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| 1 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 2 | 一种变逻辑门限值的车辆稳定性控制策略研究显示文摘本文中提出一种变逻辑门限值的车辆稳定性控制策略,并重点对动态逻辑门限值的确定方法进行了深入的研究,以改善不同工况下车辆的稳定性。由于逻辑门限值受到行驶环境和运动状态的影响,因此利用模糊推理的方法分别确定横摆角速度偏差和质心侧偏角变化率的门限值;然后利用逻辑门限PI控制方法计算出附加横摆力矩;最后在电控液压制动(EHB)系统中实现了附加横摆力矩。仿真结果表明,当车辆失稳时,所提出的控制策略能及时对车辆进行稳定校正控制,提高了车辆行驶的安全性。 | 李寿涛 马用学 郭鹏程 宗长富 Lee Gordon | 2015 | 汽车工程2015，37，7： | 13 |
| 3 | Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial显示文摘 | Harold P. Adams Birgitte H. Bendixen L. Jaap Kappelle José Biller Betsy B. Love David Lee Gordon E. Eugene Marsh | 1993 | Stroke1993，，1： | 9 |
| 4 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 5 | Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke显示文摘Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV. | Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik | 2017 | Stroke & Vascular Neurology2017，2，1： | 6 |
| 6 | Surgical outcomes for unilateral superior oblique palsy in Chinese population: a retrospective study显示文摘AIM: To evaluate the outcome after surgery for unilateral superior oblique(SO) palsy in Chinese.METHODS: The medical records of 39 patients that underwent surgery for unilateral SO palsy between January 2003 and December 2012 at Caritas Medical Centre, Hong Kong, were retrospectively reviewed. All surgeries were performed by a single surgeon. Pre-operative assessments for vertical deviation, cyclo-deviation, and Knapp's classification were obtained to determine the nature and degree of surgical correction.Vertical deviation was measured at 1wk; 1, 6mo and on last follow-up day post-operatively. Cyclo-deviation was measured on last follow-up day post-operatively.RESULTS: During the 10 y period, 39 subjects were recruited. The most common etiology was congenital(94.9%). Knapp's Type III(66.7%) and Type I(12.8%)classifications were the most common subtypes. To treat SO palsy, the most common surgical procedures were:isolated inferior oblique(IO) anteriorization(41.0%),isolated IO myectomy(10.3%), and isolated IO recession(10.3%). At 3.5 ±2.1y post-operatively, the vertical deviation was significantly reduced(15.1 ±6.2 PD versus0.5±1.4 PD, P <0.0001) without significant improvement in cyclo-deviation(P =0.5). Initial vertical deviation was correlated with cyclo-torsion(r =0.4, P =0.007). Those with over-correction had greater initial vertical deviation(19.4±7.2 PD versus 13.2±4.3 PD, P =0.003). After a single operation, 84.6% of subjects achieved a vertical deviation within ±3 PD.· CONCLUSION: The majority of subjects achieved corrected vertical deviation after a single surgery although there was no improvement in cyclo-deviation.Those with over-correction of primary position deviation had greater preoperative vertical deviation and it may be related to simultaneous multiple muscle surgery. | Gordon Shing Kin Yau Victor Tak Yau Tam Jacky Wai Yip Lee Theo Tak Kwong Chan Can Yin Fun Yuen | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 4 |
| 7 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 8 | Review on observational studies of western tropical Pacific Ocean circulation and climate显示文摘The Western Tropical Pacific(WTP) Ocean holds the largest area of warm water(>28℃) in the world ocean referred to as the Western Pacific Warm Pool(WPWP),which modulates the regional and global climate through strong atmospheric convection and its variability.The WTP is unique in terms of its complex 3-D ocean circulation system and intensive multiscale variability,making it crucial in the water and energy cycle of the global ocean.Great advances have been made in understanding the complexity of the WTP ocean circulation and associated climate impact by the international scientific community since the 1960 s through field experiments.In this study,we review the evolving insight to the 3-D structure and multi-scale variability of the ocean circulation in the WTP and their climatic impacts based on in-situ ocean observations in the past decades,with emphasis on the achievements since 2000.The challenges and open que stions remaining are reviewed as well as future plan for international study of the WTP ocean circulation and climate. | HU Dunxin WANG Fan SPRINTALL Janet WU Lixin RISER Stephen CRAVATTE Sophie GORDON Arnold ZHANG Linlin CHEN Dake ZHOU Hui ANDO Kentaro WANG Jianing LEE Jae-Hak HU Shijian WANG Jing ZHANG Dongxiao FENG Junqiao LIU Lingling VILLANOY Cesar KALUWIN Chalapan QU Tangdong MA Yixin | 2020 | Journal of Oceanology and Limnology2020，38，4： | 3 |
| 9 | Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial显示文摘 | Harold P. Adams Birgitte H. Bendixen L. Jaap Kappelle José Biller Betsy B. Love David Lee Gordon E. Eugene Marsh | 1993 | Stroke1993，，1： | 2 |
| 10 | Markedly Elevated Levels of Vascular Endothelial Growth Factor in Malignant Ascites显示文摘 | Brian K. Zebrowski MD Wenbiao Liu MD Karen Ramirez BS Yoshito Akagi MD Gordon B. Mills MD Lee M. Ellis MD | 1999 | Annals of Surgical Oncology1999，，4： | 2 |
| 11 | Expression and mapping of the mouse S7/Pmsc2 gene, homolog of an essential mitotic gene in yeast显示文摘 | Jeremy Allen Laurence Colleaux Duncan Davidson Elisabeth Graham Muriel Lee Robert Hill Cathy Abbott Colin Gordon | 1997 | Mammalian Genome1997，，5： | 1 |
| 12 | Protocol for resolving protein mixtures in CZE显示文摘 | Gordon M J Lee K J Zare R N | 1991 | Anal Chem1991，63，： | 1 |
| 13 | Interferon alfa2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C显示文摘 | McHutchison JG Gordon SC Schiff ER Shiffrnan ML Lee WM Rustgi VK Goodman ZD Ling MH Cort S Albrecht JK | | 0，，： | 1 |
| 14 | Management of splenic artery aneurysms:the significance of portal and essential hypertension显示文摘 | Lee PC Rhee RY Gordon RY | 1999 | JACS1999，189，： | 1 |
| 15 | Production of human tissue plasminogen activitor in transgenic mouse milk显示文摘 | Gordon K Lee E Vitale J A | 1987 | Biotechnology1987，5，： | 1 |
| 16 | Management of splenic artery aneurysms:the significance of portal and essential hypertension显示文摘 | LEE P C RHEE RY GORDON RY | | 0，，05： | 1 |
| 17 | Optimal setting of reactive compensation devices with an improved voltage stability index for voltage stability enhancement显示文摘 | Yang C F Lai Gordon G Lee C H | 2012 | International Journal of Electrical Power & Energy Systems2012，37，1： | 1 |
| 18 | Chemical reduction of nitrate by nanosized iron:kinetics and pathways显示文摘 | Gordon C C Yang Hsaio-Lan Lee | 2005 | Water Research2005，39，5： | 1 |
| 19 | Citrus fruit intake and stomach cancer risk: a quantitative systematic review显示文摘 | Jong-Myon Bae Eun Ja Lee Gordon Guyatt | 2008 | Gastric Cancer2008，，2： | 1 |
| 20 | The Glaucoma Symptom Scale:a brief index of glaucoma-specific symptoms显示文摘 | Lee BL Gutierrez P Gordon M | 1998 | Arch Ophthalmol1998，116，7： | 1 |
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