|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection显示文摘AIM:To investigate whether the addition of probiotics can improve the eradication effect of triple therapy for Helicobacter pylori (H. pylori ) infection. METHODS:This open randomized trial recruited 234 H. pylori positive gastritis patients from seven local centers. The patients were randomized to one-week standard triple therapy (omeprazole 20 mg bid , clarithromycin 500 mg bid , and amoxicillin 1000 mg bid ; OCA group, n = 79); two weeks of pre-treatment with probiotics, containing 3 × 107 Lactobacillus acidophilus per day, prior to one week of triple therapy (POCA group, n = 78); or one week of triple therapy followed by two weeks of the same probiotics (OCAP group, n = 77). Successful eradication was defined as a negative C13 or C14 urease breath test four weeks after triple therapy. Patients were asked to report associated symptoms at baseline and during follow-up, and side effects related to therapy were recorded. Data were analyzed by both intention-to-treat (ITT) and per-protocol (PP) methods. RESULTS:PP analysis involved 228 patients, 78 in the OCA, 76 in the POCA and 74 in the OCAP group. Successful eradication was observed in 171 patients; by PP analysis, the eradication rates were significantly higher (P = 0.007 each) in the POCA (62/76; 81.6%, 95% CI 72.8%-90.4%) and OCAP (61/74; 82.4%, 95% CI 73.6%-91.2%) groups than in the OCA group (48/78; 61.5%, 95% CI 50.6%-72.4%). ITT analysis also showed that eradication rates were significantly higher in the POCA (62/78; 79.5%, 95% CI 70.4%-88.6%) and OCAP (61/77; 79.2%, 95% CI 70%-88.4%) groups than in the OCA group (48/79; 60.8%, 95% CI 49.9%-71.7%), (P = 0.014 and P = 0.015). The symptom relieving rates in the POCA, OCAP and OCA groups were 85.5%, 89.2% and 87.2%, respectively. Only one of the 228 patients experienced an adverse reaction. CONCLUSION:Administration of probiotics before or after standard triple therapy may improve H. pylori eradication rates. | Yi-Qi Du Tun Su Jian-Gao Fan Yu-Xia Lu Ping Zheng Xing-Hua Li Chuan-Yong Guo Ping Xu Yan-Fang Gong Zhao-Shen Li | 2012 | World Journal of Gastroenterology2012，18，43： | 54 |
| 2 | Gastro-protecting effect of gefarnate on chronic erosive gastritis with dyspeptic symptoms显示文摘 | Du Yi-qi SU Tun HAO Jian-yu WANG Bang-mao CHEN Min-hu LI You-ruing TANG Cheng-wei GONG Yan-fang MAN Xiao-hua GAO Li CAI Quan-cai LI Zhao-shen | 2012 | Chinese Medical Journal2012，，16： | 20 |
| 3 | Dynamically reconfigurable topological edge state in phase change photonic crystals显示文摘The observation of topological edge states(TESs) revolutionized our understanding of scattering and propagation of electromagnetic(EM) waves. Supported by topological robustness, the TES at the interface between trivial and non-trivial insulators was not reflected from the structural disorders and imperfections. Recently topological photonic crystals(PhCs) were demonstrated to obtain remarkable one-way propagation of the TES, having the advantages of lossless propagation, dense integration, and high fabrication tolerance over conventional PhCs. Nevertheless, the lack of reversible switching of TES possesses significant limitations in helicity/spin filtering and tunable photonic devices. We proposed a topological PhC based on a prototypical phase-change material, Ge2 Sb2 Te5(GST225) to solve the problem. We find that at a particular frequency, the TES within the structure can be reversibly switched between 'on'and 'off' by transiting the GST225 structural state between amorphous and crystalline. Moreover, the topology of the PhC was maintained since the tuning of TES was achieved by varying the refractive index of GST225 instead of the structural geometry. This provides a continuous change of the spectral position of the photonic bandgap and TES by gradually crystallising the GST225. We show that the phase change of GST225 from amorphous to crystalline and vice versa can be engineered in nanoseconds. Our proof of concept may offer a platform for dynamically tuning the TESs that might otherwise be challenging to attain in photonic systems. We expect it to have potential applications for photonic devices in topological optical circuits and scatter-free one-way light propagation. | Tun Cao Linhan Fang Ying Cao Nan Li Zhiyou Fan Zhiguo Tao | 2019 | Science Bulletin2019，64，12： | 8 |
| 4 | In vitro Stent Graft Fenestration to Preserve All Supra-aortic Branches in the Treatment of a Stanford Type A Aortic Arch Dissection显示文摘 | Tun Wang Chang Shu Ming Li Alan Dardik Quan-Ming Li | 2017 | Chinese Medical Journal2017，，15： | 8 |
| 5 | Theoretical study of tunable chirality from graphene integrated achiral metasurfaces显示文摘Control of chirality using metamaterials plays a critical role in a diverse set of advanced photonics applications,such as polarization control, bio-sensing, and polarization-sensitive imaging devices. However, this poses a major challenge, as it primarily involves the geometrical reconfiguration of metamolecules that cannot be adjusted dynamically. Real-world applications require active tuning of the chirality, which can easily manipulate the magnitude, handedness, and spectral range of chiroptical response. Here, enabled by graphene, we theoretically reveal a tunable/switchable achiral metasurface in the near-infrared region. In the model, the achiral metasurface consists of an array of circular holes embedded through a metal/dielectric/metal trilayer incorporated with the graphene sheet, where holes occupy the sites of a rectangular lattice. Circular conversion dichroism(CCD) originates from the mutual orientation between the achiral metasurface and oblique incident wave.The achiral metasurface possesses dual-band sharp features in the CCD spectra, which are tuned over a broad bandwidth by electrically modulating the graphene's Fermi level. By selecting aluminium as the metal materials,we numerically achieved strong CCD and considerably reduced materials costs with our nanostructures compared with the typically used noble metals such as gold and silver. | TUN CAO YANG LI XINYU ZHANG YANG ZOU | 2017 | Photonics Research2017，5，5： | 3 |
| 6 | Nonvolatile reconfigurable dynamic Janus metasurfaces in the terahertz regime显示文摘Metasurfaces,especially tunable ones,have played a major role in controlling the amplitude,phase,and polarization of electromagnetic waves and attracted growing interest,with a view toward a new generation of miniaturized devices.However,to date,most existing reconfigurable devices are bounded in volatile nature with sustained external energy to maintain and single functionality,which restrict their further applications.Here,we demonstrate for the first time,to our knowledge,nonvolatile,reconfigurable,and dynamic Janus metasurfaces by incorporating phase-change material Ge_(2)Se_(2)Te_(5)(GST)in the terahertz(THz)regime.First,we experimentally show the reversible switching characteristic of GST on large areas by applying a single nanosecond laser pulse,which exhibits excellent contrast of THz properties in both states.Then,we present a multiplex metasurface scheme.In each metasurface,three sets of structures are adopted,in which two sets integrate GST.The effective structures can be reversely modulated by the amorphization and crystallization of GST.As a proof of concept,the dynamic beam splitter,bifocal metalens,dual-mode focusing optical vortex generators,and switchable metalens/focusing optical vortex generators are designed,fabricated,and experimentally characterized,and can be switched reversibly and repeatedly with the help of optical and thermal stimuli.Our scheme will pave the way toward the development of multifunctional and compact THz devices and may find use for applications in THz imaging,sensing,and communications. | SHOUJUN ZHANG XIEYU CHEN KUAN LIU HAIYANG LI YUEHONG XU XIAOHAN JIANG YIHAN XU QINGWEI WANG TUN CAO ZHEN TIAN | 2022 | Photonics Research2022，10，7： | 2 |
| 7 | Efficacy and Safety of Cinitapride in the Treatment of Mild to Moderate Postprandial Distress Syndrome–predominant Functional Dyspepsia显示文摘 | Yiqi Du Tun Su Xinmiao Song Jun Gao Duowu Zou Changjing Zuo Weifen Xie Bangmao Wang Zhiguang Zhang Jianming Xu Dean Tian Hesheng Luo Zhenyu Zhang Shaofeng Wang Jianping Chen Jizhong Guo Lei Gong Yanbing Ding Zhaoshen Li | 2014 | Journal of Clinical Gastroenterology2014，，4： | 1 |
| 8 | New mathemati- cal descriptions of ESD current waveform based on the polyno- mial of pulse function显示文摘 | Yuan Zhi yong Li Tun He Jin-liang | 2006 | IEEE Transactions on Electromag- netic Compatibility2006，48，3： | 1 |
| 9 | Reconfigurable and nonvolatile terahertz lithography-free photonic devices based on phase change films显示文摘High-performance terahertz(THz)devices with reconfigurable features are highly desirable in many promising THz applications.However,most of the existing reconfigurable THz elements are still limited to volatile responses,single functionality,and time-consuming multistep manufacturing procedures.In this paper,we report a lithography-free approach to create reconfigurable and nonvolatile THz components by exploring the reversible,nonvolatile,and continuous THz modulation capability of the phase change material Ge_(2)Sb_(2)Te_(5).As a proof of concept,THz gratings with significant Rayleigh anomalies and diffraction as well as ultrathin THz flat lenses with subwavelength and ultra-broadband focusing capabilities are designed and fabricated on ultrathin Ge_(2)Sb_(2)Te_(5)films using the presented photo-imprint strategy.Moreover,such a method can also be adopted to create more complex THz devices,such as Pancharatnam–Berry phase metasurfaces and grayscale holographic plates.With these findings,the proposed method will provide a promising solution to realize reconfigurable and nonvolatile THz elements. | XIEYU CHEN SHOUJUN ZHANG KUAN LIU YUEHONG XU XIAOHAN JIANG HAIYANG LI XI FENG QINGWEI WANG YONGCHANG LU KEMENG WANG TUN CAO ZHEN TIAN | 2023 | Photonics Research2023，11，4： | 1 |
| 10 | New mathematical descriptions of ESD current waveformbased on the polynomial of pulse function 显示文摘 | Yuan Zhiyong Li Tun He Jinliang | 2006 | IEEE Transactions on Electromagnetic Compatibility2006，48，3： | 1 |
| 11 | Towards Connecting Discrete Mathematics and Software Engineering显示文摘To enhance training in software development,we argue that students of software engineering should be exposed to software development activities early in the curriculum.This entails meeting the challenge of engaging students in software development before they take the software engineering course.In this paper,we propose a method to connect courses in the software engineering curriculum by setting comprehensive development projects to students in prerequisite courses for software development.Using the Discrete Mathematics(DM)course as an example,we describe the implementation of the proposed method and teaching practices using several practical and comprehensive projects derived from topics in discrete mathematics.Detailed descriptions of the sample projects,their application,and training results are given.Results and lessons learned from applying these practices show that it is a promising way to connect courses in the software engineering curriculum. | Tun Li Wanwei Liu Juan Chen Xiaoguang Mao Xinjun Mao | 2020 | Tsinghua Science and Technology2020，25，3： | 1 |
| 12 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 13 | Collagen hydro- gel as an immunomodulatory scaffold in cartilage tissue engi- neering 显示文摘 | YUAN Tun ZHANG Li LI Kuifeng | 2014 | J Biomed Mater Res g Appl Biomater2014，102，2： | 1 |
| 14 | Stock Price' s Prediction with Decision Tree 显示文摘 | LI Tun LIU Gong-shen | 2011 | Applied Mechanics and Materials2011，4849，： | 1 |
| 15 | New mathematical descriptions of ESD current waveform based on the polynomial of pulse function显示文摘 | Yuan Zhiyong Li Tun He Jinliang | 2006 | IEEE Transactions on Electromagnetic Compatibility2006，48，3： | 1 |
| 16 | A dynamic taxonomy for man- aging knowledge assets 显示文摘 | Sheng - Tun Li Ming - Hong Tsai | 2009 | Technovation2009，，29： | 1 |
| 17 | Construction of a single chain variable fragment antibody (scFv) against tetrodotoxin (TTX) and its interaction with TTX显示文摘 | Rongzhi Wang Ailing Huang Licai Liu Shuangshuang Xiang Xiufeng Li Sumei Ling Lei Wang Tun Lu Shihua Wang | 2014 | Toxicon2014，，： | 1 |
| 18 | Towards functional verifying a family of SystemC TLMs显示文摘It is often the case that in the development of a system-on-a-chip(SoC)design,a family of SystemC transaction level models(TLM)is created.TLMs in the same family often share common functionalities but differ in their timing,implementation,configuration and performance in various SoC developing phases.In most cases,all the TLMs in a family must be verified for the follow-up design activities.In our previous work,we proposed to call such family TLM product line(TPL),and proposed feature-oriented(FO)design methodology for efficient TPL development.However,developers can only verify TLM in a family one by one,which causes large portion of duplicated verification overhead.Therefore,in our proposed methodology,functional verification of TPL has become a bottleneck.In this paper,we proposed a novel TPL verification method for FO designs.In our method,for the given property,we can exponentially reduce the number of TLMs to be verified by identifying mutefeature-modules(MFM),which will avoid duplicated veri-fication.The proposed method is presented in informal and formal way,and the correctness of it is proved.The theoretical analysis and experimental results on a real design show the correctness and efficiency of the proposed method. | Tun LI Jun YE Qingping TAN | 2020 | Frontiers of Computer Science2020，14，1： | 1 |
| 19 | Data mining to aid policy making in air pollution management 显示文摘 | Sheng - Tun Lia Li - Yen Shue | 2004 | Expert Systems with Applications2004，，27： | 1 |
| 20 | The role of serum markers and uterine artery Doppler in identifying at-risk pregenancies显示文摘 | Tun li MG Odibo AO | 2011 | Clin Perinatol2011，38，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员