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| 1 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 2 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 3 | Receptor-mediated mitophagy in yeast and mammalian systems显示文摘Mitophagy,或线粒体 autophagy,在选择移动起一个关键作用损坏或讨厌的线粒体。包括在在哺乳动物的系统的酵母, NIX/BNIP3L, BNIP3 和 FUNDC1 的 Atg32,几蛋白质受体直接在 mitophagy 行动。Atg32 在线粒体的表面上与 Atg8 和 Atg11 交往,支持为 mitophagy 的核心 Atg 蛋白质汇编。NIX/BNIP3L, BNIP3 和 FUNDC1 也有一个经典主题直接为 mitophagy 的激活绑 LC3 (在哺乳动物的 Atg8 相当或相同的事物) 。最近的研究证明了调停受体的 mitophagy 被可逆蛋白质 phosphorylation 调整。酷蛋白 kinase 2 (CK2 ) phosphorylates Atg32 并且在酵母激活 mitophagy。相反,在哺乳动物的房间 Src kinase 和 CK2 phosphorylate FUNDC1 到阻止 mitophagy。尤其是响应组织缺氧和 FCCP 处理,激活 mitophagy 的 mitochondrial 磷酸酶 PGAM5 dephosphorylates FUNDC1。这里,我们主要在我们处于健康和疾病位于调停受体的 mitophagy 的激活和这个分解代谢的过程的含意下面的分子的机制的理解集中于最近的进展。 | Lei Liu Kaori Sakakibara Quan Chen Koji Okamoto | 2014 | Cell Research2014，24，7： | 28 |
| 4 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 5 | An aerospace bracket designed by thermo-elastic topology optimization and manufactured by additive manufacturing显示文摘Combination of topology optimization and additive manufacturing technologies provides an effective approach for the development of light-weight and high-performance structures.A heavy-loaded aerospace bracket is designed by topology optimization and manufactured by additive manufacturing technology in this work.Considering both mechanical forces and temperature loads,a formulation of thermo-elastic topology optimization is firstly proposed and the sensitivity analysis is derived in detail.Then the procedure of numerical optimization design is presented and the final design is additively manufactured using Selective Laser Melting(SLM).The mass of the aerospace bracket is reduced by over 18%,benefiting from topology and size optimization,and the three constraints are satisfied as well in the final design.This work indicates that the integration of thermo-elastic topology optimization and additive manufacturing technologies can be a rather powerful tool kit for the design of structures under thermal-mechanical loading. | Guanghui SHI Chengqi GUAN Dongliang QUAN Dongtao WU Lei TANG Tong GAO | 2020 | Chinese Journal of Aeronautics2020，33，4： | 21 |
| 6 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 7 | Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis显示文摘Autophagy and apoptosis are both highly regulated biological processes that play essential roles in tissue homeostasis,development and diseases.Autophagy is also described as a mechanism of death pathways,however,the precise mechanism of how autophagy links to cell death remains to be fully understood.Beclin 1 is a dual regulator for both autophagy and apoptosis.In this study we found that Beclin 1 was a substrate of caspase-3 with two cleavage sites at positions 124 and 149,respectively.Furthermore,the autophagosome formation occurred,followed by the appearance of morphological hallmarks of apoptosis after staurosporine treatment.The cleavage products of Beclin 1 reduced autophagy and promoted apoptosis in HeLa cells and the cells in which Beclin 1 was stably knocked down by specific shRNA.In addition,the cleavage of Beclin 1 resulted in abrogating the interaction between Bcl-2 with Beclin 1,which could be blocked by z-VAD-fmk.Thus,our results suggest that the cleavage of Beclin 1 by caspase-3 may contribute to inactivate autophagy leading towards augmented apoptosis. | Yushan Zhu Lixia Zhao Lei Liu Ping Gao Weili Tian Xiaohui Wang Haijing Jin Haidong Xu Quan Chen | 2010 | Protein & Cell2010，1，5： | 17 |
| 8 | Dissection of No.13 lymph node in radical gastrectomy for gastric carcinoma显示文摘AIM: To evaluate the feasibility and safety of No. 13 lymphadenectomy in radical gastrectomy for gastric carcinoma. METHODS: Medical records of the patients undergone No. 13 lymph node dissection during D2 gastrectomy for gastric carcinoma, were reviewed from March 2003 to May 2007. RESULTS: One hundred and fifty-eight patients underwent No. 13 lymph node dissection for D2 gastric carcinoma, of them, 4 (2.53%) were found to have metastasis in No. 13 lymph node. Metastasis to No. 12 lymph node was detected in 6 patients and 4 of them had positive No. 13 lymph node. The operative morbidity except for wound infection was 15.19% (24/158), and hospital death rate was 1.27% (2/158). No obstructive jaundice caused by No. 13 lymph node metastasis after No. 13 lymph node dissection in radical gastrectomy for gastric carcinoma was detected during the follow-up study to end of January 2007. CONCLUSION: Dissection of No. 13 lymph node in D2 gastrectomy for gastric carcinoma is safe with a low morbidity and mortality rate. Further study is needed to explore its long-term effect. | Ding-Feng Shen Da-Wei Chen Zhi-Wei Quan Ping Dong Xue-Feng Wang Hai-Zhou Xu Ming-Lin Zhao Lei Chen | 2008 | World Journal of Gastroenterology2008，14，6： | 16 |
| 9 | Generating dense and super-resolution ISAR image by combining bandwidth extrapolation and compressive sensing显示文摘Recent developing compressive sensing (CS) theory indicates that it is possible to obtain precise recovery of a sparse signal from very limited measurements,which provides a new way for data acquisition and signal processing as nature signals usually involve some degree of sparsity.In this paper,we present an algorithm for inversed synthetic aperture radar (ISAR) imaging with super resolution by combining CS and bandwidth extrapolation (BWE) technique.For ISAR imaging,the backscattering field of target is usually contributed by a few strong scattering centers,whose number is much less than that of image pixels.Thus,CS is intuitively suitable for constructing super resolution ISAR image.According to CS theory,the number of extracted dominating scatterers relies on the signal length,which indicates that if only limited data is available,it is difficult to generate dense ISAR image robustly by CS,and some signal components tend to lose.To soften this constraint,BWE is combined with CS imaging to increase the degree of freedom of signal while preserving its coherence.A refined CS-based formation for ISAR image-resolution enhancement is then developed.Both real and simulated data experiments are performed to evaluate the proposed approach,and an example of using this technique demonstrates the enhanced image resolution in application of maneuvering target imaging. | QUAN YingHui ZHANG Lei GUO Rui XING MengDao BAO Zheng | 2011 | Science China(Information Sciences)2011，54，10： | 15 |
| 10 | The Impacts of Mosquito Density and Meteorological Factors on Dengue Fever Epidemics in Guangzhou, China, 2006-2014: a Time-series Analysis显示文摘Objective To explore the associations between the monthly number of dengue fever(DF) cases and possible risk factors in Guangzhou, a subtropical city of China. Methods The monthly number of DF cases, Breteau Index(BI), and meteorological measures during 2006-2014 recorded in Guangzhou, China, were assessed. A negative binomial regression model was used to evaluate the relationships between BI, meteorological factors, and the monthly number of DF cases. Results A total of 39,697 DF cases were detected in Guangzhou during the study period. DF incidence presented an obvious seasonal pattern, with most cases occurring from June to November. The current month's BI, average temperature(Tave), previous month's minimum temperature(Tmin), and Tave were positively associated with DF incidence. A threshold of 18.25 °C was found in the relationship between the current month's Tmin and DF incidence. Conclusion Mosquito density, Tave, and Tmin play a critical role in DF transmission in Guangzhou. These findings could be useful in the development of a DF early warning system and assist in effective control and prevention strategies in the DF epidemic. | SHEN Ji Chuan LUO Lei LI Li JING Qin Long OU Chun Quan YANG Zhi Cong CHEN Xiao Guang | 2015 | Biomedical and Environmental Sciences2015，28，5： | 12 |
| 11 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 12 | Power Matching and Energy Efficiency Improvement of Hydraulic Excavator Driven with Speed and Displacement Variable Power Source显示文摘Mobile machinery energy efficiency and emission pollution are the national and worldwide issues. This paper contributes in solving these problems by applying a speed variable power source. Unfortunately, almost all of the speed variable systems have the dynamic response problem when the motor starts with full load or heavy load. To address this problem, a hydraulic accumulator is used to balance the load of the power source for assisting starting of the motor and a matching method combined with speed and displacement control of the pump is proposed to improve the energy efficiency and dynamic performance simultaneously under different working conditions. Also, the power source/valve combined control strategy of an independent metering system is designed to realize flow matching of the whole system. Firstly, a test system is established to study the dynamic performance and energy efficiency of the speed variable power source with an auxiliary accumulator. Working performance and energy consumption of the power source under different rotating speeds and different loads are studied. And then, the hydraulic excavator test rig with the proposed system is constructed. Furthermore, the working performance of the excavator with the speed-fixed and speed-variable strategy are studied comparatively. Results show that, compared with fixed-speed strategy, the electric power consumption during the idle period and partial load condition can be reduced about 2.05 kW and 1.37 kW. The energy efficiency of speed variable power source is about 40%-71%, which is higher than that of the fixed-speed power source by 3%–10%. | Lei Ge Long Quan Xiaogang Zhang Zhixin Dong Jing Yang | 2019 | Chinese Journal of Mechanical Engineering2019，32，6： | 10 |
| 13 | Population Genomic Analysis and De Novo Assembly Reveal the Origin of Weedy Rice as an Evolutionary Game显示文摘Crop weediness,especially that of weedy rice(Oryza sativa f.spontanea),remains mysterious.Weedy rice possesses robust ecological adaptability;however,how this strain originated and gradually formed proprietary genetic features remains unclear?Here,we demonstrate that weedy rice at Asian high latitudes(WRAH)is phylogenetically well defined and possesses unselected genomic characteristics in many divergence regions between weedy and cultivated rice.We also identified novel quantitative trait loci underlying weedy-specific traits,and revealed that a genome block on the end of chromosome 1 is associated with rice weediness.To identify the genomic modifications underlying weedy rice evolution,we generated the first de novo assembly of a high-quality weedy rice genome(WR04-6),and conducted a comparative genomics study between WR04-6 with other rice reference genomes.Multiple lines of evidence,including the results of demographic scenario comparisons,suggest that differentiation between weedy rice and cultivated rice was initiated by genetic improvement of cultivated rice and that the essence of weediness arose through semi-domestication.A plant height model further implied that the origin of WRAH can be modeled as an evolutionary game and indicated that strategy-based selection driven by fitness shaped its genomic diversity. | Jian Sun Dianrong Ma Liang Tang Minghui Zhao Guangchen Zhangh Wenjia Wang Jiayu Song Xiang Li Zimeng Liu Wenxing Zhang Quan Xu Yuncheng Zhou Jianzhong Wu Toshio Yamamoto Fei Dai Yan Lei Song Li Gang Zhou Hongkun Zheng Zhengjin Xu Wenfu Chen | 2019 | Molecular Plant2019，12，5： | 9 |
| 14 | Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease显示文摘Netrin-1,an axon guidance factor,and its receptor UNC5B play important roles in axonal development and angiogenesis.This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated their roles in angiogenesis.Netrin-1 and UNC5B were upregulated in streptozotocininduced DKD Wistar rats,and their expression was compared with that in healthy controls.However,exogenous netrin-1 in UNC5B-depleted human renal glomerular endothelial cells (HRGECs) inhibited cell migration and tubulogenesis.This effect was likely associated with SRC pathway deactivation.Netrin-1 treatment also eliminated the pro-angiogenic effects of exogenous VEGF-165 on UNC5B-silenced HRGECs.These results indicate that UNC5B antagonizes netrin-1 and that UNC5B upregulation contributes partly to enhancing angiogenesis in DKD.Therefore,introducing exogenous netrin-1 and depleting endogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidney injury in DKD. | Xiaojing Jiao Dong Zhang Quan Hong Lei Yan Qiuxia Han Fengmin Shao Guangyan Cai Xiangmei Chen Hanyu Zhu | 2020 | Frontiers of Medicine2020，14，3： | 7 |
| 15 | PEG-400 as an efficient reaction medium for the synthesis of 2,4,5-triaryl-1H-imidazoles and 1,2,4,5-tetraaryl-1H-imidazoles显示文摘为一个壶的一个有效协议多,把 PEG-400 用作反应媒介的各种各样的 2,4,5-triaryl-1H-imidazoles 和 1,2,4,5-tetraaryl-1H-imidazoles 的部件合成被描述。这个方法有好收益,更少的污染和简单反应条件的优点。 | Xi Cun Wang Hai Peng Gong Zheng Jun Quan Lei Li He Lin Ye | 2009 | Chinese Chemical Letters2009，20，1： | 6 |
| 16 | DNA cleavage mediated by water-soluble manganese corrole显示文摘水的 DNA 像核酸酶的活动可溶的锰 corrole 5, 10, 15-tris (N-methyl-4-pyridyl )- corrolatomanganese (III )(MnIIITMPyC ) 被调查了。MnIIITMPyC 可以经由由吸收系列,粘性大小和 CD 系列显示了的外面的沟绑定模式强烈绑在 DNA。MnIIITMPyC 面对 hydroperoxide 在 DNA 氧化劈开展出了优秀催化活动。 | Jun Lu Hai Yang Liu Lei Shi Xiang Li Wang Xiao Ying Lei Zhang Liang Nian Ji Lin Quan Zang Chi K. Chang | 2011 | Chinese Chemical Letters2011，22，1： | 6 |
| 17 | Alterations of brain local functional connectivity in amnestic mild cognitive impairment显示文摘Background:Resting-state functional magnetic resonance imaging studies using a regional homogeneity(ReHo)method have reported that amnestic mild cognitive impairment(aMCI)was associated with abnormalities in local functional connectivity.However,their results were not conclusive.Methods:Seed-based d Mapping was used to conduct a coordinate-based meta-analysis to identify consistent ReHo alterations in aMCI.Results:We identified 10 studies with 11 datasets suitable for inclusion,including 378 patients with aMCI and 435 healthy controls.This meta-analysis identified significant ReHo alterations in patients with aMCI relative to healthy controls,mainly within the default mode network(DMN)(bilateral posterior cingulate cortex[PCC],right angular gyrus,bilateral middle temporal gyri,and left parahippocampal gyrus/hippocampus),executive control network(right superior parietal lobule and dorsolateral prefrontal cortex),visual network(right lingual gyrus and left middle occipital gyrus),and sensorimotor network(right paracentral lobule/supplementary motor area,right postcentral gyrus and left posterior insula).Significant heterogeneity of ReHo alterations in the bilateral PCC,left parahippocampal gyrus/hippocampus,and right superior parietal lobule/angular gyrus was observed.Exploratory meta-regression analyses indicated that general cognitive function,gender distribution,age,and education level partially contributed to this heterogeneity.Conclusions:This study provides provisional evidence that aMCI is associated with abnormal ReHo within the DMN,executive control network,visual network,and sensorimotor network.These local functional connectivity alterations suggest coexistence of functional deficits and compensation in these networks.These findings contribute to the modeling of brain functional connectomes and to a better understanding of the neural substrates of aMCI.Confounding factors merit much attention and warrant future investigations. | Dan Zheng Wei Xia Zhong Quan Yi Pan Wen Zhao Jian Guo Zhong Hai Cun Shi Hua Liang Li Zhen Yu Dai Ping Lei Pan | 2018 | Translational Neurodegeneration2018，7，1： | 5 |
| 18 | Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs显示文摘 | Guan-hua RAO Hong-min LIU Bao-wei LI Jia-jie HAO Yan-lei YANG Ming-rong WANG Xiao-hui WANG Jun WANG Hai-jing JIN Lei DU Quan CHEN | 2013 | Acta Pharmacologica Sinica2013，34，6： | 5 |
| 19 | Geochemical significance of the relative enrichment of pristane and the negative excursion of δ^(13)C_(Pr) across the Permian-Triassic Boundary atMeishan, China显示文摘Changes in the distribution of isoprenoid hy-drocarbons and in δ 13Ckero or δ 13CPr across the section from the Changxing Formation to the lower Yinkeng Formation at Meishan (the GSSP of PTB) are studied, in which a relative enrichment of pristane and a sharp shift in both δ 13Ckero and δ 13Cmole near the boundary are revealed. A possible mecha-nism for the abnormal accumulation of pristane near PTB is suggested: Lipids in some marine animals and their metabo-lites, rich in pristane, can be preserved and accumulate in some suitable depositing facies under certain special condi-tions, such as the catastrophic death of animals and/or de-veloping of an anoxic water column, and thus the pristane enrichment occurs in the sediment. The occurrences of iso-prenoid enrichment and high Pr/Ph ratios have been found in other typical marine anoxic sediments accompanied by mass extinction in various extent during the most important geological periods, such as Late Ordovician, end of Devonian,Early Jurassic and Late Cretaceous. These occurrences sup-port to a certain extent the above mechanism that interprets the genesis of a high Pr/Ph ratio in some typical marine an-oxic sediments. The synchronous sharp negative shifts in δ 13Cmole, δ 13Ckero and δ 13Ccarb from Beds 24 to 26 of the Me-ishan profile indicate that a sudden and strong variation of carbon source in the atmosphere-ocean system occurred during the quick but equable evolution from the end-Permian to Early Triassic, and the coupling between the pristane enrichment and negative shift in δ 13Ckero and δ 13CPr may well indicate the importance of the release of methane hydrates and marine anoxia in the end-Permian mass extinc-tion. | WANG Chunjiang LIU Yimei LIU Hongxiu ZHU Lei SHI Quan | 2005 | Chinese Science Bulletin2005，50，19： | 5 |
| 20 | SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models显示文摘Emerging evidence demonstrates that a c-Met antibody-drug conjugate (ADC) has superior ef?cacy and safety pro?les compared with those of currently available small molecules or antibody inhibitors for the treatment of c-Met-overexpressing cancers. Here we described both the in vitro and in vivo ef?cacies of SHR-A1403, a novel c-Met ADC composed of a humanized IgG2 monoclonal antibody against c-Met conjugated to a novel cytotoxic microtubule inhibitor. SHR-A1403 showed high af?nity to c-Met proteins derived from human or monkey and potent inhibitory effects in cancer cell lines with high c-Met protein expression. In mice bearing tumors derived from cancer cell lines or patient HCC tissues with con?rmed c-Met overexpression, SHR-A1403 showed excellent anti-tumor ef?cacy. Antibody binding with c-Met contributed to SHR-A1403 endocytosis;the subsequent translocation to lysosomes and cytotoxicity of the released toxin are speculated to be predominant mechanisms underlying the anti-tumor activity of SHR-A1403. In conclusion, SHR-A1403 showed signi?cant anti-tumor activity in cancer cell lines, xenograft mouse models and an HCC PDX model, which all have high c-Met levels. These data provide references for SHR-A1403 as a potential therapy for the treatment of cancers with c-Met overexpression. | Chang-yong Yang Lei Wang Xing Sun Mi Tang Hai-tian Quan Lian-shan Zhang Li-guang Lou Shao-hua Gou | 2019 | Acta Pharmacologica Sinica2019，40，7： | 5 |
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