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| 1 | The CAMS Climate System Model and a Basic Evaluation of Its Climatology and Climate Variability Simulation显示文摘A new coupled climate system model(CSM) has been developed at the Chinese Academy of Meteorological Sciences(CAMS) by employing several state-of-the-art component models. The coupled CAMS-CSM consists of the modified atmospheric model [ECmwf-HAMburg(ECHAM5)], ocean model [Modular Ocean Model(MOM4)], sea ice model [Sea Ice Simulator(SIS)], and land surface model [Common Land Model(CoLM)]. A detailed model description is presented and both the pre-industrial and 'historical' simulations are preliminarily evaluated in this study.The model can reproduce the climatological mean states and seasonal cycles of the major climate system quantities,including the sea surface temperature, precipitation, sea ice extent, and the equatorial thermocline. The major climate variability modes are also reasonably captured by the CAMS-CSM, such as the Madden–Julian Oscillation(MJO), El Ni?o–Southern Oscillation(ENSO), East Asian Summer Monsoon(EASM), and Pacific Decadal Oscillation(PDO).The model shows a promising ability to simulate the EASM variability and the ENSO–EASM relationship. Some biases still exist, such as the false double-intertropical convergence zone(ITCZ) in the annual mean precipitation field,the overestimated ENSO amplitude, and the weakened Bjerknes feedback associated with ENSO; and thus the CAMS-CSM needs further improvements. | Xinyao RONG Jian LI Haoming CHEN Yufei XIN Jingzhi SU Lijuan HUA Tianjun ZHOU Yanjun QI Zhengqiu ZHANG Guo ZHANG Jianduo LI | 2018 | Journal of Meteorological Research2018，32，6： | 15 |
| 2 | Longitudinal study of a community hospital integrated model for diabetes management in the Beijing Jingsong community显示文摘Objective:To determine the effects of a community hospital integrated model on the longitu-dinal management of diabetic patients.Methods:Four hundred forty-one patients with type 2 diabetes residing in Jingsong Commu-nity were randomly assigned to intensive and standard groups.Metabolic parameters were meas-ured in the two groups at baseline and after 36 months of management to compare the rate of goal achievement.Results:After comprehensive management,the overall control rate in the intensive group was increased from 2.7%to 9.6%compared with 2.3%-4.5%in the standard group.Specifically,the control rates for fasting plasma glucose,glycosylated hemoglobin,and blood pressure in the intensive group were significantly increased from 54.1%,40.0%,and 68.2%to 85.5%,74.6%,and 89.1%,respectively.The control rate for glycosylated hemoglobin in the intensive group was significantly higher than the standard group after 36 months of treatment.Conclusion:The community hospital integrated model for longitudinal management effec-tively improved the control rate of glycosylated hemoglobin and the overall control rate in patients with type 2 diabetes. | Jiandong Zhang Ning Zhuang Mingxia Yuan Lijuan Gao Chuan Bian Huaining Chen Qing Chi Suqing Hui Guiying Li Yanli Su Hongsong Bao Gang Wan Guangran Yang Shenyuan Yuan | 2014 | Family Medicine and Community Health2014，2，1： | 7 |
| 3 | Mechanically reprogrammable Pancharatnam-Berry metasurface for microwaves显示文摘Metasurfaces have enabled the realization of several optical functionalities over an ultrathin platform,fostering the exciting field of flat optics.Traditional metasurfaces are achieved by arranging a layout of static meta-atoms to imprint a desired operation on the impinging wavefront,but their functionality cannot be altered.Reconfigurability and programmability of metasurfaces are the next important step to broaden their impact,adding customized on-demand functionality in which each meta-atom can be individually reprogrammed.We demonstrate a mechanical metasurface platform with controllable rotation at the meta-atom level,which can implement continuous Pancharatnam–Berry phase control of circularly polarized microwaves.As the proof-of-concept experiments,we demonstrate metalensing,focused vortex beam generation,and holographic imaging in the same metasurface template,exhibiting versatility and superior performance.Such dynamic control of electromagnetic waves using a single,low-cost metasurface paves an avenue towards practical applications,driving the field of reprogrammable intelligent metasurfaces for a variety of applications. | Quan Xu Xiaoqiang Su Xueqian Zhang Lijuan Dong Lifeng Liu Yunlong Shi Qiu Wang Ming Kang Andrea Alù Shuang Zhang Jiaguang Han Weili Zhang | 2022 | Advanced Photonics2022，4，1： | 5 |
| 4 | Analyzing and Forecasting Climate Change in Harbin City,Northeast China显示文摘Based on sounding data from 1975 to 2005 and TM/ETM+ remote sensing images in 1989, 2001 and 2007, the climate changes in Harbin City, Northeast China in recent 30 years were analyzed and forecasted. Results show that in the lower troposphere the meridional wind speed and mean annual wind speed decrease, and in the lower stratosphere the temperature decreases while the meridional wind speed increases significantly. In the study area, the climate is becoming warmer and wetter in the middle lower troposphere. The expansion of urban area has great effects on the surface air temperature and the wind speed, leading to the increase of the surface air temperature, the decrease of the surface wind speed, and the increase of the area of urban high temperature zone. The quantitative equations have been established among the surface air temperature, the carbon dioxide (CO2) concentration and the specific humidity (the water vapor content). It is predicted that the future increasing rate of the surface air temperature is 0.85℃/10yr if emission concentration of CO2 remains unchanged; if emission concentration of CO2 decreases to 75%, 50% and 25%, respectively, the surface air temperature will increase 0.65℃/10yr, 0.46℃/10yr and 0.27℃/10yr, respectively. The rise of the surface air temperature in the study area is higher than that of the global mean temperature forecasted by IPCC. | ZHANG Lijuan LIU Dong YAN Xiaodong ZHOU Dongying ZHENG Hong SU Lianling | 2011 | Chinese Geographical Science2011，21，1： | 4 |
| 5 | Preclinical evaluation and pilot clinical study of [^(18)F]AlF-labeled FAPI-tracer for PET imaging of cancer associated fibroblasts显示文摘In recent years,fibroblast activation protein(FAP)has emerged as an attractive target for the diagnosis and radiotherapy of cancers using FAP-specific radioligands.Herein,we aimed to design a novel^(18)Flabeled FAP tracer([^(18)F]Al F-P-FAPI)for FAP imaging and evaluated its potential for clinical application.The[^(18)F]Al F-P-FAPI novel tracer was prepared in an automated manner within 42 min with a non-decay corrected radiochemical yield of 32±6%(n=8).Among A549-FAP cells,[^(18)F]Al F-P-FAPI demonstrated specific uptake,rapid internalization,and low cellular efflux.Compared to the patent tracer[^(18)F]FAPI-42,[^(18)F]Al F-P-FAPI exhibited lower levels of cellular efflux in the A549-FAP cells and higher stability in vivo.Micro-PET imaging in the A549-FAP tumor model indicated higher specific tumor uptake of[^(18)F]Al F-P-FAPI(7.0±1.0%ID/g)compared to patent tracers[^(18)F]FAPI-42(3.2±0.6%ID/g)and[68 Ga]Ga-FAPI-04(2.7±0.5%ID/g).Furthermore,in an initial diagnostic application in a patient with nasopharyngeal cancer,[^(18)F]Al F-P-FAPI and[^(18)F]FDG PET/CT showed comparable results for both primary tumors and lymph node metastases.These results suggest that[^(18)F]Al F-P-FAPI can be conveniently prepared,with promising characteristics in the preclinical evaluation.The feasibility of FAP imaging was demonstrated using PET studies. | Kongzhen Hu Junqi Li Lijuan Wang Yong Huang Li Li Shimin Ye Yanjiang Han Shun Huang Hubing Wu Jin Su Ganghua Tang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 6 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 7 | Sparse representation based on projection method in online least squares support vector machines显示文摘A sparse approximation algorithm based on projection is presented in this paper in order to overcome the limitation of the non-sparsity of least squares support vector machines(LS-SVM).The new inputs are projected into the subspace spanned by previous basis vectors(BV) and those inputs whose squared distance from the subspace is higher than a threshold are added in the BV set,while others are rejected.This consequently results in the sparse approximation.In addition,a recursive approach to deleting an exiting vector in the BV set is proposed.Then the online LS-SVM,sparse approximation and BV removal are combined to produce the sparse online LS-SVM algorithm that can control the size of memory irrespective of the processed data size.The suggested algorithm is applied in the online modeling of a pH neutralizing process and the isomerization plant of a refinery,respectively.The detailed comparison of computing time and precision is also given between the suggested algorithm and the nonsparse one.The results show that the proposed algorithm greatly improves the sparsity just with little cost of precision. | Lijuan LI Hongye SU Jian CHU | 2009 | 控制理论与应用(英文版)2009，7，2： | 2 |
| 8 | The CMIP6 Historical Simulation Datasets Produced by the Climate System Model CAMS-CSM显示文摘This paper describes the historical simulations produced by the Chinese Academy of Meteorological Sciences(CAMS)climate system model(CAMS-CSM),which are contributing to phase 6 of the Coupled Model Intercomparison Project(CMIP6).The model description,experiment design and model outputs are presented.Three members’historical experiments are conducted by CAMS-CSM,with two members starting from different initial conditions,and one excluding the stratospheric aerosol to identify the effect of volcanic eruptions.The outputs of the historical experiments are also validated using observational data.It is found that the model can reproduce the climatological mean states and seasonal cycle of the major climate system quantities,including the surface air temperature,precipitation,and the equatorial thermocline.The long-term trend of air temperature and precipitation is also reasonably captured by CAMS-CSM.There are still some biases in the model that need further improvement.This paper can help the users to better understand the performance and the datasets of CAMS-CSM. | Xinyao RONG Jian LI Haoming CHEN Jingzhi SU Lijuan HUA Zhengqiu ZHANG Yufei XIN | 2021 | Advances in Atmospheric Sciences2021，38，2： | 2 |
| 9 | β-Elemene-loaded polymeric micelles intensify anti-carcinoma efficacy and alleviate side effects显示文摘β-Elemene is a volatile oil used for the treatment of cancer,but poor solubility,low bioavailability,and various adverse reactions limit its application.For amelio rating risks of the venous toxicity ofβ-elemene,intravenously injectable micelle ofβ-elemene was prepared using the thin-film hydration method.The results pointed out the micelles were uniformly spherical with about 20.96±0.1966 nm in average diameter and exhibited high entrapment efficiency(99.02%±0.88%).As revealed by drug release studies in vitro,β-elemene micelles had sustained drug release.Compared with freeβ-elemene,the micelles increased the drug cellular uptake and enhanced the anti-tumor effect in vitro through retarding cell cycle and inducing apoptosis.Meanwhile,the elevated se rum stability o fβ-elemene micelles implied less drug leakage and reduced toxicity.The wound healing and tube formation assay in vitro demonstrated the anti-metastasis and anti-angiogenesis effects ofβ-elemene micelles.Moreover,the pharmacokinetics study showed the AUC and T1/2 ofβ-elemene in micelle group were 1.79 and 1.62 times of that in free fi-elemene group,suggesting the circulation time ofβ-elemene in the blood had been prolonged.In addition,β-elemene micelles showed a favorable antitumor response compared with theβ-elemene solution on C26 colon cance r-bearing mice model.Local irritation study investigated in rabbits indicated that theβ-elemene micelles strikingly mitigated the irritation to the injection sites compared with freeβ-elemene.These results proved that the micelle could be a good candidate as an auspicious drug delivery system ofβ-elemene for the prospective clinical treatment of carcinoma. | Qiaoqiao Hu Lan Bai Zejiang Zhu Zhengying Su Peng Bai Minghai Tang Caixia Dou Junfeng Yan Rongsheng Tong Wuyu Zhang Lijuan Chen Lulu Cai | 2020 | Chinese Chemical Letters2020，31，3： | 2 |
| 10 | Design of OFF/ON fluorescent thiol probes based on coumarin fluorophore显示文摘This paper presents a series of first-and second-generation click-modified coumarin-based fluorescent probes for thiols.These molecules demonstrate high turn-on fluorescent response and good selectivity towards aromatic thiols over other relevant reactive sulfur species,reactive oxygen species and common nucleophiles.Moreover,probe 1a can detect thiols in the reduced rabbit plasma sample.Therefore,this approach provides a particularly impressive tool for detecting thiol in biological systems. | SUN Wei LI Jing LI WenHua SU LiJuan DU LuPei LI MinYong | 2012 | Science China Chemistry2012，55，9： | 2 |
| 11 | Significance of phytosterol analysis to phytosterolemia diagnosis 显示文摘 | Su Yanhua Wang Zhaoyue Cao Lijuan | 2007 | Chinese Journal of Laboratory Medicine2007，30，2： | 1 |
| 12 | Recent advances in quantum dot catalysts for hydrogen evolution:Synthesis,characterization,and photocatalytic application显示文摘Photocatalytic water splitting is beneficial for the effective mitigation of global energy and environmental crises.Owing to multi-exciton generation,impressive light harvesting,and excellent photochemical properties,the quantum dot(QD)-based catalysts reveal a considerable potential in photocatalytic hydrogen(H_(2))production compared with bulk competitors.In this review,we summarize the recent advances in QDs for photocatalytic H_(2) production by enumerating different synthetic and characterization strategies for QDs.Various QDs-based photocatalysts are introduced and summarized in categories,and the role of different QDs in varied systems,as well as the mechanism and key factors that enhance the photocatalytic H_(2) generation performance,is discussed.Finally,conclusions and future perspectives in the exploration of highly efficient QDs-based photocatalysts for innovative applications are highlighted. | Haiwei Su Weikang Wang Run Shi Hua Tang Lijuan Sun Lele Wang Qinqin Liu Tierui Zhang | 2023 | Carbon Energy2023，5，9： | 1 |
| 13 | Finite difference methods for fractional dispersion equation显示文摘 | SU Lijuan WANG Wenqia XU Qiuyan | 2010 | Appl Math Com- put2010，216，： | 1 |
| 14 | A high-accuracy MOC/FD method for solving fractional advection-diffusion equations 显示文摘 | SU Lijuan CHENG Pei | 2013 | Journal of Ap- plied Mathematics2013，，： | 1 |
| 15 | Modeling of isomerization of c8 aromatics by online least squares support vector machine显示文摘 | LI Lijuan SU Hongye CHU Jian | | 0，，17： | 1 |
| 16 | Effect of electroacupuncture at Zusanli(ST 36) on dorsal root nerve signals in normal rats显示文摘OBJECTIVE: To investigate how electroacupuncture (EA) at Zusanli (ST 36) with varying intensities of stimulation affects dorsal root nerve signals in normal rats. METHODS: Adult female Wistar rats were examined after drug-induced anesthesia and isolation of the L4 dorsal root associated with the Zusanli (ST 36) acupoint, using bipolar platinum electrodes. We applied EA at Zusanli (ST 36) with a continuous wave waveform for 1 min, and recorded action potentials in the L4 spinal cord dorsal root nerve with a frequency of 5 Hz and various current intensity levels (approximately 1-4 mA). In addition, we tested EA with a frequency of 15 Hz and current intensity of 1-4 mA. The L4 spinal cord dorsal nerve bundle action potentials were measured for 1 min of EA. To analyze the discharge frequency, we used the maximum Lyapunov exponent and Lempel-Ziv (LZ) complexity. RESULTS: At a fixed frequency, with increasing intensity of EA, dorsal root nerve filament discharge frequency revealed an initial increase, followed by a decreasing trend. A stimulation intensity of 3 mA induced a significantly greater discharge frequency, compared with stimulation intensities of 2 and 4 mA. EA stimulation evoked neuroelectric signals with chaotic characteristics. Increased intensity led to an initial increase in LZ complexity which then decreased, with a stimulation strength of 3 mA inducing the highest level of LZ complexity. CONCLUSION: EA of different intensities can induce nerve action potential encoding with different features. | Su Dongdong Geng Lianqi Zhang Jingsha Chen Yingyuan Liu Yangyang Yan Lijuan Guo Yi | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 1 |
| 17 | An Assessment of CAMS-CSM in Simulating Land–Atmosphere Heat and Water Exchanges显示文摘The Chinese Academy of Meteorological Sciences(CAMS)has been devoted to developing a climate system model(CSM)to meet demand for climate simulation and prediction for the East Asian region.In this study,we evaluated the performance of CAMS-CSM in regard to sensible heat flux(H),latent heat flux(LE),surface temperature,soil moisture,and snow depth,focusing on the Atmospheric Model Intercomparison Project experiment,with the aim of participating in the Coupled Model Intercomparison Project phase 6.We systematically assessed the simulation results achieved by CAMS-CSM for these variables against various reference products and ground observations,including the FLUXNET model tree ensembles H and LE data,Climate Prediction Center soil moisture data,snow depth climatology data,and Chinese ground observations of snow depth and winter surface temperature.We compared these results with data from the ECMWF Interim reanalysis(ERA-Interim)and Global Land Data Assimilation System(GLDAS).Our results indicated that CAMS-CSM simulations were better than or comparable to ERA-Interim reanalysis for snow depth and winter surface temperature at regional scales,but slightly worse when simulating total column soil moisture.The root-mean-square differences of H in CAMS-CSM were all greater than those from the ERA-Interim reanalysis,but less than or comparable to those from GLDAS.The spatial correlations for H in CAMS-CSM were the lowest in nearly all regions,except for North America.CAMS-CSM LE produced the lowest bias in Siberia,North America,and South America,but with the lowest spatial correlation coefficients.Therefore,there are still scopes for improving H and LE simulations in CAMS-CSM,particularly for LE. | Guo ZHANG JiANDuo LI Xinyao RONG Yufei XIN Jian LI Haoming CHEN Jingzhi SU Lijuan HUA | 2018 | Journal of Meteorological Research2018，32，6： | 1 |
| 18 | ^(137)Cs tracing of the spatial patterns in soil redistribution,organic carbon and total nitrogen in the southeastern Tibetan Plateau显示文摘The southeastern Tibetan Plateau,which profoundly affects East Asia by helping to maintain the stability of climate systems,biological diversity and clean water,is one of the regions most vulnerable to water erosion,wind erosion,tillage erosion,freeze-thaw erosion and overgrazing under global climate changes and intensive human activities.Spatial variations in soil erosion in terraced farmland(TL),sloping farmland(SL)and grassland(GL)were determined by the^(137)Cs tracing method and compared with spatial variations in soil organic carbon(SOC)and total nitrogen(total N).The^(137)Cs concentration in the GL was higher in the 0-0.03 m soil layer than in the other soil layers due to weak migration and diffusion under low precipitation and temperature conditions,while the^(137)Cs concentration in the soil layer of the SL was generally uniform in the 0-0.18 m soil layer due to tillage-induced mixing.Low^(137)Cs inventories appeared at the summit and toe slope positions in the SL due to soil loss by tillage erosion and water erosion,respectively,while the highest^(137)Cs inventories appeared at the middle slope posi-tions due to soil accumulation under relatively flat landform conditions.In the GL,the^(137)Cs data showed that higher soil erosion rates appeared at the summit due to freeze-thaw erosion and steep slope gradients and at the toe slope position due to wind erosion,gully erosion,freeze-thaw erosion and overgrazing.The^(137)Cs inventory generally increased from upper to lower slope positions within each terrace(except the lowest terrace).The^(137)Cs data along the terrace toposequence showed abrupt changes in soil erosion rates between the lower part of the upper terrace and the upper part of the immediate terrace over a short distance and net deposition on the lower and toe terraces.Hence,tillage erosion played an important role in the soil loss at the summit slope positions of each terrace,while water erosion dominantly transported soil from the upper terrace to the lower terrace and resulted in net soil deposition on the flat lower terrace.The SOC inventories showed similar spatial patterns to the^(137)Cs inventories in the SL,TL and GL,and significant correlations were found between the SOC and^(137)Cs inventories in these slope landscapes.The total N inventories showed similar spatial patterns to the inventories of,37Cs and SOC,and significant correlations were also found between the total N and^(137)Cs inventories in the SL,TL and GL Therefore,^(137)Cs can successfully be used for tracing soil,SOC and total N dynamics within slope landscapes in the southeastern Tibetan Plateau. | Zhengan Su Lijuan Wang Yihan Liu Bin Fu Jjianhui Zhang Zuo Wu Tao Zhou Junjie Wang | 2023 | International Soil and Water Conservation Research2023，11，1： | 1 |
| 19 | Spectrum reconstructionmethod for airborne temporally- spatial 1 y modulated Fouriertransform imaging spectrometers 显示文摘 | Su Lijuan Yuan Yan Bin Xiangli | 2014 | IEEE Transactions onGeoscience and Remote Sensing2014，52，6： | 1 |
| 20 | Phylogenetic relationships in Leymus (Poaceae: Triticeae) revealed by the nuclear ribosomal internal transcribed spacer and chloroplast trnL-F sequences显示文摘 | Zhipeng Liu Zhongyue Chen Jin Pan Xiaofeng Li Man Su Lijuan Wang Hongjie Li Gongshe Liu | 2007 | Molecular Phylogenetics and Evolution2007，，1： | 1 |
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