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| 1 | Supersonic flow imaging via nanoparticles显示文摘Due to influence of compressibility,shock wave,instabilities,and turbulence on supersonic flows, current flow visualization and imaging techniques encounter some problems in high spatiotemporal resolution and high signal-to-noise ratio(SNR)measurements.Therefore,nanoparticle based planar laser scattering method(NPLS)is developed here.The nanoparticles are used as tracer,and pulse planar laser is used as light source in NPLS;by recording images of particles in flow field with CCD, high spatiotemporal resolution supersonic flow imaging is realized.The flow-following ability of nanoparticles in supersonic flows is studied according to multiphase flow theory and calibrating experiment of oblique shock wave.The laser scattering characteristics of nanoparticles are analyzed with light scattering theory.The results of theoretical and experimental studies show that the dynamic behavior and light scattering characteristics of nanoparticles highly enhance the spatiotemporal resolution and SNR of NPLS,with which the flow field involving shock wave,expansion,Mach disk,boundary layer,sliding-line,and mixing layer can be imaged clearly at high spatiotemporal resolution. | ZHAO YuXin YI ShiHe TIAN LiFeng CHENG ZhongYu | 2009 | Science China(Technological Sciences)2009，52，12： | 31 |
| 2 | Behaviors and kinetics of toluene adsorption-desorption on activated carbons with varying pore structure显示文摘This work was undertaken to investigate the behaviors and kinetics of toluene adsorption and desorption on activated carbons with varying pore structure. Five kinds of activated carbon from different raw materials were selected. Adsorption isotherms and breakthrough curves for toluene were measured. Langmuir and Freundlich equations were fitted to the equilibrium data, and the Freundlich equation was more suitable for simulating toluene adsorption. The process consisted of monolayer, multilayer and partial active site adsorption types. The effect of the pore structure of the activated carbons on toluene adsorption capacity was investigated. The quasi-first-order model was more suitable for describing the process than the quasi-second-order model. The adsorption data was also modeled by the internal particle diffusion model and it was found that the adsorption process could be divided into three stages. In the external surface adsorption process, the rate depended on the specific surface area. During the particle diffusion stage, pore structure and volume were the main factors affecting adsorption rate. In the final equilibrium stage, the rate was determined by the ratio of meso-and macro-pores to total pore volume. The rate over the whole adsorption process was dominated by the toluene concentration. The desorption behavior of toluene on activated carbons was investigated,and the process was divided into heat and mass transfer parts corresponding to emission and diffusion mechanisms, respectively. Physical adsorption played the main role during the adsorption process. | Xi Yang Honghong Yi Xiaolong Tang Shunzheng Zhao Zhongyu Yang Yueqiang Ma Tiecheng Feng Xiaoxu Cui | 2018 | Journal of Environmental Sciences2018，30，5： | 28 |
| 3 | pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells显示文摘Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy.Pathogenesis of infection has been mostly attributed to excessive cytokine production.However,precise mechanisms on how C.trachomatis triggers this production,and which protein(s) stimulate inflammatory cytokines remains unknown.In the present study,the C.trachomatis pORF5 protein induced tumor necrosis factor alpha(TNF-α),interleukin-1 beta(IL-1β) and interleukin-8(IL-8) in dose-and time-dependent manners in the THP-1 human monocyte cell line.We found that intracellular p38/mitogen-activated protein kinase(MAPK) and extracellular signal-regulated kinase(ERK)/MAPK signaling pathways were required for the induction of TNF-α,IL-1β and IL-8.Blockade of toll-like receptor 2(TLR2) signaling reduced induction levels of TNF-α,IL-8 and IL-1β.We concluded that the C.trachomatis pORF5 protein might contribute to the inflammatory processes associated with chlamydial infections. | ZHOU Hui HUANG QiuLin LI ZhongYu WU YiMou XIE XiaoBing MA KangKang CAO WenJuan ZHOU Zhou LU ChunXue ZHONG GuangMing | 2013 | Science China(Life Sciences)2013，56，5： | 26 |
| 4 | The fractal measurement of experimental images of supersonic turbulent mixing layer显示文摘Flow visualization of supersonic mixing layer has been studied based on the high spatiotemporal resolution Nano-based Planar Laser Scattering(NPLS) method in SML-1 wind tunnel. The corresponding images distinctly reproduced the flow structure of laminar,transitional and turbulent region,with which the fractal measurement can be implemented. Two methods of measuring fractal dimension were introduced and compared. The fractal dimension of the transitional region and the fully developing turbulence region of supersonic mixing layer were measured based on the box-counting method. In the transitional region,the fractal dimension will increase with turbulent intensity. In the fully developing turbulent region,the fractal dimension will not vary apparently for different flow structures,which em-bodies the self-similarity of supersonic turbulence. | ZHAO YuXin YI ShiHe TIAN LiFeng HE Lin CHENG ZhongYu | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，8： | 24 |
| 5 | The experimental study of interaction between shock wave and turbulence显示文摘The interaction between shock wave and turbulence has been studied in supersonic turbulent mix layer wind tunnel. The interaction between oblique shock wave and turbulent boundary layer and the influence of large vortex in mix layer on oblique shock wave have been observed by NPLS technique. From NPLS image, not only complex flow structure is observed but also time-dependent supersonic flow visualization is realized. The mechanism of interaction between shock wave and turbulence is discussed based on high quality NPLS image. | ZHAO YuXin YI ShiHe HE Lin CHENG ZhongYu TIAN LiFeng | 2007 | Chinese Science Bulletin2007，52，10： | 18 |
| 6 | Study of density field measurement based on NPLS technique in supersonic flow显示文摘Due to the influence of shock wave and turbulence, supersonic density field exhibits strongly inhomogeneous and unsteady characteristics. Applying traditional density field measurement techniques to supersonic flows yields three problems: low spatiotemporal resolution, limitation of measuring 3D density field, and low signal to noise ratio (SNR). A new method based on Nano-based Planar Laser Scattering (NPLS) technique is proposed in this paper to measure supersonic density field. This method measures planar transient density field in 3D supersonic flow by calibrating the relationship between density and concentration of tracer particles, which would display the density fluctuation due to the influence of shock waves and vortexes. The application of this new method to density field measurement of supersonic optical bow cap is introduced in this paper, and the results reveal shock wave, turbulent boundary layer in the flow with the spatial resolution of 93.2 μm/pixel. By analyzing the results at interval of 5 μs, temporal evolution of density field can be observed. | TIAN LiFeng YI ShiHe ZHAO YuXin HE Lin CHENG ZhongYu | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，9： | 15 |
| 7 | Macrobenthic community structure in the Changjiang Estuary and its adjacent waters in summer显示文摘On the basis of data collected in the summer of 2006 from 27 sampling stations in the Changjiang Estuary and its adjacent waters, the ecological characteristics of macrobenthos and the relationship between the macrobenthos and the environmental factors were studied using hierarchical cluster and non-metric multidimensional scaling (MDS).The biomass, abundance, Shannon-Wiener's and Margalef's indices of the macrobenthos were presented. The results showed that a total of 253 macrobenthic species were found in the research region, and most of them belong to mollusks and polychaetes. The dominant species were Cossurella dimorpha, Eocylichna cylindrella, Episiphon kiaochowwanense, Nassarius semiplicatus, Ocstergrenia variabilis and Sternaspis scutata. The average abundance of the macrobenthos was (313.15±233.4) ind./m2, and the average biomass was (15.2±11.2)g/m2.The distribution patterns of the abundance and biomass of the macrobenthos were similar. The abundance and biomass in the area close to the estuary were lower than those from the area more distant to the estuary; the central part of the research region had higher abundance and biomass than other parts of the research region. In accordance with the results, four macrobenthic communities with distinct spatial differences were identified. The low abundance and biomass in the area close to the estuary should be caused by the high sedimentation rate. The statistical analysis indicated that the depth is the most important factor affecting the distribution of macrobenthos. | MENG Wei LIU Lusan ZHENG Binghui LI Xinzheng LI Zhongyu | 2007 | Acta Oceanologica Sinica2007，26，6： | 15 |
| 8 | Grey Relation between Nonlinear Characteristic and Dynamic Uncertainty of Rolling Bearing Friction Torque显示文摘The rolling bearing friction torque which is characterized by its uncertainty and nonlinearity affects heavily the dynamic performance of a system such as missiles, spacecrafts and radars, etc. It is difficult to use the classical statistical theory to evaluate the dynamic evaluation of the rolling bearing friction torque for the lack of prior information about both probability distribution and trends. For this reason, based on the information poor system theory and combined with the correlation dimension in chaos theory, the concepts about the mean of the dynamic fluctuant range (MDFR) and the grey relation are proposed to resolve the problem about evaluating the nonlinear characteristic and the dynamic uncertainty of the rolling bearing friction torque. Friction torque experiments are done for three types of the rolling bearings marked with HKTA, HKTB and HKTC separately; meantime, the correlation dimension and MDFR are calculated to describe the nonlinear characteristic and the dynamic uncertainty of the friction torque, respectively. And the experiments reveal that there is a certain grey relation between the nonlinear characteristic and the dynamic uncertainty of the rolling bearing friction torque, viz. MDFR will become the nonlinear increasing trend with the correlation dimension increasing. Under the condition of fewer characteristic data and the lack of prior information about both probability distribution and trends, the unitive evaluation for the nonlinear characteristic and the dynamic uncertainty of the rolling bearing friction torque is realized with the grey confidence level of 87.7%-96.3%. | XIA Xintao WANG Zhongyu | 2009 | Chinese Journal of Mechanical Engineering2009，22，2： | 13 |
| 9 | Photoperiodism dynamics during the domestication and improvement of soybean显示文摘Soybean(Glycine max) is a facultative short-day plant with a sensitive photoperiod perception and reaction system, which allows it to adjust its physiological state and gene regulatory networks to seasonal and diurnal changes in environmental conditions. In the past few decades, soybean cultivation has spread from East Asia to areas throughout the world. Biologists and breeders must now confront the challenge of understanding the molecular mechanism of soybean photoperiodism and improving agronomic traits to enable this important crop to adapt to geographical and environmental changes. In this review, we summarize the genetic regulatory network underlying photoperiodic responses in soybean. Genomic and genetic studies have revealed that the circadian clock, in conjunction with the light perception pathways, regulates photoperiodic flowering. Here, we provide an annotated list of 844 candidate flowering genes in soybean, with their putative biological functions. Many photoperiod-related genes have been intensively selected during domestication and crop improvement. Finally, we describe recent progress in engineering photoperiod-responsive genes for improving agronomic traits to enhance geographic adaptation in soybean, as well as future prospects for research on soybean photoperiodic responses. | Sheng-Rui Zhang Huan Wang Zhongyu Wang Yao Ren Lifang Niu Jun Liu Bin Liu | 2017 | Science China(Life Sciences)2017，60，12： | 13 |
| 10 | An experimental study of aero-optical aberration and dithering of supersonic mixing layer via BOS显示文摘The optical performance of supersonic mixing layer is heavily deteriorated by the aero-optical aberration and dithering of coherent structures, but current measuring methods limit the spatiotemporal resolution in relevant studies. A high resolution whole-field aero-optical aberration and dithering measuring method based on the Background Orient Schlieren (BOS) technique was studied. The systematic structure, sensitivity and resolution of BOS are analyzed in this paper. The aero-optical aberration and dithering of streamwise structures in supersonic mixing layers were quantificationally studied with BOS. The aberration field of spanwise structures revealed the ribbon-like aberration structures, which heavily restrict the optical performance of a mixing layer. The quantifications of aero-optical aberration and dithering are very important in studying aero-optical performance of supersonic mixing layer. | ZHAO YuXin , YI ShiHe, TIAN LiFeng, HE Lin & CHENG ZhongYu College of Aerospace and Material Engineering, National University of Defense Technology, Changsha 410073, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 13 |
| 11 | YAGG:Ce transparent ceramics with high luminous efficiency for solid-state lighting application显示文摘A series of Y2.985Al5–xGaxO12:0.015Ce(YAGG:Ce,x=0,1,2,3,4,5)transparent ceramics were prepared via a solid-state reaction method.Two-step sintering technique was proved to be an effective approach to prepare functional ceramics with high Ga concentration,and Y3Ga5O12(YGG)transparent ceramic was successfully prepared for the first time.According to the variation of Al/Ga ratio,regulation of band structure and luminescence properties of YAGG:Ce transparent ceramics were effectively investigated.When Ga substitutes Al sites,the tetrahedral site is more favorable compared to the octahedral site for Ga to occupy according to the first-principle calculation.A continuous blue shift of the emission from 565 to 515 nm was achieved as Ga was gradually introduced into Y3Al5O12:Ce matrix.High quality green light was obtained by coupling the YAGG:Ce ceramics with commercial blue InGaN chips.Transparent luminescence ceramics accomplished in this work can be quite prospective for high power LED application. | Hui HUA Shaowei FENG Zhongyu OUYANG Hezhu SHAO Haiming QIN Hui DING Qiping DU Zhijun ZHANG Jun JIANG Haochuan JIANG | 2019 | Journal of Advanced Ceramics2019，8，3： | 13 |
| 12 | Middle Triassic post-orogenic extension on Hainan Island: Chronology and geochemistry constraints of bimodal intrusive rocks显示文摘This work studies new petrological and geochemical data and zircon U-Pb ages for bimodal intrusive rocks from Xinglong region, Hainan Island. Zircon U-Pb dating yields mean 238 U/ 206 Pb ages of 238 ± 2 Ma and 234 ± 2 Ma for diabasic and granitic phases, respectively, representing the Middle Triassic emplacement. The diabase and granite bodies were formed from discrete mafic and acidic magma sources that experienced local mechanical mixing at their mutual contacts. Although SiO 2 content of intrusions is bimodal, trace element ratios indicate that both were formed in a post-orogenic extensional setting. Sr-Nd isotopic composition reflects a shared EMII type enriched mantle source component, possibly influenced by subduction-fluid metasomatism. | TANG LiMei CHEN HanLin DONG ChuanWan YANG ShuFeng SHEN ZhongYue CHENG XiaoGan FU LuLu | 2013 | Science China Earth Sciences2013，56，5： | 12 |
| 13 | Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol显示文摘OBJECTIVE: To investigate the effect of acupuncture at Neiguan(PC 6) on cardiac function using echocardiography in rat models of myocardial ischemia(MI) induced by isoproterenol(ISO).METHODS: Twenty-seven Sprague-Dawley rats were randomly assigned to normal, model, and acupuncture groups. The model and acupuncture groups were given injections of ISO(85 mg/kg) to establish the MI model. After model establishment,the acupuncture group was treated with acupuncture at Neiguan(PC 6) for 30 min. Echocardiography was used to monitor diastolic and systolic function for 30 min starting from the time after the acupuncture needles were removed. Changes in the length of left ventricular internal diameter at end-diastole(LVIDd), length of left ventricular internal diameter at end-systole(LVIDs), the ratio of mitral peak velocity at early diastole and atrial contraction(E/A), ejection fraction(EF), fractional shortening(FS), and stroke volume(SV) were measured.RESULTS: Compared with the model group at 0and 15 min after needles were removed, the means of LVIDd and LVIDs were significantly lower(P <0.01) and E/A, EF, FS, and SV significantly higher(P < 0.01) in the acupuncture group. In the acupuncture group, the means of LVIDd and LVIDs15 min after the needles were removed were significantly higher(P < 0.01) than those at 0 min. The means of E/A, EF, FS, and SV significantly decreased(P < 0.01) from 0 to 15 min in the acupuncture group.CONCLUSION: These findings indicate that acupuncture at Neiguan(PC 6) can affect cardiac function by increasing left ventricular diastolic and systolic function in MI rat models, but the effect only lasts for 15 min. | Wang Songzi Ren Lu Jia Lianqun Gu Zhongyue Fan Xu Chen Wenna Hou Ping Liang Fanrong Rong Peijing Ma Tieming Liu Xulai Chen Yiguo | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 12 |
| 14 | Gray bootstrap method for estimating frequency-varying random vibration signals with small samples显示文摘During environment testing, the estimation of random vibration signals(RVS) is an important technique for the airborne platform safety and reliability. However, the available methods including extreme value envelope method(EVEM), statistical tolerances method(STM) and improved statistical tolerance method(ISTM) require large samples and typical probability distribution. Moreover, the frequency-varying characteristic of RVS is usually not taken into account. Gray bootstrap method(GBM) is proposed to solve the problem of estimating frequency-varying RVS with small samples. Firstly, the estimated indexes are obtained including the estimated interval, the estimated uncertainty, the estimated value, the estimated error and estimated reliability. In addition, GBM is applied to estimating the single flight testing of certain aircraft. At last, in order to evaluate the estimated performance, GBM is compared with bootstrap method(BM) and gray method(GM) in testing analysis. The result shows that GBM has superiority for estimating dynamic signals with small samples and estimated reliability is proved to be 100% at the given confidence level. | Wang Yanqing Wang Zhongyu Sun Jianyong Zhang Jianjun Zissimos Mourelato | 2014 | Chinese Journal of Aeronautics2014，27，2： | 12 |
| 15 | Multiresolution analysis of density fluctuation in supersonic mixing layer显示文摘Due to the difficulties in measuring supersonic density field, the multiresolution analysis of supersonic mixing layer based on experimental images is still a formidable challenge. By utilizing the recently developed nanoparticle based planar laser scattering method, the density field of a supersonic mixing layer was measured at high spatiotemporal resolution. According to the dynamic behavior of coherent structures, the multiresolution characteristics of density fluctuation signals and density field images were studied based on Taylor’s hypothesis of space-time conversion and wavelet analysis. The wavelet coefficients reflect the characteristics of density fluctuation signals at different scales, and the detailed coefficients reflect the differences of approximation at adjacent levels. The density fluctuation signals of supersonic mixing layer differ from the periodic sine signal and exhibit similarity to the fractal Koch signal. The similarity at different scales reveals the fractal characteristic of mixing layer flowfield. The two-dimensional wavelet decomposition and reconstruction of density field images extract the approximate and detailed signals at different scales, which effectively resolve the characteristic structures of the flowfield at different scales. | ZHAO YuXin1, YI ShiHe, TIAN LiFeng, HE Lin & CHENG ZhongYu College of Aerospace and Material Engineering, National University of Defense Technology, Changsha 410073, China | 2010 | Science China(Technological Sciences)2010，53，2： | 11 |
| 16 | Anti-tumor activity and immunological modification of ribosome-inactivating protein (RIP) from Momordica charantia by covalent attachment of polyethylene glycol显示文摘使核糖体失去活性的蛋白质(裂开) 是酶的一个家庭那 depurinate rRNA 并且禁止蛋白质生合成。这里,我们报导纯化,导致 apoptosis 活动,和聚乙烯乙二醇(木钉) 修正从痛苦的甜瓜种子裂开。蛋白质有 N-Asp-Val-Ser-Phe-Arg 的一个同质的 N 终端序列。而且, RIP 显示了强壮的导致 apoptosis 活动和压制的癌症细胞生长。这可能被归因于 caspases-3 的激活。使它可得到为在 vivo 申请, immunogenicity 裂开被化学修正与 20 kDa (mPEG ) 减少 2-Lys-NHS。PEGylated 和 non-PEGylated 的抑制活动对癌症房间裂开比对正常 PEGylated 的房间,和 antigenicity 裂开的强壮得多显著地被减少。我们的结果建议 PEGylated 裂开可能潜在地作为反癌症被开发药。 | Mengen Li Yiwen Chen Zhongyu Liu Fubing Shen Xiaoxiao Bian Yanfa Meng | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 11 |
| 17 | The effect of melt overheating on the melt structure transition and solidified structures of Sn-Bi40 alloy显示文摘Evolution of the electrical resistivity of Sn-40wt%Bi melt with time under different overheating temperatures during isothermal experiments has been studied, and the relationship between different melt state, solidification behavior and solidified structure has also been investigated. The results show that the melt structure transition revealed by the abnormal change of resistivity would take place within a certain holding time just when the holding temperature is above a certain critical, and that the higher the temperature above the critical, the shorter the 'incubation period' of the melt structure transition, and the faster the transition speed. The results of solidification experiments suggest that the melt structure transition caused by different holding time at the same temperature can lead to a higher so-lidification undercooling degree, finer grain size and change of microscopic pattern. Further exploration indicates that the solidification undercooling degree can come to a head when the melt is held at the specific temperature for a given time. The functionary mechanism of the phenomena above is also discussed briefly. | CHEN HongSheng ZU FangQiu CHEN Jie ZOU Li DING GuoHua HUANG ZhongYue | 2008 | Science China(Technological Sciences)2008，51，9： | 11 |
| 18 | A flow control study of a supersonic mixing layer via NPLS显示文摘The flow control of a supersonic mixing layer was studied in a supersonic mixing layer wind tunnel with convective Mach number (Mc) at 0.5. The passive control of the mixing layer was achieved by perturbation tapes on the trailing edge of the splitter plate. The control effects of 2D and 3D perturbation tapes with different sizes were compared. The mixing layer was visualized via NPLS,and the transient fine structures were identifiable in NPLS images,which were used to analyze the effects of flow control. The results show that the 2D tapes can enhance the 2D characteristic of the mixing layer,delaying mixing layer transition; and the 3D tapes can enhance the 3D characteristic of the mixing layer,advancing mixing layer transition. 3D structures of the mixing layer were visualized,and the H-type Λ vortexes were found with 3D tapes control. | YI ShiHe HE Lin ZHAO YuXin TIAN LiFeng CHENG ZhongYu | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 10 |
| 19 | Lentiviral-mediated gene transfer into human adipose-derived stem cells:role of NELL1 versus BMP2 in osteogenesis and adipogenesis in vitro显示文摘(NELL1 ) 象 NEL 一样分子 1 是与 craniosynostosis 联系的一个有势力 osteogenic 因素。侵入人体气管粘膜的病菌,大多数通常为基因治疗使用了病毒的向量,有可以限制成骨的几劣势。以前的研究证明了 lentiviruses 能为骨头新生为基因治疗用作理想的向量。在这研究,编码人的 NELL1 和骨头的二 lentiviral 向量(LvNELL1 和 LvBMP2 ) 分别地,形态基因的 protein-2 (BMP2 ) 被构造。在 vitro 的人的脂肪质导出干细胞(hADSCs ) 的增长,成骨,和 adipogenesis 上的 LvNELL1 感染的效果被估计并且与 LvBMP2 的相比。结果显示出感染 LvNELL1 的那 hADSCs 能高效地并且稳定地 overexpress 目标基因。3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyltetrazolium 溴化物试金结果表明了那 LvBMP2,然而并非 LvNELL1,提高了 hADSCs 的增长。对碱的磷酸酶活动和细胞的矿化作用的评价显示 LvNELL1 感染支持了 hADSCs 的 osteogenic 区别,并且效果与 LvBMP2 的是可比较的。实时聚合酶链反应(PCR ) 在 hADSCs 揭示了那 LvNELL1 感染 upregulated OSX 表情然而并非 RUNX2 表示。另外,分析显示出的 adipogenic 标记(类脂化合物微滴, peroxisome 激活 proliferator 受体,和脂蛋白脂肪分解酵素) LvNELL1 能戏剧性地禁止 hADSCs,而是 LvBMP2 的 adipogenic 区别,这没有如此的效果。一起拿,这些调查结果建议在 hADSCs 的调停 lentiviral 的 NELL1 基因转移可以是一条新奇、有希望的途径完成有效、精确的骨头新生。 | Yajing Liu Caiyun Chen Huixia He Dongsheng Wang LingLing E Zhongyu Liu Hongchen Liu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 10 |
| 20 | Phylogenetic and genetic characterization of a 2017 clinical isolate of H7N9 virus in Guangzhou,China during the fifth epidemic wave显示文摘Pathogenic H7N9 influenza viruses continue to pose a public health concern. The H7N9 virus has caused five outbreak waves of human infections in China since 2013. In the present study, a novel H7N9 strain(A/Guangdong/8 H324/2017) was isolated from a female patient with severe respiratory illness during the fifth wave of the 2017 H7N9 epidemic. Phylogenetic analysis showed that the H7N9 viruses collected during the fifth wave belong to two different lineages: the Pearl River Delta lineage and the Yangtze River Delta lineage. The novel isolate is closely related to the Pearl River Delta H7N9 viruses, which were isolated from patients in Guangdong Province. The novel H7N9 isolate has an insertion of three basic amino acids in the cleavage site of hemagglutinin(HA), which may enhance virulence in poultry. The 2017 isolate also possesses an R292 K substitution in the neuraminidase(NA)protein, which confers oseltamivir resistance. This study highlights the pandemic potential of the novel H7N9 virus in mammals;thus, future characterization and surveillance is warranted. | Yongqiang Deng Chunlin Li Jianfeng Han Yingfen Wen Jian Wang Wenxing Hong Xiaofeng Li Zhongyu Liu Qing Ye Jing Li Changshuai Zhou Lei Yu Chengfeng Qin Fuchun Zhang Tao Jiang | 2017 | Science China(Life Sciences)2017，60，12： | 9 |
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