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| 1 | Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis显示文摘BACKGROUND Proton pump inhibitors(PPIs)are widely prescribed,often without clear indications.There are conflicting data on its association with mortality risk and hepatic decompensation in cirrhotic patients.Furthermore,PPI users and PPI exposure in some studies have been poorly defined with many confounding factors.AIM To examine if PPI use increases mortality and hepatic decompensation and the impact of cumulative PPI dose exposure.METHODS Data from patients with decompensated liver cirrhosis were extracted from a hospital database between 2013 to 2017.PPI users were defined as cumulative defined daily dose(cDDD)≥28 within a landmark period,after hospitalisation for hepatic decompensation.Cox regression analysis for comparison was done after propensity score adjustment.Further risk of hepatic decompensation was analysed by Poisson regression.RESULTS Among 295 decompensated cirrhosis patients,238 were PPI users and 57 were non-users.PPI users had higher mortality compared to non-users[adjusted HR=2.10,(1.20-3.67);P=0.009].Longer PPI use with cDDD>90 was associated with higher mortality,compared to non-users[aHR=2.27,(1.10-5.14);P=0.038].PPI users had a higher incidence of hospitalization for hepatic decompensation[aRR=1.61,(1.30-2.11);P<0.001].CONCLUSION PPI use in decompensated cirrhosis is associated with increased risk of mortality and hepatic decompensation.Longer PPI exposure with cDDD>90 increases the risk of mortality. | Marianne Anastasia De Roza Lim Kai Jia Wen Kam Yiong Huak Chan Andrew Kwek Tiing Leong Ang John Chen Hsiang | 2019 | World Journal of Gastroenterology2019，25，33： | 6 |
| 2 | Factors Determining Diagnostic Yield of Endoscopic Ultrasound Guided Fine-Needle Aspiration for Pancreatic Cystic Lesions: A Multicentre Asian Study显示文摘 | Lee Guan Lim Sandeep Lakhtakia Tiing Leong Ang Charles K. F. Vu Frederick Dy Vui Heng Chong Christopher J. L. Khor Wee Chian Lim Bhavesh Kishor Doshi Shyam Varadarajulu Kenjiro Yasuda Jennie Y. Y. Wong Yiong Huak Chan Min En Nga Khek Yu Ho | 2013 | Digestive Diseases and Sciences2013，，6： | 2 |
| 3 | Epidemiology of diabetic foot problems and predictive factors for limb loss 显示文摘 | Natheremail A Siok BC Huak CY | 2008 | J Diabetes Complications2008，22，2： | 1 |
| 4 | Spontaneous pneumothorax outcome study (SPOT phase Ⅰ) :a 2-year review 显示文摘 | Hock Ong Marcus Eng a Chan Yiong Huak d | 2004 | European Journal of Emergency Medicine April2004，11，2： | 1 |
| 5 | Superior Sagittal Sinus Thrombosis:Subtle Signs on Neuroimaging显示文摘 | Phua Hwee Tang Josiah Chai Yiong Huak Chan | 2008 | Ann Acad Med Singapore2008，37，5： | 1 |
| 6 | Psychological impact of the 2003 severe acute respiratory syndrome outbreak on health care workera in a medium size regional general hospital in Singapore显示文摘 | Chan A O Huak C Y | 2004 | Occup Med2004，54，3： | 1 |
| 7 | Epidemiology of diabetic foot problems and predictive factors for limb loss 显示文摘 | Natheremail A Siok BC Huak CY | 2008 | J Diabetes Complications2008，22，2： | 1 |
| 8 | Feasibility, cost-effectiveness and patients' acceptance of point-of-care INR testing in a hospital-based anticoagulation clicic显示文摘 | Ming Chai Kong Teong Guan Lim Heng Joo Ng Yiong Huak Chan Lai Heng Lee | 2008 | Ann Hematol2008，，87： | 1 |
| 9 | Epidemiology of diabetic foot problems and predictive factors for limb loss显示文摘 | Nather A Bee CS Huak CY | | 0，，02： | 1 |
| 10 | NRAMP1 and hGPX1 Gene Polymorphism and Response to Bacillus Calmette-Guérin Therapy for Bladder Cancer显示文摘 | Edmund Chiong Arshvin Kesavan Ratha Mahendran Yiong Huak Chan Jen Hwei Sng Yew Koon Lim Revathi Kamaraj Theresa M.C. Tan Kesavan Esuvaranathan | 2010 | European Urology2010，，3： | 1 |
| 11 | Epideminlngy of diabetic foot problems and predictive factors for limb loss 显示文摘 | Nather A Bee CS Huak CY | 2008 | J Diabetes Complications2008，22，2： | 1 |
| 12 | Epidemiology of diabetic foot problems and predictive factors for limb loss显示文摘 | Nather A Bee C S Huak C Y | 2008 | J Diabetes Complications2008，22，2： | 1 |
| 13 | Epidemiology of diabetic foot problems and predictive factors for limb loss 显示文摘 | Nather A Bee CS Huak CY | 2008 | JDiabetes Complications2008，22，2： | 1 |
| 14 | Epidemiology of diabetic foot problems and predictive factors for limb loss显示文摘 | Nather A Bee CS Huak CY | 2008 | J Diabetes Compli- cations2008，22，2： | 1 |
| 15 | Helicobacter pylori eradication versus prokinetics in the treatment of functional dyspepsia: a randomized, double-blind study显示文摘 | Tiing Leong Ang Kwong Ming Fock Eng Kiong Teo Yiong Huak Chan Tay Meng Ng Tju Siang Chua Jessica Yi-Lyn Tan | 2006 | Journal of Gastroenterology2006，，7： | 1 |
| 16 | Cholecystectomy for asymptomatic gallstones:Markov decision tree analysis显示文摘Gallstones are a common public health problem,especially in developed countries.There are an increasing number of patients who are diagnosed with gallstones due to increasing awareness and liberal use of imaging,with 22.6%-80% of gallstone patients being asymptomatic at the time of diagnosis.Despite being asymptomatic,this group of patients are still at life-long risk of developing symptoms and complications such as acute cholangitis and acute biliary pancreatitis.Hence,while early prophylactic cholecystectomy may have some benefits in selected groups of patients,the current standard practice is to recommend cholecystectomy only after symptoms or complications occur.After reviewing the current evidence about the natural course of asymptomatic gallstones,complications of cholecystectomy,quality of life outcomes,and economic outcomes,we recommend that the option of cholecystectomy should be discussed with all asymptomatic gallstone patients.Disclosure of material information is essential for patients to make an informed choice for prophylactic cholecystectomy.It is for the patient to decide on watchful waiting or prophylactic cholecystectomy,and not for the medical community to make a blanket policy of watchful waiting for asymptomatic gallstone patients.For patients with high-risk profiles,it is clinically justifiable to advocate cholecystectomy to minimize the likelihood of morbidity due to complications. | Brian Juin Hsien Lee Qai Ven Yap Jee Keem Low Yiong Huak Chan Vishal G Shelat | 2022 | World Journal of Clinical Cases2022，10，29： | 1 |
| 17 | Epidemiology of diabetic foot problems and predictive factors for limb loss 显示文摘 | Nather A Bee CS Huak CY etal | 2008 | J Diabetes Complications2008，22，2： | 1 |
| 18 | Family centered decision making and non-disclosure of diagnosis in a South East Asian oncology practice显示文摘 | Back MF Huak CY | 2005 | Psycho-Oncol2005，14，： | 1 |
| 19 | Epidemiology of diabetic foot problems and predictive factors for limb loss显示文摘 | Nather A Bee CS Huak CY | 2008 | J Diabetes Complieations2008，22，2： | 1 |
| 20 | Epidemiology of diabetic foot problems and predictive factors for limb loss显示文摘 | Nather A Bee CS Huak CY | 2008 | J Diabetes Complications2008，22，2： | 1 |
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