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| 1 | The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B显示文摘KDM5B 是 histone H3K4me2/3 demethylase。KDM5B 的 PHD1 领域为 demethylation 是批评的,但是位于这个领域的行动下面的机制是不清楚的。在这份报纸,我们观察了那 PHD1 < 潜水艇 class= “ a-plus-plus ” > KDM5B 与 unmethylated H3K4me0 交往。我们 PHD1 的 NMR 结构 < 潜水艇 class= “ a-plus-plus ” > 在有 H3K4me0 的建筑群的 KDM5B 表明有约束力的模式与另外的报导哲学博士手指的稍微不同。由在接口(L325A/D328A ) 的残余上的两倍变化的这个相互作用的混乱减少在在约 50% 的房间和增加的 KDM5B 的 H3K4me2/3 demethylation 活动肿瘤 suppressor 基因由的 transcriptional 压抑近似双重。这些调查结果暗示那 PHD1 < 潜水艇 class= “ a-plus-plus ” > KDM5B 可以帮助在目标基因维持 KDM5B 调停 KDM5B 的 demethylation 活动。 | Yan Zhang Huirong Yang Xue Guo Naiyan Rong Yujiao Song Youwei Xu Wenxian Lan Xu Zhang Maili Liu Yanhui Xu Chunyang Cao | 2014 | Protein & Cell2014，5，11： | 3 |
| 2 | NMR assignments and characterization of the DNA-binding domain of Arabidopsis transcription factor WRKY11--Dedicated to Professor Xiuwen Han on the occasion of her 80th birthday显示文摘The WRKY proteins are a family of plant-specific transcription factors(TFs)that are widely involved in plant development and anti-stress responses.Arabidopsis WRKY11(AtWRKY11)functions in regulating plant defense against abiotic stress and belongs to the Ild subgroup of WRKY TFs.We herein report the expres sion,purification and preliminary structural characterization of AtWRKY11 DNA-binding domain(DBD)using solution NMR Almost complete backbone chemical shift assignments of AtWRKY11-DBD have been ob-tained.Chemical shift-based secondary structure analysis suggests that AtWRKY11-DBD may exhibit local conformational diferences from the X-ray structure of the C-terminal WRKY domain of AtWRKY1,particularly in the β1 and β5 strands.Our current study provides the basis for further structural and interactional studies. | Jiannan Wang Yaling Lin Qinjun Zhu Jingfeng Zhang Maili Liu Yunfei Hu | 2021 | Magnetic Resonance Letters2021，1，2： | 2 |
| 3 | Simultaneous acquisition of multi-nuclei enhanced NMR/MRI by solution-state dynamic nuclear polarization显示文摘Dynamic nuclear polarization(DNP) has become a very important hyperpolarization method because it can dramatically increase the sensitivity of nuclear magnetic resonance(NMR) of various molecules.Liquid-state DNP based on Overhauser effect is capable of directly enhancing polarization of all kinds of nuclei in the system.The combination of simultaneous Overhauser multi-nuclei enhancements with the multi-nuclei parallel acquisitions provides a variety of important applications in both MR spectroscopy(MRS) and image(MRI).Here we present two simple illustrative examples for simultaneously enhanced multi-nuclear spectra and images to demonstrate the principle and superiority.We have observed very large simultaneous DNP enhancements for different nuclei,such as ~1H and ^(23)Na,~1H and ^(31)P,^(19)F and ^(31)P,especially for the first time to report sodium ion enhancement in liquid.We have also obtained the simultaneous images of ^(19)H and ^(31)P,^(19)F and ^(31)P at low field by solution-state DNP for the first time. | Yugui He Zhen Zhang Jiwen Feng Chongyang Huang Fang Chen Chaoyang Liu Maili Liu | 2016 | Science China Chemistry2016，59，7： | 2 |
| 4 | Mechanism of surfactant micelle formation 显示文摘 | CUN XIAOHONG MAO SHIZHENG LIU MAILI | 2008 | Langmuir2008，24，10： | 1 |
| 5 | Determination of the relative NH proton lifetimes of the peptide analogue viomycin in aqueous solution by NMR-based diffusion measurement显示文摘 | Maili Liu Harold C Toms Geoffrey E Hawkes | 1999 | Journal of Biomolecular NMR1999，13，： | 1 |
| 6 | Characterization and Comparison of Commercial Chinese Cereal and European Grape Vinegars Using ^1H NMR Spectroscopy Combined with Multivariate Analysis显示文摘对来自不同国家的醋的一个整体、比较的优秀评价与醋的国际贸易被需要变得经常。在这研究,商业等级的中国谷物和欧洲葡萄醋的混合物描述和比较用 1 结合的 H NMR 光谱学主要部件分析(PCA ) 和到潜伏的结构的直角的设计区别分析(OPLS-DA ) 。结果证明深紫色的香膏质的醋被更高的数量清楚地区别果糖并且葡萄糖当中国芳香的醋和年老的醋被氨基酸,不稳定的混合物, succinate 和 betaine 的更高的数量描绘时。在另一方面,香料在中国米饭醋加重,欧洲酒醋是不到其它。这些典型部件与特殊原料和醋的每种类型的生产过程被联系并且资助他们特殊风味。在这研究获得的结果通过 1 基于的 H NMR 加重从不同制造起源允许对醋的一个整体的优秀评价和比较的分析。 | Xiaohua Wang Jie Wang Ghulam Mustafa Kamal Bin Jiang Peng Sun Xu Zhang Maili Liu | 2016 | Chinese Journal of Chemistry2016，34，11： | 1 |
| 7 | Injured microenvironment directly guides the differentiation of engrafted Flk-1 + mesenchymal stem cell in lung显示文摘 | Xi Yan Yanning Liu Qin Han Mingyue Jia Lianming Liao Maili Qi Robert Chunhua Zhao | 2007 | Experimental Hematology2007，，9： | 1 |
| 8 | 1H-NMR study on microstructure of a novel acrylamide/methacrylic acid template copolymer in aqueous solution显示文摘 | Liu Aihong Mao Shizhen Liu Maili | 2007 | Colloid Polymer Science2007，285，4： | 1 |
| 9 | Structural and functional imaging of brains显示文摘Analyzing the complex structures and functions of brain is the key issue to understanding the physiological and pathological processes.Although neuronal morphology and local distribution of neurons/blood vessels in the brain have been known,the subcellular structures of cells remain challenging,especially in the live brain.In addition,the complicated brain functions involve numerous functional molecules,but the concentrations,distributions and interactions of these molecules in the brain are still poorly understood.In this review,frontier techniques available for multiscale structure imaging from organelles to the whole brain are first overviewed,including magnetic resonance imaging(MRI),computed tomography(CT),positron emission tomography(PET),serial-section electron microscopy(ss EM),light microscopy(LM)and synchrotron-based X-ray microscopy(XRM).Specially,XRM for three-dimensional(3D)imaging of large-scale brain tissue with high resolution and fast imaging speed is highlighted.Additionally,the development of elegant methods for acquisition of brain functions from electrical/chemical signals in the brain is outlined.In particular,the new electrophysiology technologies for neural recordings at the single-neuron level and in the brain are also summarized.We also focus on the construction of electrochemical probes based on dual-recognition strategy and surface/interface chemistry for determination of chemical species in the brain with high selectivity and long-term stability,as well as electrochemophysiological microarray for simultaneously recording of electrochemical and electrophysiological signals in the brain.Moreover,the recent development of brain MRI probes with high contrast-to-noise ratio(CNR)and sensitivity based on hyperpolarized techniques and multi-nuclear chemistry is introduced.Furthermore,multiple optical probes and instruments,especially the optophysiological Raman probes and fiber Raman photometry,for imaging and biosensing in live brain are emphasized.Finally,a brief perspective on existing challenges and further research development is provided. | Zhichao Liu Ying Zhu Liming Zhang Weiping Jiang Yawei Liu Qiaowei Tang Xiaoqing Cai Jiang Li Lihua Wang Changlu Tao Xianzhen Yin Xiaowei Li Shangguo Hou Dawei Jiang Kai Liu Xin Zhou Hongjie Zhang Maili Liu Chunhai Fan Yang Tian | 2023 | Science China Chemistry2023，66，2： | 0 |
| 10 | Impact of Magnesium(Ⅱ) on Beryllium Fluorides in Solutions Studied by ^(19)F NMR Spectroscopy显示文摘Beryllium fluorides are widely used in protein phosphorylation studies to get stable transition state analogs or near attack conformers,which has attracted much attention.BeF_(3)^(−) is one of the optimal phosphoryl(PO_(3)^(−))analogs for its identical geometry and charge,and Mg^(2+) naturally participates in the phosphoryl binding in biological systems.In solutions,BeF_(3)^(−) coexists with other beryllium fluorides(BeF_(4)^(2−),BeF_(2) and BeF^(+))and magnesium fluorides,and there are equilibriums between these species.In this article,^(19)F NMR spectroscopy was applied to the investigation of the impact of magnesium(Ⅱ)on beryllium fluorides.It has been found that when Mg^(2+) was introduced into the solutions,the chemical shifts,the intensities and the line widths of ^(19)F signals of various beryllium fluoride complexes were changed.After ionic strength correction,these effects were remarkable only for 2 BeF_(4)^(2−) and BeF_(3)^(−),especially BeF_(4)^(2−),when the concentration of the fluoride ion is relatively low.Mechanism of the effects is proposed which involves ion pair formation between Mg^(2+) and beryllium fluorides. | Yixiang Liu Xian Mao Maili Liu Ling Jiang | 2014 | Chinese Journal of Chemistry2014，32，9： | 0 |
| 11 | Preface to the Special Issue “Celebrating the 80th Birthday of Professor Chaohui Ye”显示文摘It’s hard to imagine the unlimitedness of human life until you see it with your own eyes.Professor Chaohui Ye demonstrates to us how unlimited and meaningful a life can be,by maximizing his talents and efforts in every position.He is such a gentleman,a great scientist,an encouraging supervisor,an insightful research group leader and a profound thinker,who inspired and influenced so many,including the authors and guest editors of this special issue. | Maili Liu Feng Deng Xin Zhou | 2022 | Magnetic Resonance Letters2022，2，3： | 0 |
| 12 | Introduction显示文摘Professor Chaohui Ye is one of the founders and pioneers of nuclear magnetic resonance(NMR)spectroscopy and magnetic resonance imaging(MRI)in China.He has achieved much fruitful research in the field of NMR spectroscopy,such as relaxation mechanism in solids,high-resolution solid-state NMR techniques,dynamic nuclear polarization,spin dynamics,the measurement of fundamental solid-state NMR parameters,Raman magnetic resonance,radiation damping,and the design and manufacture of magnetic resonance instrument.Besides NMR,Professor Ye was also engaged in the research of atomic frequency standard and made contributions to the design of the first Rb atomic clock in China.Professor Ye has once been the director of the Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences(CAS),the president of the Wuhan branch of CAS,the director of the State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,the director of the National Center for Magnetic Resonance in Wuhan,the director of the Committee of Magnetic Resonance Spectroscopy,Chinese Physical Society,and the editor-in-chief of Chinese Journal of Magnetic Resonance.For many years,Professor Ye has made tremendous efforts for the development of NMR and MRI research,and domestic academic journals. | Maili Liu Feng Deng Xin Zhou | 2022 | Magnetic Resonance Letters2022，2，3： | 0 |
| 13 | Editorial显示文摘We are very glad to bring you the 4th issue of MRL in 2022,which contains eight articles covering protein NMR(nuclear magnetic resonance),NMR instruments,NMR pulse sequences,MRI(magnetic resonance imaging),EPR(electron paramagnetic resonance),etc.In this issue,Prof.Guang Zhu et al.from the Hong Kong University of Science and Technology determined the DNA G-quadruplex structure adopted by two G4C2 hexanucleotide repeats with an inosine substitution at position 4,d(G4C2)2-I4 by NMR. | Maili Liu | 2022 | Magnetic Resonance Letters2022，2，4： | 0 |
| 14 | Protein dynamics elucidated by NMR technique显示文摘In 1957,Christian Anfinsen postulated his famous dogma based on the study of ribonuclease(Sela et al.,1957),stating that the amino acid sequence of a protein determines its tertiary structure,a unique and kinetically accessible energy minimum,in a given environment.As a result,determination of a global energy minimum,or the most populated structure,has been the main focus of structural biology in the ensuing half a century.With more and more structures have been determined,people have gain some insights of why protein functions,but the detailed mechanisms and the function process,or how protein functions,remains elusive. | Conggang Li Chun Tang Maili Liu | 2013 | Protein & Cell2013，4，10： | 0 |
| 15 | Meet Magnetic Resonance Letters显示文摘Today is a happy day for the community of magnetic resonance since it marks the birthday of the very first issue of Magnetic Resonance Letters(MRL),a new journal aiming to promote the multidisciplinary area. | Maili Liu | 2021 | Magnetic Resonance Letters2021，1，1： | 0 |
| 16 | New Researches of State Key Laboratories in Analytical Chemistry显示文摘In the past two decades,as the eyes of fundamental scientific research and social activities relative to human security and health,analytical chemistry has made great progress in both analytical methodologies and detection instruments by integrating multidisciplinary research achievements.Four State Key Laboratories were successively established in this rapidly developing discipline.In order to publish some of the excellent results together,we have organized this special topic with 10 Articles and Reviews from these State Key Laboratories. | Huangxian Ju Weihong Tan Lehui Lu Maili Liu | 2016 | Science China Chemistry2016，59，7： | 0 |
| 17 | REAL-t1, an Effective Approach for t1-Noise Suppression in NMR Spectroscopy Based on Resampling Algorithm显示文摘Summaryof main observation and conclusionIn multidimensional(nD)NMR spectroscopy,t1noise usually appears as ridges along indirect dimen-sions,and affects observation of weak signals.The main source of t1noise is instrumental instability,which causes random variation of FID amplitude during data acquisitions and introduces random noise-like peaks into spectrum after Fourier transformation.A number of efforts have been devoted,in order to develop new method or to improve existing approaches for suppressing t1noise.Herein,we propose a novel t1noise suppression method based on resampling algorithm for data processing,shortenedas REAL-t1.The method was verified using simulated 2D spectra,and NOESY spectra of sucrose and protein GB1,showing that the spectral quality was improved in all cases.The performance of REAL-t1was also compared with another recently pro-posed method,which showed that these two methods provided similar performance while REAL-t1cost much shorter experimental time. | Linhong Song Jiannan Wang Xuncheng Su Xu Zhang Conggang Li Xin Zhou Daiwen Yang Bin Jiang Maili Liu | 2020 | Chinese Journal of Chemistry2020，38，1： | 0 |
| 18 | Mechanisms of Chaperones as Active Assistant/Protector for Proteins:Insights from NMR Studies显示文摘Molecular chaperones are diverse families of proteins that play key roles in protein homeostasis.They assist the folding of client proteins or prevent them from rreversible aggregation under stress conditions.Diverse chaper-one families contribute to different aspects of protein homeostasis by inter-acting with a wide range of client proteins.Despite the vital roles of chaper-ones in cell survival,the molecular mechanisms underlying chaperone func-tions remain elusive,due to the non-specificity of chaperone-client interac-tions and the intrinsic flexibility of the clients. | Yunfei Hu Conggang Li Lichun He Changwen Jin Maili Liu | 2020 | Chinese Journal of Chemistry2020，38，4： | 0 |
| 19 | Probing single protein with electron spin resonance in combination with shallow nitrogen vacancy显示文摘Proteins are the main power of life with vast functions within living organisms,such as assembling the cell structure,catalyzing metabolic reactions,transcribing and replicating DNA,responding to stimuli,and transporting molecules from one location to another.The proteins’functions are closely related to their sequence,conformation and in- | Maili Liu | 2015 | Science China Chemistry2015，58，5： | 0 |
| 20 | −22-Fold of^(1)H signal enhancement in-situ low-field liquid NMR using nanodiamond as polarizer of overhauser dynamic nuclear polarization显示文摘Nanodiamond(ND)polarizer can be used for dynamic nuclear polarization(DNP),owing to unpaired electrons provided by surface defects.However,^(1)H enhancement via Overhauser DNP(ODNP)using ND in-situ liquid has been found much smaller than traditional radicals.Herein,we study the surface properties of ND using electron spin resonance(ESR)and Raman methods firstly.Then the enhancement of^(1)H ODNP is explored using ND as polarizer with different nanoparticle sizes and concentrations at home-built 0.06 T DNP spectrometer.The surface of ND with the size of 30 nm is further modification via high temperature air oxidized and the enhancement was measured.The results show that nanoparticle sizes and Raman peak intensity ratio of sp^(2)/sp^(3)hybridization are approximate negative correlation and positive correlation to enhancement,respectively.Furthermore,there is no significant enhancement in the oxidation group,and a−22.5-fold^(1)H ODNP enhancement is achieved in-situ liquid at room temperature,which demonstrate the ND can be used as an efficient enhancer.We expect ND to play a greater role in biomedical research,especially for multimodal imaging with improving the performance of ND surface. | Zhen Zhang Fang Chen Jiwen Feng Junfei Chen Li Chen Zhi Zhang Huijuan Wang Xin Cheng Maili Liu Chaoyang Liu | 2021 | Chinese Chemical Letters2021，32，11： | 0 |
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