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| 1 | Chemical characteristics of haze particles in Xi'an during Chinese Spring Festival: Impact of fireworks burning显示文摘Fireworks burning releases massive fine particles and gaseous pollutants, significantly deteriorating air quality during Chinese Lunar New Year(LNY) period. To investigate the impact of the fireworks burning on the atmospheric aerosol chemistry, 1-hr time resolution of PM_(2.5) samples in Xi'an during the winter of 2016 including the LNY were collected and detected for inorganic ions, acidity and liquid water content(LWC) of the fine aerosols. PM_(2.5) during the LNY was 167 ± 87 μg/m^3, two times higher than the China National Ambient Air Quality Standard(75 μg/m^3). K^+(28 wt.% of the total ion mass) was the most abundant ion in the LNY period, followed by SO_4^(2-)(25 wt.%) and Cl-(18 wt.%). In contrast, NO_3^-(34 wt.%) was the most abundant species in the haze periods(hourly PM32-2.5> 75 μg/m), followed by SO_4(29.2 wt.%) and NH_4^+(16.3 wt.%), while SO_4^(2-)(35 wt.%) was the most abundant species in the clean periods(hourly PM_(2.5)< 75 μg/m^3), followed by NO_3^-(23.1 wt.%) and NH_4^+(11 wt.%). Being different from the acidic nature in the non-LNY periods, aerosol in the LNY period presented an alkaline nature with a pH value of 7.8 ± 1.3. LWC during the LNY period showed a robust linear correlation with K_2SO_4 and KCl, suggesting that aerosol hygroscopicity was dominated by inorganic salts derived from fireworks burning. Analysis of correlations between the ratios of NO--3/SO_4^(2-) and NH_4^+/SO_4^(2-) indicated that heterogeneous reaction of HNO_3 with NH_3 was an important formation pathway of particulate nitrate and ammonium during the LNY period. | Can Wu Gehui Wang Jiayuan Wang Jianjun Li Yanqin Ren Lu Zhang Cong Cao Jin Li Shuagshuang Ge Yuning Xie Xinpei Wang Guoyan Xue | 2018 | Journal of Environmental Sciences2018，30，9： | 10 |
| 2 | WUSCHEL-related homeobox1(WOX1)regulates vein patterning and leaf size in Cucumis sativus显示文摘In plants,WUSCHEL-related homeobox1(WOX1)homologs promote lamina mediolateral outgrowth.However,the downstream components linking WOX1 and lamina development remain unclear.In this study,we revealed the roles of WOX1 in palmate leaf expansion in cucumber(Cucumis sativus).A cucumber mango fruit(mf)mutant,resulting from truncation of a WOX1-type protein(CsWOX1),displayed abnormal lamina growth and defects in the development of secondary and smaller veins.CsWOX1 was expressed in the middle mesophyll and leaf margins and rescued defects of the Arabidopsis wox1 prs double mutant.Transcriptomic analysis revealed that genes involved in auxin polar transport and auxin response were highly associated with leaf development.Analysis of the cucumber mf rl(round leaf)double mutant revealed that CsWOX1 functioned in vein development via PINOID(CsPID1)-controlled auxin transport.Overexpression of CsWOX1 in cucumber(CsWOX1-OE)affected vein patterning and produced‘butterfly-shaped’leaves.CsWOX1 physically interacted with CsTCP4a,which may account for the abnormal lamina development in the mf mutant line and the smaller leaves in the CsWOX1-OE plants.Our findings demonstrated that CsWOX1 regulates cucumber leaf vein development by modulating auxin polar transport;moreover,CsWOX1 regulates leaf size by controlling CIN-TCP genes. | Hu Wang Huanhuan Niu Chuang Li Guoyan Shen Xiaofeng Liu Yiqun Weng Tao Wu Zheng Li | 2020 | Horticulture Research2020，7，1： | 6 |
| 3 | SMART/ASTC dynamic soft reduction technology and its application on the bloom continuous caster at Pangang显示文摘The SMART/ASTC dynamic soft reduction technology of VAI and its application on the 6-strand bloom continuous casterat Pangang, China are presented. The operation results show that soft reduction technology is effective to improve the inner quality ofcontinuously cast blooms. At Pangang, both the central porosity and the central segregation ratings are no more than 1.0, the centralshrinkage cavity rating is no more than 0.5, and the central segregation index of carbon is no more than 1.05. Rails made from theblooms have excellent quality and are used for high-speed tracks. | Guijun Li Kaijian Zhang Chuanfi Han Yong Chen Guoyan Zhao Kaike Cai | 2006 | Journal of University of Science and Technology Beijing2006，13，2： | 6 |
| 4 | Elevated CO2 differentially affects tobacco and rice defense against lepidopteran larvae via the jasmonic acid signaling pathway显示文摘Atmospheric CO_2 levels are rapidly increasing due to human activities. However, the effects of elevated CO_2(ECO_2) on plant defense against insects and the underlying mechanisms remain poorly understood. Here we show that ECO_2 increased the photosynthetic rates and the biomass of tobacco and rice plants, and the chewing lepidopteran insects Spodoptera litura and Mythimna separata gained less and more mass on tobacco and rice plants, respectively. Consistently, under ECO_2, the levels of jasmonic acid(JA), the main phytohormone controlling plant defense against these lepidopteran insects, as well as the main defense-related metabolites, were increased and decreased in insectdamaged tobacco and rice plants. Importantly, bioassaysand quantification of defense-related metabolites in tobacco and rice silenced in JA biosynthesis and perception indicate that ECO_2 changes plant resistance mainly by affecting the JA pathway. We further demonstrate that the defensive metabolites, but not total N or protein, are the main factors contributing to the altered defense levels under ECO_2. This study illustrates that ECO_2 changes the interplay between plants and insects, and we propose that crops should be studied for their resistance to the major pests under ECO_2 to predict the impact of ECO_2 on future agroecosystems. | Chengkai Lu Jinfeng qi Christian Hettenhausen Yunting Lei Jingxiong Zhang Mou Zhang Cuiping Zhang Juan Song Jing Li Guoyan Cao Saif ul Malook Jianqiang Wu | 2018 | Journal of Integrative Plant Biology2018，60，5： | 3 |
| 5 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
| 6 | A PSO Based Multi-Domain Virtual Network Embedding Approach显示文摘This paper proposed a multi-domain virtual network embedding algorithm based on multi-controller SDN architecture. The local controller first selects candidate substrate nodes for each virtual node in the domain. Then the global controller abstracts substrate network topology based on the candidate nodes and boundary nodes of each domain, and applies Particle Swarm Optimization Algorithm on it to divide virtual network requests. Each local controller then embeds the virtual nodes of the divided single-domain virtual network requests in the domain, and cooperates with other local controllers to embed the inter-domain virtual links. Simulation experimental results show that the proposed algorithm has good performance in reducing embedding cost with good stability and scalability. | Yongjing Ni Guoyan Huang Sheng Wu Chenxi Li Peiying Zhang Haipeng Yao | 2019 | China Communications2019，16，4： | 3 |
| 7 | Role of nitric oxide and vascular endothelial growth factor in fluoride-induced goitrogenesis in rats显示文摘 | Guoyan Liu Weidong Zhang Peng Jiang Xinhong Li Chunyan Liu Chunyan Chai | 2012 | Environmental Toxicology and Pharmacology2012，，2： | 2 |
| 8 | SER analysis and power allocation for hybrid cooperative transmission system显示文摘The symbol-error-rate(SER) and power allocation for hybrid cooperative(HC) transmission system are investigated.Closed-form SER expression is derived by using the moment generating function(MGF)-based approach.However,the resultant SER contains an MGF of the harmonic mean of two independent random variables(RVs),which is not tractable in SER analysis.We present a simple MGF expression of the harmonic mean of two independent RVs which avoids the hypergeometric functions used commonly in previous studies.Using the simple MGF,closed-form SER for HC system with M-ary phase shift keying(M-PSK) signals is provided.Further,an approximation as well as an upper bound of the SER is presented.It is shown that the SER approximation is asymptotically tight.Based on the tight SER approximation,the power allocation of the HC system is investigated.It is shown that the optimal power allocation does not depend on the fading parameters of the source-destination(SD) channel and it only depends on the source-relay(SR) and relay-destination(RD) channels.Moreover,the performance gain of the power allocation depends on the ratio of the channel quality between RD and SR.With the increase of this ratio,more performance gain can be acquired. | Guoyan Li Youguang Zhang Wang Kang | 2012 | Journal of Systems Engineering and Electronics2012，23，5： | 2 |
| 9 | Structure-Mediated Excitation of Air Plasma and Silicon Plasma Expansion in Femtosecond Laser Pulses Ablation显示文摘Femtosecond laser-induced surface structures upon multiple pulses irradiation are strongly correlated with the pulse number,which in turn signifcantly afects successive laser-material interactions.By recording the dynamics of femtosecond laser ablation of silicon using time-resolved shadowgraphy,here we present direct visualization of the excitation of air plasma induced by the refected laser during the second pulse irradiation.Te interaction of the air plasma and silicon plasma is found to enhance the shockwave expansion induced by silicon ablation in the longitudinal direction,showing anisotropic expansion dynamics in diferent directions.We further demonstrate the vanishing of air plasma as the pulse number increases because of the generation of a rough surface without light focusing ability.In the scenario,the interaction of air plasma and silicon plasma disappears;the expansion of the silicon plasma and shockwave restores its original characteristic that is dominated by the laser-material coupling.Te results show that the excitation of air plasma and the laser-material coupling involved in laser-induced plasma and shockwave expansion are structure mediated and dependent on the pulse number,which is of fundamental importance for deep insight into the nature of laser-material interactions during multiple pulses ablation. | Qingsong Wang Lan Jiang Jingya Sun Changji Pan Weina Han Guoyan Wang Feifei Wang Kaihu Zhang Ming Li Yongfeng Lu | 2018 | Research2018，，1： | 2 |
| 10 | Oral lactoferrin results in T cell dependent tumor inhibition of head and neck squamous cell carcinoma in vivo 显示文摘 | Jeffrey S Wolf Guoyan Li Atul Varadhachary | 2007 | Clin Cancer Res2007，13，5： | 1 |
| 11 | Ultrasonic assisted synthesis, characterization and influence factors of monodispersed dumbbell-like YF3 nanostructures 显示文摘 | Ni Yonghong Li Guoyan Hong Jianming | 2010 | Ultrasonics Sonochemistry2010，17，3： | 1 |
| 12 | Orallactoferrin results in T cell dependent tumor inhibition ofhead and neck squamous cell carcinoma in vivo显示文摘 | Jeffrey SW Guoyan Li Atul Varadhachary | 2007 | ClinCancer Res2007，13，5： | 1 |
| 13 | Sensitive detection of DNA methyltransferase activity based on supercharged fluorescent protein and template-free DNA polymerization显示文摘DNA methylation, catalyzed by DNA methyltransferases(MTases), is a key component of genetic regulation, and DNA MTases have been regarded as potential targets in anticancer therapy. Herein, based on our previously developed DNA-mediated supercharged green fluorescent protein(Sc GFP)/graphene oxide(GO) interaction, coupled with methylation-initiated template-free DNA polymerization, we propose a novel fluorescence assay strategy for sensitive detection of DNA MTase activity. A hairpin DNA with a methylation-sensitive site and an amino-modified 3′-terminal(DNA-1) was designed and worked as a starting molecule. In the presence of DNA MTase, methylation-sensitive restriction endonuclease, and terminal deoxynucleotidyl transferase(Td T), DNA-1 can be sequentially methylated, cleaved, and further elongated. The resulting long DNA fragments quickly bind with Sc GFP and form the Sc GFP/DNA nanocomplex. Such nanocomplex can effectively protect Sc GFP from being adsorbed and quenched by GO. Without the methylation-initiated DNA polymerization, the fluorescence of Sc GFP will be quenched by GO. Thus, the DNA MTase activity, which is proportional to the amount of DNA polymerization products, can be measured by reading the fluorescence of Sc GFP/GO. The method was successfully used to detect the activity of DNA adenine methylation(Dam) MTase with a wide linear range(0.1–100 U/m L) and a low detection limit of 0.1 U/m L. In addition, the method showed high selectivity and the potential to be applied in a complex sample. Furthermore, this study was successfully extended to evaluate the inhibition effect of 5-fluorouracil on Dam MTase activity and detect Td T activity. | Daiqi Li Guoyan Lu Chunyang Lei Zhen Wang Lijun Li Zhou Nie Yan Huang Shouzhuo Yao | 2016 | Science China Chemistry2016，59，7： | 1 |
| 14 | Formation of β-SiC nanowires by annealing SiC films in hydrogen atmosphere显示文摘 | Li Yang Xing Zhang Ru Huang Guoyan Zhang Chengshan Xue | 2006 | Physica E: Low-dimensional Systems and Nanostructures2006，，1： | 1 |
| 15 | Fluoride causing abnormally elevated serum nitric oxide levels in chicks显示文摘 | Guoyan Liu Chunyan Chai Li Cui | 2003 | Environmental Toxicology and Pharmacology2003，，3： | 1 |
| 16 | Particle-filtering- based approach to undetermined blind separation显示文摘 | Zhang Hua Zhang Youguang Li Guoyan | 2012 | Advances in Information Sciences and Service Sciences2012，4，6： | 1 |
| 17 | Towards the development of a portable sensor based on a molecularly imprinted membrane for the rapid determination of salbutamol in pig urine显示文摘 | Chunyan Chai Guoyan Liu Feng Li Xiaofang Liu Bing Yao Li Wang | 2010 | Analytica Chimica Acta2010，，2： | 1 |
| 18 | Ultrasonic assisted synthesis,characterization and influence factors of monodispersed dumbbell-like YF3 nanostructures显示文摘 | Ni Yonghong Li Guoyan Hong Jianming | 2010 | Ultrason Sonochem2010，17，3： | 1 |
| 19 | Screening of Extraction Methods for Glycoproteins from Jellyfish (Rhopilema esculentum) Oral-Arms by High Performance Liquid Chromatography显示文摘In order to select an optimum extraction method for the target glycoprotein (TGP) from jellyfish (Rhopilema esculentum) oralarms, a high performance liquid chromatography (HPLC)–assay for the determination of the TGP was developed. Purified target glycoprotein was taken as a standard glycoprotein. The results showed that the calibration curves for peak area plotted against concentration for TGP were linear (r = 0.9984, y = 4.5895x+47.601) over concentrations ranging from 50 to 400 mgL-1. The mean extraction recovery was 97.84% (CV2.60%). The fractions containing TGP were isolated from jellyfish (R. esculentum) oral-arms by four extraction methods: 1) water extraction (WE), 2) phosphate buffer solution (PBS) extraction (PE), 3) ultrasound-assisted water extraction (UA-WE), 4) ultrasound-assisted PBS extraction (UA-PE). The lyophilized extract was dissolved in Milli-Q water and analyzed directly on a short TSK-GEL G4000PWXL (7.8 mm×300 mm) column. Our results indicated that the UA-PE method was the optimum extraction method selected by HPLC. | REN Guoyan LI Bafang ZHAO Xue ZHUANG Yongliang YAN Mingyan HOU Hu ZHANG Xiukun CHEN Li | 2009 | Journal of Ocean University of China2009，8，1： | 1 |
| 20 | Traditional Chinese Medicine in Cancer Care: A Review of Case Series Published in the Chinese Literature显示文摘 | Guoyan Yang Xun Li Xiaoli Li Lu Wang Jia Li Xue Song Jizhong Chen Yu Guo Xiaoxuan Sun Shana Wang Zhiqi Zhang Xiaoyun Zhou Jianping Liu Alyson Huntley | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
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