibit either abnormal p53 gene or disrupted p53 gene activation pathways, intervention to restore wild-type p53 (wt-p53) activities is an attractive anti-cancer therapy including HCC. Abnormalities of p53 are also considered a predisposition factor for hepatocarcinogenesis. p53 is frequently mutated in HCC. Most HCCs have defects in the p53-mediated apoptotic pathway although they carry wt-p53. High expression of p53 in vivo may exert therapeutic effects on HCC in two aspects: (1) High expression of exogenous p53 protein induces apoptosis of tumor cells by inhibiting proliferation of cells through several biologic pathways and (2) Exogenous p53 renders HCC more sensitive to some chemotherapeutic agents. Several approaches have been designed for the treatment of HCC via the p53 pathway by restoring the tumor suppression function from inactivation, rescuing the mutated p53 gene from instability, or delivering therapeutic exogenous p53. Products with p53 status as the target have been studied extensively in vitro and in vivo . This review elaborates some therapeutic mechanisms and advances in using recombinant human adenovirus p53 and oncolytic virus products for the treatment of HCC. | Yong-Song Guan Zi La Lin Yang Qing He Ping Li | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
| 2 | Effect of CO_2 enrichment on the glucosinolate contents under different nitrogen levels in bolting stem of Chinese kale (Brassica alboglabra L.)显示文摘The effects of CO2 enrichment on the growth and glucosinolate (GS) concentrations in the bolting stem of Chinese kale (Brassica alboglabra L.) treated with three nitrogen (N) concentrations (5, 10, and 20 mmol/L) were investigated. Height, stem thickness, and dry weights of the total aerial parts, bolting stems, and roots, as well as the root to shoot ratio, significantly increased as CO2 concentration was elevated from 350 to 800 μl/L at each N concentration. In the edible part of the bolting stem, 11 individual GSs were identified, including 7 aliphatic and 4 indolyl GSs. GS concentration was affected by the elevated CO2 concentration, N concentration, and CO2×N interaction. At 5 and 10 mmol N/L, the concentrations of aliphatic GSs and total GSs significantly increased, whereas those of indolyl GSs were not affected, by elevated atmospheric CO2. However, at 20 mmol N/L, elevated CO2 had no significant effects on the concentrations of total GSs and total indolyl GSs, but the concentrations of total aliphatic GSs significantly increased. Moreover, the bolting stem carbon (C) content increased, whereas the N and sulfur (S) contents decreased under elevated CO2 concentration in the three N treatments, resulting in changes in the C/N and N/S ratios. Also the C/N ratio is not a reliable predictor of change of GS concentration, while the changes in N and S contents and the N/S ratio at the elevated CO2 concentration may influence the GS concentration in Chinese kale bolting stems. The results demonstrate that high nitrogen supply is beneficial for the growth of Chinese kale, but not for the GS concentration in bolting stems, under elevated CO2 condition. | Gui-xiao LA Ping FAN Yi-bo TENG Ya-juan LI Xian-yong LIN | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，6： | 7 |
| 3 | Food Frequency Questionnaire for Chinese Children Aged 12-17 Years: Validity and Reliability显示文摘Objective The primary objective of this study was to examine the validity and reliability of a semi-quantitative food frequency questionnaire(FFQ) among Chinese children aged 12-17 years. Methods A semi-quantitative 72-food item FFQ was developed for children aged 12-17 years. The reliability and validity of this FFQ were evaluated against 24-h dietary recalls(24 h DRs) to measure the consumption of foods and nutrients. We administered two FFQs and three DRs to children(N = 160) over a period of 1 month to evaluate the reliability and validity. Reliability was examined by quartile agreement and intraclass correlation coefficients(ICCs), and validity was examined by quartile agreement, Bland-Altman plots and correlation with DRs. Results For reliability, the ICCs between the two FFQs ranged from 0.21 to 0.76 for foods and nutrients, and the quartile agreement ranged from 70.0% to 95.0% in the same or adjacent quartiles. Spearman’s correlation coefficients of foods and nutrients between the second FFQ and the 24 h DRs ranged from-0.04 to 0.59. The Bland-Altman plots demonstrated good agreement across the range of intakes among nutrients. The quartile agreement ranged from 50.0% to 100.0%, with infrequent misclassification. Conclusion The FFQ assessment of dietary intakes demonstrated acceptable relative validity and high reproducibility for Chinese children aged 12-17 years. | LIU Dan JU La Hong YANG Zhen Yu ZHANG Qian GAO Jian Fen GONG Di Ping GUO Dan Dan LUO Shu Quan ZHAO Wen Hua | 2019 | Biomedical and Environmental Sciences2019，32，7： | 6 |
| 4 | Characteristics of deep drainage and soil water in the mobile sandy lands of Inner Mongolia, northern China显示文摘Quantification of deep drainage and the response of soil water content to rainfall patterns are critical for an effective management strategy of soil water conservation and groundwater utilization. However, there has been little information on how rainfall characteristics influence soil water dynamics and deep drainage in mobile sandy lands. We used an underground chamber to examine the responses of deep drainage and soil water content in mobile sandy lands to rainfall characteristics in Inner Mongolia during the growing seasons of 2010, 2011 and 2012. Results showed that rainfall in this area was dominated by small events(≤5 mm), which increased soil water content in the surface soil layers(0–40 cm), but did not increase soil water content in the deeper soil layers(greater than 40 cm). Soil water content at the 0–100 cm depth increased significantly when the total amount of rain was >20 mm. Rainfall amount, intensity and the duration of dry intervals were significantly related to the soil water content in different soil layers. Deep drainage was significantly correlated with rainfall amount and intensity, but not with the duration of dry intervals. The coefficients of deep drainage in the mobile sandy lands ranged from 61.30% to 67.94% during the growing seasons. Our results suggested that rainfall infiltration in the mobile sandy lands had considerable potential to increase soil water storage while recharging the groundwater in this region. | Xin Ping LIU Yu Hui HE Xue Yong ZHAO Tong Hui ZHANG La Mei ZHANG Yun Hua MA Shu Xia YAO Shao Kun WANG Shui Lian WEI | 2015 | Journal of Arid Land2015，7，2： | 4 |
| 5 | The Tibetan Plateau Surface–Atmosphere Coupling System and Its Weather and Climate Effects: The Third Tibetan Plateau Atmospheric Science Experiment显示文摘The Tibetan Plateau(TP) is a key area affecting forecasts of weather and climate in China and occurrences of extreme weather and climate events over the world. The China Meteorological Administration, the National Natural Science Foundation of China, and the Chinese Academy of Sciences jointly initiated the Third Tibetan Plateau Atmospheric Science Experiment(TIPEX-Ⅲ) in 2013, with an 8–10-yr implementation plan. Since its preliminary field measurements conducted in 2013, routine automatic sounding systems have been deployed at Shiquanhe, Gaize, and Shenzha stations in western TP, where no routine sounding observations were available previously. The observational networks for soil temperature and soil moisture in the central and western TP have also been established. Meanwhile, the plateau-scale and regional-scale boundary layer observations, cloud–precipitation microphysical observations with multiple radars and aircraft campaigns, and tropospheric–stratospheric air composition observations at multiple sites, were performed. The results so far show that the turbulent heat exchange coefficient and sensible heat flux are remarkably lower than the earlier estimations at grassland, meadow, and bare soil surfaces of the central and western TP. Climatologically, cumulus clouds over the main body of the TP might develop locally instead of originating from the cumulus clouds that propagate northward from South Asia. The TIPEX-Ⅲ observations up to now also reveal diurnal variations, macro-and microphysical characteristics, and water-phase transition mechanisms, of cumulus clouds at Naqu station. Moreover, TIPEX-Ⅲ related studies have proposed a maintenance mechanism responsible for the Asian 'atmospheric water tower' and demonstrated the effects of the TP heating anomalies on African, Asian, and North American climates. Additionally, numerical modeling studies show that the Γ distribution of raindrop size is more suitable for depicting the TP raindrop characteristics compared to the M–P distribution, the overestimation of sensible heat flux can be reduced via modifying the heat transfer parameterization over the TP, and considering climatic signals in some key areas of the TP can improve the skill for rainfall forecast in the central and eastern parts of China. Furthermore, the TIPEX-Ⅲ has been promoting the technology in processing surface observations, soundings, and radar observations, improving the quality of satellite retrieved soil moisture and atmospheric water vapor content products as well as high-resolution gauge–radar–satellite merged rainfall products, and facilitating the meteorological monitoring, forecasting, and data sharing operations. | Ping ZHAO Yueqing LI Xueliang GUO Xiangde XU Yimin LIU Shihao TANG Wenming XIAO Chunxiang SHI Yaoming MA Xing YU Huizhi LIU La JIA Yun CHEN Yanju LIU Jian LI Dabiao LUO Yunchang CAO Xiangdong ZHENG Junming CHEN An XIAO Fang YUAN Donghui CHEN Yang PANG Zhiqun HU Shengjun ZHANG Lixin DONG Juyang HU Shuai HAN Xiuji ZHOU | 2019 | Journal of Meteorological Research2019，33，3： | 4 |
| 6 | Clinical Effects of Pulse High‐Volume Hemofiltration on Severe Acute Pancreatitis Complicated With Multiple Organ Dysfunction Syndrome显示文摘 | La‐Ping Chu Jun‐Jing Zhou Ya‐Fen Yu Yang Huang Wen‐Xia Dong | 2012 | Therapeutic Apheresis and Dialysis2012，，1： | 2 |
| 7 | Characterization of Nitrogen Metabolism in the Low-Nitrogen Tolerant lnt1 Mutant of Arabidopsis thaliana Under Nitrogen Stress显示文摘A growth experiment on agar medium and a hydroponics experiment were carried out to study the nitrogen(N) metabolism of a low-N tolerant mutant(lnt1) of Arabidopsis thaliana under different N levels as compared with the wildtype(WT) Arabidopsis.On the agar medium,no apparent growth differences were observed between the lnt1 and WT plants under a normal N level of 9 mmol L-1 NO3-.However,under a low N level of 0.18 mmol L-1 NO3-,the growth of the WT plants was greatly retarded,while the lnt1 plants were not affected by low-N stress and showed similar growth with those grown under a normal N level.In the hydroponics experiment,the lnt1 mutant had higher activities of glutamine synthetase(GS) and NADH-dependent glutamate synthase(NADH-GOGAT) in both leaves and roots under N-deficient conditions.Moreover,they accumulated less ammonium(NH+4) but more free amino acids in leaves compared with the WT plants.These observations suggest that better N assimilation might contribute to the low-N tolerant phenotype of the lnt1 mutant. | TENG Yi-Bo LI Ya-Juan FANG Ping LA Gui-Xiao | 2010 | Pedosphere2010，20，5： | 2 |
| 8 | Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat 显示文摘 | Brown LA Ping XD Harris FL | 2007 | Am J Physiol Lung Cell Mol Physiol2007，292，4： | 1 |
| 9 | Microdialysis in peripheral tissues 显示文摘 | Ping Liu Hartmut Derendort | 2000 | Advanced Drug Delivery Reviews2000，45，： | 1 |
| 10 | Chronic ethanol ingestion and the risk of acute lung injury:a role for glutathione availability?显示文摘 | Brown LA Harris FL Ping XD | 2003 | Alcohol2003，33，： | 1 |
| 11 | Chronic ethanol ingestion and the risk of acute lung injury:a role for glutathione availability?显示文摘 | Brown LA Harris FL Ping XD | 2004 | Alcohol2004，33，3： | 1 |
| 12 | Menin-mediated caspase 8 expression in suppressing multiple endocrine neplasia type显示文摘 | Ping La Yuqing Yang Satyajit K | 2007 | Bio Chem2007，282，31： | 1 |
| 13 | Glutathione availability modulates alveolar macrophage functions in the chronic ethanol-fed rat显示文摘 | Brown LA Ping XD Harris FL | 2007 | Am J Physiol Lung Cell Mol Physiol2007，292，4： | 1 |
| 14 | Gallium(III) Trifluormethanesulfonate: A Water-Tolerant, Reusable Lewis Acid Catalyst for Friedel-Crafts Reactions显示文摘 | G.K. Surya Prakash Ping Yan Béla T?r?k Imre Bucsi Mutsuo Tanaka George A. Olah | 2003 | Catalysis Letters (-)2003，，1： | 1 |
| 15 | Superacidic Trifluoromethanesulfonic Acid-Induced Cycli-Acyalkylation of Aromatics显示文摘 | G.K. Surya Prakash Ping Yan Béla T?r?k George A. Olah | 2003 | Catalysis Letters (-)2003，，3： | 1 |
| 16 | Properties of aliphatic polyurea coated concrete under salt fog exposure 显示文摘 | Huang Weibo La Ping Zhang Jing | 2011 | Advanced Materials Research2011，，168170： | 1 |
| 17 | Glutathione availability modulates alveolar maerophage functions in the chronic ethanol-fed rat显示文摘 | Brown LA Ping XD Harris FL | 2007 | Am J Physiol Lung Cell Mol Physinl2007，292，4： | 1 |
| 18 | Function of resveratrol derived from transgenic plant expressing resveratrol syn-thase gene显示文摘Two genes from grapevine coding for resvera-trol synthase, named RS1 and RS2, were cloned by RT-PCR. An Escherichia coli expression vector was constructed by insertion of RS1 into pBV221. A specific protein with the same molecular weight (42 ku) as the resveratrol synthase was expressed and used to prepare the rabbit antiserum. A plant expression vector was constructed by inserting the RS1 gene into pBin438 downstream of the doubled CaMV 35S promoter and TMV-Ω fragment. PCR-positive transgenic tobacco plants were obtained after transformation with Agrobacterium tumefaclens LBA4404 harboring the plant expression vector. Southern blot analysis demonstrated that the foreign gene was integrated into the tobacco genome. The results of RT-PCR and Western blot indicated that the RS1 gene was transcribed and expressed. Formation of resveratrol in transgenic tobacco was further determined by thin-layer chromatography of silica gel and HPLC. Increased accumulation of human breast adenocarcinoma cells in G0 and | La Ping Cai Wenqi Zhang Jiuchun Zhang Fengli Fang Rongxiang | 2001 | Chinese Science Bulletin2001，46，13： | 1 |
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