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| 1 | Quantifying the effects of short-term heat stress at booting stage on nonstructural carbohydrates remobilization in rice显示文摘Extreme heat stress events are becoming more frequent under anticipated climate change,which can have devastating impacts on rice growth and yield.To quantify the effects of short-term heat stress at booting stage on nonstructural carbohydrates(NSC)remobilization in rice,two varieties(Nanjing 41 and Wuyunjing 24)were subjected to 32/22/27°C(maximum/minimum/mean),36/26/31°C,40/30/35°C,and 44/34/39°C for 2,4 and 6 days in phytotrons at booting stage during 2014 and 2015.Yield and yield components,dry matter partitioning index(DMPI),NSC accumulation and translocation were measured and calculated.The results showed that the increase of high-temperature level and duration significantly reduced grain yield by suppressing spikelet number per panicle,seed-setting rate,and grain weight.Heat stress at booting decreased DMPI in panicles,increased DMPI in stems,but had no significant effect on photosynthetic rate.Stem NSC concentration increased whereas panicles NSC concentration,stem NSC translocation efficiency,and contribution of stem NSC to grain yield decreased.Severe heat stress even transformed the stem into a carbohydrate sink during grain filling.The heat-tolerant Wuyunjing 24 showed a higher NSC transport capacity under heat stress than the heat-sensitive Nanjing 41.Heat degree-days(HDD),which combines the effects of the intensity and duration of heat stress,used for quantifying the impacts of heat stress indicates the threshold HDD for the termination of NSC translocation is 9.82°C day.Grain yield was negatively correlated with stem NSC concentration and accumulation at maturity,and yield reduction was tightly related to NSC translocation reduction.The results suggest that heat stress at booting inhibits NSC translocation due to sink size reduction.Therefore,genotypes with higher NSC transport capacity under heat stress could be beneficial for rice yield formation. | Fengxian Zhen Junjie Zhou Aqib Mahmood Wei Wang Xini Chang Bing Liu Leilei Liu Weixing Cao Yan Zhu Liang Tang | 2020 | The Crop Journal2020，8，2： | 9 |
| 2 | Advanced reliability analysis of slopes in spatially variable soils using multivariate adaptive regression splines显示文摘This study aims to extend the multivariate adaptive regression splines(MARS)-Monte Carlo simulation(MCS) method for reliability analysis of slopes in spatially variable soils. This approach is used to explore the influences of the multiscale spatial variability of soil properties on the probability of failure(P_f) of the slopes. In the proposed approach, the relationship between the factor of safety and the soil strength parameters characterized with spatial variability is approximated by the MARS, with the aid of Karhunen-Loeve expansion. MCS is subsequently performed on the established MARS model to evaluate Pf.Finally, a nominally homogeneous cohesive-frictional slope and a heterogeneous cohesive slope, which are both characterized with different spatial variabilities, are utilized to illustrate the proposed approach.Results showed that the proposed approach can estimate the P_f of the slopes efficiently in spatially variable soils with sufficient accuracy. Moreover, the approach is relatively robust to the influence of different statistics of soil properties, thereby making it an effective and practical tool for addressing slope reliability problems concerning time-consuming deterministic stability models with low levels of P_f.Furthermore, disregarding the multiscale spatial variability of soil properties can overestimate or underestimate the P_f. Although the difference is small in general, the multiscale spatial variability of the soil properties must still be considered in the reliability analysis of heterogeneous slopes, especially for those highly related to cost effective and accurate designs. | Leilei Liu Shaohe Zhang Yung-Ming Cheng Li Liang | 2019 | Geoscience Frontiers2019，10，2： | 7 |
| 3 | Event Detection and Identification of Influential Spreaders in Social Media Data Streams显示文摘Microblogging, a popular social media service platform, has become a new information channel for users to receive and exchange the most up-to-date information on current events. Consequently, it is a crucial platform for detecting newly emerging events and for identifying influential spreaders who have the potential to actively disseminate knowledge about events through microblogs. However, traditional event detection models require human intervention to detect the number of topics to be explored, which significantly reduces the efficiency and accuracy of event detection. In addition, most existing methods focus only on event detection and are unable to identify either influential spreaders or key event-related posts, thus making it challenging to track momentous events in a timely manner. To address these problems, we propose a Hypertext-Induced Topic Search(HITS) based Topic-Decision method(TD-HITS), and a Latent Dirichlet Allocation(LDA) based Three-Step model(TS-LDA). TDHITS can automatically detect the number of topics as well as identify associated key posts in a large number of posts. TS-LDA can identify influential spreaders of hot event topics based on both post and user information.The experimental results, using a Twitter dataset, demonstrate the effectiveness of our proposed methods for both detecting events and identifying influential spreaders. | Leilei Shi Yan Wu Lu Liu Xiang Sun Liang Jiang | 2018 | Big Data Mining and Analytics2018，1，1： | 4 |
| 4 | Vapor phase fabrication of three-dimensional arrayed BiI3 nanosheets for cost-effective solar cells显示文摘Multilayered photovoltaic absorbers have triggered widespread attention for their unique structure and properties.However,multilayered materials in the randomly oriented polycrystalline thin-film lead to ineffective carrier transport and collection,which hinders the process of achieving high-performance solar cells.Herein,this issue is tackled by producing the three-dimensional(3D)heterojunction BiI3 nanosheets(NSs)solar cells,which embed vertically aligned monocrystalline BiI3 NSs into spiro-OMeTAD.The preferred orientation of BiI3 NSs and large p-n junction areas of 3D heterojunction structure enable a strong light absorption and effective carrier transport and collection,and thus a power conversion efficiency(PCE)of 1.45%was achieved.Moreover,this PCE is the highest ever reported for BiI3 based solar cells to our best knowledge.Moreover,the nonencapsulated device remained 96%of the initial PCE after 24 h continuous one sun illumination at^70%humidity condition,and 82%of the initial PCE after 1-month storage at^30%humidity condition. | Yiyi Zhu Qianpeng Zhang Matthew Kam Swapnadeep Poddar Leilei Gu Shijun Liang Pengfei Qi Feng Miao Zhiyong Fan | 2020 | InfoMat2020，2，5： | 2 |
| 5 | CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients显示文摘 | Chen Leilei Chan Tim Hon Man Yuan Yun-Fei Hu Liang Huang Jun Ma Stephanie Wang Jian Dong Sui-Sui Tang Kwan Ho Xie Dan Li Yan Guan Xin-Yuan | 2010 | Journal of Clinical Investigation2010，，4： | 2 |
| 6 | 'Three-in-One' Multi-Scale Structural Design of Carbon Fiber-Based Composites for Personal Electromagnetic Protection and Thermal Management显示文摘Wearable devices with efficient thermal management and electromagnetic interference(EMI) shielding are highly desirable for improving human comfort and safety. Herein, a multifunctional wearable carbon fibers(CF) @ polyaniline(PANI)/silver nanowires(Ag NWs) composites with a “branch-trunk” interlocked micro/nanostructure were achieved through 'three-in-one' multi-scale design. The reasonable assembly of the three kinds of one-dimensional(1D) materials can fully exert their excellent properties i.e., the superior flexibility of CF, the robustness of PANI, and the splendid conductivity of Ag NWs. Consequently, the constructed flexible composite demonstrates enhanced mechanical properties with a tensile stress of 1.2 MPa, which was almost 6 times that of the original material. This is mainly attributed to the fact that the PNAI(branch) was firmly attached to the CF(trunk) through polydopamine(PDA), forming a robust interlocked structure. Meanwhile, the composite possesses excellent thermal insulation and heat preservation capacity owing to the synergistically low thermal conductivity and emissivity. More importantly, the conductive path of the composite established by the three 1D materials greatly improved its EMI shielding property and Joule heating performance at low applied voltage. This work paves the way for rational utilization of the intrinsic properties of 1D materials, as well as provides a promising strategy for designing wearable electromagnetic protection and thermal energy management devices. | Ming Zhou Shujuan Tan Jingwen Wang Yue Wu Leilei Liang Guangbin Ji | 2023 | Nano-Micro Letters2023，15，10： | 1 |
| 7 | SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of PIRH2 and has tumor-suppressive function in the development of hepatocellular carcinoma显示文摘 | Liang Hu Ming Liu Leilei Chen | | 0，，08： | 1 |
| 8 | Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity显示文摘Aberrant activation of oncogenic signaling pathways in tumors can promote resistance to the antitumor immune response.However,single blockade of these pathways is usually ineffective because of the complex crosstalk and feedback among oncogenic signaling pathways.The enhanced toxicity of free small molecule inhibitor combinations is considered an insurmountable barrier to their clinical applications.To circumvent this issue,we rationally designed an effective tumor microenvironment-activatable prodrug nanomicelle(PNM)for cancer therapy.PNM was engineered by integrating the PI3K/m TOR inhibitor PF-04691502(PF)and the broad spectrum CDK inhibitor flavopiridol(Flav)into a single nanoplatform,which showed tumor-specific accumulation,activation and deep penetration in response to the high glutathione(GSH)tumoral microenvironment.The codelivery of PF and Flav could trigger gasdermin E(GSDME)-based immunogenic pyroptosis of tumor cells to elicit a robust antitumor immune response.Furthermore,the combination of PNM-induced immunogenic pyroptosis with antiprogrammed cell death-1(a PD-1)immunotherapy further boosted the antitumor effect and prolonged the survival time of mice.Collectively,these results indicated that the pyroptosis-induced nanoplatform codelivery of PI3K/m TOR and CDK inhibitors can reprogram the immunosuppressive tumor microenvironment and efficiently improve checkpoint blockade cancer immunotherapy. | Qichao Yang Xianbin Ma Yao Xiao Tian Zhang Leilei Yang Shaochen Yang Mengyun Liang Shuo Wang Zhizhong Wu Zhigang Xu Zhijun Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 0 |
| 9 | Release and sedimentation behaviors of biochar colloids in soil solutions显示文摘The release of biochar colloids considerably affects the stability of biochar in environment.Currently,information on the release behavior and suspension stability of biochar colloids in real soil solutions is scarce.In this study,20 soils were collected from different districts in China and the release behavior of biochar colloids and their suspension stability in soil solutions were systematically examined.The results showed that both pyrolysis temperature and biomass source had important effects on the formation of biochar colloids in soil solutions.The formation amount of biochar colloids from low pyrolysis temperatures(400℃)(average amount of 9.33-16.41 mg/g)were significantly higher than those from high pyrolysis temperatures(700℃)(average amount of less than 2 mg/g).The formation amount of wheat straw-derived biochar colloids were higher than those of rice straw-derived biochar colloids probably due to the higher O/C ratio in wheat-straw biochar.Further,biochar colloidal formation amount was negatively correlated with comprehensive effect of dissolved organic carbon,Fe and Al in soil solutions.The sedimentation curve of biochar colloids in soil solutions is well described by an exponential model and demonstrated high suspension stability.Around 40%of the biochar colloids were maintained in the suspension at the final sedimentation equilibrium.The settling efficiency of biochar colloids was positively correlated with comprehensive effect of the ionic strength and K,Ca,Na,and Mg contents in soil solutions.Our findings help promote a deeper understanding of biochar loss and stability in the soil-water environment. | Qingkang Meng Liang Jin Leilei Cheng Jing Fang Daohui Lin | 2021 | Journal of Environmental Sciences2021，33，2： | 0 |
| 10 | Reduced phosphatidylcholine synthesis suppresses the embryonic lethality of seipin deficiency显示文摘Seipin plays a vital role in lipid droplet homeostasis,and its deficiency causes congenital generalized lipodystrophy type II in humans.It is not known whether the physiological defects are all caused by cellular lipid droplet defects.Loss-of-function mutation of seip-1,the Caenorhabditis elegans seipin ortholog,causes embryonic lethality and lipid droplet abnormality.We uncover nhr-114 and spin-4 as two suppressors of seip-1 embryonic lethality.Mechanistically,nhr-114 and spin-4 act in the“B12-one-carbon cycle-phosphatidylcholine(PC)”axis,and reducing PC synthesis suppresses the embryonic lethality of seip-1 mutants.Conversely,PC deficiency enhances the lipid droplet abnormality of seip-1 mutants.The suppression of seip-1 embryonic lethality by PC reduction requires polyunsaturated fatty acid.In addition,the suppression is enhanced by the knockdown of phospholipid scramblase epg-3.Therefore,seipin and PC exhibit opposite actions in embryogenesis,while they function similarly in lipid droplet homeostasis.Our results demonstrate that seipin-mediated embryogenesis is independent of lipid droplet homeostasis. | Jinglin Zhu Sin Man Lam Leilei Yang Jingjing Liang Mei Ding Guanghou Shui Xun Huang | 2022 | Life Metabolism2022，1，2： | 0 |
| 11 | Amyloidβneurotoxicity is IDO1–Kyn–AhR dependent and blocked by IDO1 inhibitor显示文摘Dear Editor,Alzheimer’s disease(AD),the most common neurodegenerative disorder and a leading cause of dementia is characterized by progressive memory deficits,cognitive impairment and personality changes.The accumulation of extracellular amyloid beta(Aβ)plaques consisted by Aβpeptide and intracellular neurofibrillary tangles(NFTs)composed by misfolded hyperphosphorylated tau are main pathological hallmarks of AD,which ultimately lead to the dysfunction and loss of synapses and the eventual death of neuron.Neuroinflammation plays a causal role in AD pathogenesis.While the mechanism underlying neuroinflammationinduced AD pathology has not been fully elucidated,increasing evidence proposed that the kynurenine pathway(KP),a major route for L-tryptophan(L-Trp)catabolism,plays an important role. | Zhenzhen Duan Shengnan Zhang Heng Liang Zikang Xing Leilei Guo Lei Shi Lisha Du Chunxiang Kuang Osamu Takikawa Qing Yang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 12 | Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions显示文摘Drug repurposing or repositioning has been well-known to refer to the therapeutic applications of a drug for another indication other than it was originally approved for.Repurposing non-oncology small-molecule drugs has been increasingly becoming an attractive approach to improve cancer therapy,with potentially lower overall costs and shorter timelines.Several non-oncology drugs approved by FDA have been recently reported to treat different types of human cancers,with the aid of some new emerging technologies,such as omics sequencing and artificial intelligence to overcome the bottleneck of drug repurposing.Therefore,in this review,we focus on summarizing the therapeutic potential of non-oncology drugs,including cardiovascular drugs,microbiological drugs,small-molecule antibiotics,anti-viral drugs,anti-inflammatory drugs,antineurodegenerative drugs,antipsychotic drugs,antidepressants,and other drugs in human cancers.We also discuss their novel potential targets and relevant signaling pathways of these old non-oncology drugs in cancer therapies.Taken together,these inspiring findings will shed new light on repurposing more non-oncology small-molecule drugs with their intricate molecular mechanisms for future cancer drug discovery. | Leilei Fu Wenke Jin Jiahui Zhang Lingjuan Zhu Jia Lu Yongqi Zhen Lan Zhang Liang Ouyang Bo Liu Haiyang Yu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 0 |
| 13 | A Survey on Event Tracking in Social Media Data Streams显示文摘Social networks are inevitable parts of our daily life,where an unprecedented amount of complex data corresponding to a diverse range of applications are generated.As such,it is imperative to conduct research on social events and patterns from the perspectives of conventional sociology to optimize services that originate from social networks.Event tracking in social networks finds various applications,such as network security and societal governance,which involves analyzing data generated by user groups on social networks in real time.Moreover,as deep learning techniques continue to advance and make important breakthroughs in various fields,researchers are using this technology to progressively optimize the effectiveness of Event Detection(ED)and tracking algorithms.In this regard,this paper presents an in-depth comprehensive review of the concept and methods involved in ED and tracking in social networks.We introduce mainstream event tracking methods,which involve three primary technical steps:ED,event propagation,and event evolution.Finally,we introduce benchmark datasets and evaluation metrics for ED and tracking,which allow comparative analysis on the performance of mainstream methods.Finally,we present a comprehensive analysis of the main research findings and existing limitations in this field,as well as future research prospects and challenges. | Zixuan Han Leilei Shi Lu Liu Liang Jiang Jiawei Fang Fanyuan Lin Jinjuan Zhang John Panneerselvam Nick Antonopoulos | 2024 | Big Data Mining and Analytics2024，7，1： | 0 |
| 14 | Modeling the effects of extreme high-temperature stress at anthesis and grain filling on grain protein in winter wheat显示文摘Extreme high-temperature stress(HTS) associated with climate change poses potential threats to wheat grain yield and quality. Wheat grain protein concentration(GPC) is a determinant of wheat quality for human nutrition and is often neglected in attempts to assess climate change impacts on wheat production. Crop models are useful tools for quantification of temperature impacts on grain yield and quality.Current crop models either cannot simulate or can simulate only partially the effects of HTS on crop N dynamics and grain N accumulation. There is a paucity of observational data on crop N and grain quality collected under systematic HTS scenarios to develop algorithms for model improvement as well as evaluate crop models. Two-year phytotron experiments were conducted with two wheat cultivars under HTS at anthesis, grain filling, and both stages. HTS significantly reduced total aboveground N and increased the rate of grain N accumulation, while total aboveground N and the rate of grain N accumulation were more sensitive to HTS at anthesis than at grain filling. The observed relationships between total aboveground N, rate of grain N accumulation, and HTS were quantified and incorporated into the WheatGrow model. The new HTS routines improved simulation of the dynamics of total aboveground N, grain N accumulation, and GPC by the model. The improved model provided better estimates of total aboveground N, grain N accumulation, and GPC under HTS(the normalized root mean square error was reduced by 40%, 85%, and 80%, respectively) than the original WheatGrow model. The improvements in the model enhance its applicability to the assessment of climate change effects on wheat grain quality by reducing the uncertainties of simulating N dynamics and grain quality under HTS. | Raheel Osman Yan Zhu Weixing Cao Zhifeng Ding Meng Wang Leilei Liu Liang Tang Bing Liu | 2021 | The Crop Journal2021，9，4： | 0 |
| 15 | Inspired heat shock protein alleviating prodrug enforces immunogenic photodynamic therapy by eliciting pyroptosis显示文摘Despite immunotherapy involving immune checkpoint inhibitors(ICIs)have revolutionized cancer therapy,the clinical efficacy is limited due to ICI resistance.Pyroptosis is a gasdermin-mediated programmed cell death that enhances responses to ICIs.However,nontargeted elicitation of pyroptosis may induce systemic side effects and toxicity.Therefore,we reasonably design and construct a tumor-specific prodrug that combines the heat shock protein 90 inhibitor tanespimycin(17-AAG)with the photosensitizer chlorin e6(Ce6)to induce pyroptosis,by utilizing the high glutathione level in the tumor microenvironment.The released Ce6 and 17-AAG produce reactive oxygen species by laser triggering,which induces gasdermin E-mediated pyroptosis.Furthermore,17-AAG reduces myeloid-derived suppressor cells and sensitizes tumors to anti-programmed death^(-1)(PD-1)therapy.Thus,our prodrug strategy achieves tumor-targeted pyroptosis to suppress tumor growth,thereby improving the response to anti-PD-1 therapy and extending the survival of 4T1 breast tumor-bearing mice.Consequently,this pyroptosis-based prodrug represents a novel strategy for enforcing immunogenic photodynamic therapy. | Junjie Zhou Xianbin Ma Hao Li Derun Chen Liang Mao Leilei Yang Tian Zhang Wei Qiu Zhigang Xu Zhi-Jun Sun | 2022 | Nano Research2022，15，4： | 0 |
| 16 | Fluorescent Detection of Trace Water in Methanol Based on an AI(III) Chemical Sensor显示文摘 | Liang Hao Qi-ming Qiu Wen-jie Wang Leilei Gu Hui Li | 2016 | Chinese Journal of Chemistry2016，34，11： | 0 |
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