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| 1 | Psychosocial factors and their association with reflux oesophagitis,Barrett's oesophagus and oesophageal adenocarcinoma显示文摘AIM:To investigate the role of psychological characteristics as risk factors for oesophageal adenocarcinoma(OAC),as well as the reflux-mediated precursor pathway.METHODS:An all-Ireland population-based case-control study recruited 230 reflux oesophagitis(RO),224 Barrett's oesophagus(BO) and 227 OAC patients and 260 controls.Each case/control group completed measures of stress,depression,self-efficacy,self-esteem,repression and social support.A comparative analysis was undertaken using polytomous logistic regression adjusted for potential confounders.RESULTS:Compared to controls,OAC patients were almost half as likely to report high stress levels over their lifetime(P = 0.010,OR 0.51;95%CI:0.29-0.90)and 36% less likely to report having experienced depression(OR 0.64;95%CI:0.42-0.98).RO patients reported significantly higher stress than controls particularly during middle-and senior-years(P for trends < 0.001).RO patients were 37% less likely to report having been highly emotionally repressed(OR 0.63;95%CI:0.41-0.95).All case groups(OAC,RO and BO) were more likely than controls to report having had substantial amounts of social support(OR 2.84;95%CI:1.63-4.97;OR 1.97;95%CI:1.13-3.44 and OR 1.83;95%CI:1.03-3.24,respectively).CONCLUSION:The improved psychological profile of OAC patients may be explained by response shift.The role of psychological factors in the development of OAC requires further investigation. | Paul Denver Michael Donnelly Liam J Murray Lesley A Anderson | 2013 | World Journal of Gastroenterology2013，19，11： | 5 |
| 2 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 3 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 4 | A machine learning approach to model solute grain boundary segregation显示文摘Even minute amounts of one solute atom per one million bulk atoms may give rise to qualitative changes in the mechanical response and fracture resistance of modern structural materials.These changes are commonly related to enrichment by several orders of magnitude of the solutes at structural defects in the host lattice.The underlying concept—segregation—is thus fundamental in materials science.To include it in modern strategies of materials design,accurate and realistic computational modelling tools are necessary.However,the enormous number of defect configurations as well as sites solutes can occupy requires models which rely on severe approximations.In the present study we combine a high-throughput study containing more than 1 million data points with machine learning to derive a computationally highly efficient framework which opens the opportunity to model this important mechanism on a routine basis. | Liam Huber Raheleh Hadian Blazej Grabowski Jörg Neugebauer | 2018 | npj Computational Materials2018，，1： | 2 |
| 5 | Infection with virulent strains of helicobacter pylori is not associated with ischaemic heart disease:evidence from a population-based case-control study of myocardial infarction显示文摘 | Liam J Kathy B Bamford F K | 2000 | Atherosclerosis2000，149，： | 2 |
| 6 | Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis显示文摘 | Juan P Casas Weiliang Chua Stavros Loukogeorgakis Patrick Vallance Liam Smeeth Aroon D Hingorani Raymond J MacAllister | 2005 | The Lancet2005，，9502： | 1 |
| 7 | Dynamic characteristics of a base isolated building from ambient vibration measurements and low level earthquake shaking 显示文摘 | Ventura C E Liam F W D Lord J F | 2003 | Soil Dynamics and Earthquake Engineering2003，23，4： | 1 |
| 8 | Dynamic characteristics of a base isolated building from ambient vibration measurements and low level earthquake shaking显示文摘 | Ventura C E Liam Finn W D Lord J F | 2003 | Soil Dynamics and Earthquake Engineering2003，23，： | 1 |
| 9 | Mortality from pandemic A/ H1N1 2009 influenza in England:public health surveillance study 显示文摘 | Liam J Donaldson Paul D Rutter | 2009 | BMJ2009，339，： | 1 |
| 10 | Learning representations by backpropagating er- rors 显示文摘 | David E Rumelhart Geoffrey E Hintont Ronald J Wil- liams | 1986 | Nature1986，323，6088： | 1 |
| 11 | Development of an ELISA for detection of antibodies to avian reovirus in chickens显示文摘 | Liu Hung J Liam C Kuo Yu C Hu | 2002 | J Virol Meth2002，102，： | 1 |
| 12 | Development of an ELISA for detection of antibodies to avian reovirus in chickens显示文摘 | Hung J Liu Liam C Kuo Yu C Hu | 2002 | Journal of Virological Methods2002，102，： | 1 |
| 13 | Sex-specific associations between body mass index, waist circumference and the risk of Barrett’s oesophagus: a pooled analysis from the international BEACON consortium显示文摘 | Ai Kubo Michael Blaise Cook Nicholas J Shaheen Thomas L Vaughan David C Whiteman Liam Murray Douglas A Corley | 2013 | Gut2013，，12： | 1 |
| 14 | Infection with virulent strains of Helicobacter pylori is not associated with ischaemic heart disease: evidence from a population-based case-control study of myocardial infarction显示文摘 | Liam J Kathy B Bamford Fk | 2000 | Atherosclerosis2000，149，2： | 1 |
| 15 | Basilar and distal vertebral artery stenosis long- term follow-up显示文摘 | Moufarrij N A Little J R Furlan A J Leatherman J R Wil- liams G W | 1986 | Stroke1986，17，： | 1 |
| 16 | Gastro - oesoph- ageal reflux disease in ' difficult - to - control' asthma : prevalence and response to treatment with acid suppres- sive therapy 显示文摘 | Wong C H Chua C J Liam C K | 2006 | Aliment Pharmacol Ther2006，23，9： | 1 |
| 17 | The impact of consumer involvement on satisfaction with and use ofassistive technology显示文摘 | Martin Jay K Martin Liam G Stumbo Norma J | 2010 | Disability and Rehabilitation: Assistive Technology2010，6，3： | 1 |
| 18 | Hemodilution and whole body oxygen balance during normothemic cardiopulmonary bypass in dogs 显示文摘 | Liam BL Plochl W Cook D J | 1998 | J Thorac Cardiovasc Surg1998，115，5： | 1 |
| 19 | Paediatric mortality related to pandemic influenza A H1N1 infection in England: an observational population-based study显示文摘 | Nabihah Sachedina Liam J Donaldson | 2010 | The Lancet2010，，9755： | 1 |
| 20 | Characterization of the timing and prevalence of receptor tyrosine kinase expression changes in oesophageal carcinogenesis显示文摘 | Anna L Paterson Maria O’Donovan Elena Provenzano Liam J Murray Helen G Coleman Brian T Johnson Damian T McManus Marco Novelli Laurence B Lovat Rebecca C Fitzgerald | 2013 | J Pathol2013，，1： | 1 |
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