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| 1 | A mouse model for HBV immunotolerance and immunotherapy显示文摘一个适当小动物模型的缺乏仍然是一个主要障碍因为学习 immunotolerance 和 immunopathogenesis 由肝炎 B 病毒(HBV ) 导致了感染。在这研究,我们与 recombinant 在感染以后与持续 HBV viremia 报导一个老鼠模型带一个可复制的 HBV 染色体(AAV/HBV ) 的联系 adeno 的病毒(AAV ) 。类似于临床的 HBV 搬运人,感染 AAV/HBV 的老鼠为对 HBV 表面抗原(HBsAg ) 的抗体是 sero 否定的。有面对铝助手疫苗的常规 HBV 的免疫没能在这些老鼠对 HBV 得到有免疫力的回答。为了识别一支疫苗,那能潜在地围绕这忍耐, TLR9 收缩筋 CpG 作为一个助手被加到 HBsAg。有 HBsAg/CpG 的老鼠的种痘导致了 viremia,而且强壮的抗体生产和 T 房间回答的不仅清理。而且, DNA 复制和 HBV 的蛋白质表示显著地在 AAV/HBV-infected 鼠标的肝被减少。因此, AAV/HBV-infected 老鼠可以作为一个柔韧的模型被使用调查 HBV immunotolerance 并且为开发新奇免疫疗法根除的内在的机制 HBV 感染。 | Dan Yang Longchao Liu Danming Zhu Hua Peng Lishan Su Yang-Xin Fu Liguo Zhang | 2014 | Cellular & Molecular Immunology2014，11，1： | 25 |
| 2 | Pituitary tumor transforming gene: a novel therapeutic target for glioma treatment显示文摘有强壮的增长和 angiogenesis 能力的 Glioma 是在中央神经系统的最普通、恶意的主要肿瘤。垂体肿瘤转变基因(PTTG ) 在垂体肿瘤被发现,并且在房间增长,房间周期,房间 apoptosis,和 angiogenesis 起重要作用。然而,在 glioma 的 PTTG 的角色仍然不完全地被调查。这里,我们探索了在 PTTG 和 glioma 等级,以及微容器的密度(MVD ) 之间的关联。另外, siRNA 包括 U87MG, U251,和 SHG44 在 glioma 房间线习惯于沉默 PTTG 表示。房间增长, apoptosis,侵略,和 angiogenesis 在 vitro 并且在 vivo 被学习。我们的结果证明那 PTTG 表情在 glioma 是显著地起来调整的,并且与 glioma 等级和 MVD 有积极关联。PTTG 的 Silencing 禁止了 glioma 房间增长,迁居 / 侵略,和 angiogenesis,导致了房间 apoptosis,压制了房间侵略,并且逮捕了在 G0/G1 舞台的房间周期。PTTG 的 Silencing 能也在 vivo 禁止肿瘤生长,侵略,和 angiogenesis。我们的数据显示 PTTG 可能是为 glioma 处理的一个潜在的目标。 | Lishan Cui Songbai Xu Zhengmao Song Gang Zhao Xiaoqian Liu Yuwen Song | 2015 | Acta Biochimica et Biophysica Sinica2015，47，6： | 6 |
| 3 | Adaptive growth of Tamarix taklamakanensis root systems in response to wind action显示文摘Root distribution and characteristics were investigated on a 70-year-old Tamarix taklamakanensis individual through uprooting. Rooting depth was restricted by water table, and root morphology adapted to resist the wind movement associated with shallow rooting. Root systems had more structural root mass and length on the leeward side than the windward side of the tree relative to the prevailing wind direction. Additional resistance to wind bending can occur as a result of increased thickening of the lower stem along the axis of the prevailing wind direction, and in T. taklamakanensis, this thickening is greater on the lee side of the stem. We conclude that increased root distribution and thickening of the lower stem on the leeward are an important strategy for T. taklamakanensis in response to wind action in the hinterland of Taklimakan Desert. | LIU GuoJun ZHANG XiMing LI XiaoRong WEI Jiang SHAN LiShan | 2008 | Chinese Science Bulletin2008，53，S2： | 4 |
| 4 | Preventative effect of massage on gastric volvulus in infants with gastroesophageal reflux-induced pneumonia显示文摘OBJECTIVE:To study the preventative effects of massage on gastric volvulus(GV) in infants with gastroesophageal reflux(GER)-induced pneumonia.METHODS:One-hundred and eighty GV with GER-induced pneumonia inpatients were divided randomly into four groups:basic treatment 1(n =60),basic treatment 2(n = 30),massage treatment1(n = 60) and massage treatment 2(n = 30).Clinical examinations selected between groups 1 and 2were different.Radiography of the upper gastrointestinal tract using iodine-containing contrast was assessed in group 1 before and after treatment,whereas 24-h pH monitoring of the distal esophagus was assessed in group 2 before and after treatment.Symptom scores and chest radiography were assessed in all groups upon hospital admission and after procedures.Clinical effects were estimated after procedures in all groups.The prevalence of severe pneumonia among the four groups was compared.RESULTS:Massage treatment groups showed a significantly higher percentage of cure and total effect(P<0.05,P<0.01) and a lower prevalence of recurrence(but with no statistic difference,P>0.05)than basic treatment groups.Furthermore,massage treatment groups had remarkably lower scores for symptoms and signs(P<0.05,P<0.01),especially for choking on milk,than basic treatment groups.There was significant attenuation of chest inflammation(P<0.05,P<0.01),GV(P<0.05,P<0.01) and GER(P<0.05,P<0.01) in massage treatment groups compared with those in basic treatment groups.Finally,massage treatment groups demonstrated a lower prevalence of severe pneumonia than basic treatment groups(P<0.05).CONCLUSION:Massage treatment can prevent GV with GER-induced pneumonia in infants by timely correction of stomach rotation and subsequent attenuation of GER. | Yan Suqi Xiong Xiaoli Wan Qi Liu Fan Tang Jianqiao Jiang Zhixia Zhou Lishan Yuan Kai Xie Dong | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 3 |
| 5 | Secure DHCPv6 Mechanism for DHCPv6 Security and Privacy Protection显示文摘With the rapid developmen of the Internet,the exhaustion of IPv4 address limited the development of the Internet for years.IPv6,as the core technology of the next generation Internet,has since been rapidly deployed around the world.As the widely deployed address configuration protocol,DHCPv6 is responsible for allocating globally unique IPv6 addresses to clients,which is the basis for all the network services.However,the initial design of the DHCPv6 protocol gave little consideration to the privacy and security issues,which has led to a proliferation of privacy and security accidents breaches in its real deployment.In this paper,to fundamentally solve a range of possible security and privacy issues,we propose a secure DHCPv6 mechanism,which adds authentication and encryption mechanisms into the original DHCPv6 protocol.Compared with other proposed security mechanisms for the DHCPv6,our method can achieve all-around protection for the DHCPv6 protocol with minimal change to the current protocol,easier deployment,and low computing cost. | Lishan Li Gang Ren Ying Liu Jianping Wu | 2018 | Tsinghua Science and Technology2018，23，1： | 3 |
| 6 | HIV-1 can infect northern pig-tailed macaques(Macaca leonina) and form viral reservoirs in vivo显示文摘Viral reservoirs of HIV-1 are a major obstacle for curing AIDS. The novel animal models that can be directly infected with HIV-1 will contribute to develop effective strategies for eradicating infections.Here, we inoculated 4 northern pig-tailed macaques(NPM) with the HIV-1 strain HIV-1_(NL4.3) and monitored the infection for approximately 3 years(150 weeks). The HIV-1-infected NPMs showed transient viremia for about 10 weeks after infection. However, cell-associated proviral DNA and viral RNA persisted in the peripheral blood and lymphoid organs for about 3 years. Moreover, replication-competent HIV-1could be successfully recovered from peripheral blood mononuclear cells(PBMCs) during long-term infection. The numbers of resting CD4^+T cells in HIV-1 infected NPMs harboring proviruses fell within a range of 2-to 3-log_(10) per million cells, and these proviruses could be reactivated both ex vivo and in vivo in response to co-stimulation with the latency-reversing agents JQ1 and prostratin. Our results suggested that NPMs can be infected with HIV-1 and a long-term viral reservoir was formed in NPMs,which might serve as a potential model for HIV-1 reservoir research. | Wei Pang Gao-Hong Zhang Jin Jiang Hong-Yi Zheng Lin-Tao Zhang Xiao-Liang Zhang Jia-Hao Song Ming-Xu Zhang Jia-Wu Zhu Ai-Hua Lei Ren-Rong Tian Xiao-Ming Liu Liguo Zhang Guangxia Gao Lishan Su Yong-Tang Zheng | 2017 | Science Bulletin2017，62，19： | 2 |
| 7 | Asynchronous Parallel Algorithm For Constrained Optimization显示文摘 | Lishan Kang Pu Liu | 1999 | Wuhan University Journal of Natural Sciences1999，05，： | 1 |
| 8 | SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate显示文摘Loss-of-function mutations in sorting nexin 14(SNX14)cause autosomal recessive spinocerebellar ataxia 20,which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models.We generated Snx14-deficient mouse models and observed severe motor deficits and cell-autonomous Purkinje cell degeneration.SNX14 deficiency disrupted microtubule organization and mitochondrial transport in axons by destabilizing the microtubule-severing enzyme spastin,which is implicated in dominant hereditary spastic paraplegia with cerebellar ataxia,and compromised axonal integrity and mitochondrial function.Axonal transport disruption and mitochondrial dysfunction further led to degeneration of high-energy-demanding Purkinje cells,which resulted in the pathogenesis of cerebellar ataxia.The antiepileptic drug valproate ameliorated motor deficits and cerebellar degeneration in Snx14-deficient mice via the restoration of mitochondrial transport and function in Purkinje cells.Our study revealed an unprecedented role for SNX14-dependent axonal transport in cerebellar ataxia,demonstrated the convergence of SNX14 and spastin in mitochondrial dysfunction,and suggested valproate as a potential therapeutic agent. | Hongfeng Zhang Yujuan Hong Weijie Yang Ruimin Wang Ting Yao Jian Wang Ke Liu Huilong Yuan Chaoqun Xu Yuanyuan Zhou Guanxian Li Lishan Zhang Hong Luo Xian Zhang Dan Du Hao Sun Qiuyang Zheng Yun-Wu Zhang Yingjun Zhao Ying Zhou Huaxi Xu Xin Wang | 2021 | National Science Review2021，8，7： | 1 |
| 9 | Ishikawaand Mann iterative processes with errors for nonexpansive mappings in Banach spaces显示文摘 | Liu Lishan | 1995 | J Math Anal Appl1995，194，： | 1 |
| 10 | The integrin-linked kinase gene up-regulated by hypoxia plays its pro-survival role in colorectal cancer cells显示文摘 | Lei Xiao Xiaolong Yue Xiaodong Ming Lishan Xu Mingfeng Ding Jun Xu Qian Liu | 2013 | Journal of Receptors and Signal Transduction2013，，1： | 1 |
| 11 | Positive solutions of fourth-order nonlinear singular Sturm–Liouville eigenvalue problems显示文摘 | Lishan Liu Xinguang Zhang Yonghong Wu | 2006 | Journal of Mathematical Analysis and Applications2006，，2： | 1 |
| 12 | Necessary and sufficient condition for the existence of positive solutions of fourth-order singular boundary value problems 显示文摘 | Zhaocai Hao Liu Lishan Debnath L A | 2003 | Applied Mathematics Letters2003，16，3： | 1 |
| 13 | Ishikawa and Mann iterative process with errors for nonlinear strongly accretive mappings in Banach spaces显示文摘 | Liu Lishan | 1995 | J Math Anal Appl1995，194，： | 1 |
| 14 | The eigenvalue for a class of singular p - La- palacian fractional differential equations involving the Re- mann - Stieltjes integral boundarycondition 显示文摘 | Xingguang Zhang Lishan Liu Benchawan Wiwatanapataphee Yonghong Wu | 2014 | Applied Mathematics and Computation2014，，235： | 1 |
| 15 | Existence of positive solutions for second-order semipositone differential equations on the half-line显示文摘 | Zhang Xinguang Liu Lishan Wu Yonghong | 2007 | Applied Mathematics and Computation2007，185，： | 1 |
| 16 | Positive solutions for nonlinear nth-order singular eigenvalue problem with nonlocal conditions 显示文摘 | Hao Xinan Liu Lishan Wu Yonghong | 2010 | Nonlinear Anal2010，73，： | 1 |
| 17 | Common fixed points of a pair of single-valued mapping and a pair of set-valued mappings显示文摘 | Liu Lishan | 1992 | Qufu Shifan Daxue Xuebao:Ziran Kexue Ban1992，18，1： | 1 |
| 18 | Extremal solutions for p-Laplacian fractional integro-differential equation with integral conditions on infinite intervals via iterative computation显示文摘 | WANG Ying LIU Lishan WU Yonghong | 2015 | Advances in Difference Equations2015，，1： | 1 |
| 19 | Psoitive solutions of fourth-order nonlinear singular Sturm-Liouville eigenvalue problems显示文摘 | Liu Lishan Zhan Xinguangg Wu Yonghong | 2007 | Math Anal Appl2007，，326： | 1 |
| 20 | Multiple positive solutions of a singular fractional differential equation with negatively perturbed term显示文摘 | ZHANG Xinguang LIU Lishan WU Yonghong | 2012 | Mathematical and Computer Modelling2012，55，34： | 1 |
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