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| 1 | Numerical Simulation and Analysis of Solid-liquid Two-phase Flow in Centrifugal Pump显示文摘The flow with solid-liquid two-phase media inside centrifugal pumps is very complicated and the relevant method for the hydraulic design is still immature so far.There exist two main problems in the operation of the two-phase flow pumps,i.e.,low overall efficiency and severe abrasion.In this study,the three-dimensional,steady,incompressible,and turbulent solid-liquid two-phase flows in a low-specific-speed centrifugal pump are numerically simulated and analyzed by using a computational fluid dynamics(CFD) code based on the mixture model of the two-phase flow and the RNG k-two-equation turbulence model,in which the influences of rotation and curvature are fully taken into account.The coupling between impeller and volute is implemented by means of the frozen rotor method.The simulation results predicted indicate that the solid phase properties in two-phase flow,especially the concentration,the particle diameter and the density,have strong effects on the hydraulic performance of the pump.Both the pump head and the efficiency are reduced with increasing particle diameter or concentration.However,the effect of particle density on the performance is relatively minor.An obvious jet-wake flow structure is presented near the volute tongue and becomes more remarkable with increasing solid phase concentration.The suction side of the blade is subject to much more severe abrasion than the pressure side.The obtained results preliminarily reveal the characteristics of solid-liquid two-phase flow in the centrifugal pump,and are helpful for improvement and empirical correction in the hydraulic design of centrifugal pumps. | ZHANG Yuliang LI Yi CUI Baoling ZHU Zuchao DOU Huashu | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 55 |
| 2 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 3 | 跟随样品太阳电池的光伏阵列模拟器显示文摘跟随样品太阳电池的光伏阵列模拟器,用可控的白炽灯模拟太阳光强的变化,样品电池的输出电压和电流随模拟光强而变化,经放大后驱动功率器件,使其输出跟随样品太阳电池的电压和电流,以代替实际光伏阵列进行光伏系统的各项性能测试。 | Shen Yuliang (Hefei University of Technology,Hefei 230009) | 1997 | 太阳能学报1997，18，4： | 24 |
| 4 | Origin and Superposition Metallogenic Model of the Sandstone-type Uranium Deposit in the Northeastern Ordos Basin,China显示文摘这份报纸从铀来源,移植和免职的方面在东北 Ordos 盆应付沙岩类型铀存款的 metallogenic 模特儿。一个重叠 metallogenic 模型与油气体减小和热改革的重叠由于复杂的铀矿化作用过程被建立了。 | LI Ziying CHEN Anping FANG Xiheng OU Guangxi XIA Yuliang SUN Ye | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 19 |
| 5 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 6 | Recognition of wood surface defects with near infrared spectroscopy and machine vision显示文摘To improve the accuracy in recognizing defects on wood surfaces,a method fusing near infrared spectroscopy(NIR)and machine vision was examined.Larix gmelinii was selected as the raw material,and the experiments focused on the ability of the model to sort defects into four types:live knots,dead knots,pinholes,and cracks.Sample images were taken using an industrial camera,and a morphological algorithm was applied to locate the position of the defects.A portable near infrared spectrometer(900–1800 nm)collected the spectra of these positions.In addition,principal component analysis was utilized on these variables from spectral information and principal component vectors were extracted as the inputs of the model.The results show that a back propagation neural network model exhibited better discrimination accuracy of 92.7%for the training set and 92.0%for the test set.The research reveals that the NIR fusing machine vision is a feasible tool for detecting defects on board surfaces. | Huiling Yu Yuliang Liang Hao Liang Yizhuo Zhang | 2019 | Journal of Forestry Research2019，30，6： | 16 |
| 7 | In, Sn, Pb and Zn Contents and Their Relationships in Ore-forming Fluids from Some In-rich and In-poor Deposits in China显示文摘有在矿石的铟内容的所有充满铟的存款超过 100 x10^(-6)似乎具有锡石硫化物存款或 忍受Sn Pb-Zn 存款,例如在在 Guangxi 的 theDachang Sn 沉积物, Dulong Sn-Zn 在内部蒙古在云南,和 Meng'entaolegai Ag-Pb-Zndeposit 扔,在矿石的铟内容从 98 x 10 ~ (-6)到 236 x 10 ^(-6) ands 与锌和听的内容的好积极关联,和他们的相关系数怎么分别地是 0.8781 和 0.7430 。从象在 Guangxi 和 Huanren Pb-Zn 的 FozichongPb-Zn 存款的如此的 Sn 差的存款的铟内容在辽宁扔通常比 10 x10~ 低(-6), 即,锡是否在存款是在场的,在矿石暗示铟的丰富程度。是否在里面在形成液体或形成矿石的条件的矿石的丰富本身实际上在存款引起了铟的丰富 / 弄空?在学习以后,在石英的液包体在矿化作用的主要阶段结晶几在里面富有并且在中国的 In-poordeposits,这篇论文分析了内容并且学习了变化趋势在里面, Sn,在形成矿石的液体的 Pband Zn。在在里面富有、差的存款的 形成theore 液体的铅和锌的内容在一样的结果表演铺平,并且铅内容从 22 x 10 ~ (-6)到 81 x 10 ^(从 164 x 10 ^的-6)和锌(-6)到 309 x 10 ^(-6),当在在里面富有的存款的形成矿石的液体的铟和锡的内容比 In-poordeposits 的那些高远时,与 1-2 数量级的差别。在在里面富有的存款的 ore-formingfluid 的铟和锡内容是 1.9 x 10 ^(-6)-4.1 x 10 ^(-6) 和 7 x 10 ^(-6)-55 x 10 ^(-6), 并且在二个元素之间有很好的积极关联,与相关系数 of0.9552。在在里面差的存款的形成矿石的液体的铟和听内容是 0.03 x 10 ^(-6)-0.09 x10^(-6) 和 0.4 x 10 ^(-6)-2.0 x 10 ^(-6), 分别地,并且在他们之间没有明显的关联。一方面,这显示在里面富有的形成矿石的液体是在里面富有的存款的形成的材料基础,并且,在另一方面,锡可能在铟的运输和丰富起了一个很重要的作用。 | ZHANG Qian ZHU Xiaoqing HE Yuliang ZHU Zhaohui | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 15 |
| 8 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 9 | Computational Analysis of Centrifugal Pump Delivering Solid-liquid Two-phase Flow during Startup Period显示文摘The transient behavior of centrifugal pumps during transient operating periods,such as startup and stopping,has drawn more and more attention recently because of urgent needs in engineering.Up to now,almost all the existing studies on this behavior are limited to using water as working fluid.The study on the transient behavior related to solid-liquid two-phase flow has not been seen yet.In order to explore the transient characteristics of a high specific-speed centrifugal pump during startup period delivering the pure water and solid-liquid two-phase flow,the transient flows inside the pump are numerically simulated using the dynamic mesh method.The variable rotational speed and flow rate with time obtained from experiment are best fitted as the function of time,and are written into computational fluid dynamics(CFD)code-FLUENT by using a user defined function.The predicted heads are compared with experimental results when pumping pure water.The results show that the difference in the transient performance during startup period is very obvious between water and solid-liquid two-phase flow during the later stage of startup process.Moreover,the time for the solid-liquid two-phase flow to achieve a stable condition is longer than that for water.The solid-liquid two-phase flow results in a higher impeller shaft power,a larger dynamic reaction force,a more violent fluctuation in pressure and a reduced stable pressure rise comparing with water.The research may be useful to understanding on the transient behavior of a centrifugal pump under a solid-liquid two-phase flow during startup period. | ZHANG Yuliang LI Yi ZHU Zuchao CUI Baoling | 2014 | Chinese Journal of Mechanical Engineering2014，27，1： | 13 |
| 10 | Meta-analysis of cognitive function in Chinese first-episode schizophrenia: MATRICS Consensus Cognitive Battery (MCCB) profile of impairment显示文摘Background Compromised neurocognition is a core feature of schizophrenia. With increasing studies researching cognitive function of Chinese patients with first-episode schizophrenia (FES) using MATRICS Consensus Cognitive Battery (MCCB), it is not clear about the level and pattern of cognitive impairment among this population. Aim To provide a meta-analysis systematically analysing studies of neurocognitive function using MCCB in Chinese patients with FES. Methods An independent literature search of both Chinese and English databases up to 13 March 2019 was conducted by two reviewers. Standardised mean difference (SMD) was calculated using the random effects model to evaluate the effect size. Results 56 studies (FES=3167, healthy controls (HC)=3017) were included and analysed. No study was rated as 'high quality' according to Strengthening the Reporting of Observational Studies in Epidemiology. Compared with HCs, Chinese patients with FES showed impairment with large effect size in overall cognition (SMD=-1.60,95% Cl -1.82 to -1.38,厂=67%) and all seven cognitive domains, with the SMD ranging from -0.87 to -1.41. In nine MCCB subtests, patients with FES showed significant difference in Symbol Coding (SMD=-1.90), Trail Making Test (TMT)(SMD=-1.36), Continuous Performance Test-Identical Pairs (SMD=-1.33), Hopkins Verbal Learning Test (SMD=-1.24), Brief Visuospatial Memory Test (SMD=-1.18), Mazes (SMD=-1.16), Category Fluency (SMD=-1.01), Spatial Span (SMD=-0.69) and Mayer-Salovey-Caruso Emotional Intelligence Test (SMD=-0.38). Conclusions Our meta-analysis demonstrates that Chinese patients with FES show neurocognitive deficits across all seven MCCB cognitive domains and all nine subtests, particularly in two neurocognitive domains: speed of processing and attention/vigilance, with the least impairment shown in social cognition. Symbol Coding and TMT may be the most sensitive tests to detect cognitive deficit in Chinese patients with FES. | Huijuan Zhang Yao Wang Yuliang Hu Yikang Zhu Tian hong Zhang Jijun Wang Ke Ma Chuan Shi Xin Yu Chunbo Li | 2019 | General Psychiatry2019，32，3： | 13 |
| 11 | A ginkgo biloba extract promotes proliferation of endogenous neural stem cells in vascular dementia rats显示文摘The ginkgo biloba extract EGb761 improves memory loss and cognitive impairments in patients with senile dementia. It also promotes proliferation of neural stem cells in the subventricular zone in Parkinson's disease model mice and in the hippocampal zone of young epileptic rats. However, it remains unclear whether EGb761 enhances proliferation of endogenous neural stem cells in the brain of rats with vascular dementia. In this study, a vascular dementia model was established by repeatedly clipping and reperfusing the bilateral common carotid arteries of rats in combination with an intraperitoneal injection of a sodium nitroprusside solution. Seven days after establishing the model, rats were intragastrically given EGb761 at 50 mg/kg per day. Learning and memory abilities were assessed using the Morris water maze and proliferation of endogenous neural stem cells in the subventricular zone and dentate gyrus were labeled by 5-bromo-2-deoxyuridine immunofluorescence in all rats at 15 days, and 1, 2, and 4 months after model establishment. The escape latencies in Morris water maze tests of rats with vascular dementia after EGb761 treatment were significantly shorter than the model group. Immunofluorescence staining showed that the number and proliferation of 5-bromo-2-deoxyuridine-positive cells in the subventricular zone and dentate gyrus of the EGb761-treated group were significantly higher than in the model group. These experimental findings suggest that EGb761 enhances proliferation of neural stem cells in the subventricular zone and dentate gyrus, and significantly improves learning and memory in rats with vascular dementia. | Jiwei Wang Wen Chen Yuliang Wang | 2013 | Neural Regeneration Research2013，8，18： | 13 |
| 12 | Cardinal roles of miRNA in cardiac development and disease显示文摘MicroRNAs(miRNAs) are small noncoding RNAs that are emerging as pivotal modulators in virtually all aspects of cardiac biology,from cardiac development to cardiomyocyte survival and hypertrophy.The miRNA profiling,following gain-and loss-of-function studies using in vitro and in vivo models,has identified wide-ranging functions for miRNAs in the heart,providing new perspectives on their contributions to cardiac pathogenesis,and revealing potential therapeutic targets and diagnostic biomarkers.This review summarizes current progress in regulation of miRNAs in heart development and disease. | FENG YuLiang YU XiYong | 2011 | Science China(Life Sciences)2011，54，12： | 13 |
| 13 | Effects of Temperature and Moisture on Soil Organic Matter Decomposition Along Elevation Gradients on the Changbai Mountains, Northeast China显示文摘Decomposition of soil organic matter(SOM) is of importance for CO_2 exchange between soil and atmosphere and soil temperature and moisture are considered as two important factors controlling SOM decomposition. In this study, soil samples were collected at 5 elevations ranging from 753 to 2 357 m on the Changbai Mountains in Northeast China, and incubated under different temperatures(5, 10, 15, 20, 25, and 30?C) and soil moisture levels(30%, 60%, and 90% of saturated soil moisture) to investigate the effects of both on SOM decomposition and its temperature sensitivity at different elevations. The results showed that incubation temperature(F = 1 425.10, P < 0.001), soil moisture(F = 1 327.65, P < 0.001), and elevation(F = 1 937.54, P < 0.001) all had significant influences on the decomposition rate of SOM. The significant effect of the interaction of incubation temperature and soil moisture on the SOM decomposition rate was observed at all the 5 sampling elevations(P < 0.001). A two-factor model that used temperature and moisture as variables fitted the SOM decomposition rate well(P < 0.001) and could explain 80%–93% of the variation of SOM decomposition rate at the 5 elevations. Temperature sensitivity of SOM decomposition, expressed as the change of SOM decomposition rate in response to a 10?C increase in temperature(Q_(10)), was significantly different among the different elevations(P < 0.01), but no apparent trend with elevation was discernible. In addition, soil moisture and incubation temperature both had great impacts on the Q_(10) value(P < 0.01), which increased significantly with increasing soil moisture or incubation temperature. Furthermore, the SOM decomposition rate was significantly related to soil total Gram-positive bacteria(R^2= 0.33, P < 0.01) and total Gram-negative bacteria(R^2= 0.58, P < 0.001). These findings highlight the importance of soil moisture to SOM decomposition and its Q_(10) value,which needs to be emphasized under warming climate scenarios. | WANG Dan HE Nianpeng WANG Qing LV Yuliang WANG Qiufeng XU Zhiwei ZHU Jianxing | 2016 | Pedosphere2016，26，3： | 12 |
| 14 | Real-time Health Condition Evaluation on Wind Turbines Based on Operational Condition Recognition显示文摘针对大型风电机组运行工况和状态信息复杂,健康状态难以准确评价的问题,提出基于工况辨识的健康状态实时评价方法。该方法充分考虑机组运行工况的复杂性和多变性,采用工况辨识实现运行工况空间的划分。在各运行工况子空间,建立基于高斯混合模型(gaussianmixturemodel,GMM)多状态特征融合的健康状态评价模型。采用健康衰退指数(healthdegradationindex,HDI)作为机组健康状态评价指标,并给出健康衰退报警限的确定方法。该方法用于某1.5MW风电机组传动系统故障前的健康状态评价。结果表明,该方法提前监测到机组健康状态的衰退趋势,可实现故障的早期预报,避免严重故障发生,并为合理调整运行和安排维修提供依据。 | DONG Yuliang LI Yaqiong CAO Haibin HE Chengbing GU Yujiong | 2013 | 中国电机工程学报2013，33，11： | 12 |
| 15 | THREE DIMENSIONAL NONLINEAR NUMERICAL MODEL WITH INCLINED PRESSURE FOR SALTWATER INTRUSION AT THE YANGTZE RIVER ESTUARY显示文摘A three dimensional nonlinear numerical model with inclined pressure was developed to compute the saltwater intrusion at the Yangtze River Estuary. The σ transformation was introduced in the vertical plane to achieve the same lattices in the whole domain of interest. The mode splitting technique splits the three dimensional governing equations into the surface gravity waves (external mode) and the internal gravity waves (internal mode). And the external mode was solved by the improved double sweep implicit (DSI) finite difference method and the internal mode was solved by the Eulerian Lagrangian method. The Eulerian Lagrangian method could not only reduce the numerical diffusion but also increase the computational accuracy by the improvement of the finite difference scheme in the vertical direction. Application of the model to the Yangtze River Estuary was carried out for the calculation of the saltwater intrusion and the null point. Results of the temporal and spatial distribution of the flow velocity and the salinity coincide with the measured data quite well. The formation and location of the underwater sandbars in the North Channel of the Yangtze River Estuary are closely related to the local salinity, the null point, the predominant current and the residual flow. | Zhu, Yuliang Zheng, Jinhai Mao, Lihua Yan, Yixin | 2000 | Journal of Hydrodynamics2000，12，1： | 10 |
| 16 | Toosendanin-induced change of dopamine level detected by microdialysis in vivo at rat striatum显示文摘To investigate the effect on central nervous transmission of toosendanin (TSN), a presynaptic blocker, rat striatum was perfused in vivo with a TSN-containing artificial cere-brospinal fluid (ACSF) and the level of dopamine (DA) as well as related metabolites in the collected dialysates has been determined by a microbore HPLC with electrochemical detection (mi-crobore HPLC-ECD). The results are as follows: ( i ) TSN induced a biphasic change of DA from its basal level;( ii ) the basal contents of two metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) increased in turn and stayed at a higher level than basal control for a long period. The basal level of 5-hydroxyindoleacetic acid (5-HIAA), a metabolite of 5-hydroxytryptamine(5-HT), had a change similar to that of HVA; (iii) after per-fusion with TSN-containing ACSF, high K+-evoked DA release was inhibited. These results show that TSN does not selectively affect acetylcholine (ACh) release, but probably acts on a common | Wenyan Chen Pingbo Yin Weiling Ye Yuliang Shi | 1999 | Chinese Science Bulletin1999，44，12： | 10 |
| 17 | A unified approach to the weighted Grtzsch and Nitsche problems for mappings of finite distortion显示文摘This note deals with the existence and uniqueness of a minimiser of the following Grtzsch-type problem inf f ∈F∫∫_(Q_1)φ(K(z,f))λ(x)dxdyunder some mild conditions,where F denotes the set of all homeomorphims f with finite linear distortion K(z,f)between two rectangles Q_1 and Q_2 taking vertices into vertices,φ is a positive,increasing and convex function,and λ is a positive weight function.A similar problem of Nitsche-type,which concerns the minimiser of some weighted functional for mappings between two annuli,is also discussed.As by-products,our discussion gives a unified approach to some known results in the literature concerning the weighted Grtzsch and Nitsche problems. | FENG XiaoGao TANG ShuAn WU Chong SHEN YuLiang | 2016 | Science China Mathematics2016，59，4： | 9 |
| 18 | Impact of the eastern water diversion from the south to the north project on the saltwater intrusion in the Changjiang Estuary in China显示文摘The south to the north project(WDP) on the saltwater intrusion in the Changjiang Estuary is studied by the improved three-dimensional(3D) numerical model.The net unit width flux in the Changjiang Estuary as well as the sectional salt flux is calculated in the North Branch(NB),the South Branch(SB),the North Channel(NC),the South Channel(SC),the North Passage(NP) and the South Passage(SP),respectively.The net seaward water flux in the SB is reduced,and the net water flux spilling over from the NB to the SB is enhanced after the eastern WDP.Under the mean river discharge condition in the dry season,the net salt flux spilling over from the NB to the SB is increased by 2.09 t/s and 0.52 t/s during the spring and neap tides,respectively,due to the eastern WDP.The saltwater intrusion in the Changjiang Estuary is enhanced by the eastern WDP.Compared with that during the spring tide,the net water diversion ratio during the neap tide in the NC is smaller,and thus the enhancement of the saltwater intrusion by the eastern WDP is smaller in the NC,and larger in the NP and the SP.The tidally averaged surface salinity at the water intakes of the Dongfengxisha Reservoir,the Chenhang Reservoir and the Qingcaosha Reservoir rises both during the spring and neap tides. | XU Kun ZHU Jianrong GU Yuliang | 2012 | Acta Oceanologica Sinica2012，31，3： | 9 |
| 19 | Co-delivery of doxorubicin and quercetin via mPEG-PLGA copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity显示文摘橡黄素(Que ) 是自然多功能的 bioflavonoid,并且为减少不利副作用并且提高化学疗法的药的反肿瘤功效显示出大潜力。然而,它的临床的申请在生理的系统由于很低的溶解度和结构的不稳定性被限制。此处,我们共同交付由开发 amphiphilic 聚合物包括的 biocompatible nanocarrier 的恐水病的橡黄素和吸水的 doxorubicin (纪录影片) , methoxy poly (乙烯乙二醇) 并且 poly (D, L-lactide-co-glycolide ) 分别地。反肿瘤和这个系统的预防功效被评估在细胞并且动物模型。我们说明的调查结果 Dox-Que nanoparticulate 明确的表达保护了正常脉管的 endothelial 房间免受免费的任何一个或 nanoparticulate 的伤害导致 doxorubicin 的 cytotoxicity 和增加的癌症房间死亡。与免费 doxorubicin 和它的 nanoformulation 相比,用我们的 nanosystem 的橡黄素和 doxorubicin 的合作交货 synergistically 禁止了肿瘤生长,当在浆液维持心脏的功能指示物的正常层次并且在心织物恢复组织病理学说的损坏时。这研究为提高反癌症药功效并且减少 nanoparticulate 表明有希望的策略正常纸巾上的导致化疗的毒性。 | Waseem Akhtar Qureshi Ruifang Zhao Hai Wang Tianjiao Ji Yanping Ding Ayesha Ihsan Ayeesha Mujeeb Guangjun Nie Yuliang Zhao | 2016 | Science Bulletin2016，61，21： | 9 |
| 20 | Vibration target detection and vibration parameters estimation based on the DPCA technique in dual-channel SAR显示文摘This paper proposes a new method based on the displaced phase center antenna(DPCA) technique for the detection and parameters estimation of vibration target in dual-channel synthetic aperture radar(SAR).The echo model of vibration target is established in dual-channel SAR according to the equivalent phase center principle.By accumulating the DPCA signal amplitude in the azimuth direction,we realize the vibration target detection in clutter and noise background.Through the analysis of DPCA signal amplitude and phase characteristics of vibration target,we then convert the vibration parameters estimation to estimation of a signal with the form of absolute value of a sine function,and the converting conditions is also given.Accordingly,an algorithm combining the Fourier transform with least squares is proposed for estimation.The simulation results show that the algorithm can estimate each vibration parameter precisely at a low signal-to-noise ratio. | CHEN YingBin DENG Bin WANG HongQiang QIN YuLiang DING JinCan | 2012 | Science China(Information Sciences)2012，55，10： | 8 |
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