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| 1 | Analysis of demographic characteristics in 3242 young age gastric cancer patients in Korea显示文摘AIM:To evaluate the epidemiologic features of young age gastric cancer(GC). METHODS:Retrospectively,a total of 3242 patients with GC between 18 and 45 years of age and 3000 sex-and age-matched controls were reviewed.All subjects were stratified into 3 groups based on age (A,18-30 years;B,31-40 years;C,41-45 years). Epidemiologic characteristics and risk factors were investigated with reference to their age and gender. RESULTS:Compared to controls,more frequent intake of high risk diet(P=0.00075),history of heavy smoking(P=0.00087),intake of heavy alcohol(P= 0.00091),lower social economic status(P=0.00083), body mass index>30(P=0.00097),urban residence(P=0.00065),and more frequent exposure to harmful occupational environments(P=0.00072)were observed in all age groups and both genders in young age GC.These relationships were weaker in females compared to males of the same age,and were stronger as the age of patients increased.However,in group C of young age GC patients,environmental factors played important roles in females and males with a similar body weight.In females,older age at first delivery(> 35 years),lack of lactation history,nulliparity,and poor nutritional status during pregnancy were significantly associated with an increased risk of GC(P=0.00034). In this study,252 patients(7.8%)had a family history of GC with high odds ratio(OR)(3.22-4.21).In particular, family history was more closely associated with GC in males(OR,4.21 in male vs 3.46 in female)and more advanced cases(P=0.00051). CONCLUSION:Hormonal associated factors were more commonly associated with females whereas environmental factors were more commonly associated with males in young age GC patients. | Hye Won Chung Sung Hoon Noh Jong-Baeck Lim | 2010 | World Journal of Gastroenterology2010，16，2： | 26 |
| 2 | Role of the tumor microenvironment in the pathogenesis of gastric carcinoma显示文摘Gastric carcinoma(GC)is the 4thmost prevalent cancer and has the 2ndhighest cancer-related mortality rate worldwide.Despite the incidence of GC has decreased over the past few decades,it is still a serious health problem.Chronic inflammatory status of the stomach,caused by the infection of Helicobacter pylori(H.pylori)and through the production of inflammatory mediators within the parenchyma is suspected to play an important role in the initiation and progression of GC.In this review,the correlation between chronic inflammation and H.pylori infection as an important factor for the development of GC will be discussed.Major components,including tumor-associated macrophages,lymphocytes,cancer-associated fibroblasts,angiogenic factors,cytokines,and chemokines of GC microenvironment and their mechanism of action on signaling pathways will also be discussed.Increasing our understanding of how the components of the tumor microenviroment interact with GC cells and the signaling pathways involved could help identify new therapeutic and chemopreventive targets. | Hye Won Chung Jong-Baeck Lim | 2014 | World Journal of Gastroenterology2014，20，7： | 23 |
| 3 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 4 | Clinical significance and usefulness of soluble heparin binding-epidermal growth factor in gastric cancer显示文摘AIM:To evaluate the clinical usefulness of solubleheparin-binding epidermal growth factor(s HB-EGF)as a serum biomarker for gastric cancer(GC).METHODS:Serum s HB-EGF levels were measured by a commercially available human HB-EGF ELISA Kit and compared among 60 normal controls,30 highrisk patients,37 early gastric cancer(EGC),and30 advanced gastric cancer(AGC)through ANOVA test.Correlations between serum s HB-EGF and clinicopathological features of GC were analyzed through Spearman’s correlation.The diagnostic performance of serum s HB-EGF for GC was evaluated through receiver operating characteristic(ROC)curve and logistic regression analysis.RESULTS:Serum s HB-EGF levels were significantly higher in AGC group(314.4±127.5 pg/m L)than EGC(165.3±123.2 pg/m L),high-risk(98.7±67.3 pg/m L),and control(94.7±83.6 pg/m L)groups(post-hoc Bonferroni,all P<0.001),respectively.Serum s HB-EGF levels were also significantly higher in EGC group than high-risk(P=0.049)and control(P=0.006)groups.Clinicopathologically,serum s HB-EGF levels closely correlated with depth of invasion(T-stage,γs=0.669,P<0.001),lymph node metastasis(N-stage,γs=0.407,P=0.001),and distant metastasis(M-stage,γs=0.261,P=0.030).ROC curve and logistic regression analysis demonstrated a remarkable diagnostic potential of serum s HB-EGF.CONCLUSION:Serum s HB-EGF is closely correlated with advanced stage GC and can be a promising serological biomarker for GC. | Hye Won Chung Hoon Young Kong Jong-Baeck Lim | 2015 | World Journal of Gastroenterology2015，21，7： | 4 |
| 5 | A case of Clostridium difficile infection complicated by acute respiratory distress syndrome treated with fecal microbiota transplantation显示文摘Acute respiratory distress syndrome is a life-threatening disorder caused mainly by pneumonia.Clostridium difficile infection(CDI)is a common nosocomial diarrheal disease.Disruption of normal intestinal flora by antibiotics is the main risk factor for CDI.The use of broadspectrum antibiotics for serious medical conditions can make it difficult to treat CDI complicated by acute respiratory distress syndrome.Fecal microbiota transplantation is a highly effective treatment in patients with refractory CDI.Here we report on a patient with refractory CDI and acute respiratory distress syndrome caused by pneumonia who was treated with fecal microbiota transplantation. | Ji Eun Kim Tae-Geun Gweon Chang Dong Yeo Young-Seok Cho Gi Jun Kim Jae Young Kim Jong Wook Kim Hyunho Kim Hye Won Lee Taeseok Lim Hyoju Ham Hyun Jin Oh Yeongbok Lee Jaeho Byeon Sung Soo Park | 2014 | World Journal of Gastroenterology2014，20，35： | 3 |
| 6 | Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial显示文摘 | Seung-Yong Jeong Ji Won Park Byung Ho Nam Sohee Kim Sung-Bum Kang Seok-Byung Lim Hyo Seong Choi Duck-Woo Kim Hee Jin Chang Dae Yong Kim Kyung Hae Jung Tae-You Kim Gyeong Hoon Kang Eui Kyu Chie Sun Young Kim Dae Kyung Sohn Dae-Hyun Kim Jae-Sung Kim Hye Seu | 2014 | Lancet Oncology2014，，7： | 3 |
| 7 | The Effect of Fabrication Conditions for GDC Buffer Layer on Electrochemical Performance of Solid Oxide Fuel Cells显示文摘A Gd-doped ceria(GDC) buffer layer is required between a conventional yttria-stabilized zirconia(YSZ) electrolyte and a La-Sr-Co-Fe-O3(LSCF) cathode to prevent their chemical reaction. In this study,the effect of varying the conditions for fabricating the GDC buffer layer, such as sintering temperature and amount of sintering aid, on the solid oxide fuel cell(SOFC) performance was investigated. A finer GDC powder(i.e., ultra-high surface area), a higher sintering temperature(1290℃), and a larger amount of sintering aid(12%) resulted in improved densification of the buffer layer; however, the electrochemical performance of an anode-supported cell containing this GDC buffer layer was poor. These conflicting results are attributed to the formation of(Zr, Ce)O2 and/or excess cobalt grain boundaries(GBs) at higher sintering temperatures with a large amount of sintering aid(i.e., cobalt oxide). A cell comprising of a cobalt-free GDC buffer layer, which was fabricated using a low-temperature process, had lower cell resistance and higher stability. The results indicate that electrochemical performance and stability of SOFCs strongly depend on fabrication conditions for the GDC buffer layer. | Jung-Hoon Song Myung Geun Jung Hye Won Park Hyung-Tae Lim | 2013 | Nano-Micro Letters2013，5，3： | 2 |
| 8 | Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction. | JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong | 2023 | Cancer Communications2023，43，4： | 2 |
| 9 | Effect of ultra high pressure processing on immuno-modulatory activities of the fruits of Rubus coreanus Miquel显示文摘 | Yong Chang Seo Woon Yong Choi Ji Seon Kim Chang Soon Yoon Hye Won Lim Jeong Sub Cho Ju hee Ahn Hyeon Yong Lee | 2011 | Innovative Food Science and Emerging Technologies2011，，3： | 1 |
| 10 | Single-step Preparation of Nano-homogeneous NiO/YSZ Composite Anode for Solid Oxide Fuel Cells显示文摘Homogeneous co-precipitation and hydrothermal treatment were used to prepare nano- and highly dispersed Ni O/YSZ(yttria-stabilized zirconia) composite powders. Composite powders of size less than 100 nm were successfully prepared. This process did not require separate sintering of the YSZ and Ni O to be used as the raw materials for solid oxide fuel cells. The performance of a cell fabricated using the new powders(max.power density ~0.87 W/cm^2) was higher than that of a cell fabricated using conventional powders(max. power density ~0.73 W/cm^2). Co-precipitation and hydrothermal treatment proved to be very effective processes for reducing cell production costs as well as improving cell performance. | Jung-Hoon Song Mi Young Park Hye Won Park Hyung-Tae Lim | 2013 | Nano-Micro Letters2013，5，2： | 1 |
| 11 | S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for first-line treatment of patients with metastatic colorectal cancer: a randomised, non-inferiority phase 3 trial显示文摘 | Yong Sang Hong Young Suk Park Ho Yeong Lim Jeeyun Lee Tae Won Kim Kyu-pyo Kim Sun Young Kim Ji Yeon Baek Jee Hyun Kim Keun-Wook Lee Ik-Joo Chung Sang-Hee Cho Kyung Hee Lee Sang Joon Shin Hye Jin Kang Dong Bok Shin Sook Jung Jo Jae Won Lee | 2012 | Lancet Oncology2012，，11： | 1 |
| 12 | Protective effect of nectandrin B , a potent AMPK activator on neointima formation: inhibition of Pin1 expression through AMPK activation显示文摘 | Sung Hwan Ki Jung‐Woon Lee Sung Chul Lim Tran Thi Hien Ji Hye Im Won Keun Oh Moo Yeol Lee Young Hyun Ji Yoon Gyoon Kim Keon Wook Kang | 2013 | Br J Pharmacol2013，，： | 1 |
| 13 | Comparison of the Validity of Three Biomarkers for Gastric Cancer Screening: Carcinoembryonic Antigen, Pepsinogens, and High Sensitive C-reactive Protein显示文摘 | Hye Won Chung Ju Won Kim Jong-han Lee Si Young Song Jae Bock Chung Oh Hun Kwon Jong-Baeck Lim | 2009 | Journal of Clinical Gastroenterology2009，，1： | 1 |
| 14 | Serum high mobility group box‐1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma显示文摘 | Hye Won Chung Jong‐Baeck Lim Sunphil Jang Kyong Joo Lee Kyung Hwa Park Si Young Song | 2012 | Cancer Sci2012，，9： | 1 |
| 15 | Modeling of the kinetics for methanol synthesis using Cu/ZnO/AI203/ZrO2 catalyst: Influence of carbon dioxide during hydrogenation显示文摘 | Lim Hye Won Park Myung June Kang Suk Hwan | 2009 | American Chemical Society2009，48，10： | 1 |
| 16 | Clinical significance of elevated serum soluble CD40 ligand levels as a diagnostic and prognostic tumor marker for pancreatic ductal adenocarcinoma显示文摘 | Hye Won Chung Jong-Baeck Lim | 2014 | Journal of Translational Medicine2014，12，： | 1 |
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