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| 1 | Insight into the biology of Macrophage Migration Inhibitory Factor (MIF) revealed by the cloning of its cell surface receptor显示文摘MIF 受体的最近的克隆在我们分子的生物学的理解和 MIF 的免疫学充满重要差距。MIF 受体象 MIF 一样,不掉进蛋白质调停人的任何确定的家庭,提供为 MIF 信号 transduction 的结构、功能的分析的新挑战和机会。 | Lin Leng Richard Bucala | 2006 | Cell Research2006，16，2： | 10 |
| 2 | Three-dimensional-printed individualized porous implants:A new“implant-bone”interface fusion concept for large bone defect treatment显示文摘Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration. | Teng Zhang Qingguang Wei Hua Zhou Zehao Jing Xiaoguang Liu Yufeng Zheng Hong Cai Feng Wei Liang Jiang Miao Yu Yan Cheng Daoyang Fan Wenhao Zhou Xinhong Lin Huijie Leng Jian Li Xinyu Li Caimei Wang Yun Tian Zhongjun Liu | 2021 | Bioactive Materials2021，6，11： | 9 |
| 3 | Obstetric Outcomes in Chinese Women with Endometriosis: A Retrospective Cohort Study显示文摘 | Hong Lin Jin-Hua Leng Jun-Tao Liu Jing-He Lang | 2015 | Chinese Medical Journal2015，，4： | 9 |
| 4 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 5 | Assessment and Comparison of in vitro Immunoregulatory Activity of Three Astaxanthin Stereoisomers显示文摘In recent years,the immune-modulatory role of all-trans astaxanthin from different pigment sources has been studied.It was reported that all-trans astaxanthin might exist as three stereoisomers,and the composition of all-trans stereoisomers in natural materials differs from that of synthetic products.However,the different biological effects of various all-trans stereoisomers still remain unclear.In the present study,we evaluated the bioactivity of three astaxanthin stereoisomers,(3S,3'S)-trans-,(3R,3'R)-transand meso-trans-astaxanthin,in regulating cell-mediated immune response using mice lymphocytes and peritoneal exudates cells(PECs) systems.After the treatment with three astaxanthin stereoisomers(20 μmol L-1),the lymphocyte proliferation capacity,neutral red phagocytosis of PECs and natural killer(NK) cell cytotoxic activity were comparatively assessed.The results showed that all three astaxanthin stereoisomers significantly promoted lymphocyte proliferation,phagocytic capacity of PECs,and cytotoxic activity of NK cells.Moreover,the(3S,3'S)-trans-astaxanthin exhibited a much higher response than others. | SUN Weihong XING Lihong LIN Hong LENG Kailiang ZHAI Yuxiu LIU Xiaofang | 2016 | Journal of Ocean University of China2016，15，2： | 7 |
| 6 | Mechanism and kinetics study on removal of Iron from phosphoric acid by cation exchange resin显示文摘Iron element is one of the main impurities in wet-process phosphoric acid and it has a significant impact on the subsequent phosphorus chemical products. This paper studied the feasibility of using Sinco-430 cation exchange resin for iron removal from phosphoric acid. The specific surface area and the total exchange capacity of resin were 8.91 m2·g-1 and 5.18 mmol·g-1, respectively. The sorption mechanism was determined by FTIR and XPS and the results indicated that iron was combined with-SO3 H in resin. The removal process was studied as a function of temperature, H3 PO4 content and mass ratio between resin and solution. The unit mass of resin to remove iron was 0.058 g·g-1 resin when the operating parameters were T = 50 ℃, H3 PO4 content = 27.61 wt%and S/L = 0.1, respectively. Kinetics study demonstrated that pseudo-second-order reaction model fits this study best and the calculated activation energy of overall reaction is 29.10 kJ·mol-1. The overall reaction process was mainly controlled by pore diffusion. | Xinke Leng Yanjun Zhong Dehua Xu Xinlong Wang Lin Yang | 2019 | Chinese Journal of Chemical Engineering2019，27，5： | 7 |
| 7 | A remote sensing monitoring method for alpine grasslands desertification in the eastern Qinghai–Tibetan Plateau显示文摘Alpine grassland is the typical vegetation in the eastern Qinghai–Tibetan Plateau,which has important ecological service functions,and also supports the development of alpine stock farming.In recent years,under both the natural and human disturbance,alpine grasslands in this area have appeared to different degrees of desertification.A diagnosis of the desertification degree serves as the basis for grassland ecological restoration.This study constructs a comprehensive index based on remote sensing called alpine grassland desertification index(AGDI)to monitor the areas and degree of desertification.The most relevant indicators of desertification,namely,vegetation fraction,aboveground biomass,soil moisture,and land surface temperature,were selected to establish AGDI.The geographical detector is used to reselect and assess these indicators.The results show that the overall verification accuracy of AGDI is 82.05%.In particular,the accuracy of identifying severe desertification is the highest.Our study confirms that the desertification of alpine grasslands in the eastern Qinghai–Tibetan Plateau is characterized by fragmentation.Thus,Landsat-8 OLI data with a spatial resolution of 30 m is more suitable than MODIS data for alpine grasslands desertification monitoring.The research results can provide a methodological reference for monitoring desertification of alpine grasslands and other grassland regions in the world. | KUANG Qian YUAN Quan-zhi HAN Ji-chong LENG Rong WANG Yu-shuang ZHU Ke-hong LIN Shuo REN Ping | 2020 | Journal of Mountain Science2020，17，6： | 4 |
| 8 | Spatial-temporal evolution of vegetation evapotranspiration in Hebei Province,China显示文摘Evapotranspiration(ET)is the sum of soil or water body evaporation and plant transpiration from the earth surface and ocean to the atmosphere,and thus plays a significant role in regulating carbon and water resource cycles.The time-series data set from the remote sensing MOIDS product(MOD16)was used to study the spatial-temporal evolution of vegetation evapotranspiration in salinized areas during 2000–2014 by analyzing the variability,spatial patterns and Mann-Kendall(MK)nonparametric trends for the time series.The results indicate that inter-annual and intra-annual variations of ET across various vegetated areas show seasonal changes,with the abnormal months identified.The cultivated land displays a greater degree of spatial heterogeneity and the spatial pattern of ET in the area covered by broadleaved deciduous forests corresponds to a higher ET rate and increased water consumption.A widespread decline of ET is observed only in cultivated areas.However,agricultural cultivation doesn’t worsen water shortage and soil salinization problems in the region,and water shortage problems are worsening for other vegetated areas.This research provides a basis of reference for the reasonable allocation of water resources and restructuring of vegetation patterns in salinized areas. | WANG Qian-feng TANG Jia ZENG Jing-yu QU Yan-ping ZHANG Qing SHUI Wei WANG Wu-lin YI Lin LENG Song | 2018 | Journal of Integrative Agriculture2018，17，9： | 4 |
| 9 | Catalytic methanation of syngas over Ni-based catalysts with different supports显示文摘Co-precipitation method was selected for the preparation of Ni/Al_2O_3, Ni/ZrO_2 and Ni/CeO_2 catalysts, and their performances in methanation were investigated in this study. The structure and surface properties of these catalysts were characterized by BET, XRD, H_2-TPD, TEM and H_2-TPR. The results showed that the catalytic activity at low temperature followed the order: Ni/Al_2O_3>Ni/ZrO_2>Ni/CeO_2. Ni/Al_2O_3 catalyst presented the best catalytic performance with the highest CH_4 selectivity of 94.5%. The characterization results indicated that the dispersion of the active component Ni was the main factor affecting the catalytic activity and the one with higher dispersion gave better performance. | Yincong Liu Lingjun Zhu Xiaoliu Wang Shi Yin Furong Leng Fan Zhang Haizhou Lin Shurong Wang | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 3 |
| 10 | Effect of grain size on dielectric and ferroelectric properties of nanostructured Ba_0.8)Sr_(0.2)TiO_(3) ceramics显示文摘Barium strontium titanate( Ba_0.8)Sr_(0.2)TiO_(3),BST)nanocrystalline ceramics have been synthesized by high energy ball milling.As the sintering temperature increases from 1200℃to 1350℃,the average grain size of BST ceramics increases from 86 nm to 123 nm.The X-ray diffraction(XRD)studies show that these ceramics are tetragonal.The phase and grain size of the sintered pellets have been estimated from the XRD patterns,scanning electron microscopy(SEM)and transmission electron microscopy(TEM)images.The effect of grain size on dielectric and ferroelectric properties is studied.The dielectric and piezoelectric parameters are greatly improved at room temperature with increase in grain size.The Curie transition temperature is found to shift slightly towards higher temperatures as the grain increases from 86 nm to 123 nm.The coercive field decreases and the remnant polarization and spontaneous polarization increase as the grain size of BST nano ceramics increases.These ceramics are promising materials for tunable capacitor device applications. | Venkata Ramana MUDINEPALLI Leng FENG Wen-Chin LIN B.S.MURTY | 2015 | Journal of Advanced Ceramics2015，4，1： | 3 |
| 11 | Long-term Dynamics of Cultivated Land Resources and Their Driving Forces of Guyuan City in Upper Reaches of Jinghe River显示文摘The land use patterns in Guyuan City,Ningxia Hui Autonomous Region of China,have changed greatly over the years,due to population growth and farming and stock raising development.This study,using 50-year statis-tical data of cultivated land and 14-year spatial data of land use pattern,analyzed the developmental stages,the char-acter,and the spatial variance of farmland in the city,and discussed the driving forces of cultivated land changes based on empirical and conceptual statistical models.First,the change of cultivated land area went through different stages of rapid increase,fluctuating change,decrease and rapid decrease from 1949 to 2004,additionally,social and economic policies in different stages had an important impact on farmland variance.Second,from 1986 to 2000,the quantity of cultivated land increased,but its quality decreased.Third,social and economic factors are determinant factors in culti-vated land transition.Five constructed paths explain cultivated land transition.Factors that have direct or indirect ef-fects on farmland include the economy(Xeco),the population(Xpop),agricultural output(Xagr),and scientific input(Xsci).The sequence of impact was Xeco>Xpop>Xsci>Xagr.Among all these impacts,Xeco was the major positive one,and Xpop was the major negative one.It is urgent to take measures or adopt a policy to stop the vicious cycle in eco-environment and agriculture production.Otherwise,negative patterns of farmland use will increase,and high-quality cultivated land will continue to decline. | CHEN Caocao XIE Gaodi ZHEN Lin LENG Yunfa | 2008 | Chinese Geographical Science2008，18，1： | 3 |
| 12 | De-oncogenic HPV E6/E7 vaccine gets enhanced antigenicity and promotes tumoricidal synergy with cisplatin显示文摘以便与高风险的人的乳头状瘤病毒(HPV ) 对癌症开发更有效的治疗学的疫苗感染,它对关键提高 immunogenicity,消除 oncoproteins 的 oncogenicity,并且拿包含 E7 和包含 E6 疫苗的联合。它最近被看了那 PE ( III ) -E7-KDEL3 ( E7 ),包含 HPV16 oncoprotein E7 的熔化蛋白质和 Pseudomonas aeruginosa 外毒素 A 的 translocation 域,对因此,在鼠标接种的 TC-1 肿瘤房间是有效的我们设计了 PE ( III ) -E6-CRL-KDEL3 ( E6 ), E7 和 E6 熔化蛋白质的 de-oncogenic 版本[即 PE ( III )-E7(d)-KDEL3, E7 (d),和 PE ( III )-E6(d)-CRL-KDEL3, E6 (d)]并且作为单音测试了这些熔化蛋白质的 immunoefficacies --并且二原子价的疫苗。结果比它的野类型和 E6 熔化蛋白质扩充他们的 E7 对应物的 immunogenicity 和 antitumor 效果的显示 E7 (d) 得到更高的 immunogenicity。而且,面对 cisplatin,加 E6 (d) 的二原子价的疫苗的系统 E7 (d) 在 vivo 对确定的肿瘤显示出最好的 tumoristatic 和 tumoricidal 效果。因此,在进一步的优化之上,这个新奇治疗学的疫苗的系统可以在 HPV 相关的癌的临床的管理上打开新灯,这能被结束。 | Shaochun Chen Chaowei Liao Yiukay Lai Yan Fan Gang Lu Hua Wang Xiaoai Zhang Marie C.M. Lin Shuilong Leng Hsiang-Fu Kung | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 3 |
| 13 | 4D printing of personalized shape memory polymer vascular stents with negative Poisson’s ratio structure:A preliminary study显示文摘Four-dimensional(4D)printing,integrates transformation information into three-dimensional(3D)-printed structures,which means that 3D-printed structures are able to change their shapes,properties,or functionalities over time.Here,two types of shape memory personalized vascular stents with negative Poisson’s ratio structure are developed via 4D printing.The genetic algorithm is used to optimize the structure.Axial compression tests,radial compression tests and three-point bending tests are carried out to study the mechanical properties of the stents.In addition,fluid-structure interaction and stress distribution during the shape recovery process are investigated based on finite element method.The shape memory behaviors of the stents are excellent and in vitro feasibility tests demonstrate that the stents can expand the simulated narrow blood vessel rapidly.Therefore,4D printed shape memory stents with negative Poisson’s ratio structure are highly promising for the treatment of vascular stenosis. | LIN Cheng ZHANG LiJin LIU YanJu LIU LiWu LENG JinSong | 2020 | Science China(Technological Sciences)2020，63，4： | 3 |
| 14 | Phase calibration for integrated optical phased arrays using artificial neural network with resolved phase ambiguity显示文摘Phase calibration for optical phased arrays(OPAs) is a key process to compensate for the phase deviation and retrieve the initial working state. Conventional calibration approaches based on iterative optimization algorithms are tedious and time-consuming. The essential difficulty of such a problem is to inversely solve for the phase error distribution among OPA elements from the far-field pattern of an OPA. Deep-learning-based technology might offer an alternative approach without explicitly knowing the inverse solution. However, we find that the phase ambiguities, including conjugate ambiguity and periodic ambiguity, severely deter the accuracy and efficacy of deep-learning-based calibration. Device-physics-based analysis reveals the causes of the phase ambiguities, which can be resolved by creating a tailored artificial neural network with phase-masked far-field patterns in a conjugate pair and constructing a periodic continuity-preserving loss function. Through the ambiguity-resolved neural network, we can extract phase error distribution in an OPA and calibrate the device in a rapid, noniterative manner from the measured far-field patterns. The proposed approach is experimentally verified. Pure main-beam profiles with >12 dB sidelobe suppression ratios are observed. This approach can help overcome a crucial bottleneck for the further advance of OPAs in a variety of applications such as lidar. | Lemeng Leng Zhaobang Zeng Guihan Wu Zhongzhi Lin Xiang Ji Zhiyuan Shi Wei Jiang | 2022 | Photonics Research2022，10，2： | 3 |
| 15 | Synthesis of N-methylene phosphonic chitosan(NMPCS)and its potential as gene carder显示文摘N-Methylene phosphoulc chitosan (NMPCS),an amphiphilic macromolecule with powerful chelating ability of Ca^(2+) ions,was synthesized and characterized.The physicochemical properties of NMPCS and the interactions between NMPCS and plasmid DNA were investigated by FTIR,^(13)C NMR,X-ray,agarose gel electrophorcsis retardation assay,atomic force microscopy (AFM) and circular dichroism (CD).The results suggest that at charge ratio 2:1 or above,DNA could be completely entrapped and spherical complexes with mean size of 80-210 nm were formed.Taking HeLa as host cell,luciferase expression mediated by NMPCS improved about 100 times compared to the expression mediated by chitosan. | Dun Wan Zhu Jin Gen Bo Hai Ling Zhang Wen Guang Liu Xi Gang Leng Cun Xian Song Yu Ji Yin Li Ping Song Lan Xia Liu Lin Mei Xiu Lan Li Yang Zhang Kang De Yao | 2007 | Chinese Chemical Letters2007，18，11： | 3 |
| 16 | Assessment of ischemia-modified albumin levels for emergency room diagnosis of acute coronary syndrome显示文摘 | Xiao-li Shen Cai-jing Lin Li-li Han Lin Lin Leng Pan Xiao-dong Pu | 2010 | International Journal of Cardiology2010，，3： | 2 |
| 17 | Effect of sage ( Salvia officinalis ) on the oxidative stability of Chinese-style sausage during refrigerated storage显示文摘 | L. Zhang Y.H. Lin X.J. Leng M. Huang G.H. Zhou | 2013 | Meat Science2013，，2： | 2 |
| 18 | Advances in Research of Mineral Chemistry of Magmatic and Hydrothermal Biotites显示文摘Biotite is an important hydrated ferromagnesian silicate mineral in igneous rocks and porphyry deposits.The determination of chemical compositions of biotite plays an important role in both igneous petrology and ore forming processes.This paper summarizes research results of magmatic and hydrothermal biotites exemplified by the Lakange porphyry Cu–Mo deposit and the Qulong porphyry Cu deposit in the Gangdese porphyry–skarn metallogenic belt,Tibet.Biotite mineral chemistry can provide critical insights into classification,geothermometer,geothermobarometry,oxygen fugacity,petrogenesis and tectonic setting,evaluating magmatic-hydrothermal process by halogen and halogen fugacity ratios,and distinguishing between barren and mineralized rocks.Biotite provides the latest mineralogical evidence on metallogenic prognosis and prospecting evaluation for porphyry Cu polymetallic deposits or magmatic hydrothermal deposits. | TANG Pan CHEN Yuchuan TANG Juxing WANG Ying ZHENG Wenbao LENG Qiufeng LIN Bin WU Chunneng | 2019 | Acta Geologica Sinica(English Edition)2019，93，6： | 2 |
| 19 | Enzymatically-degradable hydrogel coatings on titanium for bacterial infection inhibition and enhanced soft tissue compatibility via a self-adaptive strategy显示文摘Ideal percutaneous titanium implants request both antibacterial ability and soft tissue compatibility.ZnO structure constructed on titanium has been widely proved to be helpful to combat pathogen contamination,but the biosafety of ZnO is always questioned.How to maintain the remarkable antibacterial ability of ZnO and efficiently reduce the corresponding toxicity is still challenging.Herein,a hybrid hydrogel coating was constructed on the fabricated ZnO structure of titanium,and the coating was proved to be enzymatically-degradable when bacteria exist.Then the antibacterial activity of ZnO was presented.When under the normal condition(no bacteria),the hydrogel coating was stable and tightly adhered to titanium.The toxicity of ZnO was reduced,and the viability of fibroblasts was largely improved.More importantly,the hydrogel coating provided a good buffer zone for cell ingrowth and soft tissue integration.The curbed Zn ion release was also proved to be useful to regulate fibroblast responses such as the expression of CTGF and COL-I.These results were also validated by in vivo studies.Therefore,this study proposed a valid self-adaptive strategy for ZnO improvement.Under different conditions,the sample could present different functions,and both the antibacterial ability and soft tissue compatibility were finely preserved. | Jin Leng Ye He Zhang Yuan Bailong Tao Ke Li Chuanchuan Lin Kun Xu Maowen Chen Liangliang Dai Xuemin Li Tony Jun Huang Kaiyong Cai | 2021 | Bioactive Materials2021，6，12： | 2 |
| 20 | A comparative study of proliferation and osteogenic differentiation of rat adipose-derived stem cells in β-tricalcium phosphate (β-TCP), forsterite (Mg_2SiO_4 ) and clinoenstatite (MgSiO_3)显示文摘In this study, the effects of forsterite and clinoenstatite powder extracts on the proliferation and osteogenic differentiation of rat adipose-derived stem cells (ASCs) were investigated and compared with the β-tricalcium phosphate (β-TCP) powder extracts. Methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and live-dead staining were performed to evaluate the viability and proliferation of rat ASCs. Osteogenic differentiation of rat ASCs were assayed by alkaline phosphatase (ALP) staining and ALP activity test. The expression of osteogenic marker genes (alkaline phosphatase (ALP), runt related transcription factor 2 (Runx2), collagen type Iα1 (Col1α1), secreted phosphoprotein1 (Spp1, osteopontin), integrin binding sialoprotein (Ibsp), bone gla protein (Bglap)) were detected by real-time polymerase chain reaction (PCR). The MTT assay and the live-dead staining showed that all the three ceramics possessed good cytocompatibility with rat ASCs. Furthermore, forsterite and clinoenstatite promoted the proliferation of rat ASCs compared with β-TCP. The results of the ALP activity test and the real-time PCR demonstrated that forsterite and clinoenstatite promoted the osteogenic differentiation of rat ASCs. These results suggested that forsterite and clinoenstatite are bioactive ceramics that may be used for preparation of bone tissue engineering (BTE) scaffolds. | LENG Bin JIN XiaoGang LIN QiuXia CHEN Lei WANG Yan DU ZhiYan LIN KaiLi CHANG Jiang GU XiaoMing WANG ChangYong | 2013 | Chinese Science Bulletin2013，58，24： | 2 |
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