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| 1 | BLOC-2 subunit HPS6 deficiency affects the tubulation and secretion of von Willebrand factor from mouse endothelial cells显示文摘Hermansky-Pudlak syndrome(HPS) is a recessive disorder with bleeding diathesis, which has been linked to platelet granule defects. Both platelet granules and endothelial Weibel-Palade bodies(WPBs)are members of lysosome-related organelles(LROs) whose formation is regulated by HPS protein associated complexes such as BLOC(biogenesis of lysosome-related organelles complex)-1,-2,-3, AP-3(adaptor protein complex-3) and HOPS(homotypic fusion and protein sorting complex). Von Willebrand factor(VWF) is critical to hemostasis, which is stored in a highly-multimerized form as tubules in the WPBs. In this study, we found the defective, but varying, release of VWF into plasma after desmopressin(DDAVP) stimulation in HPS1(BLOC-3 subunit), HPS6(BLOC-2 subunit), and HPS9(BLOC-1 subunit)deficient mice. In particular, VWF tubulation, a critical step in VWF maturation, was impaired in HPS6 deficient WPBs. This likely reflects a defective endothelium, contributing to the bleeding tendency in HPS mice or patients. The differentially defective regulated release of VWF in these HPS mouse models suggests the need for precise HPS genotyping before DDAVP administration to HPS patients. | Jing Ma Zhe Zhang Lin Yang Janos Kriston-Vizi Daniel F.Cutler Wei Lia | 2016 | Journal of Genetics and Genomics2016，43，12： | 4 |
| 2 | Tunica albuginea allograft: a new model of LaPeyronie's disease with penile curvature and subtunical ossification显示文摘LaPeyronie 的疾病(PD ) 的 pathophysiology 被认为是 multifactorial,包含愈合的基因倾向,损伤,发炎和改变的创伤。然而,这些因素还没用动物模型被验证了。在这研究,我们介绍了 tunica albuginea allograft 获得的一个新模型。40 的一个总数, 16-week-old 男性老鼠被使用。这些, 8 只老鼠用作控制并且经历了 10 ×有随后的 autografting 的 2-mm-wide tunical 切除,而留下 32 与另一只老鼠的 tunica 与缺点的 grafting 经历了一样的切除。词法、功能测试在 grafting 以后在 1, 3, 7 和 12 个星期被执行。Intracavernous 压力,阴茎弯曲的度和有弹性的纤维长度为在 allograft 和控制组之间的比较被评估。纸巾为组织学的检查被获得。阴茎弯曲作为与控制老鼠相比在 allografted 老鼠是显著地更大的。可勃起的功能在所有老鼠被维持,除了在在 12 个星期估计的那些。弹力素纤维长度作为与控制相比在 allografted tunica 被减少。SMAD2 表示在 allograft 的内部部分被检测,并且 collagen-II- 和 osteocalcin 积极的房间也被注意。在老鼠的 Tunica albuginea (TA ) allograft 是 PD 的一个优秀模型。在 12 个星期和在 TA 的内部层的骨化的存在以后的弯曲的坚持类似于与 PD 在人观察的那些。用这个动物模型的确认研究将为有效治疗学的干预帮助 PD pathophysiology 的理解。 | Ludovic Ferretti Thomas M Fandel Xuefeng Qiu Haiyang Zhang Hazem Orabi Alex K Wu Lia Banie Guifang Wang Guiting Lin Ching-Shwun Lin Tom FLue | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 3 | Effects of Estrogen Raloxi fene and Levormeloxifene onal A- Adrenergic receptor expression 显示文摘 | Lia Banie Guiting Lin Hong xiu Ning | 2010 | Urology2010，180，5： | 1 |
| 4 | Spatial patterns and climate drivers of carbon fluxes in terrestrial ecosystems of China显示文摘 | Gui‐Rui Yu Xian‐Jin Zhu Yu‐Ling Fu Hong‐Lin He Qiu‐Feng Wang Xue‐Fa Wen Xuan‐Ran Li Lei‐Ming Zhang Li Zhang Wen Su Sheng‐Gong Li Xiao‐Min Sun Yi‐Ping Zhang Jun‐Hui Zhang Jun‐Hua Yan Hui‐Min Wang Guang‐Sheng Zhou Bing‐Rui Jia Wen‐Hua Xiang Ying‐Nian Li Lia | 2012 | Glob Change Biol2012，，3： | 1 |
| 5 | Complex coacervates obtained from interaction egg yolk lipoprotein and polysaccharides显示文摘 | Clitor J.F. Souza Edwin E. Garcia Rojas Nathália R. Melo A. Gaspar J.F.C. Lins | 2013 | Food Hydrocolloids2013，，： | 1 |
| 6 | Acid-base enrichment enhances anaerobic hydrogen production process显示文摘 | CHEN Chinchao LIN Chiuyue LIA Mincheng | 2002 | Applied Microbiology Biotechnology2002，58，2： | 1 |
| 7 | Treatment of stress urinary incontinence with adipose tissue-derived stem cells显示文摘 | Guiting Lin Guifang Wang Lia Banie Hongxiu Ning Alan W. Shindel Thomas M. Fandel Tom F. Lue Ching-Shwun Lin | 2010 | Cytotherapy2010，，1： | 1 |
| 8 | Therapeutic Time window for the application of chondroitinase ABC after spinal cord in jury显示文摘 | Garca A lias G Lin R | 2008 | Exp Neurol2008，210，2： | 1 |
| 9 | Spatial patterns and climate drivers of carbon fluxes in terrestrial ecosystems of China显示文摘 | Gui‐Rui Yu Xian‐Jin Zhu Yu‐Ling Fu Hong‐Lin He Qiu‐Feng Wang Xue‐Fa Wen Xuan‐Ran Li Lei‐Ming Zhang Li Zhang Wen Su Sheng‐Gong Li Xiao‐Min Sun Yi‐Ping Zhang Jun‐Hui Zhang Jun‐Hua Yan Hui‐Min Wang Guang‐Sheng Zhou Bing‐Rui Jia Wen‐Hua Xiang Ying‐Nian Li Lia | 2012 | Glob Change Biol2012，，3： | 1 |
| 10 | Characterization of polyethylene glycol - modified proteins by semi - aqueous capillary electrophoresis显示文摘 | LIA Weijun ZHONG Yi LIN Bingcheng | 2001 | J Chroma A2001，905，： | 1 |
| 11 | Low-density lipoprotein augments interleukin-1-induced vascular adhesion molecule expression in human endothelial cells显示文摘 | Zhu Y Lia HL Lin JH | 1999 | Atherosclerosis1999，144，2： | 1 |
| 12 | Synthesis and coating of micro metal matrix composite by combined laser sol-gel processing显示文摘 | Tamer Ezz Philip Crouse Lin Lia | 2007 | Surface and Coatings Technology2007，201，： | 1 |
| 13 | Preparation,physicochemical characterization and cytotoxicity in vitro of gemcitabine-loaded PEG-PDLLA nanovesicles显示文摘AIM:To investigate the preparation,physicochemical characterization and cytotoxicity in vitro of Gemcitabine-loaded poly(ethylene glycol)-block-poly(D,L-lactide) (PEG-PDLLA) nanovesicles. METHODS:The nanovesicle carriers were prepared from the amphiphilic block copolymer of PEG-PDLLA by a double emulsion technique,and gemcitabine was used as the model drug. The morphology of the nanovesicles was determined by scanning and transmission electron microscopy,and the drug content,drug entrapment and drug-release curve in vitro were detected by UV-Vis-NIR spectrophotometry. Cytotoxicity in the human pancreatic cancer cell line SW1990 was tested by 3-(4,5-dimethyl) ethiazole (MTT) assay.RESULTS:The gemcitabine-loaded nanovesicles were hollow nanospheres with a mean size of 200.6 nm,drugloading of 4.14% and drug embedding ratio of 20.54%. The nanovesicles showed excellent controlled release that was characterized by a fast initial release during the first 72 h,followed by a slower and continuous release. The MTT assay demonstrated that gemcitabine-loaded nanovesicles exhibited dose-dependent and time-delayed cytotoxicity in the human pancreatic cancer cell line SW1990.CONCLUSION:Gemcitabine-loaded PEG-PDLLA nanovesicles prepared by a double emulsion technique exhibited good performance for controlled drug release,and had similar cytotoxic activity to free gem-citabine. | Lia, Lin Zheng, Jian-Jun Jiang, Shu-Man Huang, Kai-Hong | 2010 | World Journal of Gastroenterology2010，16，8： | 1 |
| 14 | Influence of cetyhrimethylammonium bromide on physicochemical properties and microstructures of chitosan-TPP nanoparticles in aqueous solutions 显示文摘 | Bao Hongqian Lia Lin Zhang Hongbin | 2008 | Journal of Colloid and Interface Science2008，328，： | 1 |
| 15 | Treatment of stress urinary incontinence with adipose tissue-derived stem cells显示文摘 | Guiting Lin Guifang Wang Lia Banie Hongxiu Ning Alan W. Shindel Thomas M. Fandel Tom F. Lue Ching-Shwun Lin | 2010 | Cytotherapy2010，，1： | 1 |
| 16 | Treatment of stress urinary incontinence with adipose tissue-derived stem cells显示文摘 | Guiting Lin Guifang Wang Lia Banie Hongxiu Ning Alan W. Shindel Thomas M. Fandel Tom F. Lue Ching-Shwun Lin | 2010 | Cytotherapy2010，，1： | 1 |
| 17 | Agglomer- ation and Productivity: Firm- level Evidence from China's Textile Industry 显示文摘 | Hui - Lin Lina Hsiao- Yun Lia Chih- Hai Yang | 2011 | China Economic Review2011，，31： | 1 |
| 18 | Process per-formance evaluation of intermittent-continuous stirred tank reactor for anaerobic hydrogen fermentation with kitchen waste显示文摘 | Shiue Lin Lia Shih Chiang Kuoa Jian Sheng Lin | 2008 | Interna-tional journal of hydrogen energy2008，33，： | 1 |
| 19 | 显示文摘 | Lin H T Chen X Y Lia H L | 2010 | Mater Lett2010，64，15： | 1 |
| 20 | Synthesis and Characterization of ZnO Bicrystalline Nanosheets Grown via Ag-Au Alloy Catalyst显示文摘ZnO bicrystalline nanosheets 被在 650 《经由蒸汽运输和冷凝作用方法使用 Ag x Au 1x 合金催化剂综合了@ | Zhi-wei Gao Yue Lin Jun-wen Lia Xiao-ping Wang | 2014 | Chinese Journal of Chemical Physics2014，27，3： | 0 |
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