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| 1 | Admission hyperglycemia predicts poorer short‐ and long‐term outcomes after primary percutaneous coronary intervention for ST ‐elevation myocardial infarction显示文摘 | Pei‐Chi Chen Su‐Kiat Chua Huei‐Fong Hung Chung‐Yen Huang Chiu‐Mei Lin Shih‐Ming Lai Yen‐Ling Chen Jun‐Jack Cheng Chiung‐Zuan Chiu Shih‐Huang Lee Huey‐Ming Lo Kou‐Gi Shyu | 2014 | J Diabetes Invest2014，，1： | 1 |
| 2 | Biodegradation of 2,4,6-trichlorophenol in the presence of primary substrate by immobilized pure culture bacteria显示文摘 | Wang Chun Chin Lee Chi Mei Lu Chih Jen | 2000 | Chemosphere2000，41，12： | 1 |
| 3 | Intratypic variants of human papillomavirus type 16 and risk of cervical Neoplasia in Taiwan显示文摘 | Ya‐Ju Chang Hui‐Chi Chen Mei‐Hung Pan Bor‐Heng Lee San‐Lin You Ching‐Yu Lin Yi‐Chun Chou Chang‐Yao Hsieh Yu‐Juen Cheng Kai‐Li Liaw Ann W. Hsing Mark Schiffman Chien‐Jen Chen | 2013 | J. Med. Virol2013，，： | 1 |
| 4 | Multifunctional carbon nanotube yarns and transparent sheets: Fabrication, properties, and applications显示文摘 | Ken R. Atkinson Stephen C. Hawkins Chi Huynh Chris Skourtis Jane Dai Mei Zhang Shaoli Fang Anvar A. Zakhidov Sergey B. Lee Ali E. Aliev Christopher D. Williams Ray H. Baughman | 2007 | Physica B: Physics of Condensed Matter2007，，： | 1 |
| 5 | Combining Anoxic Denitrifying Ability with Aerobic - anoxic Phosphorus - removal Examination to Screen Denitrifying Phosphorus -removing Bacteria显示文摘 | Shi Hoi - Ping Lee Chi - Mei | 2006 | International Biodeterioration & Biodegradation2006，57，： | 1 |
| 6 | Biodegradation of 2,4,6-trichlorophenol in the presence of primary substrate by immobilized pure culture bacteria显示文摘 | Chin Wang Chun Chi Mei Lee Chin Jen Lu | 2000 | Chemosphere2000，41，12： | 1 |
| 7 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 8 | Association of surgeon volume and hospital volume with the outcome of patients receiving definitive surgery for colorectal cancer: A nationwide population‐based study显示文摘 | Chia‐Jen Liu Yiing‐Jenq Chou Chung‐Jen Teng Chun‐Chi Lin Yu‐Ting Lee Yu‐Wen Hu Chiu‐Mei Yeh Tzeng‐Ji Chen Nicole Huang | 2015 | Cancer2015，，16： | 1 |
| 9 | Isolation and physiological characterization of the pentachlorophenol degrading bacterium Sphingomonas chlorophenolica 显示文摘 | Chu - Fang Yang Chi - Mei Lee Chun - Chin Wang | 2006 | Chemosphere2006，62，5： | 1 |
| 10 | Correlation between bio-hydrogen production and polyhydroxybutyrate(PHB)synthesis by Rhodopseudomonas palustis WP3-5显示文摘 | Siang Chen Wu Syuan Zih Liou Chi Mei Lee | 2012 | Bioresource Technology2012，113，： | 1 |
| 11 | Whole-exome sequencing of a multicenter cohort identifies genetic changes associated with clinical phenotypes in pediatric nephrotic syndrome显示文摘Understanding the association between the genetic and clinical phenotypes in children with nephrotic syndrome(NS)of different etiologies is critical for early clinical guidance.We employed whole-exome sequencing(WES)to detect monogenic causes of NS in a multicenter cohort of 637 patients.In this study,a genetic cause was identified in 30.0%of the idiopathic steroid-resistant nephrotic syndrome(SRNS)patients.Other than congenital nephrotic syndrome(CNS),there were no significant differences in the incidence of monogenic diseases based on the age at manifestation.Causative mutations were detected in 39.5%of patients with focal segmental glomerulosclerosis(FSGS)and 9.2%of those with minimal change disease(MCD).In terms of the patterns in patients with different types of steroid resistance,a single gene mutation was identified in 34.8%of patients with primary resistance,2.9%with secondary resistance,and 71.4%of children with multidrug resistance.Among the various intensified immunosuppressive therapies,tacrolimus(TAC)showed the highest response rate,with 49.7%of idiopathic SRNS patients achieving complete remission.Idiopathic SRNS patients with monogenic disease showed a similar multidrug resistance pattern,and only 31.4%of patients with monogenic disease achieved a partial remission on TAC.During an average 4.1-year follow-up,21.4%of idiopathic SRNS patients with monogenic disease progressed to end-stage renal disease(ESRD).Collectively,this study provides evidence that genetic testing is necessary for presumed steroid-resistant and idiopathic SRNS patients,especially those with primary and/or multidrug resistance. | Jia Jiao Li Wang Fenfen Ni Mo Wang Shipin Feng Xiaojie Gao Han Chan Xueying Yang Hao Lee Huan Chi Xuelan Chen Daoqi Wu Gaofu Zhang Baohui Yang Anshuo Wang Qin Yang Junli Wan Sijie Yu Xiaoqin Li Mei Wang Xiaofeng Chen Xianying Mai Xiongzhong Ruan Haiping Yang Qiu Li | 2022 | Genes & Diseases2022，9，6： | 0 |
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