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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Geothermal data analysis at the high-temperature hydrothermal area in Western Sichuan显示文摘The western Sichuan hydrothermal area is located at the northeastern margin of the eastern syntaxis of the Qinghai-Tibet Plateau, which is also the eastern end of the Mediterranean-Himalayan geothermal activity zone. There are 248 warm or hot springs in this area, and 11 have temperatures beyond the local boiling temperature. Most of these hot springs are distributed along the Jinshajiang, Dege-Xiangcheng, Ganzi-Litang, and Xianshuihe faults, forming a NW-SE hydrothermal belt. A geothermal analysis of this high-temperature hydrothermal area is an important basis for understanding the deep geodynamic process of the eastern syntaxis of the Qinghai-Tibet Plateau. In addition, this study offers an a priori view to utilize geothermal resources, which is important in both scientific research and application. We use gravity, magnetic, seismic, and helium isotope data to analyze the crust-mantle heat flow ratio and deep geothermal structure. The results show that the background terrestrial heat flow descends from southwest to northeast. The crustal heat ratio is not more than 60%. The high temperature hydrothermal active is related to crustal dynamics processes. Along the Batang-Litang-Kangding line, the Moho depth increases eastward, which is consistent with the changing Qc/Qm(crustal/mantle heat flow) ratio trend. The geoid in the hydrothermal zone is 4–6 km higher than the surroundings, forming a local 'platform'. The NW-SE striking local tensile stress zone and uplift structure in the upper and middle crust corresponds with the surface hydrothermal active zone. There is an average Curie Point Depth(CPD) of 19.5–22.5 km in Batang, Litang, and Kangding. The local shear-wave(S-wave) velocity is relatively low in the middle and lower crust. The S-wave shows a low velocity trap(Vs<3.2 km s.1) at 15–30 km, which is considered a high-temperature partial melting magma, the crustal source of the hydrothermal active zone. We conclude that the hydrothermal system in this area can be divided into Batang-type and Kangding-type, both of which rely on a crustal heating cycle of atmospheric precipitation and surface water along the fracture zone. The heat is derived from the middle and lower crust: groundwater penetrates the deep faults bringing geothermal energy back to the surface and forming high-temperature springs. | ZHANG Jian LI WuYang TANG XianChun TIAN Jiao WANG YingChun GUO Qi PANG ZhongHe | 2017 | Science China Earth Sciences2017，60，8： | 17 |
| 3 | A New Species of Cathayornis from the Lower Cretaceous of Inner Mongolia,China and Its Stratigraphic Significance显示文摘摘要:不完全的 postcranial 鸟的骨骼从西方的内部蒙古的 Otog 旗帜的更低的白垩纪 Jingchuan 形成被描述并且指了 Cathayornis 的新种, C。chabuensis sp。nov。这是从外面的辽宁省的 Cathayornis 的第一份报告。新发现显示 Cathayornis 与 Otogornis genghisi 共存了,并且更多详细说明了在 Otogornis 代表的这二 enantiornithine 类表演之间的比较一个更原始的类比 Cathayornis。我们的分析进一步显示 Cathayornis 是一只树木的鸟。从这个区域的 Cathayornis 的发现也证实鸟的忍受石块的 Jingchuan 形成比得上在西方的辽宁的上面的 Jehol 组的 Jiufotang 形成,并且应该被指中间迟了的早白垩纪。 | LI Jianjun LI Zhiheng ZHANG Yuguang ZHOU Zhonghe BAI Zhiqiang ZHANG Lifu BA Tuya | 2008 | Acta Geologica Sinica(English Edition)2008，82，6： | 11 |
| 4 | Correlation of D-dimer level with the radiological severity indexes of pulmonary embolism on computed tomography pulmonary angiography显示文摘 | Ji Yingqun Sun Bo Keeran Sandya Juggessur-Mungur Li Zhiyong Zhang Zhonghe | 2014 | Chinese Medical Journal2014，，11： | 7 |
| 5 | Million-year-old groundwater revealed by krypton-81 dating in Guanzhong Basin,China显示文摘Groundwater age,defined as the mean subsurface residence time spent isolated from the atmosphere,is of crucial significance for managing water resources and industrial waste.It is also very useful for understanding subsurface contaminant transport,and for paleoclimate reconstruction.It is an important parameter | Jie Li Zhonghe Pang Guo-Min Yang Jiao Tian Amin L.Tong Xiang-Yang Zhang Shui-Ming Hu | 2017 | Science Bulletin2017，62，17： | 6 |
| 6 | Analysis on Nutrient Compositions and Nutritional Quality of Lota lota( Linnaeus) Muscle显示文摘In order to evaluate the nutritional quality of Lota lota(Linnaeus) muscle,the common nutrient components,amino acid composition and fatty acid composition in muscle of wild Lota lota(captured in Hailang reaches of Mudan River) were determined by routine methods. The results showed that the contents of moisture,crude protein,crude fat and ash were 81. 82%,15. 93%,0. 44% and 1. 06% in fresh muscle of Lota lota,respectively. Totally 17 amino acids,including seven kinds of essential amino acids(EAA),were detected in dry muscle of Lota lota(Linnaeus),accounting for 72. 43% of total dry muscle. The content of EAA was 29. 82%,accounting for 41. 17% of TAA,meeting the amino acid composition of high-quality protein standard required by Food and Agriculture Organization /Word Health Organization(FAO /WHO). There were four delicious amino acids(DAA) in dry muscle,accounting for 28. 34% of total dry weight.The percentage of DAA to TAA was 39. 13% in dry muscle. The contents of C20:5n- 3(EPA) and C22:6n- 3(DHA) in dry muscle were 8. 65% and 20. 32%respectively,which were significantly higher than that of the artificially cultured fish species,such as Oxyeleotris marmorata(EPA:2. 24%,DHA:4. 74%),Spinibarbus sinensis(EPA:0. 87%,DHA:3. 08%) and Glossogobius giuris(EPA: 3. 94%,DHA: 8. 10%). Based on the amino acids score(AAS) and chemical score(CS),the first limited amino acid in Lota lota(Linnaeus) was sulfur-containing amino acid(methionine + cysteine). The essential amino acids index(EAAI) of Lota lota(Linnaeus) was 62.58. It is concluded that Lota lota(Linnaeus) is abundant in amino acids and high-unsaturated fatty acids,and rational in composition of amino acids. Thus,Lota lota(Linnaeus) is a high quality freshwater fish with high nutritional value and health value,possessing good exploitation and utilization prospects. | Xu Gefeng Wang Yuyu Bai Qingli Li Xiaolong Jia Zhonghe | 2014 | Animal Husbandry and Feed Science2014，6，4： | 5 |
| 7 | On the horizon of Protopteryx and the early vertebrate fossil assemblages of the Jehol Biota显示文摘Protopteryx, a monotypic fossil bird discovered from the Sichakou basin in Fengning, Hebei, is the most primitive enantiornithine currently known. The bird-bearing strata do not contain the index fossils of the Yixian Formation in western Liaoning; the fish and bird fossils have more primitive features than the related forms found in the Yixian Formation, and the conchostracans are those usually distributed in the Dabeigou and Dadianzi formations in northern Hebei. Besides, the Protopteryx-bearing strata underlie the deposits bearing the index fossils of the Yixian Formation in the neighboring basin. Thus, it could be confirmed that the horizon of Protopteryx should be lower than the Yixian Formation, and is approximately equivalent to the Dadianzi Formation in northern Hebei. This is the lowest horizon of the known fossil birds in China and Mesozoic enantiornithine birds in the world. Accompanying Protop- teryx, there are other birds, acipenseriform fishes, salamanders, and mammals, which compose the Peipiaosteus fengningensis-Protopteryx fengningensis assemblage. This new assemblage traces the vertebrate evolution history of the Jehol Biota back to 130.7 Ma before. It is suggested that the de- marcation of the Jehol Biota should be based on the large-scale tectonic-sedimentary cycles, and Peipiaosteus, instead of Lycoptera, could be taken as the vertebrate representative of the Jehol Biota. | JIN Fan ZHANG FuCheng LI ZhiHeng ZHANG JiangYong LI Chun ZHOU ZhongHe | 2008 | Chinese Science Bulletin2008，53，18： | 5 |
| 8 | GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth显示文摘 | Bicheng Zhan Jun Huang Hong-Liang Li Ting Liu Yan-Yi Wang Paul Waterman Ai-Ping Mao Liang-Guo Xu Zhonghe Zhai Depei Liu Philippa Marrack Hong-Bing Shu | 2008 | Cell Research2008，18，9： | 4 |
| 9 | Recombinant soluble TRAIL induces apoptosis of cancer cells显示文摘TRAIL is a tumor necrosis factor family member that selectively induces apoptosis of cancer cells but not of normal cells. To develop TRAIL into a potential cancer drug, three different sizes of soluble TRAIL fragments, including sTRAIL(74 - 281), sTRAIL(95 - 281) and sTRAIL(101-281), were expressed in E. coli and purified to homogeneity. Apoptosis assays indicated that sTRAIL(95-281) and sTRAIL(101-281), but not sTRAIL(74-281), can potently induce apoptosis of various cancer cell lines in 6 h, suggesting that the N-terminal fragment of aa101 has inhibitory effect on TRAIL-induced apoptosis. Moreover, we found that some cancer cells were resistant to TRAIL and the resistant cells could be converted into sensitive cells by treatment with the protein synthesis inhibitor cycloheximide, suggesting that one or more short-lived proteins are responsible for cells’ resistance to TRAIL. | LI Lianyun HU Jiancheng BIN Lianghua LI Lixia ZHA Jikun XU Liangguo ZHANG Zhen ZHAI Zhonghe SHU Hongbing | 2001 | Chinese Science Bulletin2001，46，24： | 2 |
| 10 | Design and control of chemical compositions for high-performance austempered ductile iron显示文摘This paper presents the effects of chemical compositions of austempered ductile iron(ADI)on casting quality,heat treatment process parameters and mechanical properties of final products.Through experiment and production practice,the impacts of carbon equivalent on ADI and its mechanical properties have been studied. Proper content ranges for carbon and silicon have been obtained to avoid ADI casting shrinkage and graphite floatation,as well as to achieve the optimal mechanical properties.According to the impact of silicon content on austenite phase transformation,the existing form of carbon in ADI has been analyzed,and also the formula and diagram showing the relationship between austenitizing temperature and carbon content in austenite have been deduced.The chemical composition range for high performance ADI and its control points have been recommended, to serve as a reference for production process. | Gong Wenbang Chen Guodong Luo Li Hao Jing Zhang Zhonghe | 2012 | China Foundry2012，9，2： | 2 |
| 11 | Theory and Design of Microwave-Tube Simulator Suite显示文摘 | Li Bin Yang Zhongh Hai Li Jian Qing | 2009 | IEEE Trans on Electron Devices2009，56，5： | 1 |
| 12 | Application of catalytic wet oxidation for the treatment of H-acid manufacturing process wastewater显示文摘 | ZHU Wangpeng BIN Yuejing LI Zhonghe | 2002 | Water Research2002，36，8： | 1 |
| 13 | Application of catalytic wet oxidation for the treatment of H-acid manufacturing process wastewater显示文摘 | Zhu Wangpeng Bin Yuejing Li Zhonghe | 2002 | Wat Res2002，36，8： | 1 |
| 14 | Application of catalytic wet air oxidation for the treatment of H-acid manufacturing process wastewater 显示文摘 | ZHU Wanpeng BIN Yuejing LI Zhonghe | 2002 | Water Research2002，36，8： | 1 |
| 15 | Application of Catalytic Wet Air Oxidation for the Treatment of H-Acid Manufacturing Process Wastewater显示文摘 | Zhu Wanpeng Bin Yuejing Li Zhonghe | | 0，，8： | 1 |
| 16 | Application of catalytic wet air oxidation for the treatment of H-acid manufacturing process wastewater显示文摘 | Zhu Wanpeng Bin Yuejing Li Zhonghe | 2002 | Water Research2002，36，8： | 1 |
| 17 | Water-rock interaction in CO2 sequestration in a depleted oil reservoir pilot test 显示文摘 | Pang Zhonghe Kong Yanlong Li Yiman | 2013 | Procedia Earth and Planetary Science2013，，7： | 1 |
| 18 | Application of catalytic wet air oxidation for the treatment of H-acid manufacturing process wastewater显示文摘 | ZHU Wanpeng BIN Yuejing LI Zhonghe | 2002 | Water Research2002，36，8： | 1 |
| 19 | Application of catalytic wet air oxidation for the treatment of H-acid manufacturing process wastewater显示文摘 | Zhu Wanpeng Bin Yuejing Li Zhonghe | 2002 | Water Research2002，36，： | 1 |
| 20 | Application of catalytic wet air oxidation foin the treatment of H-acid manufacturing process wastewater 显示文摘 | Bin Yuejing Li Zhonghe | 2002 | Water Research2002，36，： | 1 |
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