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| 1 | Synthesis and antiviral bioactivities of novel chiral bis-thiourea-type derivatives containing α-aminophosphonate moiety显示文摘Starting from 1-((1R,2R)-2-aminocyclohexyl)-3-substituted thioureas (3a–c) and substituted isothiocyanates (9a–d),chiral bis-thiourea derivatives containing α-aminophosphonate moiety 10a–l were prepared and completely characterized by elemental analysis,physical and spectral (IR,1H NMR,13C NMR,31P NMR) data.The results of bioassay revealed that compounds 10a and 10e possessed appreciable curative bioactivities on cucumber mosaic virus (CMV) at 0.5 mg/mL in vivo (inhibitory rate = 60.3%,64.8% respectively) and tobacco mosaic virus (TMV) at 0.5 mg/mL in vivo (inhibitory rate = 50.3%,50.8% respectively),which were comparable to the values shown by standard reference (58.7%) and commercial product Ningnanmycin (56.3%),respectively.Chiral compound 10e displayed more potent antiviral activity (EC50 = 0.149 mg/mL) than Ningnanmycin (EC50 = 0.201mg/mL) against CMV. | YANG Xuan SONG BaoAn JIN LinHong WEI Xue BHADURY S Pinaki LI XiangYang YANG Song HU DeYu | 2011 | Science China Chemistry2011，54，1： | 5 |
| 2 | Sulfoalkyl ether β-cyclodextrin derivatives synthesized by a single step method as pharmaceutical biomaterials显示文摘We report a simple 'one pot' single step method to synthesize sulfoalkyl ether β-cyclodextrin (β-CD) derivatives in aqueous solution, which avoids the limitations associated with commonly used organic synthesis of such derivatives including multi-step reactions, use of expensive, toxic, and often environmentally hazardous organic solvents and/or reagents. Using this method, we obtained sulfopropyl and sulfobutyl ethyl β-CDs. We characterized these two derivatives and evaluated their ability to enhance solubility of fluconazole, a commonly used antifungal drug with poor water solubility. Experimental results indicate that these derivatives are structurally analogous to some of the commercially available β-CD derivatives. More importantly, when they formed supramolecular inclusion complexes with fluconazole, they demonstrated similar, if not better, capacity to enhance fluconazole solubility compared with commercially available β-CD derivatives, suggesting that the simple 'one pot' single step synthesis may provide an effective alternative approach to produce large quantity of β-CD derivatives as pharmaceutical biomaterials for medicinal applications. | SONG AiJing WANG JianHua LIU ChunDong DENG LinHong | 2009 | Chinese Science Bulletin2009，54，18： | 4 |
| 3 | APPLICATION AND DEVELOPMENT OF ‘GREEN’ PREVENTIVE AND CONTROL TECHNOLOGIES IN GUIZHOU TEA PLANTATIONS显示文摘The application and development of ‘green’ preventive technologies in teaplantations is an important means of ensuring tea quality and ecologicalsafety. Ecological, agronomic and biological controls are the main preventivemeasures used in Guizhou Province. This paper summarizes the ‘green’preventive technologies being applied in Guizhou tea plantations, including theuse of plant defense inducers to regulate tea plant responses to pathogens,natural enemies to control pest species causing damage to shoots andTrifolium repens to control the main weed species. In addition, it summarizesthe integrated ‘green’ preventive technologies being used in Guizhou andprovides a foundation for the ecological maintenance of tea plantations. | Xiangyang LI Linhong JIN Zhuo CHEN Baoan SONG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，1： | 1 |
| 4 | Synthesis,X-ray crystallographic analysis,and antitumor activity of N-(benzothiazole-2-yl)-1-(fluorophenyl)-O,O-dialkyl-α-aminopbosphonates显示文摘 | Linhong Jin Baoan Song Guoping Zhang | 2006 | Bioorg Med Chem Lett2006，16，6： | 1 |
| 5 | Synthesis,X-ray crystallographic analysis,and antitumor activity of N-(benzothiazole-2-yl)-1-(fluorophenyl)-O,O-dialkyl-alpha-aminophosphonates显示文摘 | JIN Linhong SONG Baoan ZHANG Guoping | 2006 | Bioorg Med Chem Lett2006，16，6： | 1 |
| 6 | Synthesis, X-ray Crystallographic Analysis,and Antitumor Activity of N- (Benzzothiazole-2-yl)- 1- ( Fluorophenyl)-O, O-dialkyl-α-aminophosphonates 显示文摘 | J IN Linhong SONG Baoan ZHANG Guoping | 2006 | Bioorganie & Medicinal Chemistry Letters2006，，16： | 1 |
| 7 | Synthesis, X-ray crystallographic analysis and antiturmor activity of N-( benzothia- zole-2-yl)-l-(fluorophenyl) -O, O-dialkyl-α-aminophosphonates 显示文摘 | Jin Linhong Song Baoan Zhang Guoping | 2006 | Bioorganic & Medicinal Chemistry Letters2006，16，6： | 1 |
| 8 | Age-specific effectiveness of primary human papillomavirus screening versus cytology in a cervical cancer screening program: a nationwide cross-sectional study显示文摘Background:Primary human papillomavirus(HPV)screening is recommended for the detection of cervical intraepithelial neoplasia(CIN)in the general pop-ulation;however,the triage for HPV-positive women remains a challenge.This study aimed to evaluate the age-specific effectiveness of primary HPV screening versus primary cytology screening for identifying optimal strategies for women of different ages.Methods:The dataset of the prevalence round screening was derived from the National Cervical Cancer Screening Program in China.Primary cervical screen-ing protocols included cytology only,HPV testing with cytology triage,and HPV testing with HPV-16/18 genotyping plus cytology triage.The primary outcomes were age-specific detection rate,colposcopy referral rate and positive predictive value(PPV)for CIN2+.Multivariate Poisson regression was used to evaluate the relativeeffectivenessofHPVtestingandcytologyaccordingtoagegroups.TheI 2 statisticwitharandom-effectmodelwasusedtotesttheheterogeneityinrelative effectiveness of HPV testing versus cytology between age groups.Results:This study included 1,160,981 women.HPV testing with HPV-16/18 genotyping plus cytology triage significantly increased the CIN2+detection by 36%(rate ratio[RR]:1.36,95%confidential interval[CI]1.21–1.54)for women aged 35-44 years and by 34%(RR:1.34,95%CI 1.20-1.51)for women aged 45-54 years compared with cytology only.HPV testing with cytology triage had simi-lar CIN2+detection rate compared with cytology only.The PPVs were substan-tially increased for both HPV testing groups.Among women aged 55-64 years old,HPV testing with HPV-16/18 genotyping plus cytology triage increased the colposcopyreferralrateby19%(RR1.19,95%CI1.10-1.29)comparedwithcytology only,butdidnotincreasetheCIN2+detection(1.09,0.91–1.30).Theeffectiveness ofHPVtestingwithcytologytriagedidnotchangeinolderwomen.Thebetween-age-group heterogeneity in the effectiveness was statistically significant for HPV testing with HPV-16/18 genotyping plus cytology triage versus cytology only.Conclusions:Our results suggested that the effectiveness of primary HPV screeningwithdifferenttriagestrategiesdifferedamongagegroups.HPVtesting with HPV-16/18 genotyping plus cytology triage could be used for women aged 35-54 years to detect more lesions,and HPV testing with cytology triage could balance the CIN2+detection and the number of colposcopies for women aged 55-64 years.Longitudinal data including both prevalence and incidence screen-ing rounds are warranted to assess age-specific triage strategies. | Heling Bao Lan Ma Yanxia Zhao Bo Song Jiangli Di Linhong Wang Yanqiu Gao Wenhui Ren Shi Wang Jiuling Wu Hai-Jun Wang | 2022 | Cancer Communications2022，42，3： | 1 |
| 9 | REAL-t1, an Effective Approach for t1-Noise Suppression in NMR Spectroscopy Based on Resampling Algorithm显示文摘Summaryof main observation and conclusionIn multidimensional(nD)NMR spectroscopy,t1noise usually appears as ridges along indirect dimen-sions,and affects observation of weak signals.The main source of t1noise is instrumental instability,which causes random variation of FID amplitude during data acquisitions and introduces random noise-like peaks into spectrum after Fourier transformation.A number of efforts have been devoted,in order to develop new method or to improve existing approaches for suppressing t1noise.Herein,we propose a novel t1noise suppression method based on resampling algorithm for data processing,shortenedas REAL-t1.The method was verified using simulated 2D spectra,and NOESY spectra of sucrose and protein GB1,showing that the spectral quality was improved in all cases.The performance of REAL-t1was also compared with another recently pro-posed method,which showed that these two methods provided similar performance while REAL-t1cost much shorter experimental time. | Linhong Song Jiannan Wang Xuncheng Su Xu Zhang Conggang Li Xin Zhou Daiwen Yang Bin Jiang Maili Liu | 2020 | Chinese Journal of Chemistry2020，38，1： | 0 |
| 10 | OPTICALLY TRACKING THE MOTION OF MICROBEADS TO STUDY PHYSICAL BEHAVIORS OF THE LIVING CELL IN RESPONSE TO TRANSIENT STRETCH OR COMPRESSION显示文摘Optical magnetic twisting cytometry and traction force microscopy are two advanced cell mechanics research tools that employ optical methods to track the motion of microbeads that are either bound to the surface or embedded in the substrate underneath the cell.The former measures rheological properties of the cell such as cell stiffness,and the latter measures cell traction force dynamics.Here we describe the principles of these two cell mechanics research tools and an example of using them to study physical behaviors of the living cell in response to transient stretch or compression.We demonstrate that,when subjected to a stretchunstretch manipulation,both the stiffness and traction force of adherent cells promptly reduced,and then gradually recover up to the level prior to the stretch.Immunofluorescent staining and Western blotting results indicate that the actin cytoskeleton of the cells underwent a corresponding disruption and reassembly process almost in step with the changes of cell mechanics.Interestingly,when subjected to compression,the cells did not show such particular behaviors.Taken together,we conclude that adherent cells are very sensitive to the transient stretch but not transient compression,and the stretch-induced cell response is due to the dynamics of actin polymerization. | LINHONG DENG XUEMEI JIANG CHENG CHEN AIJING SONG FENG LIN | 2011 | Journal of Innovative Optical Health Sciences2011，4，2： | 0 |
| 11 | The Utilization of Health Examination by Menopausal and Older Women--6 Provinces,China,2018显示文摘What is already known about this topic?Improving their utilization of health examination is important for improving the health of menopausal and older women.What is added by this report?Only 32.3%and 29.7%of women had been screened for cervical cancer and breast cancer,respectively.The overall utilization rate of health examination for menopausal and older women is low.The health examination services for menopausal and older women were utilized less in the western regions and in rural areas than in the eastern and central regions and in urban areas.What are the implications for public health practice?The imbalance of development is an important factor affecting the utilization of health examination for menopausal and older women.It is necessary to take effective measures to improve the level of service utilization in the western region and rural areas,in order to narrow the gap in health between different regions. | Bo Song Jiangli Di Gengli Zhao Yu Ma Linhong Wang | 2020 | China CDC weekly2020，2，37： | 0 |
| 12 | Major episodes of horizontal gene transfer drove the evolution of land plants显示文摘How horizontal gene transfer(HGT)has contributed to the evolution of animals and plants remains a major puzzle.Despite recent progress,defining the overall scale and pattern of HGT events in land plants has been largely elusive.In this study,we performed systematic analyses for acquired genes in different plant groups and throughout land plant evolution.We found that relatively recent HGT events occurred in char-ophytes and all major land plant groups,but their frequency declined rapidly in seed plants.Two major ep-isodes of HGT events occurred in land plant evolution,corresponding to the early evolution of strepto-phytes and the origin of land plants,respectively.Importantly,a vast majority of the genes acquired in the two episodes have been retained in descendant groups,affecting numerous activities and processes of land plants.We analyzed some of the acquired genes involved in stress responses,ion and metabolite transport,growth and development,and specialized metabolism,and further assessed the cumulative ef-fects of HGT in land plants. | Jianchao Ma Shuanghua Wang Xiaojing Zhu Guiling Sun Guanxiao Chang Linhong Li Xiangyang Hu Shouzhou Zhang Yun Zhou Chun-Peng Song Jinling Huang | 2022 | Molecular Plant2022，15，5： | 0 |
| 13 | The Health Status of 50−70 Years Old Women in Some Areas—China,2018显示文摘What is already known about this topic?After menopause,women are prone to chronic diseases such as cardiovascular disease,diabetes and osteoporosis and gynecological diseases such as pelvic floor dysfunction and reproductive tract infection.What is added by this report?The prevalence of hypertension,diabetes,cardiovascular disease and osteoporosis increased with age,while the prevalence of vaginitis and cervicitis decreased with the increase of age.The proportions of women aged 50–70 years old suffering from chronic and gynecological diseases in western and rural areas were significantly higher than those in eastern,central and urban areas.What are the implications for public health practice?It is necessary to take targeted intervention measures in the western region and rural areas,in order to narrow the gap in health of menopausal and older women between different areas of China. | Bo Song Gengli Zhao Jiangli Di Yu Ma Linhong Wang | 2020 | China CDC weekly2020，2，28： | 0 |
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