|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of Bushenwenyanghuayu decoction on nerve growth factor and bradykinin/bradykinin B_1 receptor in a endometriosis dysmenorrhea mouse model显示文摘OBJECTIVE:To observe the effects of Bushenwenyanghuayu decoction(BD),a Traditional Chinese Medicine(TCM),on the serum concentration of nerve growth factor(NGF) and bradykinin(BK),and protein and mRNA levels of NGF and bradykinin B_1receptor(BKB1R) in a mouse model of endometriosis dysmenorrhea.METHODS:Seventy-five experimental female BALB/c mice were randomly divided into five groups,15 mice each:sham,model,BD high dose(61.67 g/kg),BD low dose(15.42 g/kg),and gestrinone(0.4 mg/kg) groups.All the mice except for those in the sham group underwent auto-transplantation surgery and were gavaged estradiol valerate(0.5 mg/kg,daily for 12 days) after surgery.On the 12 th day,1 h after administration,writhing response was induced by intraperitoneal injection of oxytocin at 2 U/mouse.The writhing frequency and latency were recorded and the volume of the ectopic foci was measured.The concentration of serum NGF and BK was detected by enzyme-linked immunosorbent assay,the protein expression of NGF and BKB1 R was tested by immunohistochemistry and western blotting,and NGF and BKB1 R mRNAs were detected by real-time PCR.RESULTS:Compared with the model group,the volume of the ectopic foci in the treatment groups was significantly lower(P < 0.01),the writhing frequency was decreased(P < 0.05),and the writhing latency was prolonged(P < 0.01).Compared with the sham group,serum NGF and BK levels in the model group were significantly increased(P <0.01).There were positive correlations for writhing frequency among the NGF and BK groups(P <0.01).The serum NGF and BK levels were significantly lower in the treatment groups than the model group(P < 0.05).The protein expression of NGF,BKB1 R was significantly decreased in the treatment groups compared with the model group(P < 0.01).NGF and BKB1 R mRNA expression was significantly decreased in the treatment groups compared with the model group(P < 0.01).CONCLUSION:NGF and BK/BKB1 R may play an important role in the development of endometriosis-associated dysmenorrhea,and BD was found to inhibit the development of endometriosis and relieve dysmenorrhea by influencing NGF and BK/BKB1 R mRNA and protein levels. | Chen Jingwei Du Huilan Tong Ruixiao Yang Hua Ma Huirong | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 12 |
| 2 | Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia/reperfusion injury and the involvement of hypoxia inducible factor-1α upregulation显示文摘Hyperlipidemia 在 ischemic 心疾病的发展被认为是一个独立风险因素,并且它能增加心肌的危险性到 ischemia/reperfusion (I/R ) 损害。Ischemic postconditioning (Postcon ) 被表明了稀释 I/R 处于正常条件导致的心肌的损害。但是 hyperlipidemic 动物上的 ischemic Postcon 的效果是未知的。组织缺氧可诱导的 factor-1 (HIF-1 ) 被表明了由 preconditioning 在 cardioprotection 起一个中央作用,它除了 Postcon 是保护的策略之一。这研究的目的是决定 Postcon 是否能在 hyperlipidemic 动物减少心肌的损害并且估计 HIF-1 是否涉及 Postcon 机制。在用高胖的饮食或正常饮食喂了 8 个星期以后,男 Wistar 老鼠经历了左前面的下降冠的吸藏因为 30 min 由灌注的 180 min 列在后面与或没有 Postcon。I/R 侮辱导致的有害索引包括了梗塞尺寸,血浆肌酸 kinase 活动和 caspase-3 活动。结果证明 hyperlipidemia 显著地提高了 I/R 导致的心肌的损害,当 Postcon 显著地减少了时在 normolipidemic 和 hyperlipidemic 老鼠的心肌的损害。而且, hyperlipidemia 和 I/R 支持了 HIF-1 表示。最重要地,我们第一次证明了 Postcon 进一步不仅在 normolipidemic 而且处于 hyperlipidemic 条件在 HIF-1 蛋白质水平导致了重要增加。因此, Postcon 减少 I/R 在正常和 hyperlipidemic 导致的心肌的损害动物,和 HIF-1 upregulation 可以在调停 Postcon 的 cardioprotective 机制包含。 | Huanxin Zhao Yehong Wang Ye Wu Xiaoyu Li Guangzhao Yang Xiurui Ma Rongmi Zhao Huirong Liu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 9 |
| 3 | Cryo-EM structure of human mTOR complex 2显示文摘 | Xizi Chen Mengjie Liu Yuan Tian Jiabei Li Yilun Qi Dan Zhao Zihan Wu Min Huang Catherine C. L. Wong Hong-Wei Wang Jiawei Wang Huirong Yang Yanhui Xu | 2018 | Cell Research2018，28，5： | 8 |
| 4 | 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1显示文摘 | Huirong Yang Jia Wang Mengjie Liu Xizi Chen Min Huang Dan Tan Meng-Qiu Dong Catherine C. L, Wong Jiawei Wang Yanhui Xu Hong-Wei Wang | 2016 | Protein & Cell2016，7，12： | 7 |
| 5 | Synthesis and characterization of tungsten and barium co-doped La2Mo2O9 by sol-gel process for solid oxide fuel cells显示文摘Herein,we demonstrate the synthesis of W and Ba co-doped La2Mo2O9(LBMWO)nanocrystalline powder by a sol-gel process.In all the compositions have general formulae La1.9Ba0.1Mo2-xWxO8.95(x=0-0.40).The crystal structure,microstructure and conductivity of LBMWO were characterized by X-ray diffraction,scanning electron microscopy and electrical impedance spectroscopy.In addition,the thermal and decomposition properties of the LBMWO gel were analyzed by differential scanning calorimetry-thermogravimetric.The results reveal that all LBMWO powders calcined at 700℃have a cubic structure;the average crystallite size is about 48 nm.The unit cell parameter of LBMWO powders increases with increase in W content.The as-synthesized nanocrystalline LBMWO samples exhibit excellent sinterability and a relatively lower sintering temperature of 900℃.A high relative density of-96%is achieved after sintering at 900℃which is in good agreeme nt with the re sults of the SEM.Moreover,W and Ba codoping suppresses the phase transition and effectively stabilizes theβ-phase at low temperature.At the same time,La1.9Ba0.1Mo1.85W0.15O8.95 exhibits high ionic conductivity,3.07 x 10^-2 S/cm at 800℃.It is therefore concluded that co-doping can improve the properties of La2MO2O9 electrolytes. | Chang′an Tian Lingbo Shao Dongdong Ji Jie Yang Jinsong Xie Qiyi Yin Huirong Le | 2019 | Journal of Rare Earths2019，37，9： | 5 |
| 6 | Influence of herb-partitioned moxibustion at Qihai (CV6) and bilateral Tianshu (ST25) and Shangjuxu (ST37) acupoints on toll-like receptors 4 signaling pathways in patients with ulcerative colitis显示文摘OBJECTIVE: To evaluate the efficacy of herb-partitioned moxibustion(HPM) at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints in relieving symptoms and the immune regulation of HPM on the toll-like receptors 4(TLR4) signaling pathway in ulcerative colitis(UC) patients.METHODS: A randomized, single-blind study was conducted 63 patients to receive HPM or sham HPM treatment. The efficacy outcomes included scores of the Mayo, Baron, inflammatory bowel disease questionnaire(IBDQ), self-rating depression scale(SDS), self-rating anxiety scale(SAS). HE staining was used to observe the histopathological changes of the colon. The expression of inflammatory cytokines and TLR4 signaling pathway related molecules were determined by enzyme-linked immunosorbent assay and immunohistochemistry.RESULTS: Baron, SDS, SAS scores were significantly decreased in moxibustion group(P < 0.05), IBDQ score was significantly greater in the moxibustion group than in the sham moxibustion group(P < 0.05). Histopathology of mucosal biopsies showed that both two groups improved in mucosa after treatment. The expression levels of tumor necrosis factor-α, interleukin-2, interleukin-12, interferon-γ, and TLR4, lipopolysaccharide, myeloid differentiation factor 88, interleukin receptor associated kinase, tumor necrosis factor receptor associated factor 6 and nuclear factor kappa-B p65 were significantly lower in the moxibustion group than in the sham moxibustion group(P < 0.05).CONCLUSION: This study showed that HPM at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints is effective to relieve symptoms, anxiety, depression and improving life quality in UC patients,which may be related to the immune regulation of HPM on TLR4 signaling pathway. | QI Qin Hyoyoung Im LI Kunshan GU Muen WU Huangan YANG Ling HUANG Yan ZHAO Jimeng CUI Yunhua LIU Huirong WU Luyi | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 5 |
| 7 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘Histone 离氨酸 methylation 能被 JmjC 包含域的蛋白质在 sequence-state-specific 和 methylation-state-specific 举止移开。然而,底层特性怎么样,决定,酶怎么被调整,大部分是未知的。我们最近发现了那 ceKDM7A,一个哲学博士 -- 并且 JmjC 包含域的蛋白质,是为 H3K9me2 特定的 histone demethylase, H3K27me2,和 PHD 摸绑定到 H3K4me3 指南在 vivo 的 demethylation 活动。为了为酶的活动和 PHD 的功能提供结构的卓见进分子的机制,摸,我们与包含 H3K4me3, H3K9me2,和 H3K27me2 修正的各种各样的联合的单身者或二肽一起在 apo 形式并且在建筑群解决了酶的六水晶结构。结构显示 H3K9me2 和 H3K27me2 以一种类似的方式与 ceKDM7A 交往,并且肽绑定特性被特定的相互作用的一个网络决定。结构的几何测量也揭示了与 PHD 手指和 H3K9me2 界限联系到 JmjC 领域的那 H3K4me3 从二个分开的分子,建议 trans-histone 肽绑定机制。因此,我们的全身的结构的研究重要地由催化领域而且更多揭示底层识别不仅,为 H3K9me2 和 H3K27me2 的 ceDKM7A 的双特性的分子的机制。 | Ying Yang Lulu Hu Ping Wang Haifeng Hou Yan Lin Yi Liu Ze Li Rui Gong Xiang Feng Lu Zhou Wen Zhang Yuhui Dong Huirong Yang Hanqing Lin Yiqin Wang Charlie Degui Chen Yanhui Xu | 2010 | Cell Research2010，20，8： | 3 |
| 8 | The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B显示文摘KDM5B 是 histone H3K4me2/3 demethylase。KDM5B 的 PHD1 领域为 demethylation 是批评的,但是位于这个领域的行动下面的机制是不清楚的。在这份报纸,我们观察了那 PHD1 < 潜水艇 class= “ a-plus-plus ” > KDM5B 与 unmethylated H3K4me0 交往。我们 PHD1 的 NMR 结构 < 潜水艇 class= “ a-plus-plus ” > 在有 H3K4me0 的建筑群的 KDM5B 表明有约束力的模式与另外的报导哲学博士手指的稍微不同。由在接口(L325A/D328A ) 的残余上的两倍变化的这个相互作用的混乱减少在在约 50% 的房间和增加的 KDM5B 的 H3K4me2/3 demethylation 活动肿瘤 suppressor 基因由的 transcriptional 压抑近似双重。这些调查结果暗示那 PHD1 < 潜水艇 class= “ a-plus-plus ” > KDM5B 可以帮助在目标基因维持 KDM5B 调停 KDM5B 的 demethylation 活动。 | Yan Zhang Huirong Yang Xue Guo Naiyan Rong Yujiao Song Youwei Xu Wenxian Lan Xu Zhang Maili Liu Yanhui Xu Chunyang Cao | 2014 | Protein & Cell2014，5，11： | 3 |
| 9 | Study on the imaging ability of the 2D neutron detector based on MWPC显示文摘A 2D neutron detector based on 3 He convertor and MWPC with an active area of 200 mm×200 mm has been successfully designed and fabricated.The detector has been tested with Am/Be neutron source and with collimated neutron beam with the wavelength of =1.37.The best spatial resolution of 1.18 mm(FWHM) and good linearity were obtained.This is in good agreement with theoretical calculations. | TIAN LiChao CHEN YuanBo TANG Bin ZHOU JianRong QI HuiRong LIU RongGuang ZHANG Jian YANG GuiAn XU Hong CHEN DongFeng SUN ZhiJia | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，10： | 3 |
| 10 | Structural insight into substrate recognition by histone demethylase LSD2/KDM1 b显示文摘 | Fei Chen Huirong Yang Zhenghong Dong Jian Fang Ping Wang Tingting Zhu Wei Gong Rui Fang Yujiang Geno Shi Ze Li Yanhui Xu | 2013 | Cell Research2013，23，2： | 2 |
| 11 | Molecular mechanism for the substrate recognition of USP7显示文摘 | Jingdong Cheng (1) (2) Ze Li (1) (2) Rui Gong (1) Jian Fang (1) Yi Yang (1) Chang Sun (1) Huirong Yang (1) Yanhui Xu (1) (2) (3) | 2015 | Protein & Cell2015，6，11： | 1 |
| 12 | Acupuncture and Moxibustion for Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials显示文摘 | Jun Ji Yuan Lu Huirong Liu Hui Feng Fuqing Zhang Luyi Wu Yunhua Cui Huangan Wu Yong-Qing Yang | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 13 | Metabolites of arsenic and increased DNA damage of p 53 gene in arsenic plant workers显示文摘 | Weihua Wen Jinghua Wen Lin Lu Hua Liu Jun Yang Huirong Cheng Wangjun Che Liang Li Guanbei Zhang | 2011 | Toxicology and Applied Pharmacology2011，，1： | 1 |
| 14 | Increased damage of exon 5 of p53 gene in workers from an arsenic plant显示文摘 | Weihua Wen Wangjun Che Lin Lu Jun Yang Xufang Gao Jinghua Wen Zhengchang Heng Shuqiao Cao Huirong Cheng | 2008 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2008，，1： | 1 |
| 15 | Prototype of a large neutron detector based on MWPC显示文摘A prototype of large-area position sensitive neutron detector was designed and constructed according to the requirements of the Small-Angle Scattering spectrometer of China Spallation Neutron Source(CSNS).The detector was based on the 3He neutron convertor and MWPC with an effective area of 650 mm×650 mm.A prototype was completed and tested with 55Fe X-ray.The high-pressure vessel was designed and constructed with high-strength aluminum alloy.A position resolution of about 4.6mm×2.3 mm(FWHM)and efficiency>65%for neutrons with wavelength of 1.8?was determined after the operational gas filled. | TIAN LiChao QI HuiRong SUN ZhiJia WANG YanFeng ZHANG Jian LIU RongGuang ZHAO YuBin ZHANG HongYu ZHAO DongXu DONG Jing XIE Wan YANG GuiAn OUYANG Qun CHEN YuanBo | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 1 |
| 16 | A New Solar Broadband Radio Spectrometer (SBRS) in China显示文摘 | Qijun Fu Huirong Ji Zihai Qin Zhicai Xu Zhiguo Xia Hongao Wu Yuying Liu Yihua Yan Guangli Huang Zhijun Chen Zhenyu Jin Qijun Yao Congling Cheng Fuying Xu Min Wang Libei Pei Shanhuai Chen Guo Yang Chenming Tan Suobiao Shi | 2004 | Solar Physics2004，，1： | 1 |
| 17 | Ajax and web services integrated- framework based on duplicate proxy pattern 显示文摘 | Gan Yifu Yang Huirong | 2007 | IEEE2007，7，1： | 1 |
| 18 | The New Development of L2 Motivation Theory——Directed Motivational Currents(DMCs)显示文摘二语动机研究著名学者D?rnyei和他的同事在系列文章中(D?rnyei,Ibrahim,&Muir,2015;D?rnyei,Muir,&Ibrahim,2014;Muir&D?rnyei,2013)提出新的二语学习动机理论—定向动机流。它指的是在一个特殊的阶段,个人或群体为了实现某个特定的目标表现出稳定而高强度的动机状态。本文旨在阐述定向动机流的定义,构成维度以及对二语学习和教学的意义和启示。 | Yang Huirong | 2017 | 校园英语2017，0，18： | 0 |
| 19 | E3 ubiquitin ligase E6AP mediated TSC2 turnover in the presence and absence of HPV16 E6显示文摘We previously found that HPV16 E6 causes the degradation of the tumor suppressor protein TSC2, resulting in the phosphorylation of S6 kinase and S6 even in the absence of insulin. | Li Zheng 1,4, Huirong Ding1, Zheming Lu1, Yong Li1, Yaqi Pan1, Tao Ning1, Yang Ke1, 2, 3 1 Beijing Institute for Cancer Research, School of Oncology, Peking University No.52 Fucheng Rd, Hai Dian District, Beijing 100036, P.R.China 2 Department of Cell Biology, Health Science Center, Peking University No.38 Xueyuan Rd.Hai Dian District, Beijing 100083, P.R.China 3 Cancer Research Center, Health Science Center, Peking University No.38 Xueyuan Rd.Hai Dian District, Beijing 100083, P.R.China 4 Institute of Biophysics, Chinese Academy of Sciences ,15 Datun Road, Room 3608, Beijing 100101, China | 2009 | 生物物理学报2009，25，S1： | 0 |
| 20 | miR-339-3p promotes AT1-AA-induced vascular inflammation by upregulating NFATc3 protein expression in vascular smooth muscle cells显示文摘Vascular inflammation induced by angiotensin II-1 receptor autoantibody(AT1-AA)is involved in the occurrence and development of various cardiovascular diseases.miR-339-3p is closely related to the degree of vasodilation of aortic aneurysm and is also involved in the occurrence and development of acute pancreatitis.However,it is still unclear whether miR-339-3p influences AT1-AA-induced vascular inflammation.In this study,the role and mechanism of miR-339-3p in AT1-AA-induced vascular inflammation are studied.RT-PCR detection shows that the miR-339-3p levels in the thoracic aorta and serum exosomes of AT1-AA-positive rats are significantly increased.The miRwalk database predicts the mRNAs that miR-339-3p can bind to their 5′UTR.Subsequently,it is found that the number of genes contained in the T cell receptor pathway is high through KEGG analysis,and NFATc3 among them can promote the secretion of various inflammatory cytokines.AT1-AA-induced upregulation of miR-339-3p expression in vascular smooth muscle cells(VSMCs)can lead to a significant increase in NFATc3 protein level and promote vascular inflammation.Inhibition of miR-339-3p with antagomir-339-3p can significantly reverse AT1-AA-induced high expressions of IL-6,IL-1βand TNF-αproteins in rat thoracic aorta and VSMCs.That is,AT1-AA can upregulate the expression of miR-339-3p in VSMCs,and the increased miR-339-3p targets the 5′UTR of NFATc3 mRNA to increase the protein level of NFATc3,thereby aggravating the occurrence of vascular inflammation.These findings provide new experimental evidence for the involvement of miRNAs in regulating vascular inflammatory diseases. | Yang Li Yaolin Long Xiaoyan Zhi Haihu Hao Xiaohui Wang Huirong Liu Li Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员