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| 1 | Spatial-temporal Characteristics of Land Subsidence Corresponding to Dynamic Groundwater Funnel in Beijing Municipality,China显示文摘Due to long-term over-exploitation of groundwater in Beijing Municipality,regional groundwater funnels have formed and land subsidence has been induced.By combining a groundwater monitoring network,GPS monitor-ing network data,radar satellite SAR data,GIS and other new technologies,a coupled process model based on the dy-namic variation of groundwater and the deformation response of land subsidence has been established.The dynamic variation of groundwater funnels and the land subsidence response process were analyzed systematically in Beijing.Study results indicate that current groundwater funnel areas are distributed mainly in the southwest of Shunyi District,the northeast of Chaoyang District and the northwest of Tongzhou District,with an average decline rate of groundwa-ter level of 2.66 m/yr and a maximum of 3.82 m/yr in the center of the funnels.Seasonal and interannual differences exist in the response model of land subsidence to groundwater funnels with uneven spatial and temporal distribution,where the maximum land subsidence rate was about-41.08 mm/yr and the area with a subsidence rate greater than 30 mm/yr was about 1637.29 km2.Although a consistency was revealed to exist between a groundwater funnel and the spatial distribution characteristics of the corresponding land subsidence funnel,this consistency was not perfect.The results showed that the response model of land subsidence to the dynamic variation of groundwater was more revealing when combining conventional technologies with InSAR,GIS,GPS,providing a new strategy for environmental and hydrogeological research and a scientific basis for regional land subsidence control. | CHEN Beibei GONG Huili LI Xiaojuan LEI Kunchao ZHANG Youquan LI Jiwei GU Zhaoqin DANG Yanan | 2011 | Chinese Geographical Science2011，21，6： | 13 |
| 2 | Silencing of PRR11 suppresses cell proliferation and induces autophagy in NSCLC cells显示文摘Our previous studies have demonstrated that proline-rich protein 11(PRR11)is a novel tumor-related gene and implicates in regulating the proliferation in lung cancer.However,its precise role in cell cycle progression remains unclear.Our recent evidences show that PRR11 silencing has an effect on autophagy in non-small-cell lung cancer(NSCLC)cells.Two human NSCLC cell lines,H1299 and A549 were transiently transfected with against PRR11 siRNA.The Cell Counting Kit-8 and plate clone formation assay showed that downregulation of PRR11 inhibited the cell proliferation associated with cell cycle related genes reduced.And our data suggested that PRR11 depletion expression enhanced the autophagosomes formation,followed with downregulation of P62 and upregulation of LC3-II protein.Furthermore,the immunoblotting results indicated that silencing of PRR11 inactivated the Akt/mTOR signaling pathway.Collectively,these results demonstrated PRR11 had an effective role in autophagy in NSCLC cells through Akt/mTOR autophagy signaling pathways.Therefore,it is helpful to clarify the function of PRR11 in tumorigenesis of NSCLC. | Lian Zhang Yunlong Lei Ying Zhang Yi Li Youquan Bu Fangzhou Song Chundong Zhang | 2018 | Genes & Diseases2018，5，2： | 6 |
| 3 | Nano CuO/ZSM-5 zeolite as a green and efficient catalyst for dehydration of 1,4-butanediol to tetrahydrofuran显示文摘Nano CuO/ZSM-5 zeolite was prepared and used as a catalyst for dehydration of 1,4-butanediol(BDO) to tetrahydrofuran(THF) in liquid-phase. It was found that the 4.6 wt% CuO/ZSM-5 displayed good catalytic performance, and nearly 100%of BDO conversion and more than 99% of THF selectivity could be achieved by a rotary evaporator reactor at 170 °C under the atmospheric pressure. With such mild reaction conditions, 2400 g BDO could be converted to THF over 1 g catalyst under semi-continuous operation. Characterizations with X-ray diffraction(XRD), temperature-programmed reduction(TPR),NH3-temperature programmed desorption(TPD), X-ray photoelectron spectroscopy(XPS), transmission electron microscope(TEM) and Brunauer-Emmett-Teller(BET) over fresh and used 4.6 wt% CuO/ZSM-5 were conducted. Based on the results of the characterization and catalytic performance of 4.6 wt% CuO/ZSM-5, it can be conjectured that the formed 1–3 nm CuO nanoparticles, suitable acidity of the catalyst due to the synergic interaction of CuO and ZSM-5 support promoted the dehydration of BDO to THF. | Yan Long Shimin Liu Yuqing Fei Qinghe Li Youquan Deng | 2017 | Science China Chemistry2017，60，7： | 3 |
| 4 | A COMPARATIVE STUDY ON SHILLING DETECTION METHODS FOR TRUSTWORTHY RECOMMENDATIONS显示文摘 | Youquan Wang Liqiang Qian Fanzhang Li Lu Zhang | 2018 | Journal of Systems Science and Systems Engineering2018，27，4： | 3 |
| 5 | 肺癌细胞中沉默PRR11诱发自噬并抑制细胞增殖显示文摘PRR11是近期研究发现的一个肿瘤相关新基因,在肺癌、胃癌及胆管癌等多种恶性肿瘤患者中呈现高表达,并与病人预后呈现负相关,提示PRR11基因高表达对于细胞增殖、侵袭迁移及体外成瘤等恶性表型具有重要作用。 | 张辉洁 Lian Zhang Yunlong Lei Ying Zhang Yi Li Youquan Bu Fangzhou Song Chundong Zhang | 2018 | 重庆医科大学学报2018，43，9： | 2 |
| 6 | Acoustoelastic effects on mode waves in a fluid-filled pressurized borehole in triaxially stressed formations显示文摘基于 acoustoelasticity 的非线性的理论,认为 triaxial 是陆上的应力,在地上凿穿的液体静电干扰压力和液体非线性的效果联合,单极 Stoneley 波浪和偶极子的分散曲线曲折波浪在同类的各向同性的形成沿着地上凿穿轴宣传被使用不安方法调查。到频率的敏感系数和速度压力系数的关系也被分析。阶段速度分散的变化弄弯的结果表演被与第三顺序的有弹性的常数有关的三个敏感系数主要影响。曲折波浪的一个裂口和分散的交叉曲折波浪弄弯的地上凿穿压力集中原因在与单轴的水平压力方向平行、正常的方向极化了。导致压力的形成 anisotropy 仅仅依赖于水平吝啬的陆上的压力,附加压力和液体静电干扰的陆上的应力和独立人士迫使的水平 deviatoric。从 0 ~ 1 的水平陆上的压力比率减少导致压力的形成 anisotropy。这做曲折波浪分散曲线的交叉不可区分。模式波浪的分散曲线上的液体非线性的效果是小的并且能被忽略。 | Ping'en Li Youquan Yin Xianyue Su | 2006 | Acta Mechanica Sinica2006，22，6： | 2 |
| 7 | ^(68)Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy显示文摘Objective: Prostate cancers(PCa) in Asian individuals are molecularly distinct from those found in their Caucasian counterparts.There is no risk stratification tool for Asian men with rapid biochemical recurrence(BCR) following radical prostatectomy(Rad P). This study aims to assess the detection rate of ^(68)Ga-prostate-specific membrane antigen-positron emission tomography/computed tomography(PSMA-PET/CT) for diagnosis of clinical recurrence and as a treatment decision making tool in Asian patients with BCR post-Rad P.Methods: ^(68)Ga PSMA-PET and CT body with/without bone scan [conventional workup(CWU)] were performed in 55 Asian patients with BCR within 36 months post-Rad P. Two blinded reviewers assessed the images. Detection rates of ^(68)Ga PSMAPET/CT were evaluated, and impact on management was reviewed by comparison with CWU.Results: Median time to BCR post-Rad P was 8.1 months. Detection rate for ^(68)Ga PSMA-PET/CT was 80%(44/55). A positive scan was significantly associated with increasing prostate-specific antigen(PSA) level [odds ratio(OR) = 1.13(95% CI 1.05–1.30), P =0.017], but not with higher Gleason grade or shorter PSA doubling time. Compared to CWU, ^(68)Ga PSMA-PET/CT detected an additional 106 lesions in 33/44 patients with a positive scan, resulting in a change in management in 25/44(56.8%) patients: 10 to hormonal therapy(HT) and whole pelvis radiotherapy(RT) in addition to bed RT, and 15 to palliative HT alone.Conclusions: In the present report, we demonstrated the diagnostic and treatment decision utility of ^(68)Ga PSMA-PET/CT in Asian men with rapid BCR. Detection of small volume nodal and systemic recurrences at low PSA levels(< 1.0 ng/mL) highlights the role of the tool in assigning patients to treatment intensification with HT-RT or palliative HT in polymetastatic disease. | Janice S.H.Tan Charles X.Y.Goh Yen Sin Koh Youquan Li Jeffrey K.L.Tuan Eu Tiong Chua Terence W.K.Tan Michael L.C.Wang Lui Shiong Lee Kae Jack Tay Ravindran Kanesvaran Chee Keong Toh Aaron K.T.Tong Winnie W.C.Lam Melvin L.K.Chua | 2019 | Cancer Biology & Medicine2019，16，1： | 2 |
| 8 | RCS reduction of ridged waveguide slot antenna array using EBG radar absorbing material 显示文摘 | Li Youquan Zhang Hui Fu Yunqi | 2008 | IEEE Antennas and Wireless Propagation Letters2008，7，： | 1 |
| 9 | A Novel MonitoringSystem for COD Using Optical Ultraviolet Absorption Method 显示文摘 | Zh ao Youquan Li Yuchun Zhen Yang | 2011 | Procedia Environmental Sciences2011，10，： | 1 |
| 10 | Characteristics estimation for high impedance surfaces based ultra-thin radar absorber显示文摘 | Li Youquan Fu Yunqin Yuan Naichang | | 0，，07： | 1 |
| 11 | PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells显示文摘Filopodia, a finger-like structure and actin-rich plasma-membrane protrusion at the leading edge of the cell, has important roles in cell motility. However, the mechanisms of filopodia generation are not well-understood via the actin-related protein 2/3 (ARP2/3) complex in Non-Small Cell Lung Cancer (NSCLC) cells. We previously have demonstrated that PRR11 associates with the ARP2/3 complex to regulate cytoskeleton-nucleoskeleton assembly and chromatin remodeling. In this study, we further demonstrate that PRR11 involves in filopodia formation, focal adhesion turnover and cell motility through ARP2/3 complex. Cell phenotype assays revealed that the silencing of PRR11 increased cellular size and inhibited cell motility in NSCLC cells. Mechanistically, PRR11 recruited and co-localized with Arp2 at the membrane protrusion to promote filopodia formation but not lamellipodia formation. Notably, PRR11 mutant deletion of the proline-rich region 2 (amino acid residues 185–200) abrogated the effect of filopodia formation. In addition, PRR11-depletion inhibited filopodial actin filaments assembly and increased the level of active integrin β1 in the cell surface, whereas reduced the phosphorylation level of focal adhesion kinase (FAKY397) to repress focal adhesion turnover and cell motility in NSCLC cells. Taken together, our findings indicate that PRR11 has critical roles in controlling filopodia formation, focal adhesion turnover and cell motility by recruiting ARP2/3 complex, thus dysregualted expression of PRR11 potentially facilitates tumor metastasis in NSCLC cells. | Zhili Wei Ru Wang Xun Yin lian Zhang Yunlong Lei Ying Zhang Yi Li Jiaqian Wu Youquan Bu Guoxiang Jin Chundong Zhang | 2022 | Genes & Diseases2022，9，1： | 1 |
| 12 | Quantum theory for mesoscopic electric circuits显示文摘 | LI Youquan CHEN Bin | 1996 | Phys Rev1996，，53： | 1 |
| 13 | RCS Reduction of Ridged Waveguide Slot Antenna Array Using EBG Radar Absorbing Material显示文摘 | Li Youquan Zhang Hui Fu Yunqi | 2008 | IEEE Antenna and Wireless Propagation Letters2008，，7： | 1 |
| 14 | Loop-mediated isothermal amplification (LAMP) method based on two species-specific primer sets for the rapid identification of Chinese Babesia bovis and B. bigemina显示文摘 | Aihong Liu Guiquan Guan Pengfei Du Huitian Gou Zhijie Liu Junlong Liu Milin Ma Jifei Yang Youquan Li Qinli Niu Qiaoyun Ren Qi Bai Hong Yin Jianxun Luo | 2012 | Parasitology International2012，，4： | 1 |
| 15 | RCS Reduction of Ridged Waveguide Slot Antenna Array Using EBG Radar Absorbing Material 显示文摘 | Li Youquan Zhang Hui Fu Yunqi | 2008 | IEEE Antenna and Wireless Propagation Letters2008，，7： | 1 |
| 16 | Evaluation of antioxidant and immune activity of Phellinus ribis glucan in mice显示文摘 | Chengfu Yuan Xiuning Huang Li Cheng Youquan Bu Geli Liu Faping Yi Zhengmei Yang Fangzhou Song | 2008 | Food Chemistry2008，，2： | 1 |
| 17 | Detecting and differentiating Theileria sergenti and Theileria sinensis in cattle and yaks by PCR based on major piroplasm surface protein (MPSP)显示文摘 | Aihong Liu Guiquan Guan Zhijie Liu Junlong Liu Neil Leblanc Youquan Li Jinliang Gao Milin Ma Qinli Niu Qiaoyun Ren Qi Bai Hong Yin Jianxun Luo | 2010 | Experimental Parasitology2010，，4： | 1 |
| 18 | Stability and dynamical property for two-species ultracold atoms in double wells显示文摘 | Xu Xiaoqiang Lu Lihua Li Youquan | | 0，，04： | 1 |
| 19 | RCS reduction ofridged waveguide slot antenna array using EBG radar absorb-ing material 显示文摘 | LI Youquan ZHANG Hui FU Yunqi | 2008 | IEEE Antennas and Wireless PropagationLetters2008，，7： | 1 |
| 20 | Spectrum of a quantum parity non-linear schrodinger model显示文摘 | Li Youquan | 1996 | Physics Letters A1996，212，5： | 1 |
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