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| 1 | Endoscopic ultrasound guided radiofrequency ablation,for pancreatic cystic neoplasms and neuroendocrine tumors显示文摘AIM: To outline the feasibility, safety, adverse events and early results of endoscopic ultrasound(EUS)-radiofrequency ablation(RFA) in pancreatic neoplasms using a novel probe. METHODS: This is a multi-center, pilot safety feasibility study. The intervention described was radiofrequency ablation(RF) which was applied with an innovative monopolar RF probe(1.2 mm Habib EUS-RFA catheter) placed through a 19 or 22 gauge fine needle aspiration(FNA) needle once FNA was performed in patients with a tumor in the head of the pancreas. The HabibTM EUSRFA is a 1 Fr wire(0.33 mm, 0.013') with a working length of 190 cm, which can be inserted through the biopsy channel of an echoendoscope. RF power is applied to the electrode at the end of the wire to coagulate tissue in the liver and pancreas.RESULTS: Eight patients [median age of 65(range 27-82) years; 7 female and 1 male] were recruited in a prospective multicenter trial. Six had a pancreatic cysticneoplasm(four a mucinous cyst, one had intraductal papillary mucinous neoplasm and one a microcystic adenoma) and two had a neuroendocrine tumors(NET) in the head of pancreas. The mean size of the cystic neoplasm and NET were 36.5 mm(SD ± 17.9 mm) and 27.5 mm(SD ± 17.7 mm) respectively. The EUSRFA was successfully completed in all cases. Among the 6 patients with a cystic neoplasm, post procedure imaging in 3-6 mo showed complete resolution of the cysts in 2 cases, whilst in three more there was a 48.4% reduction [mean pre RF 38.8 mm(SD ± 21.7 mm) vs mean post RF 20 mm(SD ± 17.1 mm)] in size. In regards to the NET patients, there was a change in vascularity and central necrosis after EUS-RFA. No major complications were observed within 48 h of the procedure. Two patients had mild abdominal pain that resolved within 3 d. CONCLUSION: EUS-RFA of pancreatic neoplasms with a novel monopolar RF probe was well tolerated in all cases. Our preliminary data suggest that the procedure is straightforward and safe. The response ranged from complete resolution to a 50% reduction in size. | Madhava Pai Nagy Habib Hakan Senturk Sundeep Lakhtakia Nageshwar Reddy Vito R Cicinnati Iyad Kaba Susanne Beckebaum Panagiotis Drymousis Michel Kahaleh William Brugge | 2015 | World Journal of Gastrointestinal Surgery2015，7，4： | 23 |
| 2 | Epidural anesthesia is effective for extracorporeal shock wave lithotripsy of pancreatic and biliary calculi显示文摘AIM: To evaluate the efficacy of thoracic epidural analgesia for extracorporeal shock wave lithotripsy (ESWL). METHODS: ESWL is an effective, non-invasive technique for the treatment of difficult pancreatic and large bile duct calculi. The procedure is often painful and requires large doses of analgesics. Many different anesthetic techniques have been used. Patients with either large bile duct calculi or pancreatic duct calculi which could not be extracted by routine endoscopic methods were selected. Thoracic epidural anesthesia (TEA) was routinely used in all the subjects unless contraindicated. Bupivacaine 0.25% with or without clonidine was used to block the segments D6 to D12. The dose was calculated depending on the age, height and weight of the patient. It was usually 1-2 mL per segment blocked.RESULTS: Ninety eight percent of the 1509 patients underwent ESWL under TEA. The subjects selected were within American Society of Anesthesiologists grade Ⅰ to Ⅲ. ESWL using EA permitted successful elimination of bile duct or pancreatic calculi with minimal morbidity. The procedure time was shorter in patients with TEA than in those who underwent ESWL under total intravenous anesthesia. CONCLUSION: Almost all patients undergoing ESWL with EA had effective blocks with a single catheter insertion and local anesthetic injection. | Santosh Darisetty Manu Tandan Duvvuru Nageshwar Reddy Rama Kotla Rajesh Gupta Mohan Ramchandani Sandeep Lakhtakia Guduru Venkat Rao Rupa Banerjee | 2010 | World Journal of Gastrointestinal Surgery2010，2，5： | 13 |
| 3 | Efficacy of low dose peginterferon alpha-2b with ribavirin on chronic hepatitis C显示文摘AIM: To assess the effi cacy of peginterferon alpha 2b at doses of 50 μg weekly and 80 μg weekly (based on body weight) plus ribavirin in HCV genotype 2 and genotype 3 chronic hepatitis C patients. METHODS: During the study period of Jan 2002 to Dec 2003, all patients diagnosed as chronic hepatitis C or HCV related compensated cirrhosis were treated with peginterferon alpha 2b 50 μg S/C weekly (body weight < 60 kg) or 80 μg S/C weekly (body weight > 60 kg) plus ribavirin 800 mg/d for 24 wk. RESULTS: Overall 28 patients, 14 patients in each group (based on body weight) were treated during the period. Out of 28 patients, 75% were genotype 3, 18% were genotype 2 and 7% were genotype 1. The mean dose of peginterferon alpha 2b was 0.91 μg/kg in group 1 and 1.23 μg/kg in group 2 respectively. The end of treatment and sustained virologic response rates were 82% and 78% respectively. Serious adverse effects were seen in 3.5% patients. CONCLUSION: Low dose peginterferon alpha 2b in combination with ribavirin for 24 wk is effective in HCV genotype 2 and 3 chronic hepatitis C patients. | Rajesh Gupta CH Ramakrishna Sandeep Lakhtakia Manu Tandan Rupa Banerjee D Nageshwar Reddy | 2006 | World Journal of Gastroenterology2006，12，34： | 10 |
| 4 | Per oral cholangiopancreatoscopy in pancreatico biliary diseases- Expert consensus statements显示文摘AIM: To provide consensus statements on the use of per-oral cholangiopancreatoscopy(POCPS).METHODS: A workgroup of experts in endoscopic retrograde cholangiopancreatography(ERCP), endosonography, and POCPS generated consensus statements summarizing the utility of POCPS in pancreaticobiliary disease. Recommendation grades used validated evidence ratings of publications from an extensive literature review.RESULTS: Six consensus statements were generated:(1) POCPS is now an important additional tool during ERCP;(2) in patients with indeterminate biliary strictures, POCS and POCS-guided targeted biopsy are useful for establishing a definitive diagnosis;(3) POCS and POCS-guided lithotripsy are recommended for treatment of difficult common bile duct stones when standard techniques fail;(4) in patients with main duct intraductal papillary mucinous neoplasms(IPMN) POPS may be used to assess extent of tumor to assist surgicalresection;(5) in difficult pancreatic ductal stones,POPS-guided lithotripsy may be useful in fragmentation and extraction of stones; and(6) additional indications for POCPS include selective guidewire placement,unexplained hemobilia, assessing intraductal biliary ablation therapy, and extracting migrated stents. CONCLUSION: POCPS is important in association with ERCP, particularly for diagnosis of indeterminate biliary strictures and for intra-ductal lithotripsy when other techniques failed, and may be useful for preoperative assessment of extent of main duct IPMN, for extraction of difficult pancreatic stones, and for unusua indications involving selective guidewire placement,assessing unexplained hemobilia or intraductal biliary ablation therapy, and extracting migrated stents. | Mohan Ramchandani Duvvur Nageshwar Reddy Sundeep Lakhtakia Manu Tandan Amit Maydeo Thoguluva Seshadri Chandrashekhar Ajay Kumar Randhir Sud Rungsun Rerknimitr Dadang Makmun Christopher Khor | 2015 | World Journal of Gastroenterology2015，21，15： | 8 |
| 5 | Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline显示文摘 | J.-M. Dumonceau M. Delhaye A. Tringali J. Dominguez-Munoz J.-W. Poley M. Arvanitaki G. Costamagna F. Costea J. Devière P. Eisendrath S. Lakhtakia N. Reddy P. Fockens T. Ponchon M. Bruno | 2012 | Endoscopy2012，，08： | 5 |
| 6 | Dyadic Green Function for an Electromagnetic Medium Inspired by General Relativity显示文摘为同类的电磁的媒介的二价的格林功能启发了由空间与时间地,引力的非同类的组成的方程结盟影响真空被导出。 | Akhlesh Lakhtakia Tom G. Mackay | 2006 | Chinese Physics Letters2006，23，4： | 2 |
| 7 | Factors Determining Diagnostic Yield of Endoscopic Ultrasound Guided Fine-Needle Aspiration for Pancreatic Cystic Lesions: A Multicentre Asian Study显示文摘 | Lee Guan Lim Sandeep Lakhtakia Tiing Leong Ang Charles K. F. Vu Frederick Dy Vui Heng Chong Christopher J. L. Khor Wee Chian Lim Bhavesh Kishor Doshi Shyam Varadarajulu Kenjiro Yasuda Jennie Y. Y. Wong Yiong Huak Chan Min En Nga Khek Yu Ho | 2013 | Digestive Diseases and Sciences2013，，6： | 2 |
| 8 | Fractal Estimation of Flank Wear in Turning显示文摘 | BUKKAPATNAM S T S KUMARA S R T LAKHTAKIA A | 2000 | ASME J Dyn Syst Meas Cont2000，122，： | 1 |
| 9 | Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline显示文摘 | J.-M. Dumonceau M. Delhaye A. Tringali J. Dominguez-Munoz J.-W. Poley M. Arvanitaki G. Costamagna F. Costea J. Devière P. Eisendrath S. Lakhtakia N. Reddy P. Fockens T. Ponchon M. Bruno | 2012 | Endoscopy2012，，08： | 1 |
| 10 | Electomagnet response of carbon nanotubes and nano ropes 显示文摘 | G Y Slepyan S A Maksimenko A Lakhtakia O M Yevtushenko | 2001 | Synths Metal2001，，124： | 1 |
| 11 | On the symmetries of the Julia sets for the process z←zp + c 显示文摘 | LAKHTAKIA A VARADEN V V MESSIER R | 1987 | J Phys A: Math Gen1987，20，： | 1 |
| 12 | Semiconductor split-ring resona- tors for thermally tunable terahertz metamaterials 显示文摘 | Han J Lakhtakia A | 2009 | Journal of Modern Optics2009，56，4： | 1 |
| 13 | Equivalent dipole moments of helical arrangements of small, isotropic, point-polarizable scatters: Application to chiral polymer design显示文摘 | Varadan V V Lakhtakia A Varadan V K | 1988 | J Appl Phys1988，63，2： | 1 |
| 14 | Varadan, Use of combinatorial algebra for diffusion on fractals 显示文摘 | Lakhtakia A Messier R Varadan V K | 1986 | Phys Rev A1986，34，： | 1 |
| 15 | Restricted equivalence of paired epsilon-negative and mu-negative layers to a negative phase- velocity material (alias left-handed material) 显示文摘 | Lakhtakia A Krowne C M | 2003 | Optik2003，114，7： | 1 |
| 16 | Simulating the river basin response to atmospheric forcing by linking a mesoscale met-eorological model and hydrologic model system显示文摘 | LAKHTAKIA M N YARNAL B | 1999 | Journal of Hydrology1999，218，： | 1 |
| 17 | Rmarks on Time domain modeling of electromagneticwave propagation in Tellegen media显示文摘 | | 2004 | Microwave and Optical Tech Lett2004，41，2： | 1 |
| 18 | On the possibility of designing anti - reflection coatings using chira] composites显示文摘 | Varadan V V Lakhtakia A | 1987 | J Wave - Material Interaction1987，，2： | 1 |
| 19 | A randomized controlled trial on use of propofol alone versus propofol with midazolam,ketamine,and pentazocine 'sedato-analgesic cocktail' for sedation during ERCP显示文摘 | ONG W C SANTOSH D LAKHTAKIA S | 2007 | Endoscopy2007，39，9： | 1 |
| 20 | Safety and efficacy of ERCP in pregnancy显示文摘 | Gupta R Tandan M Lakhtakia S | 2004 | Gastrointest Endosc2004，60，2： | 1 |
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