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| 1 | Integration of Metabolomics and Subcellular Organelle Expression Microarray to Increase Understanding the Organic Acid Changes in Post-harvest Citrus Fruit显示文摘Citric acid plays an important role in fresh fruit favor and its adaptability to post-harvest storage conditions.In order to explore organic acid regulatory mechanisms in post-harvest citrus fruit,systematic biological analyses were conducted on stored Hirado Buntan Pummelo(HBP;Citrus grandis)fruits.High-performance capillary electrophoresis,subcellular organelle expression microarray,real-time quantitative reverse transcription polymerase chain reaction,gas chromatography mass spectrometry(GC-MS),and conventional physiological and biochemical analyses were undertaken.The results showed that the concentration of organic acids in HBP underwent a regular fuctuation.GC-MS-based metabolic profling indicated that succinic acid,g-aminobutyric acid(GABA),and glutamine contents increased,but 2-oxoglutaric acid content declined,which further confrmed that the GABA shunt may have some regulatory roles in organic acid catabolism processes.In addition,the concentration of organic acids was signifcantly correlated with senescence-related physiological processes,such as hydrogen peroxide content as well as superoxide dismutase and peroxidase activities,which showed that organic acids could be regarded as important parameters for measuring citrus fruit post-harvest senescence processes. | Xiaohua Sun Andan Zhu Shuzhen Liu Ling Sheng Qiaoli Ma Li Zhang Elsayed Mohamed Elsayed Nishawy Yunliu Zeng Juan Xu Zhaocheng Ma Yunjiang Cheng Xiuxin Deng | 2013 | Journal of Integrative Plant Biology2013，55，11： | 14 |
| 2 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 3 | An integrated chemical mass balance and source emission inventory model for the source apportionment of PM2.5 in typical coastal areas显示文摘The source apportionment of PM2.5 is essential for pollution prevention.In view of the weaknesses of individual models,we proposed an integrated chemical mass balancesource emission inventory(CMB-SEI)model to acquire more accurate results.First,the SEI of secondary component precursors(SO2,NOx,NH3,and VOCs)was compiled to acquire the emission ratios of these sources for the precursors.Then,a regular CMB simulation was executed to obtain the contributions of primary particle sources and secondary components(SO4^2-,NO3^-3,NH4^+,and SOC).Afterwards,the contributions of secondary components were apportioned into primary sources according to the source emission ratios.The final source apportionment results combined the contributions of primary sources by CMB and SEI.This integrated approach was carried out via a case study of three coastal cities(Zhoushan,Taizhou,and Wenzhou;abbreviated WZ,TZ,and ZS)in Zhejiang Province,China.The regular CMB simulation results showed that PM2.5 pollution was mainly affected by secondary components and mobile sources.The SEI results indicated that electricity,industrial production and mobile sources were the largest contributors to the emission of PM2.5 gaseous precursors.The simulation results of the CMB-SEI model showed that PM2.5 pollution in the coastal areas of Zhejiang Province presented complex pollution characteristics dominated by mobile sources,electricity production sources and industrial production sources.Compared to the results of the CMB and SEI models alone,the CMB-SEI model completely apportioned PM2.5 to primary sources and simultaneously made the results more accurate and reliable in accordance with local industrial characteristics. | Nana Cheng Cheng Zhang Deji Jing Wei Li Tianjiao Guo Qiaoli Wang Sujing Li | 2020 | Journal of Environmental Sciences2020，32，6： | 8 |
| 4 | Detection of geosmin and 2-methylisoborneol by liquid-liquid extraction-gas chromatograph mass spectrum (LLE-GCMS) and solid phase extraction-gas chromatograph mass spectrum (SPE-GCMS)显示文摘Two sample preparation methods were introduced and compared in this paper to establish a simple,quick and exact analysis of geosmin and 2-methylisoborneol.LC-18 column was employed in solid phase extraction(SPE),1.0 mL of hexane was adopted in liquid-liquid extraction(LLE),and the extracts were analyzed by gas chromatograph mass spectrum(GCMS)in selected ion mode.Mean recoveries of SPE were low for 2-methylisoborneol(2-MIB)and geosmin(GSM)with values below 50%.For LLE,the recoveries were satisfyingly above 50%for 2-MIB and 80%for GSM.Detection limits of the LLE method were as low as 1.0 ng/L for GSM and 5.0 ng/L for 2-MIB.A year-long investigation on odor chemicals of drinking water in Shanghai demonstrated that in the summer,there was a serious odor problem induced by a high concentration of 2-MIB.The highest concentration of 152.82 ng/L appeared in July in raw water,while GSM flocculation was minimal with concentrations below odor threshold. | MA Xiaoyan GAO Naiyun CHEN Beibei LI Qingsong ZHANG Qiaoli GU Guofen | 2007 | Frontiers of Environmental Science & Engineering2007，1，3： | 7 |
| 5 | Effectiveness of Traditional Chinese Medicine (TCM) treatments on the cognitive functioning of elderly persons with mild cognitive impairment associated with white matter lesions显示文摘 | Songming HE Lijun LI Juying HU Qiaoli CHEN Weiqun SHU | 2015 | 上海精神医学2015，27，5： | 7 |
| 6 | Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway显示文摘The stiffness of the extracellular matrix(ECM)plays an important role in regulating the cellular programming.However,the mechanical characteristics of ECM affecting cell differentiation are still under investigated.Herein,we aimed to study the effect of ECM substrate stiffness on macrophage polarization.We prepared polyacrylamide hydrogels with different substrate stiffness,respectively.After the hydrogels were confirmed to have a good biocompatibility,the bone marrow-derived macrophages(BMMs)from mice were incubated on the hydrogels.With simulated by the low substrate stiffness,BMMs displayed an enhanced expression of CD86 on the cell surface and production of reactive oxygen species(ROS)in cells,and secreted more IL-1βand TNF-αin the supernatant.On the contrary,stressed by the medium stiffness,BMMs expressed more CD206,produced less ROS,and secreted more IL-4 and TGF-β.In vivo study by delivered the hydrogels subcutaneously in mice,more CD68+CD86+cells around the hydrogels with the low substrate stiffness were observed while more CD68+CD206+cells near by the middle stiffness hydrogels.In addition,the expressions of NIK,phosphorylated p65(pi-p65)and phosphorylated IκB(pi-IκB)were significantly increased after stimulation with low stiffness in BMMs.Taken together,these findings demonstrated that substrate stiffness could affect macrophages polarization.Low substrate stiffness promoted BMMs to shift to classically activated macrophages(M1)and the middle one to alternatively activated macrophages(M2),through modulating ROS-initiated NF-κB pathway.Therefore,we anticipated ECM-based substrate stiffness with immune modulation would be under consideration in the clinical applications if necessary. | Mimi Chen Yu Zhang Pinghui Zhou Xingzhi Liu Huan Zhao Xichao Zhou Qiaoli Gu Bin Li Xuesong Zhu Qin Shi | 2020 | Bioactive Materials2020，5，4： | 7 |
| 7 | Effect of Er-Xian decoction(二仙汤) on autoimmune premature ovarian failure in mice显示文摘OBJECTIVE:To investigate the therapeutic effect of Er-Xian decoction(二仙汤,EXD)on the autoimmune premature ovarian failure(POF)in mice,and its regulatory mechanisms.METHODS:Female BALB mice were treated with a single intraperitoneal injection of zona pellucida 3(ZP3).One week later,mice received low(5 g/kg),moderate(10 g/kg)and high(20 g/kg)doses of EXD by gastrogavage once daily for 90 d.Premarin(0.03 mg/kg)served as the positive control group.Serum levels of estradiol(E2),follicle stimulating hormone(FSH)and luteinizing hormone(LH)were measured by enzyme-linked immunosorbent assay,lymphocyte subtypes were analyzed,and follicular structure differences were observed by hematoxylin andeosin staining.The main mechanisms of POF was investigated by immunohistochemical analysis.RESULTS:Serum E2 levels in POF model mice were decreased,whereas FSH and LH levels were dramatically increased.Serum levels of LH and FSH were reduced in POF model mice treated with EXD(moderate and high doses)and premarin,while serum level of E2 were increased after POF model mice had been treated with EXD and premarin.The CD3+T,CD4+T,CD4+T/CD8+T ratio of mice in the positive control group and high and medium dose groups of EXD increased(P<0.05),and the number of CD8+T cells decreased significantly(P<0.05)when compared with the model group.Bone morphogenetic protein 15(BMP15)and Akt were repressed in autoimmune POF model mice,whereas high expression was observed in control mice and those treated with EXD(moderate and high doses)and premarin.CONCLUSION:EXD is effective in treating ZP3-induced POF in mice and increased expression of BMP-15,and Akt is represented in the mechanism accounting for this therapeutic effect. | ZHANG Xiaoli LI Jing ZHOU Xiaolin CHEN Qiaoli | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 6 |
| 8 | Cloning, Characterization, and Expression Patterns of Three Sarco/Endoplasmic Reticulum Ca^2+-ATPase Isoforms from Pearl Oyster (Pinctada fucata)显示文摘大量钙被要求因为 molluskbiomineralization.Sarco/endoplasmic 蜂窝胃 Ca^(2+)-ATPase (SERCA ) 是有支撑钙动态平衡的功能的著名蛋白质。怎么它可能在珍珠牡蛎简历矿化作用的过程工作?三 SERCA isoforms ,也就是, PSERA , PSERB ,和 PSERC 从珍珠牡蛎被克隆,三 isoforms 的 Pinctada fucata.The cDNAs 被reversetranscription聚合酶链反应( RT-PCR )和编码 1007 氨基酸的 3568 bp 的 cDNA ends.PSERAconsisted 的快速的扩大孤立, PSERB 包括了编码 1024 氨基酸的 3953 bp ,由编码 1000 氨基酸的 3450 bp 组成的 andPSERC 。三 isoforms 从另外的种类与 SERCA 显示出高相同(65%-87%) 。与从另外的无脊椎动物的结果一致, DNA 印迹分析表明三 isoforms 从麝猫帽子也与脊椎动物的 SERCA1, SERCA2,和 SERCA3 有关的一个单身者发源。 threeisoforms 的拼接的机制类似于脊椎动物 SERCA3.Semiquantitative RT-PCR 的 isoforms 的被执行学习结果显示出的三 isoforms.The 的表示模式那 PSERB 无所不在地在所有测试纸巾被表示并且是潜在的“家务” SERCA isoform ;在内转肌肌肉表示的 PSERAwas 并且脚并且是可能的是肌肉特定的 isoform ,除了内转肌肌肉或脚, andPSERC 在鳃和披风与最高的表示层次在另外的纸巾被表示,显示它是 non-muscle-specific isoform 和力量在珍珠牡蛎简历矿化作用期间涉及钙动态平衡。 | Weimin FAN Changzhong LI Shuo LI Qiaoli FENG Liping XIE Rongqing ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 4 |
| 9 | All-fiber passively mode-locked laser using nonlinear multimode interference of step-index multimode fiber显示文摘We experimentally demonstrate for the first time, to the best of our knowledge, an all-fiber passively mode-locked laser operation based on the nonlinear multimode interference of step-index multimode fiber. Such a structure couples the light in and out of the multimode fiber via single-mode fibers, and its physical mechanisms for saturable absorption have been analyzed theoretically based on the third-order nonlinear Kerr effect of multimode fiber. Using the nonlinear multimode interference structure with 48.8 mm length step-index multimode fiber, the modulation depth has been measured to be ~5%. The passively mode-locked laser output pulses have a central wavelength of 1596.66 nm, bandwidth of 2.18 nm, pulsewidth of ~625 fs, and fundamental repetition rate of8.726 MHz. Furthermore, the influence of total cavity dispersion on the optical spectrum, pulse width, and output power is investigated systematically by adding different lengths of single-mode fiber and dispersion compensation fiber in the laser cavity. | TAO CHEN QIAOLI ZHANG YAPING ZHANG XIN LI HAIKUN ZHANG WEI XIA | 2018 | Photonics Research2018，，11： | 4 |
| 10 | Optimization of broadband omnidirectional antireflection coatings for solar cells显示文摘Broadband and omnidirectional antireflection coating is generally an effective way to improve solar cell efficiency, because the destructive interference between the reflected and incident light can maximize the light transmission into the absorption layer. In this paper, we report the incident quantum efficiency ηin, not incident energy or power, as the evaluation function by the ant colony algorithm optimization method, which is a swarm-based optimization method. Also, SPCTRL2 is proposed to be incorporated for accurate optimization because the solar irradiance on a receiver plane is dependent on position, season, and time. Cities of Quito, Beijing and Moscow are selected for two-and three-layer antireflective coating optimization over λ = [300,1100] nm and θ = [0°, 90°]. The ηin increases by 0.26%, 1.37% and 4.24% for the above 3 cities, respectively, compared with that calculated by other rigorous optimization algorithms methods, which is further verified by the effect of position and time dependent solar spectrum on the antireflective coating design. | Xia Guo Qiaoli Liu Huijun Tian Ben Li Hongyi Zhou Chong Li Anqi Hu Xiaoying He | 2019 | Journal of Semiconductors2019，40，3： | 4 |
| 11 | Aβ inhibits mesenchymal stem cell-pericyte transition through MAPK pathway显示文摘 | Lixia Xu Jialin Li Zhongqiu Luo Qiaoli Wu Weijia Fan Xiuhua Yao Qingguo Li Hua Yan Jinhuan Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 3 |
| 12 | 18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs显示文摘Hepatic stellate cells(HSCs)are essential drivers of fibrogenesis.Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis.18beta-glycyrrhetinic acid(18b-GA)is a natural compound that exists widely in herbal medicines,such as Glycyrrhiza uralensis Fisch,which is used for treating multiple liver diseases,especially in Asia.In the present study,we demonstrated that 18b-GA decreased hepatic fibrosis by inducing the apoptosis in activated HSCs.18b-GA inhibited the expression of a-smooth muscle actin and collagen type Ⅰ alpha-1.Using a chemoproteomic approach derived from activity-based protein profiling,together with cellular thermal shift assay and surface plasmon resonance,we found that 18b-GA covalently targeted peroxiredoxin 1(PRDX1)and peroxiredoxin 2(PRDX2)proteins via binding to active cysteine residues and thereby inhibited their enzymatic activities.18b-GA induced the elevation of reactive oxygen species(ROS),resulting in the apoptosis of activated HSCs.PRDX1 knockdown also led to ROS-mediated apoptosis in activated HSCs.Collectively,our findings revealed the target proteins and molecular mechanisms of 18b-GA in ameliorating hepatic fibrosis,highlighting the future development of 18b-GA as a novel therapeutic drug for hepatic fibrosis. | Qian Zhang Piao Luo Liuhai Zheng Jiayun Chen Junzhe Zhang Huan Tang Dandan Liu Xueling He Qiaoli Shi Liwei Gu Jiahao Li Qiuyan Guo Chuanbin Yang Yin Kwan Wong Fei Xia Jigang Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，4： | 3 |
| 13 | Relationship between corneal biomechanical parameters and corneal sublayer thickness measured by Corvis ST and UHR-OCT in keratoconus and normal eyes显示文摘Background:To explore the relationship between corneal biomechanical parameters and corneal sublayer thickness using corneal visualization Scheimpflug technology(Corvis ST)and ultrahigh-resolution optical coherence tomography(UHR-OCT)in clinical and suspected keratoconus and normal eyes.Methods:Cross-sectional prospective study.A total of 94 eyes of 70 participants were recruited.Twenty five eyes of 19 keratoconus patients,52 eyes of 34 patients showing high risk of developing keratoconus according to the Belin/Ambrosio Enhanced Ectasia Display,and each eye of 17 normal subjects were enrolled.All participants underwent Corvis ST,Pentacam,and UHR-OCT examinations at the same time.Stiffness parameter A1(SP-A1),deformation amplitude ratio(DA ratio),and other biomechanical parameters were recorded using Corvis ST.The vertical and horizontal thickness profiles of central 3mm corneal epithelium,Bowman’s layer,and stroma as measured by the perpendicular distance between the neighboring interfaces were generated using UHR-OCT.The flat keratometry and steep keratometry were obtained using Pentacam.Analysis of correlation was applied to explore the association between variables.Results:Most of the biomechanical parameters and corneal sublayer thickness profiles showed statistical differences among three groups.A statistically significant linear relationship was noted between SP-A1 and DA ratio in all three groups.SP-A1 was found to be positively correlated with epithelial and Bowman’s layer thickness in the keratoconus(KC)group,and with stromal thickness in all three groups.In the normal and suspected keratoconus(SKC)groups,only stromal thickness was included in the stepwise linear regression to predict SP-A1,whereas in the KC group,steep keratometry and Bowman’s layer thickness were included.Conclusions:Significant and different correlations were noted between corneal stiffness and corneal sublayer thickness in different groups,indicating that corneal sublayers may play different roles in maintaining corneal biomechanical stability between keratoconus and normal eyes. | Yong Li Zhiqiang Xu Qiaoli Liu Yuzhou Wang Kan Lin Jiahui Xia Shihao Chen Liang Hu | 2021 | Eye and Vision2021，8，1： | 2 |
| 14 | A novel surrogate modeling strategy of the mechanical properties of 3D braided composites显示文摘In this paper,a surrogate-based modeling methodology is developed and presented to predict the elastic properties of three dimensional(3 D)four-directional braided composites.Using this approach,the prediction process becomes feasible with only a limited number of training points.The surrogate models constructed using Finite Element(FE)method and Diffuse Approximation,reduce the computational time and cost for preparing experimental samples.In the FE model,multiscale method is applied to couple the computations of elastic properties at microscale and mesoscale.Subsequently,a parametric study is performed to analyze the effects of the three design parameters on the elastic properties.Satisfactory results are obtained via the surrogatebased modeling predictions,which are compared with the experimental measurements.Moreover,the predictions obtained from surrogate models concur well with the FE predictions.This study orients a new direction for predicting the mechanical properties based on surrogate models which can effectively reduce the sample preparation cost and computational efforts. | Zeyi LIU Yuliang HOU Qiaoli ZHAO Cheng LI | 2020 | Chinese Journal of Aeronautics2020，33，10： | 2 |
| 15 | Novel sol-gel material for fabrication of a long period waveguide grating filter as a precise thermometer显示文摘A new kind of organic-inorganic hybrid HfO 2/SiO 2 sol-gel material with a large thermo-optic coefficient and a wide linear tunable temperature range has been developed for fabrication of a long period waveguide grating (LPWG) filter,whose parameters were optimized and designed by using finite difference time domain (FDTD) simulations.The LPWG filter,a periodic rectangle-corrugated grating structure,was easily fabricated with soft-lithography technique.At a temperature range from 19°C to 70°C,the fabricated LPWG filter element demonstrated a high temperature sensitivity of about 6.5 nm/°C and a wide linear tunable temperature range of 51°C,so that it can be used as a precise thermometer.Our results are useful for the designs of LPWG filters for the implementation of a wide range of thermo-optic functions. | WANG Xin LI XiaoChan ZHANG Tao HU CanDong ZHU QiuXiang CHEN SiHai LI Yun XU Jia HE Miao NIU QiaoLi ZHAO LingZhi LI ShuTi ZHANG Yong | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 2 |
| 16 | Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes显示文摘Severe fever with thrombocytopenia syndrome virus(SFTSV),the causative agent of a febrile human disease,was first identified from central and eastern provinces in China,and later in Japan and South Korea.Hubei Province is one of the major SFTS epidemic areas in the central part of China.This study reported the isolation of 11 new SFTSV strains from patients in Hubei Province collected in 2017.Extensive phylogenetic analyses were conducted based on the complete coding sequences of SFTSV segments including the new strains.It was suggested that five different SFTSV genotypes were circulating in Hubei,and 15 reassortment patterns and migration pathways correlated with each genotype were identified,which was more than previously recognized.Hubei Province was more involved in the evolutionary events of SFTSV than that previously thought in which the evolutionary events of SFTSV were reported to be independent from those in other epidemic regions.Further divergence of SFTSV strains was suggested by pairwise comparison of SFTSV sequences from each genotype and sequence identity normalized to representative strain in genotype C1.Subsequently,amino acid variations specific for genotype(s),strain(s),or cluster(s)were inspected,which may be related to differential biological activity of SFTSV strains/genotypes.In conclusion,we analyzed the current status of SFTSV phylogeny in Hubei Province and discussed the possible events correlated to SFTSV evolution.It provided an in-depth insight into SFTSV evolution,raising concerns for the use of proper SFTSV strains in future studies. | Xiaoli Wu Mingyue Li Yanfang Zhang Boyun Liang Junming Shi Yaohui Fang Zhengyuan Su Mengmeng Li Wenjing Zhang Ling Xu Jun Wang Qiaoli Wu Shuang Tang Hualin Wang Tao Zhang Cheng Peng Xin Zheng Fei Deng Shu Shen | 2021 | Virologica Sinica2021，36，2： | 2 |
| 17 | Facet-dependent electrochemiluminescence spectrum of nanostructured ZnO显示文摘A facet-dependent electrochemiluminescence (ECL) behavior was found for nanostructured ZnO with different dominant exposing planes.The ECL spectrum of nanostructured ZnO was recorded by the emission scan mode with a fluorescence spectrometer and applied to investigate the difference of surface state for different crystal planes.Electronic structure calculations based on density functional theory were used to study the effect of crystal plane on the band structure and density of states.It revealed that the ECL emission was originated primarily from the recombination of electrons from Zn 4s and the hole from O 2p,which could be utilized to study the physical and chemical properties of surface structures of as-prepared nanostructured ZnO.A physical model was suggested to elucidate the differences of ECL spectra.A concept was proposed that the energy released as photons during ECL process of nanocrystalline semiconductor materials will be correlated with the energy level of active sites located at different crystal planes. | WANG Lei YUE QiaoLi LI HaiBo XU ShuLing GUO LianShun ZHANG XianXi WANG HuaiSheng GAO XueXi WANG WenJun LIU JiFeng LIU Peng | 2013 | Science China Chemistry2013，56，1： | 2 |
| 18 | miR-101-3p induces vascular endothelial cell dysfunction by targeting tet methylcytosine dioxygenase 2显示文摘Endothelial cell(EC)dysfunction represents an early key event in atherosclerosis.Recently,MicroRNAs have been demonstrated to regulate EC function.miR-101-3p has been discovered to regulate cell apoptosis and proliferation in cardiovascular diseases.Therefore,the aim of the current study was to clarify whether miR-101-3p regulates the dysfunction of vascular endothelial cells.In this study,the transfection of human umbilical vein endothelial cells(HUVECs)with miR-101-3p mimic induced reactive oxygen species(ROS)production,EC dysfunction,and acti-vated nuclear factorB(NF-κB),whereas transfection with miR-101-3p inhibitor alleviated these events.The antioxidant N-acetylcysteine alleviated miR-101-3p-induced EC dysfunction.Moreover,we observed that miR-101-3p inhibited the expression of tet methylcytosine dioxygenase 2(TET2)at the posttranscriptional level,resulting in increased ROS production and activated NF-kB.TET2 overexpression inhibited ROS production,EC dysfunction,and NF-κB activation in miR-101-3p-transfected HUVECs.These results indicate that miR-101-3p induces EC dysfunction by targeting TET2,which regulates ROS production,EC dysfunction,and NF-κB activation.Taken together,our current study reveals a novel pathway associated with EC dysfunction.The modulation of miR-101-3p and TET2 expression levels may serve as a potential target for therapeutic strategies for atherosclerosis. | Qiaoli Chen Xiaoye Li Lingjun Kong Qing Xu Zi Wang Qianzhou Lv | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 2 |
| 19 | Enhancement of radiosensitivity of lung adenocarcinoma using a decoction from the Fuzhengzengxiao formula显示文摘OBJECTIVE: To study the effects of a decoction of Fuzhengzengxiao formula on lung adenocarcinoma regarding the inflammatory protein S100A9 known to enhance cancer cell sensitivity.METHODS: A nude mouse model of human lung adenocarcinoma was established. The mice were randomly divided into four groups using the random number table method: Group Ⅰ, control;Group Ⅱ, treatment with a decoction of the Fuzhengzengxiao formula alone; Group Ⅲ, treatment with radiotherapy alone; and Group Ⅳ, treatment with radiotherapy plus a decoction of Fuzhengzengxiao formula. When the tumor body was 1 cm^3 in diameter, the tumor bearing mice in GroupsⅢ and Ⅳ were irradiated at a single dose of 10 Gy and the tumor inhibition rate was evaluated.The expression of S100A9 was determined using Western blotting and q-PCR(Real-time Quantitative PCR Detecting System). The sensitivity of cells containing RNAi S100A9 to radiotherapy was evaluated using the Click multiple target model,and the cell cycle was analyzed using flow cytometry.RESULTS: Relative to the control group,the expression of S100A9 in the tumors in each treatment group was decreased,especially in Group Ⅳ. The sensitizing enhancement ratio(SER) Dq was >1 after RNAi S100A9; it decreased the surviving fraction after a 2 Gy dose exposure,and also the D_0 and Dq of the tumor cells; in addition, the radiosensitivity of G_2/M cells was significantly increased.CONCLUSION: The decoction of the Fuzhengzengxiao formula downregulated the expression of S100A9 in lung adenocarcinoma cells. | Zhang Qiaoli Wu Tong Lei Yong Li Bo Liu Weiyi Tian Yehong Zhao Weipeng Huang Jingchang | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 2 |
| 20 | Polar codes: Encoding/decoding and rate-compatible jointly design for HARQ system显示文摘Polar coding are the first class of provable capacity-achieving coding techniques for a wide range of channels.With an ideal recursive structure and many elegant mathematical properties,polar codes are inherently implemented with low complexity encoding and decoding algorithms.Since the block length of the original polar construction is limited to powers of two,rate-compatible polar codes(RCPC)are presented to meet the flexible length/rate transmission requirements in practice.The RCPC codes are well-conditioned to combine with the hybrid automatic repeat request(HARQ)system,providing high throughput efficiency and such RCPC-HAPQ scheme is commonly used in delay-insensitive communication system.This paper first gives a survey of both the classical and state-of-the-art encoding/decoding algorithms for polar codes.Then the RCPC construction methods are discussed,including the puncturing,shortening,multi-kernel construction,etc.Finally,we investigate several RCPC-HARQ jointly design systems and discuss their encoding gain and re-transmission diversity gain. | Qiaoli Zeng Quan Zhou Xiangkun He Youming Sun Xiangcheng Li Haiqiang Chen | 2021 | Intelligent and Converged Networks2021，2，4： | 1 |
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