5篇
您的检索式：作者名="Lara Lipton"
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| 1 | Metastatic colorectal cancer-past,progress and future显示文摘The clinical management of metastatic (stage Ⅳ) colorectal cancer (CRC) is a common challenge faced by surgeons and physicians. The last decade has seen exciting developments in the management of CRC, with significant improvements in prognosis for patients diagnosed with stage Ⅳ disease. Treatment options have expanded from 5-fluorouracil alone to a range of pharmaceutical and interventional therapies, improving survival, and providing a cure in selected cases. Enhanced understanding of the biologic pathways most important in colorectal carcinogenesis has led to a new generation of drugs showing promise in advanced disease. It is hoped that in the near future the treatment paradigm of metastatic CRC will be analogous to that of a chronic illness, rather than a rapidly terminal condition. This overview discusses the epidemiology of advanced CRC and currently available therapeutic options including medical, surgical, ablative and novel modalities in the management of metastatic colorectal cancer. | Kathryn Field Lara Lipton | 2007 | World Journal of Gastroenterology2007，13，28： | 8 |
| 2 | Adjuvant therapies for colorectal cancer显示文摘The management of colon and rectal cancer has changed dramatically over the last 25 years. The use of adjuvant therapies has become standard practice in locally advanced (stage Ⅲ and selected stage Ⅱ) colorectal cancer. Improved surgical techniques, chemotherapeutics and radiotherapy are resulting in higher cure rates and the development of agents targeting proliferative and angiogenic pathways offer further promise. Here we explore risk factors for local and distant recurrence after resection of colon and rectal cancer, and the role of adjuvant treatments. Discussion will focus on the evidence base for adjuvant therapies utilised in colorectal cancer, and the treatment of sub-groups such as the elderly and stage Ⅱ disease. The role of adjuvant radiotherapy in rectal cancer in reduction of recurrence will be explored and the role and optimal methods for surveillance post-curative resection with or without adjuvant therapy will also be addressed. | Suzanne Kosmider Lara Lipton | 2007 | World Journal of Gastroenterology2007，13，28： | 7 |
| 3 | Risk of Metachronous Colon Cancer Following Surgery for Rectal Cancer in Mismatch Repair Gene Mutation Carriers显示文摘 | Aung Ko Win Susan Parry Bryan Parry Matthew F. Kalady Finlay A. Macrae Dennis J. Ahnen Graeme P. Young Lara Lipton Ingrid Winship Alex Boussioutas Joanne P. Young Daniel D. Buchanan Julie Arnold Lo?c Le Marchand Polly A. Newcomb Robert W. Haile Noralane M | 2013 | Annals of Surgical Oncology2013，，6： | 1 |
| 4 | Overall Survival Improvement in Patients with Lung Cancer and Bone Metastases Treated with Denosumab Versus Zoledronic Acid: Subgroup Analysis from a Randomized Phase 3 Study显示文摘 | Giorgio Vittorio Scagliotti Vera Hirsh Salvatore Siena David H. Henry Penella J. Woll Christian Manegold Philippe Solal-Celigny Gladys Rodriguez Maciej Krzakowski Nilesh D. Mehta Lara Lipton José Angel García-Sáenz José Rodrigues Pereira Kumar Prabhash Tu | 2012 | Journal of Thoracic Oncology2012，，12： | 1 |
| 5 | Hyperplastic Polyposis Syndrome: Phenotypic Presentations and the Role of MBD4 and MYH显示文摘 | Elizabeth Chow Lara Lipton Elly Lynch Rebecca D’Souza Clelia Aragona Lindy Hodgkin Gregor Brown Ingrid Winship Melissa Barker Daniel Buchanan Shannon Cowie Steve Nasioulas Desiree du Sart Joanne Young Barbara Leggett Jeremy Jass Finlay Macrae | 2006 | Gastroenterology2006，，1： | 1 |
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