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| 1 | Pharmacokinetic evaluation of Shenfu Injection in beagle dogs after intravenous drip administration显示文摘Shenfu Injection(SFI) is a well-defined Chinese herbal formulation that is obtained from red ginseng and processed aconite root. The main active constituents in SFI are ginsenosides and aconitum alkaloids. In this work, ginsenosides(ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Rc) and aconitum alkaloids(benzoylmesaconine and fuziline) were used as the index components to explore the pharmacokinetic behavior of SFI. A selective and sensitive HPLC–MS/MS method was developed for the quantification of ginsenosides and aconitum alkaloids in dog plasma and was used to characterize the pharmacokinetics of the five index components after intravenous drip of three different dosages of SFI in beagle dogs. The pharmacokinetic properties of the index components were linear over the dose range of2–8 m L/kg. | Yuqiao Zhang Dali Tian Yuyou Huang Ling Li Juan Mao Juan Tian Jinsong Ding | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 12 |
| 2 | Enhancement of thermophilic anaerobic digestion of thickened waste activated sludge by combined microwave and alkaline pretreatment显示文摘Pretreatment of thickened waste activated sludge (TWAS) by combined microwave and alkaline pretreatment (MAP) was studied to improve thermophilic anaerobic digestion efficiency. Uniform design was applied to determine the combination of target temperature (110-210℃), microwave holding time (1-51 min), and NaOH dose (0-2.5 g NaOH/g suspended solids (SS)) in terms of their effect on volatile suspended solids (VSS) solubilization. Maximum solubilization ratio (85.1%) of VSS was observed at 210℃ with 0.2 g-NaOH/g-SS and 35 min holding time. The effects of 12 different pretreatment methods were investigated in 28 thermophilic batch reactors by monitoring cumulative methane production (CMP). Improvements in methane production in the TWAS were directly related to the microwave and alkaline pretreatment of the sludge. The highest CMP was a 27% improvement over the control. In spite of the increase in soluble chemical oxygen demand concentration and the decrease in dewaterability of digested sludge, a semi-continuous thermophilic reactor fed with pretreated TWAS without neutralization (at 170℃ with 1 min holding time and 0.05 g NaOH/g SS) was stable and functioned well, with volatile solid (VS) and total chemical oxygen demand (TCOD) reductions of 28% and 18%, respectively, which were higher than those of the control system. Additionally, methane yields (L@STP/g-COD added , at standard temperature and pressure (STP) conditions of 0℃ and 101.325 kPa) and (L@STP/g VS added ) increased by 17% and 13%, respectively, compared to the control reactor. | Yongzhi Chi Yuyou Li Xuening Fei ShaopoWang Hongying Yuan | 2011 | Journal of Environmental Sciences2011，23，8： | 9 |
| 3 | Cultivation of aerobic granular sludge in a conventional, continuous flow, completely mixed activated sludge system显示文摘氧气的小粒在常规、连续流动被形成,完全混合的激活的污泥系统(CMAS ) 。反应堆与包含很少细丝的种子污泥被接种并且用合成市政的废水喂了。污泥和一般水准的安定时间溶解了氧() 反应堆, 2 是 h 和 4.2 mg 散瑮慲楴湯 ? 敷敲甠敳 ? 湩琠敨搠獥污湩瑡潩 ? 档浡敢 ? 潴猠畴祤琠敨攠晦 ' ?景椠湯挠湯散瑮慲楴湯吗? | Xi CHEN Linjiang YUAN Wenjuan LU Yuyou LI Pei LIU Kun NIE | 2015 | Frontiers of Environmental Science & Engineering2015，9，2： | 3 |
| 4 | Compression Properties of Ti-Al-X Alloys in Relation to Site Occupancies of Alloying Elements in TiAl and Ti_3Al显示文摘 | Yulin HA O Rui YANG, Yuyou CUI and Dong LI(Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110015, China)Wanfu GAO(Fushun Petroleum Institute, Dandong Road, Fushun 113001, China) | 1999 | Journal of Materials Science & Technology1999，15，6： | 2 |
| 5 | CircRNA.0007127 triggers apoptosis through the miR-513a-5p/CASP8 axis in K-562 cells显示文摘Background:Circular RNAs(circR NAs)are covalently closed single-stranded RNAs with multiple biological functions.CircRNA.0007127 is derived from the carbon catabolite repression 4-negative on TATA-less(CCR4-NOT)complex subunit2(CNOT2),which was found to regulate tumor cell apoptosis through caspase pathway.Methods:Potential circR NA.0007127 target microRNAs(miRNAs)were analyzed by miRanda,TargetScan,and RNAhybrid software,and the miRNAs with binding sites for apoptosis-related genes were screened.The roles of circR NA.0007127 and its downstream target,microR NA(miR)-513a-5p,were validated by quantitative real-time polymerase chain reaction(qPCR),flow cytometry,mitochondrial membrane potential,immunofluorescence,western blot,and caspase-8(CASP8)protein activity in vitro in HO-induced K-562 cells.The circRNA.0007127-miR-513a-5p and CASP8-miR-513a-5p interactions were verified by luciferase reporter assays.Results:Silencing circRNA.0007127 decreased cell apoptosis by inhibiting CASP8 pathway activation in K-562 cells.Compared with the control group,the expression of CASP8 was reduced by 50%and the 43-kD fragment of CASP8 protein was significantly reduced(P≤0.05).The luciferase reporting assay showed that circRNA.0007127 combined with miR-513a-5p or CASP8,with extremely significant differences(P≤0.001).The overexpression of miR-513a-5p inhibited the gene expression level of CASP8in a human myeloid leukemia cell model(75%change)and the level of a 43-kD fragment of CASP8 protein(P small-interfering RNA(siRNA)and the miR-≤0.01).The rescue experiment showed that cotransfection with circRNA.0007127513a-5p inhibitor increased CASP8 gene expression and the apoptosis rate,suggesting that the miR-513a-5p inhibitor is a circRNA.0007127siRNA antagonist.Conclusions:CircRNA.0007127 regulates K-562 cell apoptosis through the miR-513a-5p/CASP8 axis,which can serve as a novel powerful molecular target for K-562 cells. | Xiajing LI Yiyu ZHANG Ning WANG Zhaohu YUAN Xiaojie CHEN Qicong CHEN Hui DENG Xinxin TONG Honglin CHEN Yuyou DUAN Yaming WEI | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，9： | 1 |
| 6 | A pH-and tempera- ture-phased two-stage process for hydrogen and methane production from food waste显示文摘 | Chu Chunfeng Li Yuyou Xu Kaiqin | 2008 | International Journal of Hydrogen Energy2008，33，18： | 1 |
| 7 | Effects of temperature and suhstrate concentration on biological hydrogen production from starch 显示文摘 | AKUTSU Y LI Yuyou HARADA H | 2009 | Int J Hydrogen Energy2009，34，： | 1 |
| 8 | A pH and temperature phased two-stage process for hydrogen and methane production from food waste显示文摘 | CHU Chunfeng LI Yuyou XU Kaiqin | 2008 | International Journal of Hydrogen Energy2008，33，18： | 1 |
| 9 | Synergetic pretreatment of waste activated sludge by Fe(II)–activated persulfate oxidation under mild temperature for enhanced dewaterability显示文摘 | Guangyin Zhen Xueqin Lu Baoying Wang Youcai Zhao Xiaoli Chai Dongjie Niu Aihua Zhao Yuyou Li Yu Song Xianyan Cao | 2012 | Bioresource Technology2012，，： | 1 |
| 10 | Methane fermentation of waste materials biomass显示文摘 | Li Yuyou Kobayashi T Shin U | | 0，，11： | 1 |
| 11 | Effect of degradation kinetics on the microstructure of anaerobic biogranules显示文摘 | Fang H H P Chui H K Li Yuyou | 1995 | Water Science andTechnology1995，32，8： | 1 |
| 12 | Biodegradability enhance-ment of wastewater containing cefalexin by means of the Electro - Fenton oxidation process 显示文摘 | Adriana L E Li Yuyou Wang Aimin | 2012 | Journal of Hazardous Materials2012，15，227228： | 1 |
| 13 | IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization显示文摘Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes,in which the Indian hedgehog(IHH)and parathyroid hormone-related protein-parathyroid hormone-1 receptor(PTHrP-PTH1R)feedback loop is crucial.The inositol-requiring enzyme 1a/X-box-binding protein-1 spliced(IRE1α/XBP1s)branch of the unfolded protein response(UPR)is essential for normal cartilage development.However,the precise role of ER stress effector IRE1α,encoded by endoplasmic reticulum to nucleus signaling 1(ERN1),in skeletal development remains unknown.Herein,we reported that loss of IRE1α accelerates chondrocyte hypertrophy and promotes endochondral bone growth.ERN1 acts as a negative regulator of chondrocyte proliferation and differentiation in postnatal growth plates.Its deficiency interrupted PTHrP/PTH1R and IHH homeostasis leading to impaired chondrocyte hypertrophy and differentiation.XBP1s,produced by p-IRE1α-mediated splicing,binds and up-regulates PTH1R and IHH,which coordinate cartilage development.Meanwhile,ER stress cannot be activated normally in ERN1-deficient chondrocytes.In conclusion,ERN1 deficiency accelerates chondrocyte hypertrophy and cartilage mineralization by impairing the homeostasis of the IHH and PTHrP/PTH1R feedback loop and ER stress.ERN1 may have a potential role as a new target for cartilage growth and maturation. | Mengtian Fan Nana Geng Xingyue Li Danyang Yin Yuyou Yang Rong Jiang Cheng Chen Naibo Feng Li Liang Xiaoli Li Fengtao Luo Huabing Qi Qiaoyan Tan Yangli Xie Fengjin Guo | 2024 | Genes & Diseases2024，11，1： | 0 |
| 14 | Microstructure Evolution of Rapidly Solidified Ti_3Al-2Nb Alloy显示文摘It has been found from the analysis of X-ray diffraction and the observation of TEM that the metastable ordered orthorhombic martensite phase in the rapidly solidified Ti3Al-2Nb alloy transforms to various phases at different aging temperatures. When the alloy aged at temperature of 500℃ for 20 min, the phase decomposition into B2 and O phases is related to the stressin the alloy. When the aged temperature above 600℃, the phase transforms to α2 phase by both shearing and chemical | Rui XU Yuyou CUI Dong LI and Zhuangqi HU (State Key Lab. of RSA, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China)Daming XU and Qingchun LI (Dept. of Materials Science and Technology, Harbin Institute of Technology, Harb | 1996 | Journal of Materials Science & Technology1996，12，2： | 0 |
| 15 | Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis显示文摘Progranulin(PGRN)is a multifunctional growth factor involved in many physiolog-ical processes and disease states.The apparent protective role of PGRN and the importance of chondrocyte autophagic function in the progression of osteoarthritis(OA)led us to investi-gate the role of PGRN in the regulation of chondrocyte autophagy.PGRN knockout chondro-cytes exhibited a deficient autophagic response with limited induction following rapamycin,serum starvation,and IL-1b-induced autophagy.PGRN-mediated anabolism and suppression of IL-1b-induced catabolism were largely abrogated in the presence of the BafA1 autophagy inhibitor.Mechanistically,during the process of OA,PGRN and the ATG5eATG12 conjugate form a protein complex;PGRN regulates autophagy in chondrocytes and OA through,at least partially,the interactions between PGRN and the ATG5eATG12 conjugate.Furthermore,the ATG5eATG12 conjugate is critical for cell proliferation and apoptosis.Knockdown or knockout of ATG5 reduces the expression of ATG5eATG12 conjugate and inhibits the chondroprotective effect of PGRN on anabolism and catabolism.Overexpression of PGRN partially reversed this effect.In brief,the PGRN-mediated regulation of chondrocyte autophagy plays a key role in the chondroprotective role of PGRN in OA.Such studies provide new insights into the pathogen-esis of OA and PGRN-associated autophagy in chondrocyte homeostasis. | Yiming Pan Yuyou Yang Mengtian Fan Cheng Chen Rong Jiang Li Liang Menglin Xian Biao Kuang Nana Geng Naibo Feng Lin Deng Wei Zheng Fengmei Zhang Xiaoli Li Fengjin Guo | 2023 | Genes & Diseases2023，10，4： | 0 |
| 16 | Heterogeneous precipitate microstructure in titanium alloys for simultaneous improvement of strength and ductility显示文摘The design of alloys with simultaneous high strength and high ductility is still a difficult challenge.Here,we propose a new approach to designing multi-phase alloys with a synergistic combination of strength and ductility by engineering heterogeneous precipitate microstructures through the activation of different transformation mechanisms.Using a two-phase titanium alloy as an example,phase field simulations are carried out firstly to design heat treatment schedules that involve both conventional nucleation and growth and non-conventional pseudospinodal decomposition mechanisms,and the calculated microstructures have been evaluated by crystal plasticity finite element modeling.According to simulations,we then set a two-step heat treatment to produce bimodalα+βmicrostructure in Ti-10V-2Fe-3Al.Further mechanical testing shows that the ductility of the alloy is increased by~50%and the strength is increased by~10%as compared to its unimodal counterpart.Our work may provide a general way to improve the mechanical properties of alloys through multiscale microstructure design. | Mengyuan Hao Pei Li Xuexiong Li Tianlong Zhang Dong Wang Qiaoyan Sun Libin Liu Jinshan Li Yuyou Cui Rui Yang Dongsheng Xu | 2022 | Journal of Materials Science & Technology2022，，29： | 0 |
| 17 | A comprehensive simulation approach for pollutant bio-transformation in the gravity sewer显示文摘Presently, several activated sludge models (ASMs) have been developed to describe a few biochemical processes. However, the commonly used ASM neither clearly describe the migratory transformation characteristics of fermentation nor depict the relationship between the carbon source and biochemical reactions. In addition, these models also do not describe both ammonification and the integrated metabolic processes in sewage transportation. In view of these limitations, we developed a new and comprehensive model that introduces anaerobic fermentation into the ASM and simulates the process of sulfate reduction, ammonification, hydrolysis, acidogenesis and methanogenesis in a gravity sewer. The model correctly predicts the transformation of organics including proteins, lipids, polysaccharides, etc. The simulation results show that the degradation of organics easily generates acetic acid in the sewer system and the high yield of acetic acid is closely linked to methanogenic metabolism. Moreover, propionic acid is the crucial substrate for sulfate reduction and ammonification tends to be affected by the concentration of amino acids. Our model provides a promising tool for simulating and predicting outcomes in response to variations in wastewater quality in sewers. | Nan Zhao Huu Hao Ngo Yuyou Li Xiaochang Wang Lei Yang Pengkang Jin Guangxi Sun | 2019 | Frontiers of Environmental Science & Engineering2019，13，4： | 0 |
| 18 | Path Planning and Tracking Control for Parking via Soft Actor-Critic Under Non-Ideal Scenarios显示文摘Parking in a small parking lot within limited space poses a difficult task. It often leads to deviations between the final parking posture and the target posture. These deviations can lead to partial occupancy of adjacent parking lots, which poses a safety threat to vehicles parked in these parking lots. However, previous studies have not addressed this issue. In this paper, we aim to evaluate the impact of parking deviation of existing vehicles next to the target parking lot(PDEVNTPL) on the automatic ego vehicle(AEV) parking, in terms of safety, comfort, accuracy, and efficiency of parking. A segmented parking training framework(SPTF) based on soft actor-critic(SAC) is proposed to improve parking performance. In the proposed method, the SAC algorithm incorporates strategy entropy into the objective function, to enable the AEV to learn parking strategies based on a more comprehensive understanding of the environment. Additionally, the SPTF simplifies complex parking tasks to maintain the high performance of deep reinforcement learning(DRL). The experimental results reveal that the PDEVNTPL has a detrimental influence on the AEV parking in terms of safety, accuracy, and comfort, leading to reductions of more than 27%, 54%, and 26%respectively. However, the SAC-based SPTF effectively mitigates this impact, resulting in a considerable increase in the parking success rate from 71% to 93%. Furthermore, the heading angle deviation is significantly reduced from 2.25 degrees to 0.43degrees. | Xiaolin Tang Yuyou Yang Teng Liu Xianke Lin Kai Yang Shen Li | 2024 | IEEE/CAA Journal of Automatica Sinica2024，11，1： | 0 |
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