|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Pilot Study of the Therapeutic Efficacy and Mechanism of Artesunate in the MRL/lpr Murine Model of Systemic Lupus Erythematosus显示文摘Recent evidence indicates that artesunate has immunomodulatory properties that might be useful for treating autoimmune disease.In this study,we conducted a pilot study and explored the effect and mechanism of artesunate on the treatment of systemic lupus erythematosus using an MRL/lpr murine model.MRL/lpr mice were divided into control,cyclophosphamide(CTX)and artesunate treatment groups.Blood was collected to measure serum levels of creatinine,antinuclear antibody(ANA)and anti-double-stranded DNA(anti-dsDNA)antibody.Twenty-four-hour urine was collected to measure levels of proteinuria.The concentration of monocyte chemotactic protein-1(MCP-1)in serum and urine was measured.The expression of MCP-1 in kidney was detected by Western blot and immunohistochemistry assay,respectively.The expression of B cell activating factor(BAFF)in spleen was determined by real time-PCR and immunoblotting.We found that artesunate significantly increased the survival rate,body weight and blood leukocyte counts,and reduced the serum levels of ANA and anti-dsDNA antibody titer,24 h urinary protein,and serum creatinine.Our results indicated that artesunate could decrease MCP-1,major pro-inflammation cytokine,in serum,urine and kidney.We also found that the level of BAFF,the major B cell activation factor,was decreased in artesunate treated MRL/lpr mice.Its efficacy was comparable with that of CTX in this study.Taken together,we have demonstrated that artesunate can inhibit the progression of disease and reverse the pathologic lesion of lupus nephritis. | Ouyang Jin Huayong Zhang Zhifeng Gu Shengnan Zhao Ting Xu Kangxing Zhou Bo Jiang Jie Wang Xiaofeng Zeng Lingyun Sun | 2009 | Cellular & Molecular Immunology2009，6，6： | 20 |
| 2 | Growth and characterization of 2-inch high quality β-Ga2O3 single crystals grown by EFG method显示文摘β-Ga_2O_3 is an ultra-wide band-gap semiconductor with promising applications in UV optical detectors,Schottky barrier diodes, field-effect transistors and substrates for light-emitting diodes. However, the preparation of large β-Ga_2O_3 crystals is undeveloped and many properties of this material have not been discovered yet. In this work, 2-inch β-Ga_2O_3 single crystals were grown by using an edge-defined film-fed growth method. The high quality of the crystal has been proved by high-resolution X-ray diffraction with 19.06 arcsec of the full width at half maximum. The electrical properties and optical properties of both the unintentionally doped and Si-doped β-Ga_2O_3 crystals were investigated systematically. | Shengnan Zhang Xiaozheng Lian Yanchao Ma Weidan Liu Yingwu Zhang Yongkuan Xu Hongjuan Cheng | 2018 | Journal of Semiconductors2018，39，8： | 12 |
| 3 | An impact angle constraint integral sliding mode guidance law for maneuvering targets interception显示文摘An integral sliding mode guidance law(ISMGL)combined with the advantages of the integral sliding mode control(SMC)method is designed to address maneuvering target interception problems with impact angle constraints.The relative motion equation of the missile and the target considering the impact angle constraint is established in the longitudinal plane,and an integral sliding mode surface is constructed.The proposed guidance law resolves the existence of a steady-state error problem in the traditional SMC.Such a guidance law ensures that the missile hits the target with an ideal impact angle in finite time and the missile is kept highly robust throughout the interception process.By adopting the dynamic surface control method,the ISMGL is designed considering the impact angle constraints and the autopilot dynamic characteristics.According to the Lyapunov stability theorem,all states of the closed-loop system are finally proven to be uniformly bounded.Simulation results are compared with the general sliding mode guidance law and the trajectory shaping guidance law,and the findings verify the effectiveness and superiority of the ISMGL. | ZHANG Wenjie FU Shengnan LI Wei XIA Qunli | 2020 | Journal of Systems Engineering and Electronics2020，31，1： | 10 |
| 4 | Efficient emission of InGaN-based light-emitting diodes:toward orange and red显示文摘Indium gallium nitride(InGaN)-based light-emitting diodes(LEDs)are considered a promising candidate for red-green-blue(RGB)micro displays.Currently,the blue and green LEDs are efficient,while the red ones are inefficient for such applications.This paper reports our work of creating efficient InGaN-based orange and red LEDs on silicon(111)substrates at low current density.Based on the structure of InGaN yellow LEDs,by simply reducing the growth temperature of all the yellow quantum wells(QWs),we obtained 599 nm orange LEDs with peak wall-plug efficiency(WPE)of 18.1%at 2 A/cm^2.An optimized QW structure was proposed that changed two of the nine yellow QWs to orange ones.Compared with the sample containing nine orange QWs,the sample with two orange QWs and seven yellow QWs showed similar emission spectra but a much higher peak WPE up to 24.0%at 0.8 A/cm^2 with a wavelength of 608 nm.The improvement of peak WPE can be attributed to the improved QW quality and the reduced active recombination volume.Subsequently,a series of efficient InGaN-based orange and red LEDs was demonstrated.With further development,the InGaN-based red LEDs are believed to be attainable and can be used in micro LED displays. | Shengnan Zhang Jianli Zhang Jiangdong Gao Xiaolan Wang Changda Zheng Meng Zhang Xiaoming Wu Longquan Xu Jie Ding Zhijue Quan Fengyi Jiang | 2020 | Photonics Research2020，8，11： | 10 |
| 5 | Design of sandwich-structured ZnO/ZnS/Au photoanode for enhanced efficiency of photoelectrochemical wate splitting显示文摘We developed and demonstrated a ZnO/ZnS/Au composite photoanode with significantly enhanced photoelectrochemical water-splitting performance, con- taining a ZnS interlayer and Au nanoparticles. The solar-to-hydrogen conversion efficiency of this ZnO/ZnS/Au heterostructure reached 0.21%, 3.5 times that of pristine ZnO. The comparison of the incident photon-to-current efficiency (IPCE) and the photoresponse in the white and visible light regions further verified that the enhancement resulted from contributions of both UV and visible light. The modification of the Au NPs was shown to improve the photoelectrochemical (PEC) performance to both UV and visible light, as modification encouraged effective surface passivation and surface-plasmon- resonance effects. The ZnS interlayer favored the movement of photogenerated electrons under UV light and hot electrons under visible light, causing their injection into ZnO; this simultaneously suppressed the electron-hole recombination at the photoanode-electrolyte interface. The optimized design of the interlayer within plasmonic metal/semiconductor composite systems, as reported here, provided a facile and compatible photoelectrode configuration, enhancing the utilization efficiency of incident light for photoelectrochemical applications. | Yichong Liu Yousong Gu Xiaoqin Yan Zhuo Kang Shengnan Lu Yihui Sun Yue Zhang | 2015 | Nano Research2015，8，9： | 10 |
| 6 | Abundance of antibiotic resistance genes and their association with bacterial communities in activated sludge of wastewater treatment plants: Geographical distribution and network analysis显示文摘Wastewater treatment plants(WWTPs) are deemed reservoirs of antibiotic resistance genes(ARGs). Bacterial phylogeny can shape the resistome in activated sludge. However, the co-occurrence and interaction of ARGs abundance and bacterial communities in different WWTPs located at continental scales are still not comprehensively understood. Here, we applied quantitative PCR and Miseq sequence approaches to unveil the changing profiles of ARGs(sul1, sul2, tet W, tet Q, tet X), int I1 gene, and bacterial communities in 18 geographically distributed WWTPs. The results showed that the average relative abundance of sul1 and sul2 genes were 2.08 × 10^(-1) and 1.32 × 10^(-1) copies/16 S rRNA copies, respectively. The abundance of tet W gene was positively correlated with the Shannon diversity index(H′), while both studied sul genes had significant positive relationship with the int I1 gene. The highest average relative abundances of sul1, sul2, tet X, and int I1 genes were found in south region and oxidation ditch system. Network analysis found that 16 bacterial genera co-occurred with tet W gene. Co-occurrence patterns were revealed distinct community interactions between aerobic/anoxic/aerobic and oxidation ditch systems. The redundancy analysis model plot of the bacterial community composition clearly demonstrated that the sludge samples were significant differences among those from the different geographical areas,and the shifts in bacterial community composition were correlated with ARGs. Together,these findings from the present study will highlight the potential risks of ARGs and bacterial populations carrying these ARGs, and enable the development of suitable technique to control the dissemination of ARGs from WWTPs into aquatic environments. | Haihan Zhang Huiyan He Shengnan Chen Tinglin Huang Kuanyu Lu Zhonghui Zhang Rong Wang Xueyao Zhang Hailong Li | 2019 | Journal of Environmental Sciences2019，31，8： | 9 |
| 7 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 8 | Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins显示文摘Members of the RAS proto-oncogene superfamily are indispensable molecular switches that play critical roles in cell proliferation, differentiation, and cell survival. Recent studies have attempted to prevent the interaction of RAS/GTP with RAS guanine nucleotide exchange factors(GEFs), impair RASeffector interactions, and suppress RAS localization to prevent oncogenic signalling. The present study aimed to investigate the effect of the natural triterpenoic acid inhibitor glycyrrhetinic acid, which is isolated from the roots of Glycyrrhiza plant species, on RAS stability. We found that glycyrrhetinic acid may bind to the P-loop of RAS and alter its stability. Based on our biochemical tests and structural analysis results, glycyrrhetinic acid induced a conformational change in RAS. Meanwhile, glycyrrhetinic acid abolishes the function of RAS by interfering with the effector protein RAF kinase activation and RAS/MAPK signalling. | Yuan Zhang Zhihua Wang Xiaoyao Ma Shengnan Yang Xueyan Hu Jin Tao Yuanyuan Houn Gang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 9 | Realization of population inversion between 7S_(1/2) and 6P_(3/2) levels of cesium for four-level active optical clock显示文摘We demonstrate experimentally the population inversion between 7S1/2 and 6P3/2 levels of cesium in thermal cesium cell with a 455.5 nm pumping laser.We calculate the relative population probabilities at each level theoretically with the density matrix method.In a steady state,5.8% atoms are at 7S1/2 level and 2.9% at 6P3/2 level,which builds up the population inversion between the two levels.We obtain the fluorescence spectra produced in thermal cesium cell in our experiment.The measured relative intensity of each available fluorescence spectral line in the experiment agrees very well with the theoretical result.The demonstrated population inversion between 7S1/2 and 6P3/2 levels can be used to construct an active optical clock of four-level system with a wavelength of 1469.9 nm. | WANG YanFei WANG DongYing ZHANG TongGang HONG YeLong ZHANG ShengNan TAO ZhiMing XIE XiaoPeng CHEN JingBiao | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 6 |
| 10 | A high-fiber diet synergizes with Prevotella copri and exacerbates rheumatoid arthritis显示文摘Both preclinical and established rheumatoid arthritis(RA)patients display alterations in the gut microbiome.Prevotella spp.are preferentially enriched in a subset of RA patients.Here,we isolated a Prevotella strain,P.copri RA,from the feces of RA patients and showed that colonization of P.copri RA exacerbated arthritis in a collagen-induced arthritis(CIA)model.With the presence of P.copri RA colonization,a high-fiber diet exacerbated arthritis via microbial alterations and intestinal inflammation.Colonization of P.copri together with a high-fiber diet enabled the digestion of complex fiber,which led to the overproduction of organic acids,including fumarate,succinate and short-chain fatty acids.Succinate promoted proinflammatory responses in macrophages,and supplementation with succinate exacerbated arthritis in the CIA model.Our findings highlight the importance of dysbiosis when evaluating the effects of dietary interventions on RA pathogenesis and provide new insight into dietary interventions or microbiome modifications to improve RA management. | Lingjuan Jiang Mengmeng Shang Shengnan Yu Yudong Liu Hui Zhang Yangzhong Zhou Min Wang Tingting Wang Hui Li Zhihua Liu Xuan Zhang | 2022 | Cellular & Molecular Immunology2022，19，12： | 6 |
| 11 | Fusing T5 exonuclease with Cas9 and Cas12a increases the frequency and size of deletion at target sites显示文摘CRISPR/Cas systems, especially CRISPR/Cas9, generally result in small insertions/deletions, which are unlikely to eliminate the functions of regulatory and other non-coding sequences. To generate larger genomic deletions usually requires the use of pairs of guide RNAs. Here we show that it is possible to create such deletions with a single guide RNA by fusing Cas9 or Cas12a with T5 exonuclease(T5exo). These fusion constructs were found to increase both the frequency and size of deletions at target loci in rice protoplasts and seedlings. Moreover, the genome editing efficiencies of Cas9 and Cas12a were also enhanced by fusion with T5 exonuclease. These T5exo-Cas fusions expand the CRISPR toolbox, and facilitate knockout of regulatory and non-coding DNA sequences. From a wider standpoint, our results suggest a general strategy for producing larger deletions using other Cas nucleases. | Qianwei Zhang Kangquan Yin Guanwen Liu Shengnan Li Mengou Li Jin-Long Qiu | 2020 | Science China(Life Sciences)2020，63，12： | 6 |
| 12 | Defect in Brnym1,a magnesium-dechelatase protein,causes a stay-green phenotype in an EMSmutagenized Chinese cabbage(Brassica campestris L.ssp.pekinensis)line显示文摘Leaf color is an important target trait in Chinese cabbage breeding programs.Leaf yellowing may reduce crop commercial and nutritional values.Some plants with the“stay-green”trait maintain leaf greenness during senescence and even after death.Stay-green Chinese cabbage may be a focal point of future breeding projects because it could improve crop quality and yield and prolong shelf life.A new stay-green mutant,non-yellowing mutant 1(nym1),was identified in Chinese cabbage derived from an ethyl methane sulfonate(EMS)-mutagenized population.The mutant had stay-green characteristics and a higher chlorophyll content than the wild-type during leaf senescence.The staygreen trait in the mutant Chinese cabbage was controlled by the recessive gene Brnym1.MutMap and KASP analyses showed that Brnym1(BraA03g050600.3C)encodes an mg-dechelatase(SGR protein),which might be the causal gene of the mutation in Chinese cabbage.A nonsynonymous single nucleotide base substitution(G to A)in the third exon of Brnym1 caused an amino acid substitution from L to F in the highly conserved domain of the magnesiumdechelatase.Ectopic overexpression showed that the BrNYM1 gene of wild-type Chinese cabbage complemented the SGR-defective stay-green mutant nye1-1 of Arabidopsis.The magnesium-dechelatase activity in the nym1 mutant was significantly downregulated compared to that in the wild type.Brnym1 was relatively upregulated in the mutant during late senescence,and BrNYM1 was localized to the chloroplasts.These results indicate that Brnym1(BraA03g050600.3C)is the causal gene of the stay-green mutation and could be of particular significance in the genetic improvement of Chinese cabbage. | Nan Wang Yun Zhang Shengnan Huang Zhiyong Liu Chengyu Li Hui Feng | 2020 | Horticulture Research2020，7，1： | 5 |
| 13 | Scalable synthesis of sub-lO0 nm hollow carbon nanospheres for energy storage applications显示文摘 | Hongyu Zhao Fan Zhang Shumeng Zhang Shengnan He Fei Shen Xiaogang Han Yadong Yin Chuanbo Gao | 2018 | Nano Research2018，11，4： | 4 |
| 14 | The enhanced performance of piezoelectric nanogenerator via suppressing screening effect with Au particles/ZnO nanoarrays Schottky junction显示文摘这份报纸描述新奇策略削弱由通过 Au 粒子的介绍在 ZnO 表面上形成 Schottky 连接到表面上屏蔽效果的 piezopotential。与这条途径, piezoelectric-energyconversion 表演极大地被提高。产量电压和 Au@ZnO 基于 nanoarray 的压电的 nanogenerator 的当前的密度分别地到达了 2 V 和 1 A/ 厘米 2, ,比太古的 ZnO 基于 nanoarray 的压电的 nanogenerators 的产量高 10 倍。我们由于减少的搬运人集中把这改进归因于屏蔽效果的戏剧的抑制,作为由扫描凯尔文探查显微镜大小和阻抗分析决定了。Au@ZnO nanoarraybased 的降低的电容压电的 nanogenerator 也贡献改进产量。这个工作提供一个新奇方法提高压电的 nanogenerators 的表演并且可能延长到 piezotronics 和 piezophototronics。 | Shengnan Lu Qingliang Liao Junjie Qi Shuo Liu Yichong Liu Qijie Liang Guangjie Zhang Yue Zhang | 2016 | Nano Research2016，9，2： | 4 |
| 15 | A New Robust Adaptive Neural Network Backstepping Control for Single Machine Infinite Power System With TCSC显示文摘For a single machine infinite power system with thyristor controlled series compensation(TCSC) device, which is affected by system model uncertainties, nonlinear time-delays and external unknown disturbances, we present a robust adaptive backstepping control scheme based on the radial basis function neural network(RBFNN). The RBFNN is introduced to approximate the complex nonlinear function involving uncertainties and external unknown disturbances, and meanwhile a new robust term is constructed to further estimate the system residual error,which removes the requirement of knowing the upper bound of the disturbances and uncertainty terms. The stability analysis of the power system is presented based on the Lyapunov function,which can guarantee the uniform ultimate boundedness(UUB) of all parameters and states of the whole closed-loop system. A comparison is made between the RBFNN-based robust adaptive control and the general backstepping control in the simulation part to verify the effectiveness of the proposed control scheme. | Yanhong Luo Shengnan Zhao Dongsheng Yang Huaguang Zhang | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，1： | 4 |
| 16 | Genome editing in plants with MAD7 nuclease显示文摘MAD7 is an engineered nuclease of the Class 2 type V-A CRISPR-Cas(Cas12 a/Cpf1)family with a low level of homology to canonical Cas12 a nucleases.It has been publicly released as a royalty-free nuclease for both academic and commercial use.Here,we demonstrate that the CRISPR-MAD7 system can be used for genome editing and recognizes T-rich PAM sequences(YTTN)in plants.Its editing efficiency in rice and wheat is comparable to that of the widely used CRISPR-Lb Cas12 a system.We develop two variants,MAD7-RR and MAD7-RVR that increase the target range of MAD7,as well as an M-AFID(a MAD7-APOBEC fusion-induced deletion)system that creates predictable deletions from 50-deaminated Cs to the MAD7-cleavage site.Moreover,we show that MAD7 can be used for multiplex gene editing and that it is effective in generating indels when combined with other CRISPR RNA orthologs.Using the CRISPR-MAD7 system,we have obtained regenerated mutant rice and wheat plants with up to 65.6%efficiency. | Qiupeng Lin Zixu Zhu Guanwen Liu Chao Sun Dexing Lin Chenxiao Xue Shengnan Li Dandan Zhang Caixia Gao Yanpeng Wang Jin-Long Qiu | 2021 | Journal of Genetics and Genomics2021，48，6： | 4 |
| 17 | A novel miRNA negatively regulates resistance to Glomerella leaf spot by suppressing expression of an NBS gene in apple显示文摘Glomerella leaf spot(GLS)of apple(Malus×domestica Borkh.),caused by Glomerella cingulata,is an emerging fungal epidemic threatening the apple industry.Little is known about the molecular mechanism underlying resistance to this devastating fungus.In this study,high-throughput sequencing technology was used to identify microRNAs(miRNAs)involved in GLS resistance in apple.We focused on miRNAs that target genes related to disease and found that expression of a novel miRNA,Md-miRln20,was higher in susceptible apple varieties than in resistant ones.Furthermore,its target gene Md-TN1-GLS exhibited the opposite expression pattern,which suggested that the expression levels of Md-miRln20 and its target gene are closely related to apple resistance to GLS.Furthermore,downregulation of MdmiRln20 in susceptible apple leaves resulted in upregulation of Md-TN1-GLS and reduced the disease incidence.Conversely,overexpression of Md-miRln20 in resistant apple leaves suppressed Md-TN1-GLS expression,with increased disease incidence.We demonstrated that Md-miRln20 negatively regulates resistance to GLS by suppressing Md-TN1-GLS expression and showed,for the first time,a crucial role for miRNA in response to GLS in apple. | Yi Zhang Qiulei Zhang Li Hao Shengnan Wang Shengyuan Wang Wenna Zhang Chaoran Xu Yunfei Yu Tianzhong Li | 2019 | Horticulture Research2019，6，1： | 4 |
| 18 | Bioaccumulation, subcellular distribution and chemical forms of yttrium in rice seedling显示文摘Yttrium(Y) accumulation in soil is a serious environment problem in China. To understand the mechanisms involved in Y tolerance and detoxification in rice seedling, the bioaccumulation, subcellular distribution, and chemical forms of Y was investigated in the present study. The results show that the content of Y both in roots and shoots increases with the increasing concentration of Y, and a large amount of Y is stored in roots. Subcellular distribution of Y in rice indicates that the majority of Y is bound to cell wall. Meanwhile, various chemical forms of Y is absorbed by rice. The greatest amount of Y is extracted by 2% hydrate acetic acid(HAc) and 0.6 mol/L HCl(particularly 2% HAc), which indicates that most of Y is combined with un-dissolved phosphate and oxalate(particularly phosphate). Cluster analysis, based on Y abundance levels, reveals the relationship between Y distribution patterns and chemical forms. Our results imply that Y forming of precipitates with phosphate(and/or oxalate) and depositing in the cell wall may be a key strategy for Y detoxicity and tolerance in rice. | Shengnan Zheng Caiyun Zhang Kailun Shi Jinxiao Wang Guanjun Sun Qiaochu Hu Fengyun Zhao Xue Wang | 2018 | Journal of Rare Earths2018，36，3： | 4 |
| 19 | Clinical characteristics and post-discharge follow-up analyses of 10 infants with congenital tuberculosis:A retrospective observational study显示文摘Importance Congenital tuberculosis(TB)is a rare,potentially fatal disease.There is currently a lack of detailed clinical information available regarding this disease.Objective This retrospective study investigated the clinical manifestations,treatment,and long-term prognosis of congenital TB.Methods Patients were treated in Beijing Children’s Hospital,Capital Medical University(Beijing,China)between 2009 and 2018.Their demographic data,maternal and family histories,symptoms and signs,treatment information,and follow-up data were retrospectively collected using the hospital’s electronic information system.Results Ten infants with congenital TB were enrolled.The mean gestational age was 36.6±2.2 weeks and mean birth weight was 2517±487 g.All 10 patients exhibited fever,nine patients(90%)had anemia,and six patients(60%)had extrauterine growth retardation.On chest computed tomography scans,all 10 patients presented multiple pulmonary nodules and four patients(40%)had mediastinal adenopathy.Nine out of ten(90%)completed the T-spot test,and eight of them(8/9,89%)were positive.Anti-TB treatment was initiated upon diagnostic confirmation.All patients(100%)received combined treatment with isoniazid(INH)and rifampicin(RIF).Eight of 10 patients(80%)received combined treatment with INH,RIF,and pyrazinamide.The survival rate was 100%.One patient was lost to follow-up and four patients are currently continuing treatment.Three of nine patients(33%)achieved normal developmental milestones at 6 months of age.Interpretation Early diagnosis based on maternal history,typical imaging results,and timely treatment can improve outcomes in infants with congenital TB. | Juan Du Shixiao Dong Shengnan Jia Qiaoru Zhang Mingyan Hei | 2021 | Pediatric Investigation2021，5，2： | 4 |
| 20 | Baeyer–Villiger oxidation of cyclohexanone catalyzed by cordierite honeycomb washcoated with Mg–Sn–W composite oxides显示文摘In this work, a series of Mg–Sn–W oxide powder catalysts with different tungsten oxide contents(0, 15 wt% and 30 wt%) were prepared and washcoated on cordierite honeycomb monoliths to produce monolithic catalysts,which were tested for the Baeyer–Villiger oxidation of cyclohexanone. The obtained monolithic catalysts,which combined the advantages of both homogeneous and heterogeneous catalysts, showed high catalytic efficiency and overcame the problems of product separation that occurred in the homogeneous catalytic process.SEM and EDX tests showed that the catalytic coating, with a thickness of approximately 20 μm, was compact and homogeneous, and an enlarged BET surface area was indicated by N_2 adsorption–desorption compared with the bare cordierite honeycomb. The chemical properties on the catalytic surface of the powder and monolithic catalysts were characterized by XPS, which indicated the tin and tungsten on the catalysts exhibited their full oxide states and presented mainly as stannate and tungstate, as confirmed by XRD and FTIR characterizations.Moreover, the catalytic activity test indicated that the tungsten content of the catalysts played an important role in catalytic efficiency and that monolithic catalysts were produced without obvious catalytic activity loss compared with the corresponding powders.(M)W30, which exhibited excellent mechanical stability and maintained high activity after recycling three times, was the optimal catalyst, showing a high selectivity that exceeded 86%and a conversion above 64%. Therefore, the structured Mg–Sn–W oxide catalysts have great potential for application in practical production. | Yang Han Shengnan Li Rong Ding Wenjin Xu Guangxu Zhang | 2019 | Chinese Journal of Chemical Engineering2019，27，3： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员