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| 1 | 旧建筑的改造性再利用显示文摘旧建筑是历史的见证,其经济价值和文化意义使建筑的保护问题逐渐受到普遍关注。本文借鉴国外先进经验,分析我国现状,结合广州芳村水泥厂的改造方案,提出对旧建筑进行改造性再利用的构想,并将保护对象由单纯的文物建筑扩展为更大范围的旧建筑。 | Lin Zhaozhang Ni Wenyan ( The Architecture College of South China Science and Engineering University 510641) | 2000 | 建筑学报2000，，1： | 30 |
| 2 | Advanced hydrogels for the repair of cartilage defects and regeneration显示文摘Cartilage defects are one of the most common symptoms of osteoarthritis(OA),a degenerative disease that affects millions of people world-wide and places a significant socio-economic burden on society.Hydrogels,which are a class of biomaterials that are elastic,and display smooth surfaces while exhibiting high water content,are promising candidates for cartilage regeneration.In recent years,various kinds of hydrogels have been developed and applied for the repair of cartilage defects in vitro or in vivo,some of which are hopeful to enter clinical trials.In this review,recent research findings and developments of hydrogels for cartilage defects repair are summarized.We discuss the principle of cartilage regeneration,and outline the requirements that have to be fulfilled for the deployment of hydrogels for medical applications.We also highlight the development of advanced hydrogels with tailored properties for different kinds of cartilage defects to meet the requirements of cartilage tissue engineering and precision medicine. | Wei Wei Yuanzhu Ma Xudong Yao Wenyan Zhou Xiaozhao Wang Chenglin Li Junxin Lin Qiulin He Sebastian Leptihn Hongwei Ouyang | 2021 | Bioactive Materials2021，6，4： | 8 |
| 3 | MiR-147b influences vascular smooth muscle cell proliferation and migration via targeting YY1 and modulating Wnt/β-catenin activities显示文摘 | Yulun Yue Wenyan Lv Lin Zhang Wei Kang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 7 |
| 4 | Preparation of SiC powders by carbothermal reduction with bamboo charcoal as renewable carbon source显示文摘Bamboo charcoal was expected to be a renewable carbon source for carbide materials in carbothermal reduction because of its superior characteristics.SiC powders with characteristic shapes were fabricated by carbothermal reduction with industrial silica sol and bamboo charcoal particles as silicon and carbon sources respectively,and the effects of reacting temperature and time on shape evolutions and properties of the as-prepared SiC powders were investigated.The silica sol/bamboo charcoal system was firstly transformed into SiO_(2)/C system by the transition of silica sol and graphitization of bamboo charcoal,and the carbothermal reduction between SiO_(2) and C occurred at/above 1600℃.The characteristic shapes of SiC particles were transformed from string-beads-like to dumbbell-like and rod-like with the increase of reacting temperature.The prepared SiC powders are expected to become new raw material for silicon carbide ceramic composites. | Xingzhong GUO Lin ZHU Wenyan LI Hui YANG | 2013 | Journal of Advanced Ceramics2013，2，2： | 4 |
| 5 | Effects of electric-acoustic and acoustic-electric conversions of transducers on acoustic logging signal显示文摘Based on an acoustic logging transmission network and the engineering pattern of a sliding wave in acoustic logging, analysis and calculations have been performed in a study of the effects of the electric-acoustic and acoustic-electric conversions of the transducers on the acoustic logging signal. The results show that acoustic-electric conversion through the transducer can cause not only a serious disturbance in the signal amplitude, but also an apparent transmission delay. For engineering applications, the amplitude variation and transmission delay must be accounted for in a practical analysis of the acoustic logging signal in rocks. The results also show that with enhanced understanding and proper justification, the error caused by the acoustic-electric conversion can be significantly reduced in evaluation of the cement bond quality of a cased well, and the accuracy of rock porosity calculated using the measured acoustic velocity can be increased. | FA Lin XIE WenYan TIAN Yong ZHAO MeiShan MA Li DONG DaQun | 2012 | Chinese Science Bulletin2012，57，11： | 2 |
| 6 | Single cell analysis reveals inhibition of angiogenesis attenuates the progression of heterotopic ossification in Mkx^(−/−)mice显示文摘Tendon heterotopic ossification(HO)is characterized by bone formation inside tendon tissue,which severely debilitates people in their daily life.Current therapies fail to promote functional tissue repair largely due to our limited understanding of HO pathogenesis.Here,we investigate the pathological mechanism and propose a potential treatment method for HO.Immunofluorescence assays showed that the Mohawk(MKX)expression level was decreased in human tendon HO tissue,coinciding with spontaneous HO and the upregulated expression of osteochondrogenic and angiogenic genes in the tendons of Mkx^(−/−)mice.Single-cell RNA sequencing analyses of wild-type and Mkx^(−/−)tendons identified three cell types and revealed the excessive activation of osteochondrogenic genes during the tenogenesis of Mkx^(−/−)tendon cells.Single-cell analysis revealed that the gene expression program of angiogenesis,which is strongly associated with bone formation,was activated in all cell types during HO.Moreover,inhibition of angiogenesis by the small-molecule inhibitor BIBF1120 attenuated bone formation and angiogenesis in the Achilles tendons of both Mkx mutant mice and a rat traumatic model of HO.These findings provide new insights into the cellular mechanisms of tendon HO and highlight the inhibition of angiogenesis with BIBF1120 as a potential treatment strategy for HO. | Junxin Lin Yuwei Yang Wenyan Zhou Chao Dai Xiao Chen Yuanhao Xie Shan Han Huanhuan Liu Yejun Hu Chenqi Tang Varitsara Bunpetch Dandan Zhang Yishan Chen Xiaohui Zou Di Chen Wanlu Liu Hongwei Ouyang | 2022 | Bone Research2022，10，4： | 1 |
| 7 | 拓普替康联合全脑照射肺癌脑转移的Ⅰ期临床试验(英文)显示文摘Objective:The aim of this study was to define the maximum-tolerated dose (MTD) and observe the toxicity of escalating topotecan combined whole brain radiotherapy for brain metastasis in lung cancer. Methods:Patients with brain metastasis of lung cancer received conventional fractionation radiotherapy, with 5 daily fractions of 2 Gy per week, the total radiation dose was 40 Gy, while the larger lesions were boosted to 50-60 Gy. The initial dose of topotecan was 1.0 mg/m 2 . Escalation dose was 0.25 mg/m 2.Every cohort contained at least 3 patients.If no dose-limiting toxicity (DLT) was observed,the next dose level was opened for entry. These courses were repeated until DLT appeared. MTD was declared as one dose level below which DLT appeared. Results:Eighteen patients were recruited. Two cases of grade 3 leucopenia/neutropenia was observed as DLT at the level of topotecan 2.0 mg/m 2 . MTD of topotecan was defined as 1.75 mg/m 2 .The major side effects were leucopenia/neutropenia, nausea and vomiting. Conclusion:Topotecan combined with whole brain radiotherapy for brain metastasis in lung cancer is well tolerated. Maximum-tolerated dose of topotecan is 1.75 mg/m 2 , once a week of a total of four. | Xiaohui Ge Wenyan Zhao Xiaocang Ren Yongqiang Wang Zhigang Li Yanqi Li Yuee Liu Qiang Lin | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，8： | 1 |
| 8 | Programming of Regulatory T Cells In Situ for Nerve Regeneration and Long-Term Patency of Vascular Grafts显示文摘Rapid integration into the host tissue is critical for long-term patency after small diameter tissue engineering vascular grafts(sdTEVGs)transplantation.Neural recognition may be required for host integration and functionalization of the graft.However,immune rejection and inflammation hinder nerve regeneration of sdTEVGs.Here,a CRISPR/dCas9-nanocarrier was used for targeted programming of regulatory T cells(Treg cells)in situ to promote nerve regeneration of sdTEVGs by preventing excessive inflammation.Treg cells and(C-C chemokine receptor)CCR2+macrophage recruitment occurred after transplantation.The nanodelivery system upregulated ten eleven translocation(TET2)in Treg cells in vitro.Reprogrammed Treg cells upregulated anti-inflammatory cytokines and decreased the proportion of CCR2+macrophages.IL-6 concentrations decreased to the levels required for nerve regeneration.Implantation of CRISPR/dCas9 nanodelivery system-modified sdTEVGs in rats resulted in Treg cell editing,control of excessive inflammation,and promoted nerve regeneration.After 3 months,nerve regeneration was similar to that observed in normal blood vessels;good immune homeostasis,consistency of hemodynamics,and matrix regeneration were observed.Neural recognition promotes further integration of the graft into the host,with unobstructed blood vessels without intimal hyperplasia.Our findings provide new insights into vascular implant functionalization by the host. | Yanhong Wang Fangchao Xue Yanzhao Li Lin Lin Yeqin Wang Shanlan Zhao Xingli Zhao Yong Liu Ju Tan Gang Li Haoran Xiao Juan Yan Hao Tian Min Liu Qiao Zhang Zhaojing Ba Lang He Wenyan Zhao Chuhong Zhu Wen Zeng | 2022 | Research2022，，4： | 1 |
| 9 | Analysis of amino acids in tobacco by derivatization and dispersive liquid–liquid microextraction based on solidification of floating organic droplet method显示文摘 | Gang Li Da Wu Wenyan Xie Yunfei Sha Huaqing Lin Baizhan Liu | 2013 | Journal of Chromatography A2013，，： | 1 |
| 10 | Improving tensile-shear properties of friction stir lap welded dissimilar Al/Mg joints by eliminating hook defect and controlling interfacial reaction显示文摘To improve tensile-shear properties of fiction stir lap welded(FSLW) dissimilar Al/Mg joints, pin-tip profiles were innovatively designed and welding speed was optimized, and effects of them on formation, interface microstructure and mechanical properties of different FSLW joints were investigated. With increasing the welding speed, the tensile-shear load of FSLW joints produced by three pins presents an increasing firstly and then decreasing trend. Compared with Rpin, the hook and hole defect in the joints made by S-pin and T-pin are eliminated owing to additional eccentric force. Moreover, the joints obtained by T-pin at 75 mm/min have the highest tensile-shear load, and a maximum value of 3.425 kN is produced, which increases by 96.8%.Meanwhile, the pin-tip profile improves significantly the interface reaction depending on the welding temperature. For R-pin, thick brittle intermetallic compounds of about 6.9 μm Al3Mg2and 13.3 μm Al12Mg17layers at the welding interface derived from diffusion reaction are formed, resulting in continuous cracks. However, using T-pin can raise the interface temperature, and which makes the interface liquefy locally to generate only 2.2 μm Al3Mg2layer and dispersive(Al12-Mg17+Mg) eutectic structure. This can release high residual stress and remove welding crack, consequently enhancing the interface properties of T-pin joints. | Yuqing MAO Ping YANG Wenyan ZHANG Ning LI Hao NIE Danyang LIN Liming KE | 2023 | Chinese Journal of Aeronautics2023，36，7： | 1 |
| 11 | BING: Binarized normed gradients for objectness estimation at 300fps 显示文摘 | Cheng Mingming Zhang Ziming Lin Wenyan | 2014 | IEEE Conference on Computer Vision & Pattern Recognition2014，，： | 1 |
| 12 | Evolution of composite fouling on a vertical stainless steel surface caused by treated sewage显示文摘 | Cheng Zan Lin Shi Wenyan Yang Xiujuan Ma | 2010 | Research article Front Energy Power Eng China 20102010，4，2： | 1 |
| 13 | Identification of quantitative trait loci for seed storability in rice ( Oryza sativa L.)显示文摘 | LINFANG LI QIUYUN LIN SHIJIA LIU XI LIU WENYAN WANG NGO THI HANG FENG LIU ZHIGANG ZHAO LING JIANG JIANMIN WAN | 2012 | Plant Breeding2012，，6： | 1 |
| 14 | Evolution of Composite Fouling on A Vertical Stainless Steel Surface Caused by Treated Sewage 显示文摘 | ZAN Cheng SHI Lin YANG Wenyan | 2010 | Front Energy2010，4，2： | 1 |
| 15 | Evolution of composite fouling on a vertical stainless steel surface caused by treated sewage 显示文摘 | Zan Cheng Shi Lin Yang Wenyan Ma Xuiuan | 2010 | Frontiers of Energy and Power Engineering in China2010，4，2： | 1 |
| 16 | A high-resolution route map reveals distinct stages of chondrocyte dedifferentiation for cartilage regeneration显示文摘Articular cartilage damage is a universal health problem.Despite recent progress,chondrocyte dedifferentiation has severely compromised the clinical outcomes of cell-based cartilage regeneration.Loss-of-function changes are frequently observed in chondrocyte expansion and other pathological conditions,but the characteristics and intermediate molecular mechanisms remain unclear.In this study,we demonstrate a time-lapse atlas of chondrocyte dedifferentiation to provide molecular details and informative biomarkers associated with clinical chondrocyte evaluation.We performed various assays,such as single-cell RNA sequencing(scRNA-seq),live-cell metabolic assays,and assays for transposase-accessible chromatin with high-throughput sequencing(ATAC-seq),to develop a biphasic dedifferentiation model consisting of early and late dedifferentiation stages.Early-stage chondrocytes exhibited a glycolytic phenotype with increased expression of genes involved in metabolism and antioxidation,whereas late-stage chondrocytes exhibited ultrastructural changes involving mitochondrial damage and stress-associated chromatin remodeling.Using the chemical inhibitor BTB06584,we revealed that early and late dedifferentiated chondrocytes possessed distinct recovery potentials from functional phenotype loss.Notably,this two-stage transition was also validated in human chondrocytes.An image-based approach was established for clinical use to efficiently predict chondrocyte plasticity using stage-specific biomarkers.Overall,this study lays a foundation to improve the quality of chondrocytes in clinical use and provides deep insights into chondrocyte dedifferentiation. | Yishan Chen Yeke Yu Ya Wen Juan Chen Junxin Lin Zixuan Sheng Wenyan Zhou Heng Sun Chengrui An Jiansong Chen Weiliang Wu Chong Teng Wei Wei Hongwei Ouyang | 2022 | Bone Research2022，10，3： | 1 |
| 17 | The national multi-center artificial intelligent myopia prevention and control project显示文摘In recent years,the incidence of myopia has increased at an alarming rate among children and adolescents in China.The exploration of an effective prevention and control method for myopia is in urgent need.With the development of information technology in the past decade,artificial intelligence with the Internet of Things technology(AIoT)is characterized by strong computing power,advanced algorithm,continuous monitoring,and accurate prediction of long-term progression.Therefore,big data and artificial intelligence technology have the potential to be applied to data mining of myopia etiology and prediction of myopia occurrence and development.More recently,there has been a growing recognition that myopia study involving AIoT needs to undergo a rigorous evaluation to demonstrate robust results. | Xun Wang Yahan Yang Yuxuan Wu Wenbin Wei Li Dong Yang Li Xingping Tan Hankun Cao Hong Zhang Xiaodan Ma Qin Jiang Yunfan Zhou Weihua Yang Chaoyu Li Yu Gu Lin Ding Yanli Qin Qi Chen Lili Li Mingyue Lian Jin Ma Dongmei Cui Yuanzhou Huang Wenyan Liu Xiao Yang Shuiming Yu Jingjing Chen Dongni Wang Zhenzhe Lin Pisong Yan Haotian Lin Chinese Association of Artificial Intelligence,Medical Artificial Intelligence Branch of Guangdong Medical Association | 2021 | Intelligent Medicine2021，1，2： | 1 |
| 18 | Highly Prevalent SARS-CoV-2 Antigenemia in COVID-19 Patients显示文摘Background:Many issues,such as severity assessment and antibody responses,remain to be answered eagerly for evaluation and understanding of COVID-19.Immune lesion is one of key pathogenesis of the disease.It would be helpful to understand the disease if an investigation on antigenemia and association was conducted in the patients with SARS-CoV-2 infection.Methods:A total of 156 patients admitted to the First People’s Hospital of Hefei or Anhui Provincial Hospital on January to February 2020 were involved in this study.SARS-CoV-2 nucleocapsid(NP)antigen,specific IgM/IgG antibodies,and RNA were detected in sequential sera from three COVID-19 patients,and additional 153 COVID-19 patients by means of NP-antigen capture enzyme-linked immunosorbent assay,colloidal gold quick diagnosis,and real-time RT-PCR,respectively.The clinical types of COVID-19 patients were classified into asymptomatic,mild,moderate,severe,and critical,following on the Chinese guideline of COVID-19 diagnosis and treatment.The demographic and clinical data of patients were obtained for comparable analysis.Results:NP antigen was detected in 5 of 20 sequential sera collected from three COVID-19 patients with typically clinical symptoms,and 60.13%(92/153)expanded samples collected within 17days after illness onset.No SARS-CoV-2 RNA segment was detected in these sera.The NP positive proportion reached a peak(84.85%,28/33)on 6 to 8days after illness onset.Both NP concentration and positive proportion were increased with the increase of clinical severity of COVID-19.Compared to NP negativepatients,NP positive patients had older age[years,medians(interquartileranges(IQR)),49(6)vs.31(11)],lowerpositive proportion of NP specific IgM[27.17%(25/92)vs.59.02%(36/61)],and IgG[21.74%(20/92)vs.59.02%(36/61)]antibodies,and longer duration[days,medians(IQR),24(10)vs.21(13)]from illness to recovery.Conclusions:SARS-CoV-2 NP antigenemia occurred in COVID-19,and presented highly prevalent at early stage of the disease.The antigenemia was related to clinical severity of the disease,and may beresponsible for the delay of detectable SARS-Cov-2IgM. | Wenyan Zhang Wei Liu Jiawang Lin Jing Jin Kefu Zhao Liwei Zhu Xiuzhen Wang Lijie Wang Renshu Tang Yindi Zhu Wei Zhou Enqing You Lei Zhang Xuxiang Liu Jinju Wu Lili Chen Wenjing Wang Qiang Zhang Rongbao Gao | 2022 | Infectious Diseases & Immunity2022，2，3： | 0 |
| 19 | Electrochemical synthesis of dipyrazolo/dipyrimidine-fused pyridines via oxidative domino cyclization of C(sp^(3))–H bonds显示文摘An electrochemically oxidative domino cyclization reaction of methyl azaarenes/ketones with pyrazol-5-amines and 6-amino-pyrimidine-2,4-diones was developed, providing a variety of dipyrazolo[3,4-b:4’,3’-e]pyridines and dipyrimidine-fused pyridines with moderate to good yields. The reaction involved two C–C bond formations and one C–N bond formation in one pot. Moreover, the photoluminescence properties of the representative dipyrazolo[3,4-b:4’,3’-e]pyridines were investigated. | Peng Qian Linna Xu Wenyan Wang Lin Zhang Liang Tang Jiaojiao Liu Liangquan Sheng | 2022 | Organic Chemistry Frontiers2022，9，6： | 0 |
| 20 | Effects of Wuling Powder Mediating Notch Pathway on Mice with Nephrotic Syndrome显示文摘[Objectives]This study was conducted to investigate the renal protective effects of Wuling Powder on mice with nephrotic syndrome(NS)based on Notch pathway.[Methods]Sixty KM mice were randomly divided into normal group,model group,prednisone acetate positive group,high-dose Wuling Powder group,medium-dose Wuling Power group and low-dose Wuling Power group,with 10 mice in each group.Three days after prophylactic administration,a comprehensive nephropathy model was prepared by injecting 1 mg/ml doxorubicin hydrochloride solution(7.5 mg/kg)into the tail vein.After successful modeling,prednisone acetate and Wuling SAN were given high,medium and low doses for intervention for 28 d,respectively.After that,urinary protein and creatinine contents of mice in each group were detected,and pathological damage of renal tissue was observed by HE and Masson staining.The mRNA levels of Notch1,Jagged1 and Hes1 in mouse kidney tissues were detected by RT-PCR,and the expression levels of Notch1,Jagged1 and Hes1 proteins were detected by Western blot.[Results]Wuling Powder could effectively reduce the contents of urine protein(P<0.01)and Scr(P<0.01)in NS mice,and alleviate the pathological injury of kidney.Compared with the model group,the prednisone acetate group and various Wuling Powder groups could down-regulate the expressions of Notch1,Jagged1 and Hes1 mRNA in the kidney tissue of mice(P<0.01),and the expression of Notch1 protein in the renal tissue of mice decreased(P<0.01).The contents of Hes1 in the prednisone acetate group and the high-and medium-dose Wuling Powder groups significantly decreased(P<0.05).[Conclusions]Wuling Powder could protect the kidneys in mice with NS through Notch pathway. | Luotong JING Yihan LI Honglanxi LI Wenyan ZHANG Lin QIN Ning LIANG | 2023 | Agricultural Biotechnology2023，12，6： | 0 |
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