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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | RDX crystals with high sphericity prepared by resonance acoustic mixing assisted solvent etching technology显示文摘In order to obtain high-quality spherical RDX crystal particles,the RDX crystals were suspended in a mixed solvent of cyclohexanone and cyclohexane,subsequently a solvent etching study was carried out under the action of vibration/acoustic flow coupled flow field,which generated by resonance acoustic mixing.The effects of solvent ratio,temperature,acceleration and experiment time on morphology as well as particle size of RDX crystals were studied.Not only were the morphology,particle size distribution and crystal form of RDX crystals determined,but also the thermal decomposition performance and mechanical sensitivity of spherical RDX were examined and discussed.Results indicated that under the process of solvent/non-solvent volume ratio at 1:2,temperature of 40℃,acceleration of 40 g and experiment time of 4 h,α-type RDX crystal with sphericity of 0.92 can be obtained.Furthermore,the median particle size(D_(50))of spherical RDX crystals is 215.8 μm with a unimodal particle size distribution(size span 1.34).For one thing,the thermal decomposition peak temperature of spherical RDX is about 2.5℃ higher than that of raw RDX,and apparent activation energy reaches 444.68 kJ/mol.For another thing,impact sensitivity and friction sensitivity of spherical RDX are 18.18% and 33.33% lower than that of raw RDX,respectively.It demonstrates that safety of spherical RDX under thermal,impact and friction stimuli has been improved. | Dongjie Liao Qian Liu Chunyan Li Ning Liu Mingchang Wang Chongwei An | 2023 | Defence Technology(防务技术)2023，28，10： | 1 |
| 3 | Purification and Characterization of Cry1Ac Toxin Binding Proteins from the Brush Border Membrane of Helicoverpa armigera Midgut显示文摘 | Chunyan Liao Stephen C. Trowell Ray Akhurst | 2005 | Current Microbiology2005，，6： | 1 |
| 4 | High-reflectance 193nm Al2O3/MgF2 mirrors 显示文摘 | Shang Shuzhen Shao Jianda Liao Chunyan Yi Kui Fan Zhengxiu Chen Lei | 2005 | Applied Surface Science2005，249，： | 1 |
| 5 | Fabrication of core–shell microspheres using alginate and chitosan–polycaprolactone for controlled release of vascular endothelial growth factor显示文摘 | Hua Wu Chunyan Liao Qianyi Jiao Zheng Wang Wenze Cheng Ying Wan | 2012 | Reactive and Functional Polymers2012，，7： | 1 |
| 6 | Azobenzene quaternary ammonium salt for photo-controlled and reusable disinfection without drug resistance显示文摘The abuse of antibiotics causes severe bacterial resistance, and the shortage of antibiotics has created a global public health crisis. This situation has prompted people to develop new antibacterial agents independent of traditional antibiotics. Here, we created a series of photosensitive azobenzene-quaternary ammonium salt smart antibacterial agents by connecting azobenzene with amines with different chain lengths to improve the antibacterial selectivity of quaternary ammonium salt(QAS) and prevent the accumulation of active QAS in the environment. After trans-cis isomerization, the solubility of the title compound(compound 4) increased and the antibacterial property enhanced. The experimental results suggested that the antibacterial effect of compound 4 was significantly enhanced after 365 nm light irradiation, and it had photosensitive intelligent antibacterial activity and could be reused. Notably, we did not obtain any mutants of Staphylococcus aureus or Escherichia coli resistant to compound 4. In general,compound 4 has the advantages of high yield, photo-controllable antibacterial properties, reusability, and does not induce bacterial resistance. This photosensitive antibacterial compound provides a new idea for the construction of intelligent disinfectants and is expected to be a candidate for disinfectants in public facilities and medical architecture. | Yuhong Zhu Pengfei Li Caikun Liu Mengqi Jia Yadong Luo Dengfeng He Chunyan Liao Shiyong Zhang | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 7 | Binding of Cry δ-endotoxins to brush border membrane vesicles of Helicoverpa armigera and Helicoverpa punctigera (Lepidoptera: Noctuidae)显示文摘到 Cry1Ac 的 Helicoverpa 有佩带徽章权利的人 a 的相对低的危险性,它到在在转基因的棉花的 Cry1Ac 的表示的化学杀虫药剂和季节的衰落的抵抗的历史要求了表示二杀虫的蛋白质提供这个多民族的害虫的持续控制的棉花的开发。管理抵抗问题,第二杀虫的蛋白质有行动 toCry1Ac 的一个显著地不同的模式,是必要的。到在象 H 一样的几种的 Cry1A 蛋白质的抵抗的一个普通特征。有佩带徽章权利的人啊哈是在有约束力的地点的一个变化。为在刷子的一些叫喊蛋白质的有约束力的地点的研究毗邻 H 的膜泡(BBMV ) 。有佩带徽章权利的人 and Helicoverpa punctigera 被承担。为 Cry1Ac 的 Thebinding 亲密关系比为 Cry1Ab 高,匹配他们毒性, andCry1Ac 和 Cry1Ab 被发现分享在两 H 的至少一个有约束力的地点的亲戚。有佩带徽章权利的人 and H.punctigera。然而, Cry2Aa 没为绑定与 Cry1Ac 竞争能那么与 Cry1Ac 在联合在转基因的棉花被使用控制 H。有佩带徽章权利的人一 and 管理抵抗。Variationin 三不同 H 的危险性。有佩带徽章权利的人一到 Cry1Ac 的紧张与参数 B_( 最大)/K_(com ) 相关。 | CHUNYAN LIAO LIZ BROOKS STEPHEN C. TROWELL RAYMOND J. AKHURST | 2005 | Insect Science2005，12，4： | 0 |
| 8 | Cross-linked lipoic acid nanocapsules serve as H_(2)O_(2) amplifier to strengthen the H_(2)O_(2)-sensitive prodrug activation显示文摘The H_(2)O_(2) -triggered prodrug activation represents a hot topic while the low H_(2)O_(2) level of cancer cells hindered the complete activation of parent drugs and resulted in the poor therapeutic effect. Here, we developed an H_(2)O_(2) amplifier fabricated by crosslinked lipoic acid nanocapsules(cLANCs), which would selectively elevate the intracellular H_(2)O_(2) level of cancer cells 3.4-fold higher than that of untreated cancer cells so as to speed up the activation of parent drug from the loaded prodrugs(Pro-5-FU). The cytotoxicity showed that the killing effect of Pro-5-FU loaded in cLANCs(Pro-5-FU@cLANCs) arrived up to 1.6-time higher than that of Pro-5-FU alone against A549 cells, and was even close to free 5-FU. The in vivo anticancer evaluation gave the tumor inhibition rate(TIR) and survival rate(SR) of Pro-5-FU@cLANCs against A549 tumor-bearing nude mice up to 73.1% and 80%,respectively, much higher than those of Pro-5-FU(TIR: 41.2%, SR: 20%) or free 5-FU(TIR: 50.6%, SR: 0%). This nanodrug constructed the first example that utilizes the drug carriers as H_(2)O_(2) amplifier to strengthen the prodrug activation. | Jiangbing Tan Pei Jing Xiao Xiao Yulong Liao Chunyan Liao Shiyong Zhang | 2023 | Science China Chemistry2023，66，9： | 0 |
| 9 | Characterization of Nucleation Behavior in Temperature-Induced BCC-to-HCP Phase Transformation for High Entropy Alloy显示文摘Phase transformation is one of the essential topics in the studies on high entropy alloys(HEAs).However,characterization of the nucleation behavior in the phase transformation for HEAs is still challenging through experimental methods.In the present work,HfNbTaTiZr HEA was chosen as the representative material,and molecular dynamics/Monte Carlo(MD/MC)simulations were performed to investigate the nucleation behavior in temperature-induced BCC-to-HCP transformation for this HEA system.The results indicate that Nb–Ta,Ti–Zr,Hf–Zr and Hf–Ti atom pairs are preferred in the BCC solid solution of HfNbTaTiZr HEA and Hf–Ti–Zr-rich atom cluster with chemical short range order acts as the nucleation site for HCP phase.The nucleation process follows the non-classical two-step nucleation model:BCC-like structure with severe lattice distortion forms first and then HCP structure nucleates from the BCC-like structure.Moreover,at low temperature,the BCC-to-HCP nucleation hardly occurs,and the BCC solid solution is stabilized.The present work provides more atomic details of the nucleation behavior in temperature-induced BCC-to-HCP phase transformation for HEA,and can help in deep understanding of the phase stability for HEAs. | Xiusong Huang Lehua Liu Weibing Liao Jianjun Huang Huibin Sun Chunyan Yu | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，11： | 0 |
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