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| 1 | Effect and Prospect of Basic Geological Survey Based on Airborne Gravimetry in China显示文摘The airborne gravimetry was an important leap and innovation in the world's history of geophysical exploration.China's first test of the airborne gravity geological survey in the onshore-offshore transitional area of the western and southern part of the Bohai Sea was successful and effective in geology.Based on the airborne gravity data,and combining previous ground gravity,seismic and drilling data etc.,we carried out the geological interpretation by forward and inverse methods.The result shows that the airborne Bouguer gravity anomaly was clear,the fracture interpretation was reliable,and the inversion depth of the main geological interfaces was relatively accurate.This airborne gravity geological survey not only filled the exploring gaps in the onshore-offshore transitional area,and realized the geological and tectonic junction between the sea and the land,but also discovered four local gravity anomalies,11 fractures and three sags or subsags,and so on.The good geological effect of airborne gravimetry not restricted by terrain condition shows that it can be served as a new geophysical method in the exploration of complex terrain physiognomy area such as mountain,jungle,desert,marsh,onshore-offshore transitional area and so on,and has an extensive application prospect in China in the future. | LI Wenyong ZHOU Jianxin XIONG Shengqing GUO Zhihong LU Wenfen XU Jianchun LIU Yanxu | 2012 | Acta Geologica Sinica(English Edition)2012，86，1： | 11 |
| 2 | Study of Residual Basin and Tectonolayering Based on Airborne Gravity and Magnetic Data显示文摘This paper takes the South Yellow Sea as an example to show a new method for comprehensive geological-geophysical research such as residual basin and tectonolayering using airborne gravity and magnetic data in China. Based on airborne gravity and magnetic data, by measuring and analyzing stratigraphic density and susceptibility, the depths to the pre-Sinian magnetic basement top, the pre-Jurassic top and the Cenozoic bottom, are obtained by forward and inverse methods constrained by seismic and drilling data; and furthermore, the residual thicknesses of the Sinian-Triassic, the Jurassic-Cretaceous and the Cenozoic are calculated. Based on airborne gravity and magnetic anomalies, the faults in the pre-Sinian magnetic basement, the Jurassic-Cretaceous and the Cenozoic are respectively interpreted by the qualitative and quantitative methods. On the basis of the above study, and combining regional important tectonic events, four tectonolayers are divided in the vertical succession in South Yellow Sea, namely the pre-Sinian magnetic basement, the Sinian-Triassic, the Jurassic-Cretaceous and the Cenozoic. The result shows that there are thick Cenozoic and Jurassic-Cretaceous strata and thin residual Sinian-Triassic strata in the Suzhong-Huangnan depression area, but there are thin or only sporadic Mesozoic-Cenozoic terrestrial strata and thick Sinian-Triassic marine strata reserved in Subei-Huangzhong uplift area and Sunan-Wunansha uplift area. The four tectonolayers are very different in structures as well as distributions in plane. | LI Wenyong ZHOU Jianxin XIONG Shengqing LIU Yanxu XU Jianchun | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 6 |
| 3 | High Frequency Communication Network with Diversity: System Structure and Key Enabling Techniques显示文摘High frequency sky wave communication suffers from poor performance including poor link quality and low link success rate. To enhance performance, diversity technology is proposed in the high frequency communication network(HFCN) in this paper.First, we present the benefits and the challenges by introducing diversity technology into the existing HFCN. Secondly, to exploit the benefits fully and overcome the challenges, we propose a system structure suitable for deploying diversity technology in HFCN in large scale,based on the cloud radio access network and software defined network. Moreover, we present a general structure for the real-time updating frequency management system that plays a more important role especially when resource consuming(e.g., frequency) diversity technology is deployed. Thirdly, we investigate the key techniques enabling diversity technology deployment. Finally, we point out the future research directions to help the HFCN with diversity work more efficiently and intelligently. | Kun Xu Bin Jiang Zeyou Su Shengqing Wang Makun Guo Xiao Li Zhiyong Du | 2018 | China Communications2018，15，9： | 3 |
| 4 | A FAST BIT-LOADING ALGORITHM FOR HIGH SPEED POWER LINE COMMUNICATIONS显示文摘Adaptive bit-loading is a key technology in high speed power line communications with the Orthogonal Frequency Division Multiplexing (OFDM) modulation technology. According to the real situation of the transmitting power spectrum limited in high speed power line communications, this paper explored the adaptive bit loading algorithm to maximize transmission bit number when transmitting power spectral density and bit error rate are not exceed upper limit. With the characteristics of the power line channel, first of all, it obtains the optimal bit loading algorithm, and then provides the improved algorithm to reduce the computational complexity. Based on the analysis and simulation, it offers a non-iterative bit allocation algorithm, and finally the simulation shows that this new algorithm can greatly reduce the computational complexity, and the actual bit allocation results close to optimal. | Zhang Shengqing Zhao Li Zou Cairong | 2012 | Journal of Electronics(China)2012，29，5： | 2 |
| 5 | Low-density extraction solvent-based solvent terminated dispersive liquid–liquid microextraction combined with gas chromatography-tandem mass spectrometry for the determination of carbamate pesticides in water samples显示文摘 | Hao Chen Ruiwen Chen Shengqing Li | 2009 | Journal of Chromatography A2009，，8： | 1 |
| 6 | Compatibilization effects of block copolymers in high density polyethylene/syndiotactic polystyrene blends显示文摘 | Chen Bin Li Xilang Xu Shengqing | 2002 | Polymer2002，43，： | 1 |
| 7 | 显示文摘 | LI Shengqing CAI Shun HU Wei | 2009 | Spectrochim Acta Part B2009，6，7： | 1 |
| 8 | Compatiblization effects of block copolymers in high density polyethylene/syndiotactic polystyrene blends显示文摘 | Chen Bin Li Xiliang Xu Shengqing | 2002 | Polymer2002，43，3： | 1 |
| 9 | Organ function support in patients with coronavirus disease 2019:Tongji experience显示文摘Coronavirus disease 2019(COVID-19)is a highly contagious disease and a serious threat to human health.COVID-19 can cause multiple organ dysfunction,such as respiratory and circulatory failure,liver and kidney injury,disseminated intravascular coagulation,and thromboembolism,and even death.The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%.Currently,the number of severe cases worldwide has increased rapidly,but the experience in the treatment of infected patients is still limited.Given the lack of specific antiviral drugs,multi-organ function support treatment is important for patients with COVID-19.To improve the cure rate and reduce the mortality of patients with severe-and critical-type COVID-19,this paper summarizes the experience of organ function support in patients with severe-and criticaltype COVID-19 in Optical Valley Branch of Tongji Hospital,Wuhan,China.This paper systematically summarizes the procedures of functional support therapies for multiple organs and systems,including respiratory,circulatory,renal,hepatic,and hematological systems,among patients with severe-and critical-type COVID-19.This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide. | Yong Li Fan He Ning Zhou Jia Wei Zeyang Ding Luyun Wang Peng Chen Shuiming Guo Binhao Zhang Xiaoning Wan Wei Zhu 无 Xiaoping Chen Xiaomei Guo Rui Li Shengqing Li Daowen Wang Hui Wang Gang Xu Zhenyu Yin Wenkui Yu Bixiang Zhang Jianping Zhao Jianfeng Zhou | 2020 | Frontiers of Medicine2020，14，2： | 1 |
| 10 | Ionic liquid-based ultrasound-assisted dispersive liquid - liquid microextraction combined with electrothermal atomic absorption spectrometry for a sensitive determination of cadmium in water samples 显示文摘 | Li Shengqing Cai Shun Hu Wei | 2009 | Spectrochimica Acta Part B: Atomic Spectroscopy2009，64，7： | 1 |
| 11 | Low-density extraction solvent-based solvent terminated dispersive liquid-liquid microextraction combined with gas chromatography- tandem mass spectrometry for the determination of carbamate pesticides in water samples显示文摘 | CHEN Hao CHEN Ruiwen LI Shengqing | 2010 | Journal of Chromatography A2010，1217，8： | 1 |
| 12 | The effect of concentrations and properties of phenanthrene, pyrene, and benzo( a )pyrene on desorption in contaminated soil aged for 1 year显示文摘 | Xiaojun Li Shengqing Shuang Xinyong Li Lingxue Kong Ling Xu Peidong Tai Xin Lin Chunyun Jia Zongqiang Gong | 2013 | Journal of Soils and Sediments2013，，2： | 1 |
| 13 | A New MPPT Control Method of Photovoltaic Grid-connected Inverter System 显示文摘 | Li Shengqing Zhang Bin Xu Tianjun | 2014 | Con- trol and Decision Conference(2014 CCDC)2014，，： | 1 |
| 14 | ECMO/CRRT Combined Support in the Treatment of Critically Ill SARS-CoV-2 Pneumonia Patients显示文摘Objective: To explore the experience with and complications of extracorporeal membrane oxygenation (ECMO)combined with continuous renal replacement therapy (CRRT) for treatment of critically ill patients with severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia.Methods: The data on critically ill COVID-19 patients who received ECMO/CRRT at Tongji Hospital, which isaffi liated with Huazhong University of Science and Technology, in February and March 2020 were collected andanalyzed. All three patients were male, and the mean age was 50.6 years (range 44 – 58 years). The indications forECMO in critically ill SARS-CoV-2 pneumonia patients at our center were severe acute respiratory distress syndromewith Pa o 2 /F i o 2 below 100 mmHg under an effective protective pulmonary ventilation strategy and infl ammatory stormaccompanied by acute kidney injury. One patient, with severe heart failure, was selected for venoarterial ECMO, andthe other two patients were selected for venovenous ECMO.Results: In the three patients who received ECMO combined with bedside CRRT, the mean duration was 9.7 days(range 7 – 13 days). Four complications occurred during ECMO/CRRT, especially thrombocytopenia. Laboratorytesting showed increased counts of leukocytes and lymphocytes and decreased levels of infl ammatory factors. LungCT was suggestive of signifi cantly absorbed and reduced lesions and interstitial fi brosis.Conclusions: The survival rate of patients with cardiopulmonary failure treated with ECMO/CRRT in whomconventional treatment failed in this group was 100%, which indicates that combined treatment with ECMO and CRRTis an important treatment technique. | Hai Zou Shengqing Li | 2021 | Cardiovascular Innovations and Applications2021，，1： | 0 |
| 15 | Machine Learning Modeling of Protein-intrinsic Features Predicts Tractability of Targeted Protein Degradation显示文摘Targeted protein degradation(TPD)has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation machinery.However,the susceptibility of proteins for targeting by TPD approaches,termed“degradability”,is largely unknown.Here,we developed a machine learning model,model-free analysis of protein degradability(MAPD),to predict degradability from features intrinsic to protein targets.MAPD shows accurate performance in predicting kinases that are degradable by TPD compounds[with an area under the precision–recall curve(AUPRC)of 0.759 and an area under the receiver operating characteristic curve(AUROC)of 0.775]and is likely generalizable to independent non-kinase proteins.We found five features with statistical significance to achieve optimal prediction,with ubiquitination potential being the most predictive.By structural modeling,we found that E2-accessible ubiquitination sites,but not lysine residues in general,are particularly associated with kinase degradability.Finally,we extended MAPD predictions to the entire proteome to find964 disease-causing proteins(including proteins encoded by 278 cancer genes)that may be tractable to TPD drug development. | Wubing Zhang Shourya S.Roy Burman Jiaye Chen Katherine A.Donovan Yang Cao Chelsea Shu Boning Zhang Zexian Zeng Shengqing Gu Yi Zhang Dian Li Eric S.Fischer Collin Tokheim X.Shirley Liu | 2022 | Genomics, Proteomics & Bioinformatics2022，20，5： | 0 |
| 16 | Dynamic fluid transport property of hydraulic fractures and its evaluation using acoustic logging显示文摘The existing acoustic logging methods for evaluating the hydraulic fracturing effectiveness usually use the fracture density to evaluate the fracture volume, and the results often cannot accurately reflect the actual productivity. This paper studies the dynamic fluid flow through hydraulic fractures and its effect on borehole acoustic waves. Firstly, based on the fractal characteristics of fractures observed in hydraulic fracturing experiments, a permeability model of complex fracture network is established. Combining the dynamic fluid flow response of the model with the Biot-Rosenbaum theory that describes the acoustic wave propagation in permeable formations, the influence of hydraulic fractures on the velocity dispersion of borehole Stoneley-wave is then calculated and analyzed, whereby a novel hydraulic fracture fluid transport property evaluation method is proposed. The results show that the Stoneley-wave velocity dispersion characteristics caused by complex fractures can be equivalent to those of the plane fracture model, provided that the average permeability of the complex fracture model is equal to the permeability of the plane fracture. In addition, for fractures under high-permeability(fracture width 10~100 μm, permeability ~100 μm^(2)) and reduced permeability(1~10 μm, ~10 μm^(2), as in fracture closure) conditions, the Stoneley-wave velocity dispersion characteristics are significantly different. The field application shows that this fluid transport property evaluation method is practical to assess the permeability and the connectivity of hydraulic fractures. | LI Huanran TANG Xiaoming LI Shengqing SU Yuanda | 2022 | Petroleum Exploration and Development2022，49，1： | 0 |
| 17 | NUSAP1 potentiates chemoresistance in glioblastoma through its SAP domain to stabilize ATR显示文摘NUSAP1,which is a microtubule-associated protein involved in mitosis,plays essential roles in diverse biological processes,especially in cancer biology.In this study,NUSAP1 was found to be overexpressed in GBM tissues in a grade-dependent manner compared with normal brain tissues.NUSAP1 was also highly expressed in GBM patients,dead patients,and GBM cells.In addition,NUSAP1 was found to participate in cell proliferation,apoptosis,and DNA damage in GBM cells.Ataxia telangiectasia and Rad3-related protein(ATR)are a primary sensor of DNA damage,and ATR is also a promising target in cancer therapy.Here,we found that NUSAP1 positively regulated the expression of ATR.Mechanistically,NUSAP1 suppressed the ubiquitin-dependent proteolysis of ATR.The SAP(SAF-A/B,Acinus,and PIAS)domain is a common motif of many SUMO(small ubiquitin-like modifier)E3 ligases,and this domain is involved in substrate recognition and ligase activity.This study further demonstrated that the SAP domain of NUSAP1 promoted the sumoylation of ATR,and thereby antagonized the ubiquitination of ATR.These results suggest that NUSAP1 stabilizes ATR by sumoylation.Moreover,NUSAP1 potentiated chemotherapeutic resistance to temozolomide(TMZ)and doxorubicin(DOX)through its SAP domain.Overall,this study indicates that NUSAP1 is a promising therapeutic target in GBM. | Yuzu Zhao Jiang He Yongsen Li Shengqing Lv Hongjuan Cui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 18 | CoBRA: Containerized Bioinformatics Workflow for Reproducible Ch IP/ATAC-seq Analysis显示文摘Chromatin immunoprecipitation sequencing(Ch IP-seq)and the Assay for Transposase-Accessible Chromatin with high-throughput sequencing(ATAC-seq)have become essential technologies to effectively measure protein–DNA interactions and chromatin accessibility.However,there is a need for a scalable and reproducible pipeline that incorporates proper normalization between samples,correction of copy number variations,and integration of new downstream analysis tools.Here we present Containerized Bioinformatics workflow for Reproducible Ch IP/ATAC-seq Analysis(Co BRA),a modularized computational workflow which quantifies Ch IP-seq and ATAC-seq peak regions and performs unsupervised and supervised analyses.Co BRA provides a comprehensive state-of-the-art Ch IP-seq and ATAC-seq analysis pipeline that can be used by scientists with limited computational experience.This enables researchers to gain rapid insight into protein–DNA interactions and chromatin accessibility through sample clustering,differential peak calling,motif enrichment,comparison of sites to a reference database,and pathway analysis.Co BRA is publicly available online at http://gffzzdf4c9811637e4d7esv6p5bqxqp60k6fwu.ffgz.tsg.suse.edu.cn/cfce/cobra. | Xintao Qiu Avery S.Feit Ariel Feiglin Yingtian Xie Nikolas Kesten Len Taing Joseph Perkins Shengqing Gu Yihao Li Paloma Cejas Ningxuan Zhou Rinath Jeselsohn Myles Brown XShirley Liu Henry W.Long | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 0 |
| 19 | NDRG1 promotes endothelial dysfunction and hypoxia-induced pulmonary hypertension by targeting TAF15显示文摘Background:Pulmonary hypertension(PH)represents a threatening pathophysiologic state that can be induced by chronic hypoxia and is characterized by extensive vascular remodeling.However,the mechanism underlying hypoxia-induced vascular remodeling is not fully elucidated.Methods and Results:By using quantitative polymerase chain reactions,western blotting,and immunohistochemistry,we demon-strate that the expression of N-myc downstream regulated gene-1(NDRG1)is markedly increased in hypoxia-stimulated endothelial cells in a time-dependent manner as well as in human and rat endothelium lesions.To determine the role of NDRG1 in endothelial dysfunction,we performed loss-of-function studies using NDRG1 short hairpin RNAs and NDRG1 over-expression plasmids.In vitro,silencing NDRG1 attenuated proliferation,migration,and tube formation of human pulmonary artery endothelial cells(HPAECs)un-der hypoxia,while NDRG1 over-expression promoted these behaviors of HPAECs.Mechanistically,NDRG1 can directly interact with TATA-box binding protein associated factor 15(TAF15)and promote its nuclear localization.Knockdown of TAF15 abrogated the effect of NDRG1 on the proliferation,migration and tube formation capacity of HPAECs.Bioinformatics studies found that TAF15 was involved in regulating PI3K-Akt,p53,and hypoxia-inducible factor 1(HIF-1)signaling pathways,which have been proved to be PH-related pathways.In addition,vascular remodeling and right ventricular hypertrophy induced by hypoxia were markedly alleviated in NDRG1 knock-down rats compared with their wild-type littermates.Conclusions:Taken together,our results indicate that hypoxia-induced upregulation of NDRG1 contributes to endothelial dysfunction through targeting TAF15,which ultimately contributes to the development of hypoxia-induced PH. | Chengwei Li Junzhu Lv Gulinuer Wumaier Yu Zhao Liang Dong Yuzhen Zeng Ning Zhu Xiujuan Zhang Jing Wang Jingwen Xia Shengqing Li | 2023 | Precision Clinical Medicine2023，6，4： | 0 |
| 20 | Comprehensive Control Measures and Effect Evaluation of Groundwater Over-exploitation Areas in High-tech Zone,Jining in 2020显示文摘Groundwater over-exploitation is a major problem in groundwater development, utilization and protection. At present, the area of shallow groundwater over-exploitation in the High-tech Zone is 76 km^(2). In this study, the system and mechanism construction, engineering measure construction, and control effect of national comprehensive control project of groundwater over-exploitation areas in the High-tech Zone in 2020 were evaluated, and the comprehensive control of groundwater over-exploitation in the High-tech Zone in the year was summarized to provide effective basis for the continuous implementation of comprehensive control of groundwater over-exploitation. At the same time, the water-saving and exploitation reduction effect and generalizability of different measures were studied to provide useful reference for other over-exploitation areas. | Shengqing LI Fei XIE | 2022 | Meteorological and Environmental Research2022，13，3： | 0 |
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