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| 1 | Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis显示文摘像域的蛋白质(Mlkl ) 最近被发现与受体交往交往的混合的系 kinase 蛋白质 3 (Rip3 ) 并且导致的坏死因素(TNF ) 在有教养的房间线规划了坏死(necroptosis ) 为肿瘤必要。我们由抄写产生了 Mlkl 缺乏的老鼠像使活跃之物的受动器核酸酶(TALEN ) 调停了基因混乱和发现 Mlkl 到为象有免疫力的房间开发一样的正常老鼠开发非必需。胚胎的成纤维细胞(MEF ) 和巨噬细胞两个都显示出的 Mlkl 缺乏的老鼠抵抗到坏死然而并非 apoptotic 刺激。Mlkl 缺乏的 MEF 和巨噬细胞与处于他们激活 NF-κ 的能力的野类型的房间难区分;响应 TNF 和 lipopolysaccharides (LPS ) 的 B,英皇家空军之阶级最低之兵, JNK,和 p38 分别地。一致地, Mlkl 缺乏的巨噬细胞和老鼠展出了正常 interleukin-1β(IL-1β) ,在 LPS 处理以后的 IL-6,和 TNF 生产。Mlkl 缺乏保护老鼠免受导致天蓝色的尖锐胰腺炎的伤害,坏死相关的疾病,但是没在 polymicrobial 上有效果腐败导致吃惊的动物死亡。我们的结果在 necroptosis 为 Mlkl 的角色提供基因证据。 | Jianfeng Wu Zhe Huang Junming Ren Zhirong Zhang Peng He Yangxin Li Jianhui Ma Wanze Chen Yingying Zhang Xiaojuan Zhou Zhentao Yang Su-Qin Wu Lanfen Chen Jiahuai Han | 2013 | Cell Research2013，23，8： | 35 |
| 2 | Genetic diversity and construction of core collection in Chinese wheat genetic resources显示文摘Genetic diversity among 5029 accessions representing a proposed Chinese wheat core collection was analyzed using 78 pairs of fluorescent microsatellite (SSR) primers mapped to 21 chromosomes. A stepwise hierarchical sampling strategy with priority based on 4×105 SSR data-points was used to construct a core collection from the 23090 initial collections. The core collection consisted of 1160 accessions, including 762 landraces, 348 modern varieties and 50 introduced varieties. The core ac-counts for 23.1% of the 5029 candidate core accessions and 5% of the 23090 initial collections, but retains 94.9% of alleles from the candidate collections and captures 91.5% of the genetic variation in the initial collections. These data indicate that it is possible to maintain genetic diversity in a core collection while retaining fewer accessions than the accepted standard, i.e., 10% of the initial collections captured more than 70% of their genetic diversity. Estimated genetic representation of the core con-structed by preferred sampling (91.5%) is much higher than that by random sampling (79.8%). Both mean genetic richness and genetic diversity indices of the landraces were higher than those of the modern varieties in the core. Structure and principal coordinate analysis revealed that the landraces and the modern varieties were two relatively independent subpopulations. Strong genetic differentiation associated with ecological environments has occurred in the landraces, but was relatively weak in the modern cultivars. In addition, a mini-core collection was constructed, which consisted of 231 accessions with an estimated 70% representation of the genetic variation from the initial collections. The mini-core has been distributed to various research and breeding institutes for detailed phenotyping and breeding of genetic introgression lines. | HAO ChenYang DONG YuChen WANG LanFen YOU GuangXia ZHANG HongNa GE HongMei JIA JiZeng ZHANG XueYong | 2008 | Chinese Science Bulletin2008，53，10： | 27 |
| 3 | Genetic diversity in Chinese modern wheat varieties revealed by microsatellite markers显示文摘Genetic diversity of 1680 modern varieties in Chinese candidate core collections was analyzed at 78 SSR loci by fluorescence detection system. A total of 1336 alleles were detected, of which 1253 alleles could be annotated into 71 loci. For these 71 loci, the alleles ranged from 4 to 44 with an average of 17.6, and the PIC values changed from 0.19 to 0.89 with an average of 0.69. (1) In the three genomes of wheat, the average genetic richness was B>A>D, and the genetic diversity indexes were B>D>A. (2) Among the seven homoeologous groups, the average genetic richness was 2=7>3>4>6>5>1, and the genetic diversity indexes were 7>3>2>4>6>5>1. As a whole, group 7 possessed the highest genetic diversity, while groups 1 and 5 were the lowest. (3) In the 21 wheat chromosomes, 7A, 3B and 2D possessed much higher genetic diversity, while 2A, 1B, 4D, 5D and 1D were the lowest. (4) The highest average genetic diversity index existed in varieties bred in the 1950s, and then it declined continually. However, the change tendency of genetic diversity among decades was not greatly sharp. This was further illustrated by changes of the average genetic distance between varieties. In the 1950s it was the largest (0.731). Since the 1960s, it has decreased gradually (0.711, 0.706, 0.696, 0.695). The genetic base of modern varieties is becoming narrower and narrower. This should be given enough attention by breeders and policy makers. | HAO Chenyang, WANG Lanfen, ZHANG Xueyong, YOU Guangxia, DONG Yushen, JIA Jizeng, LIU Xu, SHANG Xunwu, LIU Sancai & CAO Yongsheng Key Laboratory of Crop Germplasm & Biotechnology, MOA, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China Agronomy College, Gansu Agricultural University, Lanzhou 730070, China | 2006 | Science China(Life Sciences)2006，49，3： | 19 |
| 4 | The Hippo signaling pathway in liver regeneration and tumorigenesis显示文摘表明小径的河马是在肝尺寸控制和 tumorigenesis 起关键作用的一个 evolutionarily 保存的发信号的模块。河马小径由在的核心 kinase 串联组成哺乳动物的象 Ste20 一样 kinases (Mst1/2,果蝇河马的 orthologs ) 并且他们的余因子萨尔瓦多(Sav1 ) 形成建筑群到 phosphorylate 并且激活大肿瘤 suppressor (Lats1/2 ) 。Lats1/2 kinases 接着 phosphorylate 并且与 PDZ 有约束力的主题(TAZ ) 禁止抄写激活剂,联系是的蛋白质(笨蛋) 和 transcriptional 激活剂,河马小径的二个主要下游的受动器。河马小径部件的损失导致异常肝肿大和 tumorigenesis,笨蛋在协调房间增长和 apoptosis 的规定并且起一个必要作用。这评论总结在肝新生和 tumorigenesis 发信号的河马的规定的当前的调查结果,集中河马小径的肿瘤 suppressor 部件的损失怎么导致肝癌症并且讨论调整它在肝 tumorigenesis 的下游的受动器笨蛋的表示和激活的分子的机制。 | Lixin Hong Yabo Cai Mingting Jiang Dawang Zhou Lanfen Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，1： | 12 |
| 5 | Remote sensing based shrub above-ground biomass and carbon storage mapping in Mu Us desert,China显示文摘The estimation of above-ground biomass(AGB) and carbon storage is very important for arid and semi-arid ecosystems.HJ-1A/B satellite data combined with field measurement data was used for the estimation of shrub AGB and carbon storage in the Mu Us desert,China.The correlations of shrub AGB and spectral reflectance of four bands as well as their combined vegetation indexes were respectively analyzed and stepwise regression analysis was employed to establish AGB prediction equation.The prediction equation based on ratio vegetation index(RVI)was proved to be more suitable for shrub AGB estimation in the Mu Us desert than others.Shrub AGB and carbon storage were mapped using the RVI based prediction model in final.The statistics showed the western Mu Us desert has relatively high AGB and carbon storage,and that the gross shrub carton storage in Mu Us desert reaches 16 799 200 t,which has greatly contributed to the carbon fixation in northern China. | XU Min 1,2,CAO ChunXiang 1,TONG QingXi 1,LI ZengYuan 3,ZHANG Hao 1,HE QiSheng 1,2,GAO MengXu 1,2,ZHAO Jian 1,2,ZHENG Sheng 1,2,CHEN Wei 1,2 & ZHENG LanFen 1 1State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University,Beijing 100101,China 2 Graduate School of the Chinese Academy of Sciences,Beijing 100049,China 3 Research Institute of Forest Resources and Information Techniques,Chinese Academy of Forestry,Beijing 10009,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 5 |
| 6 | Role of Hippo signaling in regulating immunity显示文摘The Hippo signaling pathway has been established as a key regulator of organ size control,tumor suppression,and tissue regeneration in multiple organisms.Recently,emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals.In particular,patients bearing a loss-of-function mutation of MST1 are reported to have an autosomal recessive primary immunodeficiency syndrome.MST1/2 kinases,the mammalian orthologs of Drosophila Hippo,may activate the non-canonical Hippo signaling pathway via MOB1A/B and/or NDR1/2 or cross-talk with other essential signaling pathways to regulate both innate and adaptive immunity.In this review,we present and discuss recent findings of cellular mechanisms/functions of Hippo signaling in the innate immunity in Drosophila and in mammals,T cell immunity,as well as the implications of Hippo signaling for tumor immunity. | Lixin Hong Xun Li Dawang Zhou Jing Geng Lanfen Chen | 2018 | Cellular & Molecular Immunology2018，15，12： | 5 |
| 7 | Hippo pathway in intestinal homeostasis and tumorigenesis显示文摘The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death.Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis.Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis,regeneration and tumorigenesis,and the crosstalk between the Hippo signaling pathway and other major signaling pathways,i.e.Wnt,Notch and Jak/Stat signaling pathways in intestinal compartment. | Lanfen Chen Funiu Qin Xianming Deng Joseph Avruch Dawang Zhou | 2012 | Protein & Cell2012，3，4： | 4 |
| 8 | Fast integration and accumulation of beneficial breeding alleles through an AB–NAMIC strategy in wheat显示文摘Wheat(Triticum aestivum)is among the most important staple crops for safeguarding the food security of the growing world population.To bridge the gap between genebank diversity and breeding programs,we developed an advanced backcross-nested association mapping plus inter-crossed population(AB-NAMIC)by crossing three popular wheat cultivars as recurrent founders to 20 germplasm lines from a mini core collection.Selective backcrossing combined with selection against undesirable traits and extensive crossing within and between sub-populations created new opportunities to detect unknown genes and increase the frequency of beneficial alleles in the AB-NAMIC population.We performed phenotyping of 590 AB-NAMIC lines and a natural panel of 476 cultivars for six consecutive growing seasons and genotyped these 1066 lines with a 660K SNP array.Genome-wide association studies of both panels for plant development and yield traits demonstrated improved power to detect rare alleles and loci with medium genetic effects in AB-NAMIC.Notably,genome-wide association studies in AB-NAMIC detected the candidate gene TaSWEET6-7B(TraesCS7B03G1216700),which has high homology to the rice SWEET6b gene and exerts strong effects on adaptation and yield traits.The commercial release of two derived AB-NAMIC lines attests to its direct applicability in wheat improvement.Valuable information on genome-wide association studymapping,candidate genes,and their haplotypes for breeding traits are available through WheatGAB.Our research provides an excellent framework for fast-tracking exploration and accumulation of beneficial alleles stored in genebanks. | Chengzhi Jiao Chenyang Hao Tian Li Abhishek Bohra Lanfen Wang Jian Hou Hongxia Liu Hong Liu Jing Zhao Yamei Wang Yunchuan Liu Zhiwei Wang Xin Jing Xiue Wang Rajeev K.Varshney Junjie Fu Xueyong Zhang | 2023 | Plant Communications2023，4，3： | 3 |
| 9 | Genetic studies of schizophrenia:an update显示文摘Schizophrenia(SCZ) is a complex and heterogeneous mental disorder that affects about 1% of global population. In recent years,considerable progress has been made in genetic studies of SCZ. A number of common variants with small effects and rare variants with relatively larger effects have been identifi ed. These variants include risk loci identifi ed by genome-wide association studies,rare copy-number variants identifi ed by comparative genomic analyses,and de novo mutations identified by high-throughput DNA sequencing. Collectively,they contribute to the heterogeneity of the disease. In this review,we update recent discoveries in the fi eld of SCZ genetics,and outline the perspectives of future directions. | Jingchun Chen Fei Cao Lanfen Liu Lina Wang Xiangning Chen | 2015 | Neuroscience Bulletin2015，31，1： | 3 |
| 10 | The application of hyperspectral remote sensing to coast environment investigation显示文摘Requirements for monitoring the coastal zone environment are first summarized.Then the application of hyperspectral remote sensing to coast environment investigation is introduced,such as the classification of coast beaches and bottom matter,target recognition,mine detection,oil spill identification and ocean color remote sensing.Finally,what is needed to follow on in application of hyperspectral remote sensing to coast environment is recommended. | ZHANG Liang ZHANG Bin CHEN Zhengchao ZHENG Lanfen TONG Qingxi | 2009 | Acta Oceanologica Sinica2009，28，2： | 3 |
| 11 | Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA显示文摘钟(生理节奏的运动输出周期不行了) 并且 BMAL1 (大脑和肌肉象 ARNT 一样 1 ) 两个都是在哺乳动物的生理节奏的核心循环的抄写因素。最近出版的老鼠 CLOCK-BMAL1 bHLH (基本 helix-loop-helix ) 舞步(period-ARNT-single-minded ) 建筑群结构为 heterodimer 形成,而是机制仍然是的 protein-DNA 识别的结构的细节使机制清楚些逃犯。这里,我们阐明了人的 CLOCK-BMAL1 bHLH 领域的水晶结构跳了到正规电子盒子 DNA。我们证明钟和 BMAL1 bHLH 领域能互相被选择,并且结合氢的网络调停他们的电子盒子识别。我们识别了在 BMAL1 Ile80 和 flanking 胸腺嘧啶核苷酸之间的恐水病的接触,建议 CLOCK-BMAL1 实际上读 7-bp DNA 并且不以前相信的 6-bp DNA。为了发现潜在的不在经典中的电子盒子那,能被 CLOCK-BMAL1 认出,我们在电子盒子上构造了系统的单个核苷酸的变化并且测量了他们的相关亲密关系。我们与高亲密关系, AACGTGA 和 CATGTGA 定义二个不在经典中的电子盒子模式,在里面它 flanking A7-T7′基础对为识别是不可缺少的。这些结果将帮助我们在 vivo 识别功能的 CLOCK-BMAL1-binding 地点并且寻找控制钟的基因。而且,我们在 bHLH 区域估计了潜在的 phosphorylation 地点的禁止的角色。我们发现 BMAL1 Ser78 上的 phospho-mimicking 变化能高效地堵住有约束力的 DNA 以及在房间废除正常生理节奏的摆动。我们建议 BMAL1 Ser78 应该是调停的关键残余输入调整信号的 transcriptional 抑制让外部暗示乘火车由 kinase 的生理节奏的钟串联。 | Zixi Wang Yaling Wu Lanfen Li Xiao-Dong Su | 2013 | Cell Research2013，23，2： | 3 |
| 12 | Molecular cloning and characterization of a gene encoding the proline transporter protein in common bean(Phaseolus vulgaris L.)显示文摘As a typical compatible solute, proline is accumulated in plants under environmental stresses. Proline transporter(Pro T) plays an important role in proline distribution between plant organs. Using a candidate gene approach, we cloned a c DNA sequence for Pro T from common bean(Phaseolus vulgaris L.) and designated the gene Pv Pro T. The deduced amino acid sequence of Pv Pro T showed high similarity to Bet/Pro T proteins from other leguminous plants, and the highest similarity was observed with mothbean(Vigna aconitifolia L.) Vu Pro T.Relative quantification of the m RNA level of Pv Pro T using real-time PCR analysis showed that the Pv Pro T transcript level was higher in leaves than in stems and roots of common bean plants subjected to drought and salt stress. Under 20%(w/w) PEG-6000 treatment,drought-resistant plants expressed a higher level of Pv Pro T transcripts than droughtsensitive plants. Although heterologous expression of Pv Pro T in the Escherichia coli mutant mkh13 showed that Pv Pro T exhibited uptake activities for proline and betaine, no betaine content was detected in the common bean. These findings suggest that Pv Pro T plays an important role in the transportation of proline in common bean plants exposed to drought and salt stress. | Jibao Chen Jing Wu Yunfeng Lu Yuannan Cao Hui Zeng Zhaoyuan Zhang Lanfen Wang Shumin Wang | 2016 | The Crop Journal2016，4，5： | 2 |
| 13 | Why B - ring is the active center for genistein to scavenge peroxylradical: a DFT study显示文摘 | Zhang Hongyu Wang Lanfen Sun Youmin | 2003 | Bioorganic & Medicinal Chemistry Letters2003，，13： | 1 |
| 14 | A theoretical investigation on DPPH radical-scavenging mechanism of edaravone显示文摘 | Wang Lanfen Zhang Hongyu | 2003 | Bioorganic & Medicinal Chemistry Letters2003，，13： | 1 |
| 15 | Identification of Radio Environments in Software Antenna for High-Speed Millimeter Wave Wireless Communication Systems显示文摘 | Ping Tan Lanfen Qi | 2003 | International Journal of Infrared and Millimeter Waves2003，，6： | 1 |
| 16 | Determination of azithromycin in gastric biopsy samples显示文摘 | Krichoff RM Lanfen H Schacke G | 1999 | Int J Clin Pharmcol Ther1999，37，7： | 1 |
| 17 | Molecular mapping and detection of the yellow rust resistance gene Yr26 in wheat transferred from Triticum turgidum L. using microsatellite markers显示文摘 | Jianxin Ma Ronghua Zhou Yushen Dong Lanfen Wang Xiaoming Wang Jizeng Jia | 2001 | Euphytica2001，，2： | 1 |
| 18 | Analysis and application of NRD-guide excitor显示文摘 | Ma Hong Qi Lanfen | 1993 | The Int J of Infrared and Millimeter Waves1993，14，2： | 1 |
| 19 | Why B-ring is the active center for genistein to scavenge peroxyl radical: a DFT study显示文摘 | ZHANG Hongyu WANG Lanfen SUN Youming | 2003 | Bioorg Med Chem Lett2003，13，： | 1 |
| 20 | Development of nonradiative dielectric waveguide transmitting front-end in Ka-band显示文摘 | Ma Hong Qi Lanfen | 1996 | The Int J of Infrared and Millimeter Waves1996，17，10： | 1 |
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