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| 1 | Chronic stress sensitizes rats to pancreatitis induced by cerulein:Role of TNF-α显示文摘AIM:To investigate chronic stress as a susceptibility factor for developing pancreatitis,as well as tumor necrosis factor-α (TNF-α) as a putative sensitizer.METHODS:Rat pancreatic acini were used to analyze the influence of TNF-α on submaximal (50 pmol/L) cholecystokinin (CCK) stimulation.Chronic restraint (4 h every day for 21 d) was used to evaluate the effects of submaximal (0.2 μg/kg per hour) cerulein stimulation on chronically stressed rats.RESULTS:In vitro exposure of pancreatic acini toTNF-α disorganized the actin cytoskeleton.This was further increased by TNF-α/CCK treatment,which additionally reduced amylase secretion,and increased trypsin and nuclear factor-κB activities in a protein-kinase-C δ and ε-dependent manner.TNF-α/CCK also enhanced caspases' activity and lactate dehydrogenase release,induced ATP loss,and augmented the ADP/ATP ratio.In vivo,rats under chronic restraint exhibited elevated serum and pancreatic TNF-α levels.Serum,pancreatic,and lung inflammatory parameters,as well as caspases' activity in pancreatic and lung tissue,were substantially enhanced in stressed/cerulein-treated rats,which also experienced tissues' ATP loss and greater ADP/ATP ratios.Histological examination revealed that stressed/cerulein-treated animals developed abundant pancreatic and lung edema,hemorrhage and leukocyte infiltrate,and pancreatic necrosis.Pancreatitis severity was greatly decreased by treating animals with an anti-TNF-αantibody,which diminished all inflammatory parameters,histopathological scores,and apoptotic/necrotic markers in stressed/cerulein-treated rats.CONCLUSION:In rats,chronic stress increases susceptibility for developing pancreatitis,which involves TNF-α sensitization of pancreatic acinar cells to undergo injury by physiological cerulein stimulation. | Marcelo G Binker Andres A Binker-Cosen Daniel Richards Herbert Y Gaisano Rodica H de Cosen Laura I Cosen-Binker | 2010 | World Journal of Gastroenterology2010，16，44： | 7 |
| 2 | Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury显示文摘Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Immunization with neural derived peptides(INDP), inhibition of glial scar formation(dipyridyl: DPY), as well as the use of biocompatible matrix(fibrin glue: FG) impregnated with bone marrow mesenchymal stem cells(MSCs) were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI. Sprague-Dawley female rats were subjected to a moderate spinal cord injury and then randomly allocated into five groups: 1) phosphate buffered saline; 2) DPY; 3) INDP + DPY; 4) DPY+ FG; 5) INDP + DPY + FG + MSCs. In all rats, intervention was performed 72 hours after spinal cord injury. Locomotor and sensibility recovery was assessed in all rats. At 60 days after treatment, histological examinations of the spinal cord(hematoxylin-eosin and Bielschowsky staining) were performed. Our results showed that the combination therapy(DPY+ INDP + FG+ MSCs) was the best strategy to promote motor and sensibility recovery. In addition, significant increases in tissue preservation and axonal density were observed in the combination therapy group. Findings from this study suggest that the combination theapy(DPY+ INDP + FG + MSCs) exhibits potential effects on the protection and regeneration of neural tissue after acute spinal cord injury. All procedures were approved by the Animal Bioethics and Welfare Committee(approval No. 178544; CSNBTBIBAJ 090812960)on August 15, 2016. | Elisa García Roxana Rodríguez-Barrera Vinnitsa Buzoianu-Anguiano Adrian Flores-Romero Emanuel Malagón-Axotla Marco Guerrero-Godinez Estefanía De la Cruz-Castillo Laura Castillo-Carvajal Monserrat Rivas-Gonzalez Paola Santiago-Tovar Ivis Morales Cesar Borlongan Antonio Ibarra | 2019 | Neural Regeneration Research2019，14，6： | 6 |
| 3 | Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation显示文摘 | Jose A. Rodríguez-Navarro Laura Rodríguez María J. Casarejos Rosa M. Solano Ana Gómez Juan Perucho Ana María Cuervo Justo García de Yébenes María A. Mena | 2010 | Neurobiology of Disease2010，，3： | 2 |
| 4 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 5 | Ventilator - associated pneu- monia in an adult clinical surgical intensive care unit of a brazilian uni- versity hospltal: incidence, risk factors, etiology, and antibiotic resist- ance 显示文摘 | Laura de A Carolina V Renata C | 2008 | Braz J Infect Dis2008，12，1： | 1 |
| 6 | A study of the retrograda- tion process in five argentine rice starches显示文摘 | LAURA B I de MISHIMA B L MARIA C A | 2010 | LWT-Food Science and Technology2010，43，4： | 1 |
| 7 | Acute and chronic hemodynamic changes after propranolol in patients with cirrhosis under primary and secondary prophylaxis of variceal bleeding: a pilot study显示文摘 | Enrique de-Madaria José María Palazón Flavia Tamara Hernández José Sánchez-Paya Pedro Zapater Javier Irurzun Francisco de Espa?a Sonia Pascual José Such Laura Sempere Fernando Carnicer Antonio García-Herola Jaime Valverde Miguel Pérez-Mateo | 2010 | European Journal of Gastroenterology & Hepatology2010，，5： | 1 |
| 8 | Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients显示文摘BACKGROUND Life-long removal of gluten from the diet is currently the only way to manage celiac disease(CeD). Until now, no objective test has proven useful to objectively detect ingested gluten in clinical practice. Recently, tests that determine consumption of gluten by assessing excretion of gluten immunogenic peptides(GIP) in stool and urine have been developed. Their utility, in comparison with conventional dietary and analytical follow-up strategies, has not been fully established.AIM To assess the performance of enzyme-linked immunosorbent assay(ELISA) and point-of-care tests(PoCTs) for GIP excretion in CeD patients on gluten-free diet(GFD).METHODS We conducted an observational, prospective, cross-sectional study in patients following a GFD for at least two years. Using the Gastrointestinal Symptom Rating Scale questionnaire, patients were classified at enrollment as asymptomatic or symptomatic. Gluten consumption was assessed twice by 3-d dietary recall and GIP excretion(by ELISA in stool and PoCTs(commercial kits for stool and urine) in two consecutive samples. These samples and dietary reports were obtained 10 day apart one from the other. Patients were encouraged to follow their usual GFD during the study period.RESULTS Forty-four patients were enrolled, of which 19(43.2%) were symptomatic despite being on a GFD. Overall, 83 sets of stool and/or urine samples were collected.Eleven out of 44 patients(25.0%) had at least one positive GIP test. The occurrence of at least one positive test was 32% in asymptomatic patients compared with 15.8% in symptomatic patients. GIP was concordant with dietary reports in 65.9% of cases(Cohen′s kappa: 0.317). PoCT detected dietary indiscretions. Both ELISA and PoCT in stool were concordant(concomitantly positive or negative) in 67 out of 74(90.5%) samples. Excretion of GIP was detected in 7(8.4%) stool and/or urine samples from patients considered to be strictly compliant with the GFD by dietary reports.CONCLUSION GIP detects dietary transgressions in patients on long-term GFD, irrespective of the presence of symptoms. PoCT for GIP detection constitutes a simple homebased method for self-assessment of dietary indiscretions. | Ana Florencia Costa Emilia Sugai María de la Paz Temprano Sonia Isabel Niveloni Horacio Vázquez María Laura Moreno M.Remedios Domínguez-Flores Alba Mu?oz-Suano Edgardo Smecuol Juan Pablo Stefanolo Andrea F González Angel Cebolla-Ramirez Eduardo Mauri?o Elena F Verdú Julio César Bai | 2019 | World Journal of Gastroenterology2019，25，11： | 1 |
| 9 | Cross-sectional study to determine viral hepatitis knowledge in different urban populations in Brazil显示文摘AIM To evaluate viral hepatitis knowledge among individuals from different resource areas and health conditions to identify possible gaps.METHODS A cross-sectional, descriptive study was carried out among 447 individuals from five distinct populations in Brazil: Southeast Viral Hepatitis Ambulatory(n = 100), South(n = 89) and Northeast(n = 114) Health Center, Southeast(n = 77) and Northeast(n = 67) low resource areas. All individuals answered a questionnaire assessing sociodemographic characteristics and viral hepatitis awareness. The perception was scored based on the average number of correct answers of all participants and categorized as 'low'(0-28 correct answers) or 'desirable'(29-46 correct answers). Associations between sociodemographic characteristics and perception were also evaluated.RESULTS A low level of knowledge was observed in individuals from Northeast Health Center, Northeast and Southeast low resource areas while desirable knowledge was observed in individuals from Viral Hepatitis Ambulatory and South Health Center. According to sociodemographic characteristics, desirable scores were more common among those with secondary education(47.1%), those who declared themselves as white(46.3%), and those who lived in houses with three individuals(25.5%). Multivariate analysis showed an association between viral hepatitis perception and type of population. CONCLUSION The results demonstrated high level of knowledge among study participants from health clinics from the Southeast region of Brazil and the importance of education programs in increasing the level of knowledge in low resource areas. | Helena Medina Cruz Jakeline Ribeiro Barbosa Jeová Keny Baima Colares Antonio Henrique Almeida de Moraes Neto Maria de Fátima Leal Alencar Francisco Inácio Bastos Jurema Corrêa da Mota Filipe Aníbal Carvalho-Costa Claudia Alexandra Pontes Ivantes Lia Laura Lewis-Ximenez Livia Melo Villar | 2018 | World Journal of Hepatology2018，10，11： | 1 |
| 10 | 显示文摘 | María de la Paz Jimenez Ana de la Horra Laura Pruzzo Martha R. Palma | 2002 | Biology and Fertility of Soils2002，，4： | 1 |
| 11 | Assessment of CO 2 Arteriography in Arterial Occlusive Disease of the Lower Extremities显示文摘 | Laura Paúl Díaz Isabel Pinto Pabón Jesuús Alfayate García Miguel Angel de la Cal López | 2000 | Journal of Vascular and Interventional Radiology2000，，2： | 1 |
| 12 | Early management of type 2 diabetes based on a SMBG strategy: the way to diabetes regression—the St Carlos study显示文摘 | Nuria García de la Torre Alejandra Durán Laura Valle Manuel Fuentes Idoya Barca Patricia Martín Carmen Monta?ez Natalia Perez-Ferre Rosario Abad Fuencisla Sanz Mercedes Galindo Miguel A. Rubio Alfonso L. Calle-Pascual | 2013 | Acta Diabetologica2013，，4： | 1 |
| 13 | Presence of Clostridium botulinum spores in Matriearia chamomilla ( chamomile ) and its relationship with infant botulism显示文摘 | Mar i a I Bianco Carolina L O quez Laura IT de Jong | 2008 | International Journal of Food Microbiology2008，121，3： | 1 |
| 14 | 长期交通相关空气污染暴露与亚临床动脉粥样硬化的关联:REGICOR研究显示文摘[背景]长期空气污染暴露对动脉粥样硬化形成慢性过程影响的流行病学证据并不多。[目的]通过测量颈动脉内膜中层厚度(IMT)和踝臂指数(ABI),探讨长期交通相关空气污染暴露与亚临床动脉粥样硬化的关联。[方法]采用REGICOR(RegistreGironidelCor:赫罗纳心脏病注册)研究中2780名参加者复检期间(2007--2010年)的数据进行横断面分析,REGICOR是在西班牙赫罗纳进行的、以人群为基础的前瞻性队列研究。 | Marcela Rivera Xavier Basagaa Inmaculada Aguilera Maria Foraster David Agis Eric de Groot Laura Perez Michelle A.Mendez Laura Bouso Jaume Targa Rafael Ramos Joan Sala Jaume Marrugat Roberto Elosua Nino Künzli | 2013 | 环境与职业医学2013，30，5： | 1 |
| 15 | Determination of the ground vibration attenuation law from a singleblast: A particular case of trench blasting显示文摘The general transmissivity law of ground vibrations was studied,and a user-friendly methodology for determining the behavior of vibrations generated in any rock mass is proposed.The study was based on a single blast in a trench excavation,analyzing the vibration components recorded from two fixed locations.The attenuation law and the main variables according to the legal requirements,frequency and peak particle velocity(PPV),are defined with this novel method,achieving a high confidence level in a simple manner.The proposed approach can also have an important impact in terms of reducing the potential consequences of vibrations for the surrounding construction and achieving the required definition of rock mass.Reducing the cost and time in many projects where blasting techniques are applied is particularly useful for the design of future blasts. | Rafael Rodríguez Laura García de Marina Marc Bascompta Cristóbal Lombardía | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，5： | 1 |
| 16 | Complexation of apple antioxidants: Chlorogenic acid,quercetin and rutin by -cyclodextrin ( -CD) 显示文摘 | ALVAREZ-PARRILLA EMILIO DE LA ROSA LAURA A TORRES-RIVAS FRANCISCO | 2005 | Journal of Inclusion Phenomena and Macrocyclic Chemistry2005，53，12： | 1 |
| 17 | Effects of Colon Capsule Endoscopy on Medical Decision-Making in Patients With Incomplete Colonoscopies显示文摘 | Onofre Alarcón-Fernández Laura Ramos-López Zaida Adrián de Ganzo Antonio Zebenzuy Gimeno-García David Nicolás-Pérez Alejandro Jiménez Enrique Quintero | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 18 | 显示文摘 | María de la Paz Jimenez Ana de la Horra Laura Pruzzo Martha R. Palma | 2002 | Biology and Fertility of Soils2002，，4： | 1 |
| 19 | Measured Copper Toxicity to Cnesterodon decemmaculatus (Pisces: Poeciliidae) and Predicted by Biotic Ligand Model in Pilcomayo River Water: A Step for a Cross-Fish-Species Extrapolation显示文摘 | María Victoria Casares Laura I. de Cabo Rafael S. Seoane Oscar E. Natale Milagros Castro Ríos Cristian Weigandt Alicia F. de Iorio Anthony DeCaprio | 2012 | Journal of Toxicology2012，，： | 1 |
| 20 | Synergistic cytotoxicity of the poly ( ADP ‐ribose) polymerase inhibitor ABT ‐888 and temozolomide in dual‐drug targeted magnetic nanoparticles显示文摘 | José A Mu?oz‐Gámez Julián López Viota Andrés Barrientos ángel Carazo Laura Sanjuán‐Nu?ez Rosa Quiles‐Perez Paloma Mu?oz‐de‐Rueda ángel Delgado ángeles Ruiz‐Extremera Javier Salmerón | 2015 | Liver Int2015，，4： | 1 |
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