|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of warming Yang and removing blood stasis method on matrix metalloproteinases/tissue inhibitor metalloproteinases levels secreted by cultured endometrial cells from patients with endometriosis显示文摘OBJECTIVE:To investigate the effect of Chinese medicines using the warming Yang and removing blood stasis method on levels of matrix metalloproteinases(MMPs)/tissue inhibitor metalloproteinases(TIMPs) secreted by cultured endometrial cells from patients with endometriosis.METHODS:Ectopic and eutopic endometrial cells obtaind from 15 endometriosis patients were cultured in vitro,and divided randomly into five groups:high dose;moderate dose;low dose;nemestran;blank control.The three dose groups were treated with a decoction prepared according to the principle of warming Yang and removing blood stasis;nemestran and 0.9%NaCI were administered to the nemestran group and balnk control group,respectively.Eutopic endometrial cells obtaind from 10 hysteromyoma patients were cultured in vitro,as the normal control group,0.9%NaCI were administered to the normal control group.Cell culture supernatants were collected and levels of matrix metalloproteinase-1(MMP-1),matrix metalloproteinase-2(MMP-2),matrix metalloproteinase-9(MMP-9),tissue inhibitor metalloproteinase-1(TIMP-1) and tissue inhibitor metalloproteinase-2(TIMP-2) detected by enzyme-linked immuno sorbent assay(ELISA).RESULTS:Compared with the normal control group,levels of MMP-1,MMP-2,and MMP-9 in eutopic and ectopic endometrium cell supernatants in the blank control group were increased,whereas levels of TIMP-1 and TIMP-2 were decreased(P <0.05).Compared with the blank control group,levels of MMP-1 and MMP-2 in ectopic and eutopic endometrium cell supernatants cultured in low-dose,middle-dose,and high-dose groups were decreased,whereas levels of TIMP-1 and TIMP-2 were increased significantly(P < 0.05).CONCLUSION:The warming Yang and removing blood stasis method affects expression of MMPs andTIMPs. | Huang Yanhui Shen Lin Cai Anhe Xiao Jing | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 10 |
| 2 | Layered double hydroxide(LDH) for multi-functionalized corrosion protection of metals: A review显示文摘Layered double hydroxide(LDH) has been widely developed in the field of corrosion and protection in recent years based on its unique characteristics including anion capacity, anion exchange ability, structure memory effect, and barrier resistance. This paper comprehensively reviews recent work on the preparations, properties of LDH in the forms of powder and film and their applications in different environments in corrosion and protection. Some novel perspectives are also proposed at the end of the review for future research in corrosion and protection field. | Yanhui Cao Dajiang Zheng Fan Zhang Jinshan Pan Changjian Lin | 2022 | Journal of Materials Science & Technology2022，，7： | 9 |
| 3 | Unsteady Numerical Simulation of Flow around 2-D Circular Cylinder for High Reynolds Numbers显示文摘在这份报纸, 2-D 计算分析在 supercritical 和上面转变的流动政体在光滑的圆形的柱体附近为不稳定的高级雷纳兹数字流动被进行,即 8. | Yanhui Ai Dakui Feng Hengkui Ye Lin Li | 2013 | Journal of Marine Science and Application2013，12，2： | 7 |
| 4 | Removal of humic acid from aqueous solution by cetylpyridinium bromide modified zeolite显示文摘Natural zeolite was modified by loading cetylpyridinium bromide(CPB) to create more efficient sites for humic acid(HA) adsorption.The natural and CPB modified zeolites were characterized with X-ray diffraction, field emission scanning electron microscopy, Fourier transform infrared spectroscopy and elemental analysis.The effects of various experimental parameters such as contact time, initial HA concentration, solution pH and coexistent Ca2+, upon HA adsorption onto CPB modified zeolites were evaluated.The results showed that natural zeolite had negligible affinity for HA in aqueous solutions, but CPB modified zeolites exhibited high adsorption efficiency for HA.A higher CPB loading on natural zeolites exhibited a larger HA adsorption capacity.Acidic pH and coexistent Ca2+ were proved to be favorable for HA adsorption onto CPB modified zeolite.The kinetic process was well described by pseudo second-order model.The experimental isotherm data fitted well to Langmuir and Sips models.The maximum monolayer adsorption capacity of CPB modified zeolite with surfactant bilayer coverage was found to be 92.0 mg/g. | Yanhui Zhan Zhiliang Zhu Jianwei Lin Yanling Qiu Jianfu Zhao | 2010 | Journal of Environmental Sciences2010，22，9： | 6 |
| 5 | RLS3, a protein with AAA+ domain localized in chloroplast, sustains leaf longevity in rice显示文摘Leaf senescence plays an important role in crop developmental processes that dramatically affect crop yield and grain quality. The genetic regulation of leaf senescence is complex, involving many metabolic and signaling pathways.Here, we identified a rapid leaf senescence 3(rls3) mutant that displayed accelerated leaf senescence, shorter plant height and panicle length, and lower seed set rate than the wild type. Map-based cloning revealed that RLS3 encodes a protein with AAA+ domain, localizing it to chloroplasts. Sequence analysis found that the rls3 gene had a single-nucleotide substitution(G→A) at the splice site of the 10^(th)intron/11^(th) exon, resulting in the cleavage of the first nucleotide in 11 ^(th) exon and premature termination of RLS3 protein translation.Using transmission electron microscope, the chloroplasts of the rls3 mutant were observed to degrade much faster than those of the wild type. The investigation of the leaf senescence process under dark incubation conditions furtherrevealed that the rls3 mutant displayed rapid leaf senescence.Thus, the RLS3 gene plays key roles in sustaining the normal growth of rice, while loss of function in RLS3 leads to rapid leaf senescence. The identification of RLS3 will be helpful to elucidate the mechanisms involved in leaf senescence in rice. | Yanhui Lin Lubin Tan Lei Zhao Xianyou Sun Chuanqing Sun | 2016 | Journal of Integrative Plant Biology2016，58，12： | 6 |
| 6 | Effect of precipitation pH and coexisting magnesium ion on phosphate adsorption onto hydrous zirconium oxide显示文摘To understand the effect of precipitation pH and coexisting Mg^(2+) on phosphate adsorption onto zirconium oxide(ZrO_2), ZrO_2 particles precipitated at pH 5.3, 7.1 and 10.5, i.e., ZrO_2(5.3), ZrO_2(7.1)and ZrO_2(10.5), respectively were prepared and characterized, then their adsorption performance and mechanism in the absence and presence of Mg^(2+) were comparatively investigated in this study. The results showed that the Elovich, pseudo-second-order and Langmuir isotherm models correlated with the experimental data well. The adsorption mechanism involved the complexation between phosphate and zirconium. Coexisting Mg^(2+) slightly inhibited the adsorption of phosphate on ZrO_2(5.3), including the adsorption capacity and rate, but coexisting Mg^(2+) greatly increased the adsorption capacity and rate for ZrO_2(7.1)and ZrO_2(10.5). The enhanced adsorption of phosphate on ZrO_2(7.1) and ZrO_2(10.5) in the presence of Mg^(2+) was mainly due to the formation of Mg^(2+)-HPO_4^(2-) ion pair(MgHPO_4~0) in the solution and then the adsorption of MgHPO_4~0 on the adsorbent surface, forming the phosphatebridged ternary complex Zr(OPO_3H)Mg. In the absence of Mg^(2+) , the maximum phosphate adsorption capacity at pH 7 calculated from the Langmuir isotherm model decreased in the order of ZrO 2(7.1)(67.3 mg/g) > ZrO_2(5.3)(53.6 mg/g) ≈ ZrO_2(10.5)(53.1 mg/g), but it followed the order of Zr O2(7.1)(97.0 mg/g) > ZrO_2(10.5)(79.7 mg/g) > ZrO_2(5.3)(51.3 mg/g) in the presence of Mg^(2+) . The results of this work suggest that ZrO_2(7.1) is more suitable for use as an adsorbent for the effective removal of phosphate from municipal wastewater than ZrO_2(5.3) and ZrO_2(10.5),because Mg^(2+) is generally present in this wastewater. | Jianwei Lin Xingxing Wang Yanhui Zhan | 2019 | Journal of Environmental Sciences2019，31，2： | 5 |
| 7 | Preparation of poly(glutamic acid) shielding micelles self-assembled from polylysine-b-polyphenylalanine for gene and drug codelivery显示文摘A novel amphiphilic cationic block copolymer polylysine-b-polyphenylalanine(PLL-b-PPhe)was synthesized and self-assembled into micelles in aqueous solution,then shielded with poly(glutamic acid)(marked as PG/PLL-b-PPhe)to codeliver gene and drug for combination cancer therapy.Here,doxorubicin(DOX)was selected to be loaded into PLL-b-PPhe micelles and the drug loading efficiency was 8.0%.The drug release studies revealed that the PLL-b-PPhe micelles were pH sensitive and the released DOX could reach to 53.0%,65.0%,72.0%at pH 7.4,6.8 and 5.0,respectively.In order to reduce positive charge and cytotoxicity of PLL-b-PPhe micelles,PG was used as shelding,simultaneously condensed with Bcl2 siRNA to form gene carrier system.Compared with PEI,PG/PLL-b-PPhe had excellent gene transfection efficiency,especially when the molar ratio of PLL to PPhe was 30:60 and the mixed mass ratio of PLL-b-PPhe to gene was 5:1.More importantly,DOX and Bcl2 siRNA gene codelivery system displayed remarkable cytotoxicity against B16 F10 cells.Confocal laser scanning microscopy(CLSM)and flow cytometry were used to characterize endocytosis of the codelivery system,and confirmed that both DOX and Bcl2 siRNA had been endocytosed into B16 F10 cells.The above results indicated that gene and drug codelivery was a promising strategy in future cancer therapy. | Jing Ma Jingpeng Zhang Lin Chi Chong Liu Yanhui Li Huayu Tian | 2020 | Chinese Chemical Letters2020，31，6： | 4 |
| 8 | A study on the changes of dynamic feature code when fixing bugs: towards the benefits and costs of Python dynamic features显示文摘Dynamic features in programming languages support the modification of the execution status at runtime, which is often considered helpful in rapid development and prototyping. However, it was also reported that some dynamic feature code tends to be change-prone or error-prone. We present the first study that analyzes the changes of dynamic feature code and the roles of dynamic features in bug-fix activities for the Python language. We used an AST-based differencing tool to capture fine-grained source code changes from 17926 bug-fix commits in 17 Python projects. Using this data, we conducted an empirical study on the changes of dynamic feature code when fixing bugs in Python. First, we investigated the characteristics of dynamic feature code changes, by comparing the changes between dynamic feature code and non-dynamic feature code when fixing bugs, and comparing dynamic feature changes between bug-fix and non-bugfix activities. Second, we explored 226 bug-fix commits to investigate the motivation and behaviors of dynamic feature changes when fixing bugs. The study results reveal that(1) the changes of dynamic feature code are significantly related to bug-fix activities rather than non-bugfix activities;(2) compared with non-dynamic feature code, dynamic feature code is inserted or updated more frequently when fixing bugs;(3) developers often insert dynamic feature code as type checks or attribute checks to fix type errors and attribute errors;(4) the misuse of dynamic features introduces bugs in dynamic feature code, and the bugs are often fixed by adding a check or adding an exception handling. As a benefit of this paper, we gain insights into the manner in which developers and researchers handle the changes of dynamic feature code when fixing bugs. | Zhifei CHEN Wanwangying MA Wei LIN Lin CHEN Yanhui LI Baowen XU | 2018 | Science China(Information Sciences)2018，61，1： | 4 |
| 9 | Electronic-property dependent interactions between tetracycline and graphene nanomaterials in aqueous solution显示文摘Understanding the interactions between graphene nanomaterials(GNMs) and antibiotics in aqueous solution is critical to both the engineering applications of GNMs and the assessment of their potential impact on the fate and transport of antibiotics in the aquatic environment. In this study, adsorption of one common antibiotic, tetracycline, by graphene oxide(GO) and reduced graphene oxide(RGO) was examined with multi-walled carbon nanotubes(MWCNTs) and graphite as comparison. The results showed that the tetracycline adsorption capacity by the four selected carbonaceous materials on the unit mass basis followed an order of GO > RGO > MWCNTs > graphite. Upon normalization by surface area,graphite, RGO and MWCNTs had almost the same high tetracycline adsorption affinity while GO exhibited the lowest. We proposed π-electron-property dependent interaction mechanisms to explain the observed different adsorption behaviors. Density functional theory(DFT) calculations suggested that the oxygen-containing functional groups on GO surface reduced its π-electron-donating ability, and thus decreased the π-based interactions between tetracycline and GO surface. Comparison of adsorption efficiency at different p H indicated that electrostatic interaction also played an important role in tetracycline-GO interactions. Site energy analysis confirmed a highly heterogeneous distribution of the binding sites and strong tetracycline binding affinity of GO surface. | Lin He Fei-fei Liu Mengyao Zhao Zhen Qi Xuefei Sun Muhammad Zaheer Afzal Xiaomin Sun Yanhui Li Jingcheng Hao Shuguang Wang | 2018 | Journal of Environmental Sciences2018，30，4： | 4 |
| 10 | Polymer matrix mediated solvation of LiNO3 in carbonate electrolytes for quasi-solid high-voltage lithium metal batteries显示文摘Lithium(Li)metal is one of the most promising anodes for next-generation energy storage systems.However,the Li dendrite formation and unstable solid-electrolyte interface(SEI)have hindered its further application.Lithium nitrate(LiNO3)is extensively used as an effective electrolyte additive in ether-based electrolytes to improve the stability of lithium metal.Nevertheless,it is rarely utilized in carbonate electrolytes due to its low solubility.Here,a novel gel polymer electrolyte(GPE)consisting of poly(vinylidene fluoride)(PVDF),poly(methyl methacrylate)(PMMA),poly(ethylene oxide)(PEO)with LiN03 additive is proposed to solve this issue.In this GPE,polyether-based PEO serves as a matrix for dissolving LiNO3 which can be decomposed into a fast Li-ion conductor(Li3N)in conventional carbonate electrolytes to enhance the stability and Li^+conductivity of the SEI film.As a result,dendrite formation is effectively suppressed,and a significantly improved average Coulombic efficiency(CE)of 97.2%in Li-Cu cell is achieved.By using this novel GPE coupled with Li anode and LiNi0.5Mn0.3Co0.2O2(NMC532),excellent capacity retention of 94.1%and high average CE of over 99.2%are obtained after 200 cycles at 0.5 C.This work presents fresh insight into practical modification strategies on high-voltage Li metal batteries. | Zijian Wang Kai Yang Yongli Song Hai Lin Ke Li Yanhui Cui Luyi Yang Feng Pan | 2020 | Nano Research2020，13，9： | 3 |
| 11 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘Histone 离氨酸 methylation 能被 JmjC 包含域的蛋白质在 sequence-state-specific 和 methylation-state-specific 举止移开。然而,底层特性怎么样,决定,酶怎么被调整,大部分是未知的。我们最近发现了那 ceKDM7A,一个哲学博士 -- 并且 JmjC 包含域的蛋白质,是为 H3K9me2 特定的 histone demethylase, H3K27me2,和 PHD 摸绑定到 H3K4me3 指南在 vivo 的 demethylation 活动。为了为酶的活动和 PHD 的功能提供结构的卓见进分子的机制,摸,我们与包含 H3K4me3, H3K9me2,和 H3K27me2 修正的各种各样的联合的单身者或二肽一起在 apo 形式并且在建筑群解决了酶的六水晶结构。结构显示 H3K9me2 和 H3K27me2 以一种类似的方式与 ceKDM7A 交往,并且肽绑定特性被特定的相互作用的一个网络决定。结构的几何测量也揭示了与 PHD 手指和 H3K9me2 界限联系到 JmjC 领域的那 H3K4me3 从二个分开的分子,建议 trans-histone 肽绑定机制。因此,我们的全身的结构的研究重要地由催化领域而且更多揭示底层识别不仅,为 H3K9me2 和 H3K27me2 的 ceDKM7A 的双特性的分子的机制。 | Ying Yang Lulu Hu Ping Wang Haifeng Hou Yan Lin Yi Liu Ze Li Rui Gong Xiang Feng Lu Zhou Wen Zhang Yuhui Dong Huirong Yang Hanqing Lin Yiqin Wang Charlie Degui Chen Yanhui Xu | 2010 | Cell Research2010，20，8： | 3 |
| 12 | Hydrogen production via chemical looping reforming of coke oven gas显示文摘Coke oven gas(COG)is one of the most important by-products in steel industry,and the conversion of COG to value-added products has attracted much attention from both economic and environmental views.In this work,we use the chemical looping reforming technology to produce pure H_(2) from COG.A series of La1-xSrxFeO_(3)(x?0,0.2,0.3,0.4,0.5,0.6)perovskite oxides were prepared as oxygen carriers for this purpose.The reduction behaviors of La1-xSrxFeO_(3) perovskite by different reducing gases(H_(2),CO,CH4 and the mixed gases)are investigated to discuss the competition effect of different components in COG for reacting with the oxygen carriers.The results show that reduction temperatures of H_(2) and CO are much lower than that of CH4,and high temperatures(>800℃)are requested for selective oxidation of methane to syngas.The co-existence of CO and H_(2) shows weak effect on the equilibrium of methane conversion at high temperatures,but the oxidation of methane to syngas can inhibit the consumption of CO and H_(2).The doping of suitable amounts of Sr in LaFeO_(3) perovskite(e.g.,La0.5Sr0.5FeO_(3))significantly promotes the activity for selective oxidation of methane to syngas and inhibits the formation of carbon deposition,obtaining both high methane conversion in the COG oxidation step and high hydrogen yield in the water splitting step.The La0.5Sr0.5FeO_(3) shows the highest methane conversion(67.82%),hydrogen yield(3.34 mmol g^(-1))and hydrogen purity(99.85%).The hydrogen yield in water splitting step is treble as high as the hydrogen consumption in reduction step.These results reveal that chemical looping reforming of COG to produce pure H_(2) is feasible,and an O_(2)-assistant chemical looping reforming process can further improves the redox stability of oxygen carrier. | Kun Yang Zhenhua Gu Yanhui Long Shen Lin Chunqiang Lu Xing Zhu Hua Wang Kongzhai Li | 2021 | Green Energy & Environment2021，6，5： | 2 |
| 13 | State and tendency: an empirical study of deep learning question&answer topics on Stack Overflow显示文摘Deep learning has developed rapidly in recent years, attracting the attention of numerous researchers. Since a wide range of topics are covered in this field, we are wondering what topics researchers have concerned about. However, after investigation, we find that very few researchers have paid attention to this demand. In this paper, we conduct a large-scale study to analyze the questions faced by deep learning developers. We use Stack Overflow, one of the largest question&answer sites, as our data source, and extract32969 posts about deep learning as our studied dataset. After filtering, augmenting and pre-processing the post datasets from Stack Overflow, we use the latent Dirichlet allocation(LDA) topic model to summarize30 topics based on their text content. In addition, we measure the difficulty and popularity of each topic,compare the different issues faced by different deep learning frameworks, and analyze the development trend of each topic. Our main results are as follows:(1) developers ask a broad spectrum of questions about deep-learning, ranging from Data Shape to Object Detection;(2) Gradient Propagation is the most popular among all the topics and(3) Object Detection is the most difficult;(4) issues of Package Installation, Code Understanding and Method Introduction are common in the current different deep learning frameworks;(5) there are three trends in these topics, e.g., a significant rising trend is found in the number of discussion on Data Shape. Finally, based on our research findings, we make some targeted and valuable suggestions for developers, researchers, educators, and framework providers of deep learning. | Henghui ZHAO Yanhui LI Fanwei LIU Xiaoyuan XIE Lin CHEN | 2021 | Science China(Information Sciences)2021，64，11： | 2 |
| 14 | Adsorption of humic acid from aqueous solution on bilayer hexadecyltrimethyl ammonium bromide-modified zeolite显示文摘Surfactant-modified natural zeolites(SMNZ)with different coverage types were prepared by loading hexadecyltrimethyl ammonium bromide(HTAB)onto the surface of a natural zeolite.The adsorption behavior of humic acid(HA)on SMNZ was investigated.Results indicate that the adsorbent SMNZ exhibited a higher affinity toward HA than the natural zeolite.HA removal efficiency by SMNZ increased with HTAB loading.Coexisting Ca2+in solution favored HA adsorption onto SMNZ.Adsorption capacity decreased with an increasing solution pH.For typical SMNZ with bilayer HTAB coverage,HA adsorption process is well described by a pseudo-second-order kinetic model.The experimental isotherm data fitted well with the Langmuir model.Calculated maximum HA adsorption capacities for SMNZ with bilayer HTAB coverage at pH 5.5 and 7.5 were 63 and 41 mg·g^(-1),respectively.E2/E3(absorbance at 250 nm to that at 365 nm)and E4/E6(absorbance at 465 nm to that at 665 nm)ratios of the residual HA in solution were lower than that of the original HA solution.This indicates that the HA fractions with high polar functional groups,low molecular weight(MW),and aromaticity had a stronger tendency for adsorption onto SMNZ with bilayer HTAB coverage.Results show that HTABmodified natural zeolite is a promising adsorbent for removal of HA from aqueous solution. | Yanhui ZHAN Jianwei LIN Yanling QIU Naiyun GAO Zhiliang ZHU | 2011 | Frontiers of Environmental Science & Engineering2011，5，1： | 2 |
| 15 | Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘H3K9me2 和 H3K27me2 是与抄写压抑联系的重要 epigenetic 标记,当 H3K4me3 与抄写激活被联系时。活跃、压抑的 histone methylations 以一种互相独占的方式散布,这被显示出,但是内在的机制糟糕被理解。这里,我们识别了 ceKDM7A,一个哲学博士(植物 homeodomain )- 并且 JmjC 包含域的蛋白质,为 H3K9me2 和 H3K27me2 特定的 histone demethylase。我们进一步证明 ceKDM7A 的 PHD 领域在染色体宽的水平绑了 H3K4me3 和与 ceKDM7A co 局部性的 H3K4me3。到 H3K4me3 的 PHD 域绑定的混乱在 vivo 减少了 demethylase 活动,并且 ceKDM7A 的损失减少了它的联系目标基因的表达式。这些结果显示 ceKDM7A 被招募到倡导者到 demethylate H3K9me2 和 H3K27me2 并且通过 PHD 领域的绑定激活基因表示到 H3K4me3。因此,我们的学习识别双特性的 histone demethylase 并且提供新奇卓见进 histone methylation 的规定。 | Hanqing Lin Yiqin Wang Yanru Wang Feng Tian Pu Pu Yi Yu Hailei Mao Ying Yang Ping Wang Lulu Hu Yan Lin Yi Liu Yanhui Xu Charlie Degui Chen | 2010 | Cell Research2010，20，8： | 2 |
| 16 | Argonaute protein as a linker to command center of physiological processes显示文摘MicroRNAs (miRNAs) post-transcriptionally regulate gene expression by binding to target mRNAs with perfect or imperfect complementarity, recruiting an Argonaute (AGO) protein complex that usually results in degradation or translational repression of the target mRNA. AGO proteins function as the Slicer enzyme in miRNA and small interfering RNA (siRNA) pathways involved in human physiological and pathophysiological processes, such as antiviral responses and disease formation. Although the past decade has witnessed rapid advancement in studies of AGO protein functions, to further elucidate the molecular mechanism of AGO proteins in cellular function and biochemical process is really a challenging area for researchers. In order to understand the molecular causes underlying the pathological processes, we mainly focus on five fundamental problems of AGO proteins, including evolution, functional domain, subcellular location, post-translational modification and protein-protein interactions. Our discussion highlight their roles in early diagnosis, disease prevention, drug target identification, drug response, etc. | Kaifa Wei Lingjuan Wu Yanhui Chen Yina Lin Yanmei Wang Xiaoyao Liu Daoxin Xie | 2013 | Chinese Journal of Cancer Research2013，25，4： | 2 |
| 17 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 18 | Field study on occupants’ thermal comfort and residential thermal environment in a hot-humid climate of China显示文摘 | Jie Han Guoqiang Zhang Quan Zhang Jinwen Zhang Jianlong Liu Liwei Tian Cong Zheng Junhong Hao Jianping Lin Yanhui Liu Demetrios. J. Moschandreas | 2006 | Building and Environment2006，，12： | 1 |
| 19 | An ionic liquid-modified graphene based molecular imprinting electrochemical sensor for sensitive detection of bovine hemoglobin显示文摘 | Zonghua Wang Feng Li Jianfei Xia Lin Xia Feifei Zhang Sai Bi Guoyu Shi Yanzhi Xia Jingquan Liu Yanhui Li Linhua Xia | 2014 | Biosensors and Bioelectronics2014，，： | 1 |
| 20 | Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients显示文摘 | Yanhui Xu Hong Li Rui Lin Gao Oluwasayo Adeyemo Maxim Itkin David E. Kaplan | 2011 | Clinical Immunology2011，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员