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| 1 | Genetic diversity and construction of core collection in Chinese wheat genetic resources显示文摘Genetic diversity among 5029 accessions representing a proposed Chinese wheat core collection was analyzed using 78 pairs of fluorescent microsatellite (SSR) primers mapped to 21 chromosomes. A stepwise hierarchical sampling strategy with priority based on 4×105 SSR data-points was used to construct a core collection from the 23090 initial collections. The core collection consisted of 1160 accessions, including 762 landraces, 348 modern varieties and 50 introduced varieties. The core ac-counts for 23.1% of the 5029 candidate core accessions and 5% of the 23090 initial collections, but retains 94.9% of alleles from the candidate collections and captures 91.5% of the genetic variation in the initial collections. These data indicate that it is possible to maintain genetic diversity in a core collection while retaining fewer accessions than the accepted standard, i.e., 10% of the initial collections captured more than 70% of their genetic diversity. Estimated genetic representation of the core con-structed by preferred sampling (91.5%) is much higher than that by random sampling (79.8%). Both mean genetic richness and genetic diversity indices of the landraces were higher than those of the modern varieties in the core. Structure and principal coordinate analysis revealed that the landraces and the modern varieties were two relatively independent subpopulations. Strong genetic differentiation associated with ecological environments has occurred in the landraces, but was relatively weak in the modern cultivars. In addition, a mini-core collection was constructed, which consisted of 231 accessions with an estimated 70% representation of the genetic variation from the initial collections. The mini-core has been distributed to various research and breeding institutes for detailed phenotyping and breeding of genetic introgression lines. | HAO ChenYang DONG YuChen WANG LanFen YOU GuangXia ZHANG HongNa GE HongMei JIA JiZeng ZHANG XueYong | 2008 | Chinese Science Bulletin2008，53，10： | 27 |
| 2 | Genetic diversity in Chinese modern wheat varieties revealed by microsatellite markers显示文摘Genetic diversity of 1680 modern varieties in Chinese candidate core collections was analyzed at 78 SSR loci by fluorescence detection system. A total of 1336 alleles were detected, of which 1253 alleles could be annotated into 71 loci. For these 71 loci, the alleles ranged from 4 to 44 with an average of 17.6, and the PIC values changed from 0.19 to 0.89 with an average of 0.69. (1) In the three genomes of wheat, the average genetic richness was B>A>D, and the genetic diversity indexes were B>D>A. (2) Among the seven homoeologous groups, the average genetic richness was 2=7>3>4>6>5>1, and the genetic diversity indexes were 7>3>2>4>6>5>1. As a whole, group 7 possessed the highest genetic diversity, while groups 1 and 5 were the lowest. (3) In the 21 wheat chromosomes, 7A, 3B and 2D possessed much higher genetic diversity, while 2A, 1B, 4D, 5D and 1D were the lowest. (4) The highest average genetic diversity index existed in varieties bred in the 1950s, and then it declined continually. However, the change tendency of genetic diversity among decades was not greatly sharp. This was further illustrated by changes of the average genetic distance between varieties. In the 1950s it was the largest (0.731). Since the 1960s, it has decreased gradually (0.711, 0.706, 0.696, 0.695). The genetic base of modern varieties is becoming narrower and narrower. This should be given enough attention by breeders and policy makers. | HAO Chenyang, WANG Lanfen, ZHANG Xueyong, YOU Guangxia, DONG Yushen, JIA Jizeng, LIU Xu, SHANG Xunwu, LIU Sancai & CAO Yongsheng Key Laboratory of Crop Germplasm & Biotechnology, MOA, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China Agronomy College, Gansu Agricultural University, Lanzhou 730070, China | 2006 | Science China(Life Sciences)2006，49，3： | 19 |
| 3 | Fast integration and accumulation of beneficial breeding alleles through an AB–NAMIC strategy in wheat显示文摘Wheat(Triticum aestivum)is among the most important staple crops for safeguarding the food security of the growing world population.To bridge the gap between genebank diversity and breeding programs,we developed an advanced backcross-nested association mapping plus inter-crossed population(AB-NAMIC)by crossing three popular wheat cultivars as recurrent founders to 20 germplasm lines from a mini core collection.Selective backcrossing combined with selection against undesirable traits and extensive crossing within and between sub-populations created new opportunities to detect unknown genes and increase the frequency of beneficial alleles in the AB-NAMIC population.We performed phenotyping of 590 AB-NAMIC lines and a natural panel of 476 cultivars for six consecutive growing seasons and genotyped these 1066 lines with a 660K SNP array.Genome-wide association studies of both panels for plant development and yield traits demonstrated improved power to detect rare alleles and loci with medium genetic effects in AB-NAMIC.Notably,genome-wide association studies in AB-NAMIC detected the candidate gene TaSWEET6-7B(TraesCS7B03G1216700),which has high homology to the rice SWEET6b gene and exerts strong effects on adaptation and yield traits.The commercial release of two derived AB-NAMIC lines attests to its direct applicability in wheat improvement.Valuable information on genome-wide association studymapping,candidate genes,and their haplotypes for breeding traits are available through WheatGAB.Our research provides an excellent framework for fast-tracking exploration and accumulation of beneficial alleles stored in genebanks. | Chengzhi Jiao Chenyang Hao Tian Li Abhishek Bohra Lanfen Wang Jian Hou Hongxia Liu Hong Liu Jing Zhao Yamei Wang Yunchuan Liu Zhiwei Wang Xin Jing Xiue Wang Rajeev K.Varshney Junjie Fu Xueyong Zhang | 2023 | Plant Communications2023，4，3： | 3 |
| 4 | Genetic studies of schizophrenia:an update显示文摘Schizophrenia(SCZ) is a complex and heterogeneous mental disorder that affects about 1% of global population. In recent years,considerable progress has been made in genetic studies of SCZ. A number of common variants with small effects and rare variants with relatively larger effects have been identifi ed. These variants include risk loci identifi ed by genome-wide association studies,rare copy-number variants identifi ed by comparative genomic analyses,and de novo mutations identified by high-throughput DNA sequencing. Collectively,they contribute to the heterogeneity of the disease. In this review,we update recent discoveries in the fi eld of SCZ genetics,and outline the perspectives of future directions. | Jingchun Chen Fei Cao Lanfen Liu Lina Wang Xiangning Chen | 2015 | Neuroscience Bulletin2015，31，1： | 3 |
| 5 | Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA显示文摘钟(生理节奏的运动输出周期不行了) 并且 BMAL1 (大脑和肌肉象 ARNT 一样 1 ) 两个都是在哺乳动物的生理节奏的核心循环的抄写因素。最近出版的老鼠 CLOCK-BMAL1 bHLH (基本 helix-loop-helix ) 舞步(period-ARNT-single-minded ) 建筑群结构为 heterodimer 形成,而是机制仍然是的 protein-DNA 识别的结构的细节使机制清楚些逃犯。这里,我们阐明了人的 CLOCK-BMAL1 bHLH 领域的水晶结构跳了到正规电子盒子 DNA。我们证明钟和 BMAL1 bHLH 领域能互相被选择,并且结合氢的网络调停他们的电子盒子识别。我们识别了在 BMAL1 Ile80 和 flanking 胸腺嘧啶核苷酸之间的恐水病的接触,建议 CLOCK-BMAL1 实际上读 7-bp DNA 并且不以前相信的 6-bp DNA。为了发现潜在的不在经典中的电子盒子那,能被 CLOCK-BMAL1 认出,我们在电子盒子上构造了系统的单个核苷酸的变化并且测量了他们的相关亲密关系。我们与高亲密关系, AACGTGA 和 CATGTGA 定义二个不在经典中的电子盒子模式,在里面它 flanking A7-T7′基础对为识别是不可缺少的。这些结果将帮助我们在 vivo 识别功能的 CLOCK-BMAL1-binding 地点并且寻找控制钟的基因。而且,我们在 bHLH 区域估计了潜在的 phosphorylation 地点的禁止的角色。我们发现 BMAL1 Ser78 上的 phospho-mimicking 变化能高效地堵住有约束力的 DNA 以及在房间废除正常生理节奏的摆动。我们建议 BMAL1 Ser78 应该是调停的关键残余输入调整信号的 transcriptional 抑制让外部暗示乘火车由 kinase 的生理节奏的钟串联。 | Zixi Wang Yaling Wu Lanfen Li Xiao-Dong Su | 2013 | Cell Research2013，23，2： | 3 |
| 6 | Molecular cloning and characterization of a gene encoding the proline transporter protein in common bean(Phaseolus vulgaris L.)显示文摘As a typical compatible solute, proline is accumulated in plants under environmental stresses. Proline transporter(Pro T) plays an important role in proline distribution between plant organs. Using a candidate gene approach, we cloned a c DNA sequence for Pro T from common bean(Phaseolus vulgaris L.) and designated the gene Pv Pro T. The deduced amino acid sequence of Pv Pro T showed high similarity to Bet/Pro T proteins from other leguminous plants, and the highest similarity was observed with mothbean(Vigna aconitifolia L.) Vu Pro T.Relative quantification of the m RNA level of Pv Pro T using real-time PCR analysis showed that the Pv Pro T transcript level was higher in leaves than in stems and roots of common bean plants subjected to drought and salt stress. Under 20%(w/w) PEG-6000 treatment,drought-resistant plants expressed a higher level of Pv Pro T transcripts than droughtsensitive plants. Although heterologous expression of Pv Pro T in the Escherichia coli mutant mkh13 showed that Pv Pro T exhibited uptake activities for proline and betaine, no betaine content was detected in the common bean. These findings suggest that Pv Pro T plays an important role in the transportation of proline in common bean plants exposed to drought and salt stress. | Jibao Chen Jing Wu Yunfeng Lu Yuannan Cao Hui Zeng Zhaoyuan Zhang Lanfen Wang Shumin Wang | 2016 | The Crop Journal2016，4，5： | 2 |
| 7 | Why B - ring is the active center for genistein to scavenge peroxylradical: a DFT study显示文摘 | Zhang Hongyu Wang Lanfen Sun Youmin | 2003 | Bioorganic & Medicinal Chemistry Letters2003，，13： | 1 |
| 8 | A theoretical investigation on DPPH radical-scavenging mechanism of edaravone显示文摘 | Wang Lanfen Zhang Hongyu | 2003 | Bioorganic & Medicinal Chemistry Letters2003，，13： | 1 |
| 9 | Molecular mapping and detection of the yellow rust resistance gene Yr26 in wheat transferred from Triticum turgidum L. using microsatellite markers显示文摘 | Jianxin Ma Ronghua Zhou Yushen Dong Lanfen Wang Xiaoming Wang Jizeng Jia | 2001 | Euphytica2001，，2： | 1 |
| 10 | Why B-ring is the active center for genistein to scavenge peroxyl radical: a DFT study显示文摘 | ZHANG Hongyu WANG Lanfen SUN Youming | 2003 | Bioorg Med Chem Lett2003，13，： | 1 |
| 11 | Experiments and model for the surface tension of carbonated monoethanolamine aqueous solutions显示文摘The surface tension of carbonated monoethanolamine aqueous solutions from 293.15 to 323.15 K was measured by using an automatic surface tension-meter.A model applicable for the surface tension of MEA-CO2-water mixtures was proposed and the calculated results agreed well with the experiments.The influences of temperature,MEA concentration and CO2 loading were demonstrated on the basis of experiments and calculations. | FU Dong XU YiFei WANG LanFen CHEN LiHong | 2012 | Science China Chemistry2012，55，7： | 1 |
| 12 | Molecular tagging of the yellow rust resistance gene Yr10 in common wheat, P.I.178383 (Triticum aestivum L.)显示文摘 | Lanfen Wang Jianxin Ma Ronghua Zhou Xiaoming Wang Jizeng Jia | 2002 | Euphytica2002，，1： | 1 |
| 13 | QTL and candidate genes associated with common bacterial blight resistance in the common bean cultivar Longyundou 5 from China显示文摘Common bacterial blight(CBB), caused by Xanthomonas axonopodis pv. phaseoli and Xanthomonas fuscans subsp. fuscans(Xff), is a worldwide disease of common bean(Phaseolus vulgaris L.).Longyundou 5, a Chinese cultivar in the Mesoamerican gene pool of common bean, displays resistance to the Xff strain XSC3-1. To identify the genetic mechanisms behind this resistance,we crossed Long 5 with a susceptible genotype to develop a mapping population of F2 plants.Plant resistance to CBB was identified at 14 and 21 days after inoculation with Xff strain XSC3-1.A major QTL at 14 and 21 days after inoculation was mapped on chromosome Pv10 with LOD scores of 6.41 and 5.35, respectively. This locus was associated with SAP6, a previouslyidentified and much-used dominant marker, but in a 4.2 cM interval between new codominant markers BMp10s174 and BMp10s244. Ten candidate genes were found between markers BMp10s174 and BMp10s244 on chromosome Pv10 and could encode defense response proteins responding to CBB pathogens. Four pairs each of epistatic QTL for CBB resistance were detected at 14 and 21 days after inoculation. Phenotypic variation explained by the epistatic QTL ranged from 7.19% to 12.15% and 7.72% to 8.80% at 14 and 21 days after inoculation, respectively. These results confirmed the importance of epistasis in CBB resistance in common bean. The adjacent markers found may be more efficient for marker assisted selection in common bean breeding for CBB resistance owing to their closer linkage to the target QTL. | Jifeng Zhu Jing Wu Lanfen Wang Matthew W.Blair Zhendong Zhu Shumin Wang | 2016 | The Crop Journal2016，4，5： | 1 |
| 14 | 肝肠循环因子FGF15/19调节胆汁酸代谢从而控制肝脏尺寸大小与肝癌发生显示文摘文章简介肝脏是人体的一个重要代谢器官,它的大小相对于整个个体大小始终维持在一个合适的比例。肝脏如何感知生长起始和停止是肝脏发育、再生以及癌症生物学中一个有待解决的基本科学问题。近年来研究发现,Hippo信号通路在从果蝇到哺乳动物个体的器官发育及大小调控中都起着至关重要的作用。然而具体何种外部因子在调控Hippo信号通路来维持肝脏大小稳态及抑制癌症发生,一直是领域内未解决的问题。 | 姬素渊 刘清许 张世浩 陈青花 王聪 Weiji Zhang Chen Xiao Yuxi Li Cheng Nian Jiaxin Li Junhong Li Jing Geng Lixin Hong Changchuan Xie Ying He Xing Chen Xun Li Zhen-Yu Yin Han You Kwang-Huei Lin Qiao Wu Chundong Yu Randy L.Johnson Li Wang Lanfen Chen Fen Wang 周大旺 | 2020 | 科学新闻2020，，2： | 1 |
| 15 | An exploratory theoretical elucidation on the peroxyl-radieal- scavenging mechanism and structure~activity relationship ofnonsteroidal anti-inflammatory drugs 显示文摘 | WANG Lanfen SONG Yuguang ZHANG Xiufeng | 2006 | Bioorganic Medicinal Chemistry Letters2006，16，12： | 1 |
| 16 | Mendelian randomization study to investigate the causal relationship between plasma homocysteine and chronic obstructive pulmonary disease显示文摘BACKGROUND:Several observational studies have shown an association between homocysteine(Hcy)levels and chronic obstructive pulmonary disease(COPD),but causal relationships are not clear.Our study aimed to explore the causal relationship between plasma Hcy and COPD by two-sample Mendelian randomization(MR).METHODS:A two-sample MR study was performed to infer the causal link.Genetically predicted plasma Hcy was selected as an instrumental variable(Ⅳ)from published genome-wide association study(GWAS)meta-analyses.COPD with different etiologies was extracted as outcome variables from other GWAS meta-analyses.The main MR analysis was performed using the inversevariance weighted(IVW)method.Additional analyses were further performed using Cochran’s Q-test and MR-Egger regression to evaluate the heterogeneity or horizontal pleiotropy of our findings.RESULTS:MR analysis showed no significant association between plasma Hcy and COPD.The results of the groups were consistent with the sensitivity analysis and repeated analysis,without heterogeneity or horizontal pleiotropy.The IVW results showed COPD hospital admissions(odds ratio[OR]1.06,95%confidence interval[CI]0.91-1.24,P=0.42),asthma/COPD(OR 0.97,95%CI0.89-1.06,P=0.55),COPD-related chronic infection(OR 1.50,95%CI 0.57-3.99,P=0.41),COPDI asthma/interstitial lung disease(ILD)-related pneumonia or pneumonia-derived septicemia(OR 0.93,95%CI 0.86-1.02,P=0.13),and COPD-related respiratory insufficiency(OR 1.00,95%CI 0.7-1.44,P=0.99).CONCLUSION:There is no direct causal relationship between plasma Hcy and COPD in our study.As Hcy is known to have deleterious effects on endothelial function and vascular homeostasis,further studies are needed to investigate whether additional factors mediate the association between Hcy and COPD. | Yanlan Hu Ping Tan Juntao Wang Jun Zeng Quan Li Shijiao Yan Wenjie Hao Lanfen He Xingyue Song Caihong Zhang Chuanzhu Lyu | 2023 | World Journal of Emergency Medicine2023，14，5： | 0 |
| 17 | Efficient triplet pair separation from intramolecular singlet fission in dibenzopentalene derivatives显示文摘In intramolecular SF(iSF), the strong coupling nature and confinement of diffusional separation of ^1(TT) limits the extraction and harnessing of triplet energy. In order to investigate the possible ^1(TT) separation and the role of molecular parameters on it, a series of iSF-capable dibenzopentalene derivatives(DBPs) have been synthesized and their photoinduced dynamics are monitored. iSF takes place in DBPs, accompanied by consecutive ^1(TT) separation in polycrystalline film with almost ^100% yield. It is suggested the strong intermolecular coupling provided by the closely packing configuration in the film facilitates the disentanglement of correlated ^1(TT). Highly efficient triplet pair separation to yield free triplets makes one step forward for utilizing triplet energy from iSF materials for further optoelectronic applications. | Yanping Liu Yishi Wu Long Wang Lanfen Wang Jiannian Yao Hongbing Fu | 2019 | Science China Chemistry2019，62，8： | 0 |
| 18 | Genetic dissection of yield-related traits in response to drought stress in common bean显示文摘Drought stress severely impairs common bean production.For facilitating drought-resistance breeding in common bean,molecular markers were identified in a genome-wide level marker–trait association study.A panel of 210 common bean accessions showed large variation in 11 agronomic traits at the adult stage(plant height,pod number per plant,seed number per pod,seed number per plant,seed yield per plant,pod length,harvest index,pod harvest index,days to maturity,hundred-seed weight,and seed yield)under two water conditions.The coefficient of variation ranged from 6.21% for pod harvest index to51.00% for seed number per plant under well-watered conditions,and from 4.05% for days to maturity to 40.72% for seed number per plant under drought stress.In a genome-wide association study,119quantitative-trait loci were associated with drought resistance,including 41 adjacent to known loci.Among these loci,12 were found to be associated with at least two traits.Three major loci were identified at Pv01 and Pv02.A set of candidate genes were found that encode MYBs,AREBs,WKRYs,and protein kinases.These results reveal promising alleles that control drought resistance,shedding light on the genetic basis of drought resistance and accelerating future efforts for drought resistance improvement in common bean. | Lei Wu Yujie Chang Lanfen Wang Liang Ji Lin Peng Shumin Wang Jing Wu | 2023 | The Crop Journal2023，11，4： | 0 |
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