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| 1 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 2 | Silencing of PRR11 suppresses cell proliferation and induces autophagy in NSCLC cells显示文摘Our previous studies have demonstrated that proline-rich protein 11(PRR11)is a novel tumor-related gene and implicates in regulating the proliferation in lung cancer.However,its precise role in cell cycle progression remains unclear.Our recent evidences show that PRR11 silencing has an effect on autophagy in non-small-cell lung cancer(NSCLC)cells.Two human NSCLC cell lines,H1299 and A549 were transiently transfected with against PRR11 siRNA.The Cell Counting Kit-8 and plate clone formation assay showed that downregulation of PRR11 inhibited the cell proliferation associated with cell cycle related genes reduced.And our data suggested that PRR11 depletion expression enhanced the autophagosomes formation,followed with downregulation of P62 and upregulation of LC3-II protein.Furthermore,the immunoblotting results indicated that silencing of PRR11 inactivated the Akt/mTOR signaling pathway.Collectively,these results demonstrated PRR11 had an effective role in autophagy in NSCLC cells through Akt/mTOR autophagy signaling pathways.Therefore,it is helpful to clarify the function of PRR11 in tumorigenesis of NSCLC. | Lian Zhang Yunlong Lei Ying Zhang Yi Li Youquan Bu Fangzhou Song Chundong Zhang | 2018 | Genes & Diseases2018，5，2： | 6 |
| 3 | Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected patients显示文摘Dear Editor,In late December 2019,an outbreak of severe pneumonia caused by an unknown etiological agent was initially reported in Wuhan,China,and then quickly spread throughout China and even abroad(Zhu et al.,2020).Swift control measures and etiological investigations were conducted by the Chinese government,physicians and researchers,and by using high throughput sequencing and virological testing,the mysterious pneumonia pathogen was shown to be a novel coronavirus(SARS-CoV-2)capable of person-to-person transmission(Zhu et al.,2020).Coronaviruses are a group of non-segmented,enveloped and positive-sense RNA viruses that belong to the subfamily of Coronavirinae in the family of Coronavirdiae and order of Nidovirales. | Dachuan Lin Lei Liu Mingxia Zhang Yunlong Hu Qianting Yang Jiubiao Guo Yongchao Guo Youchao Dai Yuzhong Xu Yi Cai Xinchun Chen Zheng Zhang Kaisong Huang | 2020 | Science China(Life Sciences)2020，63，4： | 6 |
| 4 | Time correction of the ocean bottom seismometers deployed at the southwest Indian ridge using ambient noise cross-correlation显示文摘Seismic monitoring using ocean bottom seismometers(OBS) is an efficient method for investigating earthquakes in mid-ocean ridge far away from land. Clock synchronization among the OBSs is difficult without direct communication because electromagnetic signals cannot propagate efficiently in water. Time correction can be estimated through global positioning system(GPS) synchronization if clock drift is linear before and after the deployment. However, some OBSs in the experiments at the southwest Indian ridge(SWIR) on the Chinese DY125-34 cruise had not been re-synchronized from GPS after recovery. So we attempted to estimate clock drift between each station pairs using time symmetry analysis(TSA) based on ambient noise cross-correlation. We tested the feasibility of the TSA method by analyzing daily noise cross-correlation functions(NCFs) that extract from the data of another OBS experiment on the Chinese DY125-40 cruise with known clock drift and the same deployment site. The results suggest that the NCFs' travel time of surface wave between any two stations are symmetrical and have an opposite growing direction with the date. The influence of different band-pass filters,different components and different normalized methods was discussed. The TSA method appeared to be optimal for the hydrophone data within the period band of 2–5 s in dozens of km-scale interstation distances. A significant clock drift of ~2 s was estimated between OBSs sets through linear regression during a 108-d deployment on the Chinese cruise DY125-34. Time correction of the OBS by the ambient noise cross-correlation was demonstrated as a practical approach with the appropriate parameters in case of no GPS re-synchronization. | LIU Yunlong LIU Cai TAO Chunhui YAO Huajian QIU Lei WANG Ao RUAN Aiguo WANG Hanchuang ZHOU Jianping LI Huaiming DONG Chuanwan | 2018 | Acta Oceanologica Sinica2018，37，5： | 5 |
| 5 | Parallel Spectral Clustering Based on MapReduce显示文摘Clustering is one of the most widely used techniques for exploratory data analysis.Spectral clustering algorithm,a popular modern clustering algorithm,has been shown to be more effective in detecting clusters than many traditional algorithms.It has applications ranging from computer vision and information retrieval to social science and biology.With the size of databases soaring,clustering algorithms have scaling computational time and memory use.In this paper,we propose a parallel spectral clustering implementation based on MapReduce.Both the computation and data storage are distributed,which solves the scalability problems for most existing algorithms.We empirically analyze the proposed implementation on both benchmark networks and a real social network dataset of about two million vertices and two billion edges crawled from Sina Weibo.It is shown that the proposed implementation scales well,speeds up the clustering without sacrificing quality,and processes massive datasets efficiently on commodity machine clusters. | Qiwei Zhong Yunlong Lin Junyang Zou Kuangyan Zhu Qiao Wang Lei Hu | 2013 | ZTE Communications2013，11，2： | 3 |
| 6 | Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles显示文摘我们以前识别了 subcortical 在老鼠为早 embryogenesis 和女富饶是必要的母亲的建筑群(SCMC ) 。然而, SCMC 由影响女富饶的分子的机制大部分仍然是 uncharacterized。这里,我们报导那新奇母亲的蛋白质,包含 3 的锌手指床类型(Zbed3 ) ,参予 SCMC。母亲的 Zbed3 的弄空导致女性的减少的肥沃,因为在变异的胚胎的一个比例的损害并且推迟的发展。母亲的 Zbed3 的损失在影响卵母细胞和接合子导致不对称的 zygotic 分割和细胞器的反常分布,类似于与破坏核心 SCMC 基因在女性观察的显型。进一步的调查表明这些显型与微导管的破坏动力学或细胞质的格子(CPL ) 的形成被联系。Zbed3 的稳定性和本地化取决于,但是没被要求为, SCMC 的形成。因此,我们的数据作为调停的下游的蛋白质之一建议 Zbed3 SCMC 功能并且在女富饶提供进一步的卓见进 SCMC 和 CPL 的角色。 | Zheng Gao Xiaoxin Zhang Xingjiang Yu Dandan Qin Yi Xiao Yang Yu Yunlong Xiang Xiaoqing Nie Xukun Lu Wenbo Liu Zhaohong Yi Lei Li | 2018 | Journal of Molecular Cell Biology2018，10，1： | 2 |
| 7 | 肺癌细胞中沉默PRR11诱发自噬并抑制细胞增殖显示文摘PRR11是近期研究发现的一个肿瘤相关新基因,在肺癌、胃癌及胆管癌等多种恶性肿瘤患者中呈现高表达,并与病人预后呈现负相关,提示PRR11基因高表达对于细胞增殖、侵袭迁移及体外成瘤等恶性表型具有重要作用。 | 张辉洁 Lian Zhang Yunlong Lei Ying Zhang Yi Li Youquan Bu Fangzhou Song Chundong Zhang | 2018 | 重庆医科大学学报2018，43，9： | 2 |
| 8 | Colonization of endophyte Acremonium sp. D212 in Panax notoginseng and rice mediated by auxin and jasmonic acid显示文摘Endophytic fungi can be beneficial to plant growth. However, the molecular mechanisms under-lying colonization of Acremonium spp. remain unclear. In this study, a novel endophytic Acremonium strain was isolated from the buds of Panax notoginseng and named Acremonium sp. D212. The Acremonium sp. D212 could colonize the roots of P. notoginseng, enhance the resistance of P. notoginseng to root rot disease, and promote root growth and saponin bio-synthesis in P. notoginseng. Acremonium sp. D212 could secrete indole-3-acetic acid (IAA) and jasmonic acid (JA), and inoculation with the fungus increased the endogenous levels of IAA and JA in P. noto-ginseng. Colonization of the Acremonium sp. D212 in the roots of the rice line Nipponbare was dependent on the concentration of methyl jasmonate (MeJA) (2–15μmol/L) and 1-naphthalenacetic acid (NAA) (10–20μmol/L). Moreover, the roots of the JA signaling-defective coi1-18 mutant were colonized by Acremonium sp. D212 to a lesser degree than those of the wild-type Nipponbare and miR393b-overexpressing lines, and the colonization was res-cued by MeJA but not by NAA. It suggests that the cross-talk between JA signaling and the auxin biosynthetic pathway plays a crucial role in the colonization of Acremonium sp. D212 in host plants. | Li Han Xuan Zhou Yiting Zhao Shusheng Zhu Lixia Wu Yunlu He Xiangrui Ping Xinqi Lu Wuying Huang Jie Qian Lina Zhang Xi Jiang Dan Zhu Chongyu Luo Saijie Li Qian Dong Qijing Fu Kaiyuan Deng Xin Wang Lei Wang Sheng Peng Jinsong Wu Weimin Li JiǐíFriml Youyong Zhu Xiahong He Yunlong Du | 2020 | Journal of Integrative Plant Biology2020，62，9： | 2 |
| 9 | Formative pluripotent stem cells show features of epiblast cells poised for gastrulation显示文摘The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells(ESCs)and primed epiblast stem cells(EpiSCs),respectively.However,these two states of pluripotency may not be sufficient to reflect the full complexity and developmental potency of the epiblast during mammalian early development.Here we report the establishment of self-renewing formative pluripotent stem cells(fPSCs)which manifest features of epiblast cells poised for gastrulation.fPSCs can be established from different mouse ESCs,pre-/early-gastrula epiblasts and induced PSCs.Similar to pre-/early-gastrula epiblasts,fPSCs show the transcriptomic features of formative pluripotency,which are distinct from naïve ESCs and primed EpiSCs.fPSCs show the unique epigenetic states of E6.5 epiblast,including the super-bivalency of a large set of developmental genes.Just like epiblast cells immediately before gastrulation,fPSCs can efficiently differentiate into three germ layers and primordial germ cells(PGCs)in vitro.Thus,fPSCs highlight the feasibility of using PSCs to explore the development of mammalian epiblast. | Xiaoxiao Wang Yunlong Xiang Yang Yu Ran Wang Yu Zhang Qianhua Xu Hao Sun Zhen-Ao Zhao Xiangxiang Jiang Xiaoqing Wang Xukun Lu Dandan Qin Yujun Quan Jiaqi Zhang Ng Shyh-Chang Hongmei Wang Naihe Jing Wei Xie Lei Li | 2021 | Cell Research2021，31，5： | 2 |
| 10 | Rice FLOURY ENDOSPERM22, encoding a pentatricopeptide repeat protein, is involved in both mitochondrial RNA splicing and editing and is crucial for endosperm development显示文摘Most of the reported P-type pentatricopeptide repeat(PPR) proteins play roles in organelle RNA stabilization and splicing. However, P-type PPRs involved in both RNA splicing and editing have rarely been reported, and their underlying mechanism remains largely unknown. Here, we report a rice floury endosperm22(flo22) mutant with delayed amyloplast development in endosperm cells. Map-based cloning and complementation tests demonstrated that FLO22 encodes a mitochondrion-localized P-type PPR protein.Mutation of FLO22 resulting in defective transsplicing of mitochondrial nad1 intron 1 and perhaps causing instability of mature transcripts affected assembly and activity of complex Ⅰ, and mitochondrial morphology and function. RNA-seq analysis showed that expression levels of many genes involved in starch and sucrose metabolism were significantly down-regulated in the flo22mutant compared with the wild type, whereas genes related to oxidative phosphorylation and the tricarboxylic acid cycle were significantly upregulated. In addition to involvement in splicing as a P-type PPR protein, we found that FLO22 interacted with DYW3, a DYW-type PPR protein, and they may function synergistically in mitochondrial RNA editing. The present work indicated that FLO22 plays an important role in endosperm development and plant growth by participating in nad1 maturation and multi-site editing of mitochondrial messager RNA. | Hang Yang Yunlong Wang Yunlu Tian Xuan Teng Zehui Lv Jie Lei Erchao Duan Hui Dong Xue Yang Yuanyan Zhang Yinglun Sun Xiaoli Chen Xiuhao Bao Rongbo Chen Chuanwei Gu Yipeng Zhang Xiaokang Jiang Wenyu Ma Pengcheng Zhang Yi Ji Yu Zhang Yihua Wang Jianmin Wan | 2023 | Journal of Integrative Plant Biology2023，65，3： | 1 |
| 11 | PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells显示文摘Filopodia, a finger-like structure and actin-rich plasma-membrane protrusion at the leading edge of the cell, has important roles in cell motility. However, the mechanisms of filopodia generation are not well-understood via the actin-related protein 2/3 (ARP2/3) complex in Non-Small Cell Lung Cancer (NSCLC) cells. We previously have demonstrated that PRR11 associates with the ARP2/3 complex to regulate cytoskeleton-nucleoskeleton assembly and chromatin remodeling. In this study, we further demonstrate that PRR11 involves in filopodia formation, focal adhesion turnover and cell motility through ARP2/3 complex. Cell phenotype assays revealed that the silencing of PRR11 increased cellular size and inhibited cell motility in NSCLC cells. Mechanistically, PRR11 recruited and co-localized with Arp2 at the membrane protrusion to promote filopodia formation but not lamellipodia formation. Notably, PRR11 mutant deletion of the proline-rich region 2 (amino acid residues 185–200) abrogated the effect of filopodia formation. In addition, PRR11-depletion inhibited filopodial actin filaments assembly and increased the level of active integrin β1 in the cell surface, whereas reduced the phosphorylation level of focal adhesion kinase (FAKY397) to repress focal adhesion turnover and cell motility in NSCLC cells. Taken together, our findings indicate that PRR11 has critical roles in controlling filopodia formation, focal adhesion turnover and cell motility by recruiting ARP2/3 complex, thus dysregualted expression of PRR11 potentially facilitates tumor metastasis in NSCLC cells. | Zhili Wei Ru Wang Xun Yin lian Zhang Yunlong Lei Ying Zhang Yi Li Jiaqian Wu Youquan Bu Guoxiang Jin Chundong Zhang | 2022 | Genes & Diseases2022，9，1： | 1 |
| 12 | Preparation of nano-PANI@MnO_2 by surface initiated polymerization method using as a nano-tubular electrode material:The amount effect of aniline on the microstructure and electrochemical performance显示文摘In this study,nano-polyanline and manganese oxide nanometer tubular composites(nano-PANI@MnO2)were prepared by a surface initiated polymerization method and used as electrochemical capacitor electrode materials; and the effect of aniline amount on the microstructure and electrochemical performance was investigated. The microstructures and surface morphologies of nano-PANI@MnO2 were characterized by X-ray diffraction,scanning electron microscopy and fourier transformation infrared spectroscope. The electrochemical performance of these composite materials was performed with cyclic voltammetry,charge–discharge test and electrochemical impedance spectroscopy,respectively. The results demonstrate that the feed ratio of aniline to MnO2 played a very important role in constructing the hierarchically nano-structure,which would,hence,determine the electrochemical performance of the materials. Using the templateassisted strategy and controlling the feed ratio of aniline to MnO2,the nanometer tubular structure of nanoPANI@MnO2 was obtained. A maximum specific capacitance of 386 F/g was achieved in aqueous 1 mol/L Na NO3 electrolyte with the potential range from 0 to 0.6 V(vs. SCE). | Fen Ran Yunlong Yang Lei Zhao Xiaoqin Niu Dingjun Zhang Lingbin Kong Yongchun Luo Long Kang | 2015 | Journal of Energy Chemistry2015，24，4： | 1 |
| 13 | Haze Control by Industrialization:A Win-win Mode of Ecological Civilization and Economic Development显示文摘Haze control is a difficult and arduous battle,and it is a major decision concerning the people's livelihood and national ecological civilization construction.Taking Heilongjiang Province as an example,this paper introduced a new idea for haze control.Haze in Heilongjiang Province was mainly resulted from straw burning.Market-oriented,large-scale,and industrialized haze control relying on science and technology is new opportunity and challenge for realizing ecological civilization and revitalizing the economy of Heilongjiang Province. | Yan HAN Qingyu CHAI Lei WANG Yunlong YAO Yunna JIA Jiahui SHAO Hongxian YU Fangying CHAI | 2017 | Asian Agricultural Research2017，9，2： | 1 |
| 14 | Preface: innovative flexible energy显示文摘Continuous progress in energy science and technology improves the quality of our life.The realization of flexibility and stretchability in electronics is expected to open up the possibility of many new applications.Innovation in | Lei Fu Yunlong Guo Yu Wang | 2016 | Science China Materials2016，59，6： | 1 |
| 15 | BRITTLE PLANT1 is required for normal cell wall composition and mechanical strength in rice显示文摘A series of nucleotide sugar interconversion enzymes(NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins. UDPglucose 4-epimerases(UGEs) are NSEs that function in the interconversion of UDP-glucose(UDP-Glc) and UDP-galactose(UDP-Gal). The roles of UDP-glucose 4-epimerases in monocots remain unclear due to redundancy in the pathways. Here, we report a brittle plant(bp1) rice mutant that exhibits brittle leaves and culms at all growth stages. The mutant culms had reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins.Moreover, the mutant had altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose. Map-based cloning demonstrated that OsBP1 encodes a UDPglucose 4-epimerase(OsUGE2), a cytosolic protein. We also show that BP1 can form homoand hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2(OsUGT2) and 3(OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans. Our results demonstrate that BP1 participates in regulating the sugar composition and structure of rice cell walls. | Yuanyan Zhang Yihua Wang Chunming Wang Carsten Rautengarten Erchao Duan Jianping Zhu Xiaopin Zhu Jie Lei Chao Peng Yunlong Wang Xuan Teng Yunlu Tian Xi Liu Joshua LHeazlewood Aimin Wu Jianmin Wan | 2021 | Journal of Integrative Plant Biology2021，63，5： | 1 |
| 16 | 海马Rac1蛋白的激活调节新物体识别记忆的遗忘过程显示文摘在神经生物学的研究当中,遗忘过程普遍被认为属于被动过程即记忆不能够形成和维持,因而大部分的研究集中在记忆形成和维持的分子机制上,而忽略了遗忘本身的分子机制,即记忆形成过程中生物体通过激活自身的分子信号途径介导主动遗忘过程。 | Yunlong Liu Shuwen Du Li Lv Bo Lei Wei Shi Yikai Tang Lianzhang Wang 钟毅 | 2017 | 科学新闻2017，19，4： | 1 |
| 17 | Allelic impacts on pre-harvest sprouting resistance and favorable haplotypes in Ta PHS1 of Chinese wheat accessions显示文摘Pre-harvest sprouting(PHS)influences yield and end-use quality of bread wheat.Developing varieties with PHS resistance is the most effective way to reduce this problem.In this study,a panel of 725 Chinese wheat accessions were evaluated for PHS resistance in three environments.There was abundant variation in PHS resistance and 63 accessions showing high resistance had germination rates of less than 10%across three experiments.The distribution of three causal single nucleotide polymorphisms in Ta PHS1 at bases-222,+646,and+666 were assessed and frequencies were determined.Favorable alleles conferring PHS resistance were identified for each locus.Haplotype analysis showed that bases C,G,and A at each of the three loci comprised the best haplotype for PHS resistance,whereas TAT showed the highest sprouting rate.Accessions with the superior Ta PHS1 haplotypes proved to be resistant to PHS providing a basis to develop varieties with PHS resistance through marker assisted breeding. | Danfeng Wang Yunlong Pang Lei Dong Anfei Li Lingrang Kong Shubing Liu | 2020 | The Crop Journal2020，8，4： | 1 |
| 18 | Thermal-sensitive ionogel with NIR-light controlled adhesion for ultrasoft strain sensor显示文摘With the widespread prevailing of flexible electronics in human-machine interfaces,health monitor,and human motion detection,ultrasoft flexible sensors are urgently desired with critical demands in conformality.Herein,a temperature-sensitive ionogel with near-infrared(NIR)-light controlled adhesion is prepared by electrostatic interaction of poly(diallyl dimethylammonium chloride)(PDDA)and acrylic acid,as well as the incorporation of the conductive polydopamine modified polypyrrole nanoparticles(PPy-PDA NPs).The PPy-PDA NPs could weaken the tough interaction between polymer chains and depress the Young’s modulus of the ionogel,thus promoting the ionogel ultrasoft(34 kPa)and highly stretchable(1,013%)performance to tensile deformations.In addition,the high photothermal conversion capacity of PPy-PDA NPs ensured the ionogel excellent NIR-light controlled adhesion and temperature sensitivity,which facilitated the ionogel on-demand removal and promised a reliable thermal sensor.Moreover,the resulted ultrasoft flexible sensor exhibited high sensitivity and stability to both strain and pressure in a broad range of deformations,enabling a precise monitoring on various human motions and physiological activities.The temperature-sensitive,ultrasoft,and controlled adhesive capabilities prompted great potential of the flexible ionogel in medical diagnosis and wearable electronics. | Bing Lei Longxue Cao Xinyu Qu Yunlong Liu Jinjun Shao Qian Wang Shuhong Li Wenjun Wang Xiaochen Dong | 2023 | Nano Research2023，16，4： | 0 |
| 19 | Targeted combination therapy for glioblastoma by co-delivery of doxorubicin,YAP-siRNA and gold nanorods显示文摘The combination of brain targeting drug delivery systems and multi-modal intervention pose a promising therapeutic approach for glioblastoma therapy.In this study,we developed an angiopep-2 peptide modified cationic liposome loaded with doxorubicin,YAP-siRNA and gold nanorods(D/R@Ang2-Lip+Au)simultaneously,which has high encapsulating efficiency for doxorubicin(95.4%)and effective binding of siRNA at N/P ratio of 20:1.The fluorescence imaging and flow cytometry analysis revealed high cellular uptake of D/R@Ang2-Lip+Au.Real-time quantitative polymerase chain reaction and western blot analysis indicated that D/R@Ang2-Lip+Au could effectively inhibit the expression of YAP protein.In vitro and in vivo studies showed that D/R@Ang2-Lip+Au had the ability to target glioblastoma cells,and achieved better anti-proliferative effects compared with non-targeted D/R@Lip+Au.Moreover,in vivo experiment demonstrated that D/R@Ang2-Lip+Au was able to cross the blood-brain barrier,and combination therapy could significantly inhibit tumor growth.Therefore,the multifunctional D/R@Ang2-Lip+Au might provide a novel approach for effectively delivery of DOX,YAP-siRNA and AuNRs into the glioblastoma cells simultaneously and exerting synergistic therapeutic effects. | Lihuang Li Qiuyan Guo Yanxiu Liu Mindan Lu Jun Yang Yunlong Ge Qiang Zhang Benqiang Sun Xiumin Wang Li Liang-cheng Lei Ren | 2021 | Journal of Materials Science & Technology2021，，4： | 0 |
| 20 | Effect of Refresh Time on XeF2 Gas-assisted FIB Milling of GaAs显示文摘Focused ion beam (FIB) machining can be used to fabricate gallium arsenide-based devices, which have a surface fnish of several nanometers, and the FIB machining speed and surface fnish can be greatly improved using xenon difuoride (XeF2) gas-assisted etching. Although the refresh time is one of the most important parameters in the gas-assisted etching process, its efect on the machining quality of the surface fnish has rarely been studied. Therefore, in this work, we investigated the efect of the refresh time on the etching process, including the dissociation process of XeF2, the refresh time dependency of the sputter in yield under diferent incident angles, and the surface fnish under diferent refresh times. The results revealed that a selective etching mechanism occurred at diferent refresh times. At an incidence angle of 0°, the sputtering yield increased with the refresh time and reached its maximum value at 500 ms;at an incidence angle of 30°, the sputtering yield reached its minimum value at a refresh time of 500 ms. For surface roughness, the incident angle played a more important role than the refresh time. The surface fnish was slightly better at an incidence angle of 30° than at 0°. In addition, both F and Xe elements were detected in the processed area: Xe elements were evenly distributed throughout the processing area, while F elements tended to accumulate in the whole processing area. The results suggest that the optimum surface can be obtained when a larger refresh time is employed. | Jining Sun Lei Zhang Yi Zhang Yunlong Han Lei Zhang | 2023 | Nanomanufacturing and Metrology2023，6，4： | 0 |
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