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| 1 | Bone marrow mesenchymal stem cells repair spinal cord ischemia/reperfusion injury by promoting axonal growth and anti-autophagy显示文摘Bone marrow mesenchymal stem cells can differentiate into neurons and astrocytes after transplantation in the spinal cord of rats with ischemia/reperfusion injury. Although bone marrow mesenchymal stem cells are known to protect against spinal cord ischemia/reperfusion injury through anti-apoptotic effects, the precise mechanisms remain unclear. In the present study, bone marrow mesenchymal stem cells were cultured and proliferated, then transplanted into rats with ischemia/reperfusion injury via retro-orbital injection. Immunohistochemistry and immunofluorescence with subsequent quantification revealed that the expression of the axonal regeneration marker, growth associated protein-43, and the neuronal marker, microtubule-associated protein 2, significantly increased in rats with bone marrow mesenchymal stem cell transplantation compared with those in rats with spinal cord ischemia/reperfusion injury. Furthermore, the expression of the autophagy marker, microtubule-associated protein light chain 3B, and Beclin 1, was significantly reduced in rats with the bone marrow mesenchymal stem cell transplantation compared with those in rats with spinal cord ischemia/reperfusion injury. Western blot analysis showed that the expression of growth associated protein-43 and neurofilament-H increased but light chain 3B and Beclin 1 decreased in rats with the bone marrow mesenchymal stem cell transplantation. Our results therefore suggest that bone marrow mesenchymal stem cell transplantation promotes neurite growth and regeneration and prevents autophagy. These responses may likely be mechanisms underlying the protective effect of bone marrow mesenchymal stem cells against spinal cord ischemia/reperfusion injury. | Fei Yin Chunyang Meng Rifeng Lu Lei Li Ying Zhang Hao Chen Yonggang Qin Li Guo | 2014 | Neural Regeneration Research2014，9，18： | 16 |
| 2 | Hierarchical Magnetic Network Constructed by CoFe Nanoparticles Suspended Within “Tubes on Rods” Matrix Toward Enhanced Microwave Absorption显示文摘Hierarchical magnetic-dielectric composites are promising functional materials with prospective applications in microwave absorption(MA)field.Herein,a three-dimension hierarchical“nanotubes on microrods,”core–shell magnetic metal–carbon composite is rationally constructed for the first time via a fast metal–organic frameworksbased ligand exchange strategy followed by a carbonization treatment with melamine.Abundant magnetic CoFe nanoparticles are embedded within one-dimensional graphitized carbon/carbon nanotubes supported on micro-scale Mo2N rod(Mo2N@CoFe@C/CNT),constructing a special multi-dimension hierarchical MA material.Ligand exchange reaction is found to determine the formation of hierarchical magnetic-dielectric composite,which is assembled by dielectric Mo2N as core and spatially dispersed CoFe nanoparticles within C/CNTs as shell.Mo2N@CoFe@C/CNT composites exhibit superior MA performance with maximum reflection loss of−53.5 dB at 2 mm thickness and show a broad effective absorption bandwidth of 5.0 GHz.The Mo2N@CoFe@C/CNT composites hold the following advantages:(1)hierarchical core–shell structure offers plentiful of heterojunction interfaces and triggers interfacial polarization,(2)unique electronic migration/hop paths in the graphitized C/CNTs and Mo2N rod facilitate conductive loss,(3)highly dispersed magnetic CoFe nanoparticles within“tubes on rods”matrix build multi-scale magnetic coupling network and reinforce magnetic response capability,confirmed by the off-axis electron holography. | Chunyang Xu Lei Wang Xiao Li Xiang Qian Zhengchen Wu Wenbin You Ke Pei Gang Qin Qingwen Zeng Ziqi Yang Chen Jin Renchao Che | 2021 | Nano-Micro Letters2021，13，3： | 10 |
| 3 | Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice显示文摘A neuroinflammatory response is commonly involved in the progression of many neurodegenerative diseases. Potassium 2-(1-hydroxypentyl)-benzoate(PHPB), a novel neuroprotective compound, has shown promising effects in the treatment of ischemic stroke and Alzheimer's disease(AD). In the present study, the anti-inflammatory effects of PHPB were investigated in the plasma and brain of C57BL/6 mice administered a single intraperitoneal(i.p.) injection of lipopolysaccharide(LPS). Levels of i NOS and the cytokines TNFα, IL-1β and IL-10 were elevated in plasma, cerebral cortex and hippocampus after LPS injection and the number of microglia and astrocytes in cortex and hippocampus were increased. LPS also upregulated the expression of heme oxygenase-1(HO-1) in the cortex and hippocampus. PHPB reduced the levels of i NOS and cytokines in the plasma and brain, decreased the number of microglia and astrocytes and further enhanced the upregulation of HO-1. In addition, PHPB inhibited the LPS-induced phosphorylation of ERK, P38 and JNK. These results suggest that PHPB is a potential candidate in the treatment of neurodegenerative diseases through inhibiting neuroinflammation. | Chunyang Zhao Weizhen Hou Hui Lei Longjian Huang Shan Wang Dandan Cui Changhong Xing Xiaoliang Wang Ying Peng | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 9 |
| 4 | A method to determine Young's modulus of soft gels for cell adhesion显示文摘一种方便技术为为细胞的粘附测量极其软的材料的有弹性的模量在这笔记被报导。在严肃下面把柱体弄弯的标本被用来避免在严峻的设备和样品之间的接触问题,并且一个横梁模型为与大有弹性的变丑评估胶化横梁的弯曲被介绍。一个自我适应的算法也被建议由把试验性的弯曲弯曲与那些与 preestimated moduli 从横梁模型计算了作比较寻找胶化的有弹性的 moduli 的最好的评价。到 polyacrylamide 胶化的性质的测量的申请显示材料依从与 bis-acrylamide,和胶化的集中变化在为时间的一个时期沉浸于文化媒介以后变得更软,不管到到什么程度,他们是 polymerized。 | Xiaoling Peng Jianyong Huang Lei Qin Chunyang Xiong Jing Fang | 2009 | Acta Mechanica Sinica2009，25，4： | 7 |
| 5 | Mission planning of the flying robot for powerline inspection显示文摘Mission planning is an important step in the powerline inspection flying robots.To deal with the tasks of powerline flying robots,a flying robot mission-planning system is established based on the unmanned mini-helicopter model described in this paper.It can deter-mine the best checking order,the optimal space path and the best flight trajectory.The objective function and the constraints are described by establishing the mathematical model,and the mission-planning system is decomposed by using the tiered methods.Multi-agent technology is chosen to solve the mission-planning issue.Finally,simulation is conducted to verify that the mission-planning system is feasible and efficient. | Chang’an Liu,Lei Wang,Chunyang Liu School of Computer Science and Technology,North China Electric Power University,Beijing 102206,China | 2009 | Progress in Natural Science:Materials International2009，19，10： | 4 |
| 6 | 3D Seed-Germination-Like MXene with In Situ Growing CNTs/Ni Heterojunction for Enhanced Microwave Absorption via Polarization and Magnetization显示文摘Ti_(3)C_(2)Tx MXene is widely regarded as a potential micro-wave absorber due to its dielectric multi-layered structure.However,missing magnetic loss capability of pure MXene leads to the unmatched electromagnetic parameters and unsatisfied impedance matching condi-tion.Herein,with the inspiration from dielectric-magnetic synergy,this obstruction is solved by fabricating magnetic CNTs/Ni hetero-structure decorated MXene substrate via a facile in situ induced growth method.Ni2+ions are successfully attached on the surface and interlamination of each MXene unit by intensive electrostatic adsorption.Benefiting from the possible“seed-germination”effect,the“seeds”Ni^(2+)grow into“buds”Ni nanoparticles and“stem”carbon nanotubes(CNTs)from the enlarged“soil”of MXene skeleton.Due to the improved impedance matching con-dition,the MXene-CNTs/Ni hybrid holds a superior microwave absorp-tion performance of−56.4 dB at only 2.4 mm thickness.Such a distinctive 3D architecture endows the hybrids:(i)a large-scale 3D magnetic coupling network in each dielectric unit that leading to the enhanced magnetic loss capability,(ii)a massive multi-heterojunction interface structure that resulting in the reinforced polarization loss capability,confirmed by the off-axis electron holography.These outstanding results provide novel ideas for developing magnetic MXene-based absorbers. | Xiao Li Wenbin You Chunyang Xu Lei Wang Liting Yang Yuesheng Li Renchao Che | 2021 | Nano-Micro Letters2021，13，10： | 4 |
| 7 | STUDY ON MECHANICAL INTERACTIONS BETWEEN SINGLE CARDIAC MYOCYTE AND ELASTIC SUBSTRATE显示文摘Quantitative investigation on mechanical characteristics of cardiac myocytes has important physiological significance.Based on elastic substrate technique,this paper develops a set of algorithms for high-effciency cellular traction recovery.By applying a gradient-based digital image correlation method to track randomly distributed fluorescence microbeads on the deformed substrate induced by single cardiac myocyte,high-resolution substrate displacement field can readily be obtained.By using a numerical algorithm based on the integral Boussinesq solution,cell-substrate tractions are reconstructed in a stable and reliable manner.Finally,spatiotemporal dynamics of a single cardiac myocyte is investigated as it adheres to a polyacrylamide elastic substrate. | Jianyong Huang Tao Zhu Lei Qin Xiaoling Peng Chunyang Xiong Jing Fang | 2009 | Acta Mechanica Solida Sinica2009，22，6： | 3 |
| 8 | Scheme design of the CHANG'E-5T1 extended mission显示文摘Flight schemes for the CHANG'E-5T1 extended mission are investigated in this paper.In the flight scheme and trajectory design, the remaining propellant of the CHANG'E-5T1 mission is utilized. The CHANG'E-5T1 mission is firstly introduced with feasible flight goals derived based on the terminal trajectory and satellite status. The flight schemes are designed to include a lunar return and the libration points in the Sun-Earth/Moon and Earth-Moon systems, with an emphasis on the Earth-Moon triangle libration point thus far unexplored. Secondly, three schemes are proposed for the CHANG'E-5T1 extended mission with different flight goals. The direct libration point orbit transfer and injection method is adopted to solve the issue in the transfer trajectory design.Furthermore, an innovative concept is proposed to transfer from the Earth-Moon collinear libration point to the triangle point using the Sun-Earth/Moon libration point. Finally, the merits and drawbacks of the three schemes are discussed in terms of flight time, control energy and frequency, flight distance, and goal value. As a result, the scheme including a lunar return and the Earth-Moon L2 libration point is selected for the CHANG'E-5T1 extended mission. A flight to the Earth-Moon libration point is achieved, replicating the achievement of the ARTEMIS mission. | Lei LIU Chunyang HU | 2018 | Chinese Journal of Aeronautics2018，31，7： | 3 |
| 9 | High-loading single cobalt atoms on ultrathin MOF nanosheets for efficient photocatalytic CO_(2) reduction显示文摘Based on suitable scaffolds,constructing high-loading single-atom catalysts is a promising strategy to achieve highly efficient catalysis.Herein,using ultrathin metal-organic framework(MOF)nanosheets(2.4±0.5 nm)as the support,single-atom catalysts with high cobalt loading(6.0 wt%)were constructed(denoted as Co-MNSs)by a simple bottom-up synthetic strategy.The catalytic system of Co-MNSs exhibited an outstanding photocatalytic CO_(2)-to-CO evolution rate of 7,041μmol g^(-1)h^(-1)and a selectivity of 86%in aqueous media under visible-light irradiation,which has reached the top level of the reported MOF-based photocatalysts.The control experiments and theoretical calculation revealed that the Co-N_(4)moiety in the MOF nanosheets acted as the active site for the photocatalytic CO_(2)-to-CO conversion.The boosted photocatalytic performance could be ascribed to the high aspect-ratio of layered Co-MNSs providing abundant accessible active sites on their surfaces,which reduced the energy barrier,improved the charge separation efficiency,and also facilitated the adsorption of CO_(2)to form the reactive radicals of*COOH.Our study provides an appealing strategy for constructing high-loading single-atom catalysts and demonstrates the significance of 2D ultrathin MOF nanosheets as the support in boosting CO_(2)photoreduction efficiency. | Quan Zuo Rui Cui Lei Wang Yuling Wang Chunyang Yu Liang Wu Yiyong Mai Yongfeng Zhou | 2023 | Science China Chemistry2023，66，2： | 2 |
| 10 | Vortex tuning magnetization configurations in porous Fe_(3)O_(4) nanotube with wide microwave absorption frequency显示文摘The design and optimization of one-dimension(1D)magnetic material are of great importance for the energy conversion,storage and spin electron devices,which remain a huge challenge.Herein,1D porous Fe_(3)O_(4) nanotubes(NTs)have been fabricated via a combined process of electrospinning and calcination.In the electrospinning precursors,by regulating the content ratio between two types of polyvinyl pyrrolidone with different molecular weight,porous Fe_(3)O_(4) NTs with vortex-domain configuration have been fabricated.Based on the unique 1D nanotube structure encapsulated with multi-domains,the composite Fe_(3)O_(4) NTs exhibit high complex permeability(μʹ,μʺ)values,and hold both strong magnetic storage and dissipation capacity.Our Fe_(3)O_(4) NTs exhibit excellent microwave absorption(MA)performance with the maximum reflection loss value of−57.1 dB and the efficient absorption bandwidth of 12.0 GHz.The generated magnetic vortices make the crucial contribution to the spin-wave resonance which improves the MA dissipation under high-frequency.Related magnetic flux line distribution and magnetic domain moment were confirmed by the electron holography and micro-magnetic simulation,respectively,providing the deep insight to the microwave absorption mechanism. | Ruixuan Zhang Lei Wang Chunyang Xu Chongyun Liang Xianhu Liu Xuefeng Zhang Renchao Che | 2022 | Nano Research2022，15，7： | 2 |
| 11 | Sex-specific association between coffee consumption and incident chronic kidney disease: a population-based analysis of 359,906 participants from the UK Biobank显示文摘Background:The risk for chronic kidney disease(CKD)is influenced by genetic predisposition,sex,and lifestyle.Previous research indicates that coffee is a potentially protective factor in CKD.The current study aims to investigate whether sex disparity exists in the coffee–CKD association,and whether genetic risk of CKD or genetic polymorphisms of caffeine metabolism affect this association.Methods:A total of 359,906 participants from the UK Biobank who were enrolled between 2006 and 2010 were included in this prospective cohort study,which aimed to estimate the hazard ratios for coffee intake and incident CKD using a Cox proportional hazard model.Allele scores of CKD and caffeine metabolism were additionally adjusted for in a subsample with qualified genetic data(n=255,343).Analyses stratified by genetic predisposition,comorbidities,and sex hormones were performed.Tests based on Bayesian model averaging were conducted to ascertain the robustness of the results.Results:Coffee was inversely associated with CKD in a dose-dependent manner.The effects of coffee did not differ across different strata of genetic risk for CKD,but were more evident among slower genetically predicted caffeine metabolizers.Significant sex disparity was observed(P value for interaction=0.013),in that coffee drinking was only associated with the risk reduction of CKD in females.Subgroup analysis revealed that testosterone and sex hormone-binding globulin(SHBG),but not estradiol,modified the coffee–CKD association.Conclusions:In addition to the overall inverse coffee–CKD association that was observed in the general population,we could also establish that a sex disparity existed,in that females were more likely to experience the benefit of the association.Testosterone and SHBG may partly account for the sex disparity. | Lei Tang Lina Yang Wenwen Chen Chunyang Li Yu Zeng Huazhen Yang Yao Hu Yuanyuan Qu Huan Song Xiaoxi Zeng Ping Fu | 2022 | Chinese Medical Journal2022，，12： | 2 |
| 12 | Species-specific responses to drought,salinity and their interactions in Populus euphratica and P.pruinosa seedlings显示文摘干旱和盐胁迫是严重的非生物胁迫因子,限制植物的生长和生产力,特别是在沙漠地区。本研究采用两种沙漠杨树—胡杨(Populus euphratica)和灰杨(P.pruinosa)幼苗,比较它们对干旱、盐胁迫和两者交互胁迫的耐受性。研究了在干旱、盐胁迫和交互胁迫下,胡杨和灰杨在生长、光合能力和色素含量、非结构性碳水化合物浓度、Cl−分配、渗透调节和活性氧积累等方面的物种特异性响应。研究结果表明,与胡杨相比,灰杨在干旱、盐胁迫,特别是交互胁迫下表现出更高的生长抑制作用,光合作用下降,气孔关闭和活性氧积累,抗氧化酶活性和渗透调节能力下降。此外,在盐胁迫下,胡杨限制了盐从根部向叶片的转运,并且向粗根分配的Cl−较多,向叶片分配的Cl−较少,而灰杨向叶片分配较多的Cl−。表明这两种杨树存在着物种特异性变化,在干旱、盐胁迫,特别是交互胁迫下,灰杨受到更大的负面作用。因此,在未来干旱和盐胁迫加重的气候环境下,在生态恢复和植树造林时,应考虑这两种杨树对干旱和盐胁迫的物种特异性响应和耐受性。 | Lei Yu Haojie Dong Zhijun Li Zhanjiang Han Helena Korpelainen Chunyang Li | 2020 | Journal of Plant Ecology2020，13，5： | 1 |
| 13 | Sensitive detection of DNA methyltransferase activity based on supercharged fluorescent protein and template-free DNA polymerization显示文摘DNA methylation, catalyzed by DNA methyltransferases(MTases), is a key component of genetic regulation, and DNA MTases have been regarded as potential targets in anticancer therapy. Herein, based on our previously developed DNA-mediated supercharged green fluorescent protein(Sc GFP)/graphene oxide(GO) interaction, coupled with methylation-initiated template-free DNA polymerization, we propose a novel fluorescence assay strategy for sensitive detection of DNA MTase activity. A hairpin DNA with a methylation-sensitive site and an amino-modified 3′-terminal(DNA-1) was designed and worked as a starting molecule. In the presence of DNA MTase, methylation-sensitive restriction endonuclease, and terminal deoxynucleotidyl transferase(Td T), DNA-1 can be sequentially methylated, cleaved, and further elongated. The resulting long DNA fragments quickly bind with Sc GFP and form the Sc GFP/DNA nanocomplex. Such nanocomplex can effectively protect Sc GFP from being adsorbed and quenched by GO. Without the methylation-initiated DNA polymerization, the fluorescence of Sc GFP will be quenched by GO. Thus, the DNA MTase activity, which is proportional to the amount of DNA polymerization products, can be measured by reading the fluorescence of Sc GFP/GO. The method was successfully used to detect the activity of DNA adenine methylation(Dam) MTase with a wide linear range(0.1–100 U/m L) and a low detection limit of 0.1 U/m L. In addition, the method showed high selectivity and the potential to be applied in a complex sample. Furthermore, this study was successfully extended to evaluate the inhibition effect of 5-fluorouracil on Dam MTase activity and detect Td T activity. | Daiqi Li Guoyan Lu Chunyang Lei Zhen Wang Lijun Li Zhou Nie Yan Huang Shouzhuo Yao | 2016 | Science China Chemistry2016，59，7： | 1 |
| 14 | OBV(obscure vein),a C_(2)H_(2)zinc finger transcription factor,positively regulates chloroplast development and bundle sheath extension formation in tomato(Solanum lycopersicum)leaf veins显示文摘Leaf veins play an important role in plant growth and development,and the bundle sheath(BS)is believed to greatly improve the photosynthetic efficiency of C_(4) plants.The OBV mutation in tomato(Solanum lycopersicum)results in dark veins and has been used widely in processing tomato varieties.However,physiological performance has difficulty explaining fitness in production.In this study,we confirmed that this mutation was caused by both the increased chlorophyll content and the absence of bundle sheath extension(BSE)in the veins.Using genome-wide association analysis and map-based cloning,we revealed that OBV encoded a C_(2)H_(2) L domain class transcription factor.It was localized in the nucleus and presented cell type-specific gene expression in the leaf veins.Furthermore,we verified the gene function by generating CRISPR/Cas9 knockout and overexpression mutants of the tomato gene.RNA sequencing analysis revealed that OBV was involved in regulating chloroplast development and photosynthesis,which greatly supported the change in chlorophyll content by mutation.Taken together,these findings demonstrated that OBV affected the growth and development of tomato by regulating chloroplast development in leaf veins.This study also provides a solid foundation to further decipher the mechanism of BSEs and to understand the evolution of photosynthesis in land plants. | Jinghua Lu Chunyang Pan Xin Li Zejun Huang Jinshuai Shu Xiaoxuan Wang Xiaoxiao Lu Feng Pan Junling Hu Hui Zhang Wenyue Su Min Zhang Yongchen Du Lei Liu Yanmei Guo Junming Li | 2021 | Horticulture Research2021，8，1： | 1 |
| 15 | Injury to the Endothelial Surface Layer Induces Glomerular Hyperfiltration Rats with Early-Stage Diabetes显示文摘 | Chunyang Zhang Yao Meng Qi Liu Miao Xuan Lanyu Zhang Bo Deng Keqin Zhang Zhimin Liu Tao Lei Hiroshi Okamoto | 2014 | Journal of Diabetes Research2014，，： | 1 |
| 16 | Occurrence and human exposure of p-hydroxybenzoic acid esters (parabens) , bisphenol A diglycidyl ether (BADGE), and their hydrolysis products in indoor dust from the United States and three east asian countries显示文摘 | WANG Lei LIAO Chunyang LIU Fang | 2012 | Environ Sci Technol2012，46，11： | 1 |
| 17 | Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair显示文摘Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by 60Co irradiation for 24 hours prior to implantation in the right thigh of rats following sciatic nerve damage. Results showed that the material was nontoxic to the kidneys and the liver, and did not induce an inflammatory response in the muscles. The composite material enhanced the recovery of sciatic nerve damage in rats. These experimental findings indicate that the composite material offers good biocompatibility and has a positive effect on injured nerve rehabilitation. | Qing Wang Xiaolei Yang Ming Ren Yulin Hu Qiang Chen Lei Xing Chunyang Meng Tiemei Liu | 2012 | Neural Regeneration Research2012，7，15： | 1 |
| 18 | Coupling of proteolysis-triggered transcription and CRISPR-Cas12a for ultrasensitive protease detection显示文摘The efficient signal amplification capacity of several class 2 CRISPR-Cas systems with trans-cleavage activity has exhibited great value in molecular diagnostics,but its potential application for non-nucleic-acid targets is yet underdeveloped.Here,we deploy CRISPR-Cas system for the ultrasensitive detection of protease biomarkers by the coupling of proteolysis-triggered transcription.In this strategy,a protease-activatable RNA polymerase is adopted for the conversion of each protease-catalyzed proteolysis event into the output of multiple programable RNA sequences by in vitro transcription,and the transcribed RNA subsequently serves as the guide RNA of Cas12a proteins with trans-cleavage activity.The rational design of the transcribed RNA efficiently couples the signal conversion and amplification of proteolysis-triggered transcription and the self-signal amplification of CRISPR-Cas12a,resulting in a two-stage amplified detection of target protease.The versatility of this strategy has been demonstrated in the detection of protease biomarkers including MMP-2 and thrombin with femtomolar sensitivity,which is 5–6 orders of magnitude lower than that of the standard peptide-based methods.Moreover,the proposed method has been further applied in the analysis of MMP-2 secreted by different cancer cell lines as well the assessment of MMP-2 activity in clinical serum samples,providing a generic method for the ultrasensitive detection of protease biomarkers in biochemical research and clinical diagnosis. | Min Yang Kai Shi Fang Liu Wenyuan Kang Chunyang Lei Zhou Nie | 2021 | Science China Chemistry2021，64，2： | 1 |
| 19 | Responsive MXene nanovehicles deliver CRISPR/Cas12a for boolean logic-controlled gene editing显示文摘Programmable and precise regulation of genetic information is crucial in bioengineering and biomedicine;however, it remains challenging to implement this objective. Here we deployed DNA-functionalized MXenes as a smart delivery system for spatiotemporally controllable genome editing. The MXene nanovehicles rationally integrated photothermal effect with nucleic acid strand displacement reaction, thereby allowing for the binary logic gate-controlled release of Cas ribonucleoprotein complexes in response to different input patterns of NIR light and nucleic acids. This system was highly programmable and could be harnessed to construct 2-input(AND, OR, and N-IMPLY) and 3-input(AND/OR and N-IMPLY/OR) logic gates for precise gene editing in mammalian cells. Moreover, an AND logic gate-controlled delivery system achieved selective induction of tumor cell death in a xenograft mice model using tissue-penetrating NIR light and cancer-relevant microRNA as the inputting cues.Therefore, the MXene nanovehicles adopted both the external and endogenous signals as the stimuli to precisely control gene editing under logic computation, presenting a helpful strategy for therapeutic genome editing. | Song Wang Zhenhua Zhang Rui Tang Fang He Yan Huang Zhou Nie Chunyang Lei | 2022 | Science China Chemistry2022，65，11： | 0 |
| 20 | Endogenous nucleotide as drug carrier:base-paired guanosine-5’-monophosphate:pemetrexed vesicles with enhanced anticancer capability显示文摘Endogenous substance such as nucleotide as a drug carrier has been proposed as a novel drug delivery system.The nucleotide guanosine-5’-monophosphate(GMP) is used to transport an anticancer drug pemetrexed disodium heptahydrate(PMX) via specific base pairing.The endogenous nature of GMP helps to avoid biocompatibility issues that are generally accompanied with nanocarriers including cytotoxicity,immunogenicity and blood compatibility.Furthermore,the low-molecular weight of the GMP nucleotide carrier significantly boosts the drug loading capacity compared to traditional liposomes and high-molecular weight carriers.Hydrogen-bonding interaction between the carrier and drug realizes the controlled release of loaded drug,and also facilitates large scale manufacture since no additional chemical synthesis is required.More importantly,in vivo experiments reveal that the base-paired GMP:PMX nanovesicles improve the target specificity and pharmacokinetic properties of PMX,and exhibit remarkably enhanced anticancer abilities compared to standalone PMX without any carriers.We envision that this strategy could be extended to other endogenous substances and drugs bearing functional groups capable of specific interaction,and promote the construction of drug delivery systems with inherent biocompatibility,enhanced drug delivery efficacy,and a simplified preparation method. | Lei Xu Chunyang Yu Dali Wang Ji Pang Leilei Shi Yue Su Lidong Gong Deyue Yan Xinyuan Zhu | 2020 | Science China Chemistry2020，63，2： | 0 |
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