|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells显示文摘Background:Immunotherapy has been shown to be a promising strategy against human cancers.A better understanding of the immune regulation in hepatocellular carcinoma(HCC)could help the development of immunotherapy against HCC.The epidermal growth factor receptor(EGFR)signaling is frequently activated in HCC and plays important roles in tumorigenesis.However,its role in HCC immunity is still largely unknown.This study aimed to investigate the impact of EGFR signaling on programmed death-ligand 1(PD-L1)and human leukocyte antigen class-I(HLA-I)expression in HCC cells and its underlying mechanisms.Methods:The expression of phosphorylated EGFR(p-EGFR),PD-L1,and HLAI(HLA-ABC)in HCC specimens was detected by immunohistochemistry,and their correlations were analyzed.PD-L1 and HLA-ABC expression in EGFRactivated HCC cells were detected by quantitative real-time PCR,Western blotting,and flow cytometry,and T cell-mediated lysis was performed to test the immunosuppressive effects of PD-L1 and HLA-ABC alterations in HCC cells.Furthermore,the underlying mechanisms of EGFR activation-induced PD-L1 up-regulation and HLA-ABC down-regulation were explored by animal experiments,luciferase reporter assay,and gene gain-and loss-of-function studies.Results:p-EGFR was positively correlated with PD-L1 and negatively correlated with HLA-ABC expression in HCCs.EGFR activation by its ligand EGF up-regulated PD-L1 and down-regulated HLA-ABC in HCC cells,which was functionally important and could be abolished by the EGFR inhibitor,gefitinib,both in vitro and in vivo.Mechanistically,enhanced P38 mitogenactivated protein kinase(MAPK)activation down-regulated microRNA-675-5p(miR-675-5p)and up-regulated glycolysis-related enzyme hexokinase 2(HK2);miR-675-5p down-regulation enhanced the stability of PD-L1 mRNA probably via the 3’-untranslated region(3’-UTR)of PD-L1 and thereby caused PD-L1 accumulation,and HK2 up-regulation enhanced aerobic glycolysis and mediated a decrease in HLA-ABC.Conclusions:The EGFR-P38 MAPK axis could up-regulate PD-L1 through miR-675-5p and down-regulate HLA-ABC via HK2 in HCC cells.Our study reveals a novel signaling network that may cause immune suppression in HCC and suggests that EGFR signaling can be targeted for HCC immunotherapy. | Zongcai Liu Fen Ning Yanna Cai Huiying Sheng Ruidan Zheng Xi Yin Zhikun Lu Ling Su Xiaodan Chen Chunhua Zeng Haifang Wang Li Liu | 2021 | Cancer Communications2021，41，1： | 5 |
| 2 | CXCL16 deficiency attenuates acetaminopheninduced hepatotoxicity through decreasing hepatic oxidative stress and inflammation in mice显示文摘Chemokine C-X-C ligand 16 (CXCL16 ) ,一种单个通行证的类型我属于 CXC chemokine 家庭的膜蛋白质,与在肝损害的煽动性的反应有关。在现在的学习,我们调查了 CXCL16 的 pathophysiological 角色,唯一的膜界限 chemokine,在导致的 acetaminophen (APAP ) 在老鼠的 hepatotoxicity。老鼠与 APAP 被注射,并且血和织物样品在不同时间点被收获。浆液高活动性的组盒子 1 并且 CXCL16 层次被三明治免疫分析确定。肝织物节与 hematoxylin 曙红或与染色的 dihydroethidium 被染色。CXCL16 和另外的 cytokines 的表情被即时聚合酶链反应检验。Ly6-B, p-jun N 终端 kinase (p-JNK ) ,和 JNK 表情被西方的污点分析测量。细胞内部的谷胱甘肽,反应的氧种类,和 malondialdehyde 层次也被测量。APAP 服药过量增加了肝的 CXCL16 mRNA 和浆液 CXCL16 蛋白质层次。CXCL16 缺乏的老鼠显著地展出了更少的肝损害和肝的坏死,以及更低的死亡比野类型(WT ) 响应 APAP 服药过量处理的老鼠。提高的 APAP 在 WT 老鼠的呼吸的链激活,它是强烈在 CXCL16 大美人老鼠颠倒了的氧化应力和减少的 mitochondrial 的生产。另外, CXCL16 缺乏禁止了嗜中性的渗入和 APAP 服药过量处理触发的 proinflammatory cytokines 的生产。我们的学习表明 CXCL16 是对导致 APAP 的 hepatotoxicity 的肝免疫者反应的一个批评管理者,因此由指向 CXCL16 为导致药的尖锐的肝失败的处理提供潜在的策略。 | Hong Wang Yihui Shao Saisai Zhang Anqi Xie Yanna Ye Lihua Shi Leigang Jin Xuebo Pan Zhuofeng Lin Xiaokun Li Shulin Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 4 |
| 3 | A study of chemical structure changes of Chinese lignite during fluidized-bed drying in nitrogen and air显示文摘 | Arash Tahmasebi Jianglong Yu Yanna Han Xianchun Li | 2012 | Fuel Processing Technology2012，，： | 4 |
| 4 | Farmland mercury contamination in the vicinity of an organic chemical factory in Guizhou,China显示文摘This study assesses the level of contamination of Hg in farmland soils along the irrigating channel down-stream from Guizhou Organic Chemical Factory (GOCF),where metallic mercury is used as a catalyst to produce acetic acid. The total input of mercury into the environment,as announced by GOCF,is 140 t in the past 30 years (1971-2000). Sampling sites were chosen based on the distance from the source of pollution—the chemical factory. A total of 39 samples were collected from the study area and analyzed for total mercury concentrations and methyl mercury concentrations. The characteristics of vertical and horizontal distributions of total mercury and methyl mer-cury in the study area (farmland) are described in this paper. Much attention was paid to the transformation of inor-ganic Hg into organic mercury species in soils as well. The results showed that the farmland has been heavily con-taminated by Hg. Land cultivation activity,land utilization style and distance from the pollution source could be the dominant factors controlling the distribution of THg and MeHg. It is observed that active transformation of inorganic Hg into organic mercury species (MeHg) usually takes place in paddy soils. | ZHANG Junfang QU Liya FENG Xinbin ZHANG Wei GUO Yanna LIN Kai LI Mei | 2008 | Chinese Journal Of Geochemistry2008，27，4： | 3 |
| 5 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 6 | DI-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis显示文摘DI-3-n-butylphthalide is used to treat mild and moderate acute ischemic stroke.However,the precise underlying mechanism requires further investigation.In this study,we investigated the molecular mechanism of DI-3-n-butylphthalide action by various means.We used hydrogen peroxide to induce injury to PC12cells and RAW264.7 cells to mimic neuronal oxidative stress injury in stroke in vitro and examined the effects of DI-3-n-butylphthalide.We found that DI-3-nbutylphthalide pretreatment markedly inhibited the reduction in viability and reactive oxygen species production in PC12 cells caused by hydrogen peroxide and inhibited cell apoptosis.Furthermore,DI-3-n-butylphthalide pretreatment inhibited the expression of the pro-apoptotic genes Bax and Bnip3.DI-3-nbutylphthalide also promoted ubiquitination and degradation of hypoxia inducible factor 1α,the key transcription factor that regulates Bax and Bnip3 genes.These findings suggest that DI-3-n-butylphthalide exhibits a neuroprotective effect on stroke by promoting hypoxia inducible factor-1α ubiquitination and degradation and inhibiting cell apoptosis. | Shuai Li Jingyuan Zhao Yan Xi Jiaqi Ren Yanna Zhu Yan Lu Deshi Dong | 2023 | Neural Regeneration Research2023，18，11： | 3 |
| 7 | Resilient outage recovery of a distribution system: co-optimizing mobile power sources with network structure显示文摘Outage recovery is important for reducing the economic cost and improving the reliability of a distribution system(DS)in extreme weather and with equipment faults.Previous studies have separately considered network reconfigu-ration(NR)and dispatching mobile power sources(MPS)to restore the outage load.However,NR cannot deal with the scenario of an electrical island,while dispatching MPS results in a long power outage.In this paper,a resilient outage recovery method based on co-optimizing MPS and NR is proposed,where the DS and traffic network(TN)are considered simultaneously.In the DS,the switch action cost and power losses are minimized,and the access points of MPSs are changed by carrying out the NR process.In the TN,an MPS dispatching model with the objective of mini-mizing power outage time,routing and power generation cost is developed to optimize the MPSs’schedule.A solu-tion algorithm based on iteration and relaxation methods is proposed to simplify the solving process and obtain the optimal recovery strategy.Finally,numerical case studies on the IEEE 33 and 119-bus systems validate the proposed resilient outage recovery method.It is shown that the access point of MPS can be changed by NR to decrease the power outage time and dispatching cost of MPS.The results also show that the system operation cost can be reduced by considering power losses in the objective function. | Chenchen Li Yanna Xi Yufan Lu Nian Liu Liudong Chen Li Ju Yibin Tao | 2022 | Protection and Control of Modern Power Systems2022，7，1： | 2 |
| 8 | A review on water in low rank coals: The existence, interaction with coal structure and effects on coal utilization显示文摘 | Jianglong Yu Arash Tahmasebi Yanna Han Fengkui Yin Xianchun Li | 2013 | Fuel Processing Technology2013，，： | 2 |
| 9 | Transcriptional regulation of fleshy fruit texture显示文摘Fleshy fruit texture is a critically important quality characteristic of ripe fruit.Softening is an irreversible process which operates in most fleshy fruits during ripening which,together with changes in color and taste,contributes to improvements in mouthfeel and general attractiveness.Softening results mainly from the expression of genes encoding enzymes responsible for cell wall modifications but starch degradation and high levels of flavonoids can also contribute to texture change.Some fleshy fruit undergo lignification during development and post-harvest,which negatively affects eating quality.Excessive softening can also lead to physical damage and infection,particularly during transport and storage which causes severe supply chain losses.Many transcription factors(TFs)that regulate fruit texture by controlling the expression of genes involved in cell wall and starch metabolism have been characterized.Some TFs directly regulate cell wall targets,while others act as part of a broader regulatory program governing several aspects of the ripening process.In this review,we focus on advances in our understanding of the transcriptional regulatory mechanisms governing fruit textural change during fruit development,ripening and postharvest.Potential targets for breeding and future research directions for the control of texture and quality improvement are discussed. | Yanna Shi Bai-Jun Li Guanqing Su Mengxue Zhang Donald Grierson Kun-Song Chen | 2022 | Journal of Integrative Plant Biology2022，64，9： | 2 |
| 10 | Environmental factors affecting degradation of perfluorooctanoic acid(PFOA) by In2O3 nanoparticles显示文摘Nanophotocatalysts have shown great potential for degrading poly-and perfluorinated substances(PFAS).In light of the fact that most of these catalysts were studied in pure water,this study was designed to elucidate effects from common environmental factors on decomposing and defluorinating perfluorooctanoic acid(PFOA)by In2O3 nanoparticles.Results from this work demonstrated that among the seven parameters,pH,sulfate,chloride,H2O2,In2O3 dose,NOM and O2,the first four had statistically significant negative effects on PFOA degradation.Since PFOA is a strong acid,the best condition leading to the highest PFOA removal was identified for two pH ranges.When pH was between 4 and 8,the optimal condition was:pH=4.2;sulfate=5.00 mg/L;chloride=20.43 mg/L;H2O2=0 mmol/L.Under this condition,PFOA decomposition and defluorination were 55.22 and 23.56%,respectively.When pH was between 2 and 6,the optimal condition was:pH=2;sulfate=5.00 mg/L;chloride=27.31 mg/L;H2O2=0 mmol/L.With this condition,the modeled PFOA decomposition was 97.59%with a defluorination of approximately 100%.These predicted results were all confirmed by experimental data.Thus,In2O3 nanoparticles can be used for degrading PFOA in aqueous solutions.This approach works best when the target contaminated water contains low concentrations of NOM,sulfate and chloride and at a low pH. | Weilan Zhang Harry Efstathiadis Lingyun Li Yanna Liang | 2020 | Journal of Environmental Sciences2020，32，7： | 2 |
| 11 | Effects of fertigation scheme on N uptake and N use efficiency in cotton显示文摘 | Zhenan Hou Pinfang Li Baoguo Li Jiang Gong Yanna Wang | 2007 | Plant and Soil (-)2007，，1： | 2 |
| 12 | Distribution and wet deposition fluxes of total and methyl mercury in Wujiang River Basin, Guizhou, China显示文摘 | Yanna Guo Xinbin Feng Zhonggen Li Tianrong He Haiyu Yan Bo Meng Junfang Zhang Guangle Qiu | 2008 | Atmospheric Environment2008，，30： | 1 |
| 13 | Preparation and in vitro immunomodulatory effect of curdlan sulfate显示文摘 | Pingli Li Xinke Zhang Yanna Cheng Juan Li Yuliang Xiao Qian Zhang Aizhen Zong Chuanqing Zhong Fengshan Wang | 2013 | Carbohydrate Polymers2013，，： | 1 |
| 14 | Geochronology,Petrogenesis and Tectonic Setting of the Late Jurassic I-type Granites in the North Qinling Orogenic Belt,Central China显示文摘The North Qinling Orogenic Belt(NQOB)is a composite orogenic belt in central China.It started evolving during the Meso-Neoproterozoic period and underwent multiple stages of plate subduction and collision before entering intra-continental orogeny in the Late Triassic.The Meso-Cenozoic intra-continental orogeny and tectonic evolution had different responses in various terranes of the belt,with the tectonic evolution of the middle part of the belt being particularly controversial.The granites distributed in the Dayu and Kuyu areas in the middle part of the NQOB can provide an important window for revealing the geodynamic mechanisms of the NQOB.The main lithology of Dayu and Kuyu granites is biotite monzogranite,and the zircon U-Pb dating yielded intrusive ages of 151.3±3.4 Ma and 147.7±1.5 Ma,respectively.The dates suggest that the biotite monzogranite were formed at the end of the Late Jurassic.The whole-rock geochemistry analysis shows that the granites in the study areas are characterized by slightly high SiO_(2)(64.50-68.88 wt%)and high Al_(2)O_(3)(15.12-16.24 wt%)and Na_(2)O(3.55-3.80 wt%)contents.They are also enriched in light rare earth elements,large ion lithophile elements(e.g.,Ba,K,La,Pb and Sr),and depleted in high field strength elements(HFSEs)(e.g.,Ta,Nb,P and Ti).Additionally,the granites have weakly negative-slightly positive Eu anomalies(δEu=0.91-1.19).Zircon Lu-Hf isotopic analysis showedε_(Hf)(t)=-6.1--3.8,and the two-stage model age is T_(2DM(crust))=1.5-1.6 Ga.The granites in the study areas are analyzed as weak peraluminous high-K calc-alkaline I-type granites.They formed by partial melting of the thickened ancient lower crust,accompanied by the addition of minor mantle-derived materials.During magma ascent,they experienced fractional crystallization,with residual garnet and amphibole for a certain proportion in the magma source region.Comprehensive the geotectonic data suggest that the end of the Late Jurassic granite magmatism in the Dayu and Kuyu areas represents a compression-extension transition regime.It may have been a response to multiple tectonic mechanisms,such as the late Mesozoic intra-continental southward subduction of the North China Craton and the remote effect of the Paleo-Pacific Plate subduction. | HUANG Yanna LI Dunpeng XIAO Aifang XU Songming | 2023 | Acta Geologica Sinica(English Edition)2023，97，4： | 1 |
| 15 | Distribution and wet deposition fluxes of total and methyl mercury in Wujiang River Basin, Guizhou, China显示文摘 | Yanna Guo Xinbin Feng Zhonggen Li Tianrong He Haiyu Yan Bo Meng Junfang Zhang Guangle Qiu | 2008 | Atmospheric Environment2008，，30： | 1 |
| 16 | Mutations in the miRNA165/166 binding site of the HB2 gene result in pleiotropic effects on morphological traits in wheat显示文摘Leaf,spike,stem,and root morphologies are key factors that determine crop growth,development,and productivity.Multiple genes that control these morphological traits have been identified in Arabidopsis,rice,maize,and other plant species.However,little is known about the genomic regions and genes associated with morphological traits in wheat.Here,we identified the ethyl methanesulfonate-derived mutant wheat line M133 that displays multiple morphological changes that include upward-curled leaves,paired spikelets,dwarfism,and delayed heading.Using bulked segregant RNA sequencing(BSR-seq)and a high-resolution genetic map,we identified TraesCS1D02G155200(HBD2)as a potential candidate gene.HB-D2 encodes a class III homeodomain-leucine zipper(HD-ZIP III)transcription factor,and the mutation was located in the miRNA165/166 complementary site,resulting in a resistant allele designated rHb-D2.The relative expression of rHb2 in the mutant plants was significantly higher(P<0.01)than in plants homozygous for the WT allele.Independent resistant mutations that disrupt the miRNA165/166 complementary sites in the A-(rHb-A2)and B-genome(rHb-B2)homoeologs showed similar phenotypic alterations,but the relative intensity of the effects was different.Transgenic plants expressing rHb-D2 gene driven by the maize UBIQUITIN(UBI)promoter showed similar phenotypes to the rHb-D2 mutant.These results confirmed that HB-D2 is the causal gene responsible for the mutant phenotypes.Finally,a survey of 1397 wheat accessions showed that the complementary sites for miRNA165/166 in all three HB2 homoeologs are highly conserved.Our results suggest that HB2 plays an important role in regulating growth and development in wheat. | Dengji Jiang Lei Hua Chaozhong Zhang Hongna Li Zheng Wang Jian Li Guiping Wang Rui Song Tao Shen Hongyu Li Shengsheng Bai Yanna Liu Jian Wang Hao Li Jorge Dubcovsky Shisheng Chen | 2023 | The Crop Journal2023，11，1： | 1 |
| 17 | Capillary electrophoresis separation of the six pairs of chiral pharmaceuticals enantiomers 显示文摘 | XUE Hongbao JIAO Yanna LI Hui | 2013 | Asian Journal of Chemistry2013，25，5： | 1 |
| 18 | Impact of Smoking Status on EGFR-TKI Efficacy for Advanced Non–Small-Cell Lung Cancer in EGFR Mutants: A Meta-analysis显示文摘 | Yaxiong Zhang Shiyang Kang Wenfeng Fang Shaodong Hong Wenhua Liang Yue Yan Tao Qin Yanna Tang Jin Sheng Li Zhang | 2014 | Clinical Lung Cancer2014，，： | 1 |
| 19 | Synthesis and properties of the novel surface-active dyes containing fluorocarbon groups: part 2 : dyeing diffusion kinetics of the novel surface-active dyes on silk fabric 显示文摘 | XIE Kongliang LIU Yanna LI Xiaochun | 2007 | Materials Chemistry and Physics2007，105，23： | 1 |
| 20 | Mesoporous magnesium manganese silicate as cathode materials for rechargeable magnesium batteries显示文摘 | Nuli Yanna Yang J Li Y S | 2010 | Chemical Communications2010，46，21： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员