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| 1 | Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation显示文摘在房间期间,分割要求忠诚有丝分裂的锭子汇编和染色体分离的基因信息的稳定的传播。运用了 GTPase 戏在有丝分裂的锭子汇编的一个关键角色。然而,在锭子的 Ran-GTP 的一个化学坡度的产生怎么被联合到有丝分裂的 translational 以后修正,从来没被描绘过。这里,我们解决了复杂结构与核苷酸版本因素 Mog1 跑了并且描出一个新奇有丝分裂特定的调整 acetylation 的 Ran-Mog1 相互作用在染色体分离期间。我们的指导结构的功能的分析表明那 Mog1 与 RCC1 竞争为以一种 GTP/GDP-dependent 方式变有约束力。生物化学的描述表明了那 Mog1 固定跑阻止 RCC1 有约束力、随后的 GTP 装载。令人惊讶地,跑了是 TIP60 的真正的底层,并且由 TIP60 的 Lys134 的 acetylation 解放 Mog1 从在有丝分裂期间变有约束力。重要地,这个得到 acetylation 的开关对 RCC1 变有约束力支持 Ran-GTP 的高水平,它为染色体排列是必要的。这些结果建立一以前 TIP60 由调节在提供 Ran-GTP 水平的 homeostatic 控制的规章的机制运用了的 uncharacterized 为在有丝分裂的染色体分离的受动器绑定。 | Xiaoling Bao Heng Liu Xing Liu Ke Ruan Yonshui Zhang Zhiyong Zhang Qi Hu Ying Liu Saima Akram Jiahai Zhang Qingguo Gong Wenwen wang Xiao Yuan Jian-Li Lingli Zhao Zhen Dou Ruijun Tian Xuebiao Yao Jihui Wu Yunyu Shi | 2018 | Journal of Molecular Cell Biology2018，10，1： | 8 |
| 2 | A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga- | Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong | 2017 | Virologica Sinica2017，32，2： | 4 |
| 3 | Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration显示文摘Ezrin,a membrane–cytoskeleton linker protein,plays an essential role in cell polarity establishment,cell migration,and division.Recent studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes intrahepatic metastasis via cell migration.However,it was less characterized whether there are additional post-translational modifications and/or post-translational crosstalks on ezrin underlying context-dependent breast cancer cell migration and invasion.Here we show that ezrin is acetylated by p300/CBP-associated factor(PCAF)in breast cancer cells in response to CCL18 stimulation.Ezrin physically interacts with PCAF and is a cognate substrate of PCAF.The acetylation site of ezrin was mapped by mass spectrometric analyses,and dynamic acetylation of ezrin is essential for CCL18-induced breast cancer cell migration and invasion.Mechanistically,the acetylation reduced the lipid-binding activity of ezrin to ensure a robust and dynamic cycling between the plasma membrane and cytosol in response to CCL18 stimulation.Biochemical analyses show that ezrin acetylation prevents the phosphorylation of Thr567.Using atomic force microscopic measurements,our study revealed that acetylation of ezrin induced its unfolding into a dominant structure,which prevents ezrin phosphorylation at Thr567.Thus,these results present a previously undefined mechanism by which CCL18-elicited crosstalks between the acetylation and phosphorylation on ezrin control breast cancer cell migration and invasion.This suggests that targeting PCAF signaling could be a potential therapeutic strategy for combating hyperactive ezrin-driven cancer progression. | Xiaoyu Song Wanjuan Wang Haowei Wang Xiao Yuan Fengrui Yang Lingli Zhao McKay Mullen Shihao Du Najdat Zohbi Saravanakumar Muthusamy Yalei Cao Jiying Jiang Peng Xia Ping He Mingrui Ding Nerimah Emmett Mingming Ma Quan Wu Hadiyah-Nicole Green Xia Ding Dongmei Wang Fengsong Wang Xing Liu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
| 4 | China’s facility-based birth strategy and neonatal mortality: a population-based epidemiological study显示文摘 | Xing Lin Feng Sufang Guo David Hipgrave Jun Zhu Lingli Zhang Li Song Qing Yang Yan Guo Carine Ronsmans | 2011 | 2011 (9801)2011，，9801： | 1 |
| 5 | Impact of a new teaching model on the fine cosmetic suturing operation and quantitative assessment of the training effect on plastic surgeons显示文摘Background Traditional lecture-based teaching(TLT)has long been the primary method of teaching plastic suturing techniques and even surgical education.It has been challenging to adapt this approach to fit the educational objectives of plastic surgery,which is a very practical science.Additionally,it is mainly teacher-led,and the course content is teacher-driven,which has disadvantages such as difficulty in motivating students and disconnection from clinical practice.Therefore,we developed a video point-to-point teaching(VPT)method and teamwork-based teaching(TBT)to study the effect of the new teaching model on fine cosmetic suturing operation(FCSO)and training outcomes for plastic surgeons.Methods We selected 30 junior doctors from the Department of Plastic and Reconstructive Surgery of the Chinese PLA General Hospital.All trainees were randomly assigned to three groups:TLT,VPT,and TBT.All trainees had their performances photographed,and a senior attending physician was appointed as a rater.We rated the process and results of FCSO according to a uniform rubric following the double-blind principle to compare the effects of different teaching modes on the trainees’FCSO and differences in training outcomes.Results There was no significant effect of video recording on trainees’FCSO(P>0.05).The total scores of the first suturing in the three groups were as follows:TLT group(13.18±1.66),VPT group(13.63±1.97),and TBT group(13.50±2.26),with no significant difference among the groups(P>0.05),indicating that the starting level of the trainees in the three groups was basically the same.There was no significant difference(P>0.05)between the VPT(20.30±2.17)and TBT(20.38±2.29)groups,but both of these groups were significantly better than the TLT group(16.43±1.86,P<0.01).Conclusion The TBT and VPT methods are significantly better than TLT.However,the TBT method is more economical and optimal for teachers and better utilizes students’initiative in learning and operation,which improves the teaching level and training efficiency. | Yichi Xu Jiahua Xing Hasi Wulan Lingli Guo | 2023 | Chinese Journal Of Plastic and Reconstructive Surgery2023，5，1： | 0 |
| 6 | Distribution of rare earth elements in PM10 emitted from burning coals and soil-mixed coal briquettes显示文摘Emission from burning coals is one of the major sources of the airborne particles in China.We carried out a study on the rare earth elements(REEs)in the inhalable particulate matter(PM10)emitted from burning coals and soil-coal honeycomb briquettes with different volatile contents and ash yields in a combustion-dilution system.Gravimetric analysis indicates that the equivalent mass concentration of the PM10 emitted from burning the coals is higher than that emitted from burning the briquettes.The ICP-MS analysis indicates that the contents of total REEs in the coal-burning PM10 are lower than those in the briquetteburning PM10.In addition,the contents of the light rare earth elements(LREEs)are higher than those of the heavy rare earth elements(HREEs)in the PM10 emitted from burning the coals and briquettes,demonstrating that the REEs in both the coal-burning and briquetteburning PM10 are dominated by LREEs.The higher contents of total REEs and LREEs in the coal-burning PM10 are associated with the higher ash yields and lower volatile contents in the raw coals.A comparative analysis indicates that the La/Sm ratios in the PM10 emitted from burning the coals and briquettes,being lower than 2,are lower than those in the particles from gasoline-powered vehicle emission. | Longyi Shao Lingli Chang Robert B.Finkelman Wenhua Wang Junxia Liu Jie Li Jiaoping Xing Cong Hou 无 | 2020 | Journal of Environmental Sciences2020，32，11： | 0 |
| 7 | Research progress on intervention of traditional Chinese medicine on myocardial glucose and lipid metabolism in heart failure显示文摘Disorder of energy metabolism is a major pathological change in the progression of heart failure.This process leads to insufficient myocardial energy and further aggravates cardiac dysfunction.Disorders of metabolic substrate utilization,mainly glucose and fatty acids,play an important role in this process.Research over the years has shown that some traditional Chinese medicines or compound prescriptions whose main role is to replenish qi and warm yang have good effects in regulating energy metabolism disorders.It has been found that some active ingredients in traditional Chinese medicine can regulate the uptake and utilization of myocardial cell metabolic substrate,so that the metabolism of myocardial cells can be adjusted in a direction that is beneficial to the body under hypoxic conditions,increasing the overall energy supply of the myocardium and improving heart function.This article reviewed the research of traditional Chinese medicine intervention on glucose and lipid metabolism of heart failure myocardial cells,and preliminarily summarizes the law and mechanism of traditional Chinese medicine intervention in heart failure myocardial glucose and fatty acid metabolism,hoping to provide clues for energy metabolism therapy research from the perspective of traditional Chinese medicine. | WANG Xiao-lin CHE Chi CHEN Zhi-yong HUANG Wan-qing WANG Xing LINGLi LIU Zhi-ming LI Lin | 2022 | Journal of Hainan Medical University2022，28，16： | 0 |
| 8 | Ultrafast Joule heating synthesis of hierarchically porous graphene-based Co-N-C single-atom monoliths显示文摘Herein,we develop a transient heating-quenching strategy triggered by Joule heating for the synthesis of single-atom cobalt-and nitrogen-doped graphene materials with three-dimensional porous monolithic architecture(denoted as CoNG-JH).The ultrafast Joule heating procedure simultaneously enables the reduction of graphene oxide and the incorporation of metal and nitrogen atoms into the graphene matrix within 2-second period.Meanwhile,the transient quenching avoids the extended heating-induced atom aggregation,ensuring the rapid and stable dispersion of atomic-scale CoNx active sites in graphene.Additionally,the interconnected macropores and nanopores formed by the self-assembly of graphene sheets facilitate the unimpeded ion and gas transport during the catalytic process.When used as an electrode for the hydrogen evolution reaction(HER),the fabricated free-standing CoNG-JH exhibits high catalytic activity and durability with a low overpotential of 106 mV at 10 mA·cm^(-2) and a small Tafel slope of 66 mV·dec^(-1) in 0.5 M H_(2)SO_(4) electrolyte.The presented synthesis and design strategy open up a rapid and facile route for the manufacturing of single atom catalysts. | Lingli Xing Rui Liu Zhichao Gong Jingjing Liu Jianbin Liu Haisheng Gong Kang Huang Huilong Fei | 2022 | Nano Research2022，15，5： | 0 |
| 9 | Innovative combined therapy for multiple keloidal dermatofibromas of the chest wall: A novel case report显示文摘Dermatofibromas are benign soft tissue tumors that predominantly affect the limbs, and more rarely the chest.Keloidal dermatofibroma is a rare subtype with distinct clinicopathological features and an aggressive clinical course. By researching the evolution of the disease in this study, we aimed to summarize our experience of managing a rare patient who underwent five surgeries for keloidal dermatofibroma that developed sequentially in the upper arm and chest and propose a novel treatment for keloidal dermatofibroma. We concluded that keloidal dermatofibroma involving larger areas, high tension sites, and multiple localizations can be treated using the principles of pathological scar management. | Jiahua Xing Yi Chen Liwu Zheng Yan Shao Yichi Xu Lingli Guo | 2022 | Chinese Journal Of Plastic and Reconstructive Surgery2022，4，4： | 0 |
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