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| 1 | Locking plate fixation combined with iliac crest bone autologous graft for proximal humerus comminuted fracture显示文摘 | Zhu Lian Liu Yueju Yang Zongyou Li Han Wang Juan Zhao Changping Chen Xiao Zhang Yingze | 2014 | Chinese Medical Journal2014，，9： | 40 |
| 2 | ^(14)C measurement of forest soils in Dinghushan Biosphere Reserve显示文摘Organic carbon in forest soils of Qingyunsi and Wukesong profiles can be divided into fast and slow components. Δ14C values of these profiles decrease with increasing of depth. The Δ14C values in 30—40 cm depth interval of Wukesong profile are decreasing sharply until a very low value,showing that a strong geological environment change occurred about 1 560 years ago. The 14C apparent ages of Wukesong profile show that the coniferous and broad-leaf mixed forests around Wukesong profile have been developing since 425 a BP, which is consistent with historical documents. The penetrating depths of 'bomb 14C' in Qingyunsi and Wukesong profiles are 10 and 20 cm, respectively. | SHEN Chengde , LIU Dongsheng (LIU Tungsheng) , PENG Shaolin, SUN Yanmin , JIANG Mantao , Yl Weixi , XING Changping , GAO Quanzhou , LI Zhi’an and ZHOU Guoyi Guangzhou Institute of Geochemisry, Chinese Academy of Sciences, Guangzhou 510640, China Institute of Geology, Chinese Academy of Sciences , Beijing 100029, China South China Institute of Botany, Chinese Academy of Sciences, Guangzhou 510650, China | 1999 | Chinese Science Bulletin1999，44，3： | 7 |
| 3 | Pertuzumab in combination with trastuzumab and chemotherapy for Chinese patients with HER2-positive metastatic gastric or gastroesophageal junction cancer:a subpopulation analysis of the JACOB trial显示文摘Background:The JACOB trial(NCT01774786)was a double-blinded,placebo-controlled,randomized,multicenter,international,phase III trial evaluating the efficacy and safety of adding pertuzumab to trastuzumab and chemo-therapy in first-line treatment of human epidermal growth factor receptor 2(HER2)-positive metastatic gastric cancer/gastroesophageal junction cancer(GEJC).The aim of this analysis was to investigate efficacy and safety outcomes in the Chinese subpopulation from the JACOB trial.Methods:This post hoc subpopulation analysis included all patients recruited in China's Mainland(n=163;20.9%)between June 2013 and January 2016.The patients were randomly assigned in a 1:1 ratio to receive pertuzumab plus trastuzumab and chemotherapy(pertuzumab group;n=82)or placebo plus trastuzumab and chemotherapy(con-trol group;n=81).Intravenous pertuzumab(840 mg)and trastuzumab(8 mg/kg loading and 6 mg/kg maintenance doses)were given every 3 weeks until disease progression or unacceptable toxicity.Chemotherapy was given as per standard regimens/doses of capecitabine or 5-fluorouracil plus cisplatin.The primary endpoint was overall survival(OS);secondary efficacy endpoints included progression-free survival(PFS),and overall objective response rate(ORR).Results:The median OS was 18.7 months in the pertuzumab group and 16.1 months in the control group(hazard ratio[HR]0.75;95%confidence interval[CI]0.49 to 1.14).The median PFS was 10.5 and 8.6 months in the pertuzumab and control groups,respectively(HR 0.85;95%CI 0.60 to 1.21),and the median ORRs were 68.9%and 55.7%,respectively.The treatment effect in this Chinese subpopulation showed consistency with that in the global ITT population with numerically lower HR for OS and PFS compared with the control group.The safety profiles of the pertuzumab and control groups in this Chinese subpopulation analysis were generally comparable.The most common grade 3-5adverse events were neutropenia,anemia,and leukopenia.However,due to the nature of being a post hoc subgroup analysis,the results presented here are descriptive only and need to be interpreted with caution.Conclusions:OS and PFS were numerically improved by adding pertuzumab to trastuzumab and chemotherapy as first-line treatment in Chinese HER2-positive gastric cancer/GEJC patients,and this regimen demonstrated an acceptable safety profile. | Tianshu Liu Yanru Qin Jin Li Ruihua Xu Jianming Xu Shujun Yang Shukui Qin Yuxian Bai Changping Wu Yixiang Mao Haiyan Wu Yilin Ge Lin Shen | 2019 | Cancer Communications2019，39，1： | 6 |
| 4 | Investigation into the flotation response of refractory molybdenum ore to depressant mixtures:A case study显示文摘In this paper, bulk flotation followed by separation was investigated to concentrate purified molybdenite product from Jinduicheng molybdenum ores(Shanxi province, China). The bench scale tests mainly focussed on separation of molybdenite from other sulfide minerals using the new type of depressants.The effect of each single depressant, including organic depressant-modified dextrin(MD), P-Nokes reagent(PN) and sodium trithiocarbonate(ST), and their mixtures on galena, chalcopyrite and other sulfide ores, was examined in turn by changing the concentrations used in cleaner flotation tests. Closed circuit experiments were carried out under the optimal condition and satisfying recovery and grade of molybdenite concentrate could be achieved(86.294% and 53.157%, respectively). A potential reagent regime was developed, with more environmental friendly and more economical advantages due to the introduction of modified dextrin. | Yin Zhigang Sun Wei Liu Jiandong Hu Yuehua Guan Qingjun Zhang Chenhu Tang Honghu Guan Changping | 2016 | International Journal of Mining Science and Technology2016，26，6： | 4 |
| 5 | Unveiling the mechanical response and accommodation mechanism of pre-rolled AZ31 magnesium alloy under high-speed impact loading显示文摘Split Hopkinson pressure bar(SHPB)tests were conducted on pre-rolled AZ31 magnesium alloy at 150–350℃ with strain rates of 2150s-1,3430s^(-1) and 4160s-1.The mechanical response,microstructural evolution and accommodation mechanism of the pre-rolled AZ31 magnesium alloy under high-speed impact loading were investigated.The twin and shear band are prevailing at low temperature,and the coexistence of twins and recrystallized grains is the dominant microstructure at medium temperature,while at high temperature,dynamic recrystallization(DRX)is almost complete.The increment of temperature reduces the critical condition difference between twinning and DRX,and the recrystallized temperature decreases with increasing strain rate.The mechanical response is related to the competition among the shear band strengthen,the twin strengthen and the fine grain strengthen and determined by the prevailing grain structure.The fine grain strengthen could compensate soften caused by the temperature increase and the reduction of twin and shear band.During high-speed deformation,different twin variants,introduced by pre-rolling,induce different deformation mechanism to accommodate plastic deformation and are in favor for non-basal slip.At low temperature,the high-speed deformation is achieved by twinning,dislocation slip and the following deformation shear band at different deformation stages.At high temperature,the high-speed deformation is realized by twinning and dislocation slip of early deformation stage,transition shear band of medium deformation stage and DRX of final deformation stage. | Xiao Liu Hui Yang Biwu Zhu Yuanzhi Wu Wenhui Liu Changping Tang | 2022 | Journal of Magnesium and Alloys2022，10，4： | 2 |
| 6 | Unveiling the underlying mechanism of forming edge cracks upon high strain-rate rolling of magnesium alloy显示文摘In the current study,high strain-rate rolling(≥10 s-1) has been successfully employed to produce Mg-3 A1-1 Zn alloy sheets to a high reduction of 82% with a fine grain structure in a single pass.The underlying mechanism of forming primary and secondary edge cracks has been investigated.It is found that dynamic recrystallization(DRX) induced by subgrains tends to blunt cracks,while twinning-induced D RX is mainly observed around sharp crack tips.The motion of emitted dislocations from blunted cracks is inhibited by the DRX grain boundaries.This,on one hand,increases local work hardening,and on the other hand,causes stress concentration alo ng grain boundaries especially in the triple junctions leading to the formation of secondary cracks. | Biwu Zhu Xiao Liu Chao Xie Jing Su Pengcheng Guo Changping Tang Wenhui Liu | 2020 | Journal of Materials Science & Technology2020，47，15： | 2 |
| 7 | Horizontal and vertical gene transfer drive sediment antibiotic resistome in an urban lagoon system显示文摘Rapid urbanization has resulted in pervasive occurrence of antibiotic resistance genes(ARGs)in urban aquatic ecosystems.However,limited information is available concerning the ARG profiles and the forces responsible for their assembly in urban landscape lagoon systems.Here,we employed high-throughput quantitative PCR(HT-q PCR)to characterize the spatial variations of ARGs in surface and core sediments of Yundang Lagoon,China.The results indicated that the average richness and absolute abundance of ARGs were 11 and 53 times higher in the lagoon sediments as compared to pristine reference Tibetan lake sediments,highlighting the role of anthropogenic activities in ARG pollution.Co-occurrence network analysis indicated that various anaerobic prokaryotic genera belonging to Alpha-,Deltaproteobacteria,Bacteroidetes,Euryarchaeota,Firmicutes and Synergistetes were the potential hosts of ARGs.The partial least squares-path modeling(PLS-PM)analysis revealed positive and negative indirect effects of physicochemical factors and heavy metals on the lagoon ARG profiles,via biotic factors,respectively.The horizontal(mediated by mobile genetic elements)and vertical(mediated by prokaryotic communities)gene transfer may directly contribute the most to drive the abundance and composition of ARGs,respectively.Furthermore,the neutral community model demonstrated that the assembly of sediment ARG communities was jointly governed by deterministic and stochastic processes.Overall,this study provides novel insights into the diversity and distribution of ARGs in the benthic habitat of urban lagoon systems and underlying mechanisms for the spread and proliferation of ARGs. | Hongjie Wang Liyuan Hou Yongqin Liu Keshao Liu Lanping Zhang Fuyi Huang Lin Wang Azhar Rashid Anyi Hu Changping Yu | 2021 | Journal of Environmental Sciences2021，33，4： | 2 |
| 8 | Polyploidy events shaped the expansion of transcription factors in Cucurbitaceae and exploitation of genes for tendril development显示文摘Cucurbitaceae is one of the most important plant families distributed worldwide.Transcription factors(TFs)regulate plant growth at the transcription level.Here,we performed a systematic analysis of 42641 TFs from 63 families in 14 Cucurbitaceae and 10 non-cucurbit species.Whole-genome duplication(WGD)was the dominant event type in almost all Cucurbitaceae plants.The TF families were divided into 1210 orthogroups(OGs),of which,112 were unique to Cucurbitaceae.Although the loss of several gene families was detected in Cucurbitaceae,the gene families expanded in five species that experienced a WGD event comparing with grape.Our findings revealed that the recent WGD events that had occurred in Cucurbitaceae played important roles in the expansion of most TF families.The functional enrichment analysis of the genes that significantly expanded or contracted uncovered five gene families,AUX/IAA,NAC,NBS,HB,and NF-YB.Finally,we conducted a comprehensive analysis of the TCP gene family and identified 16 tendril-related(TEN)genes in 11 Cucurbitaceae species.Interestingly,the characteristic sequence changed from CNNFYFP to CNNFYLP in the TEN gene(Bhi06M000087)of Benincasa hispida.Furthermore,we identified a new characteristic sequence,YNN,which could be used for TEN gene exploitation in Cucurbitaceae.In conclusion,this study will serve as a reference for studying the relationship between gene family evolution and genome duplication.Moreover,it will provide rich genetic resources for functional Cucurbitaceae studies in the future. | Yu Zhang Yingchao Zhang Bing Li Xiao Tan Changping Zhu Tong Wu Shuyan Feng Qihang Yang Shaoqin Shen Tong Yu Zhuo Liu Xiaoming Song | 2022 | Horticultural Plant Journal2022，8，5： | 2 |
| 9 | miR?181b as a key regulator of the oncogenic process and its clinicalimplications in cancer (Review)显示文摘 | Juan Liu Weifeng Shi Changping Wu Jingfang Ju Jingting Jiang | 2014 | Biomedical Reports2014，，： | 1 |
| 10 | Value of 18 F-FDG PET/CT in the diagnosis of primary gastric cancer via stomach distension显示文摘 | Quanmei Ma Jun Xin Zhoushe Zhao Qiyong Guo Shupeng Yu Weina Xu Changping Liu Wei Zhai | 2013 | European Journal of Radiology2013，，6： | 1 |
| 11 | Effects of Si addition on microstructure and mechanical properties of Mg–8Gd–4Y–Nd–Zr alloy显示文摘 | Xinming Zhang Jilong Hu Lingying Ye Yunlai Deng Changping Tang Liu Yang Zhaoyang Liu | 2013 | Materials and Design2013，，： | 1 |
| 12 | Single-walled carbon nanotube-ionic liquid paste electrode for the sensitive voltammetric determination of folic acid 显示文摘 | XIAO Fei RUAN Changping LIU Lihong | 2008 | Sens Actuators : B2008，134，2： | 1 |
| 13 | S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery显示文摘Photocleavable hydrogels are of great importance in the field of controlled drug delivery,stem cell fate regulation,surface patterning,and intelligent devices.However,the development of novel photocleavable gel systems by visible light is usually met with challenges such as the lack of efficient and tunable photocleavable groups and reactions.Herein,we reported the facile fabrication of a new type of photocleavable hydrogels by the direct gelation of 4-arm thiol-terminated polyethylene glycol with 3,6-dichloro-1,2,4,5-tetrazine via the formation of S,S-tetrazine linkages.The prepared hydrogels underwent efficient degradation upon irradiation by ultraviolet or green light,and the degradation kinetics could be significantly promoted by hydrogen peroxide.Correspondingly,the hydrogels loaded with calcium peroxide microparticles or glucose oxidase/catalase enzymes enabled the precise and efficient in vivo photocontrol of gel degradation and drug release for cancer treatment.This work offers a promising and facile strategy towards the fabrication of visible light cleavable hydrogels with tunable and ondemand drug release properties. | Changping Wang Chongyi Liu Qiyao Wei Lei Yang Peng Yang Yiwen Li Yiyun Cheng | 2020 | Research2020，，1： | 1 |
| 14 | A shearlet based separation method of 3D engineering surface using high definition metrology显示文摘 | Du Shichang Liu Changping Huang Delin | 2015 | Precision Engineering2015，40，： | 1 |
| 15 | Treatment outcomes of transcatheter arterial chemoembolization combined with local ablative therapy versus monotherapy in hepatocellular carcinoma: a meta-analysis显示文摘 | Lili Gu Huiling Liu Linlin Fan Yuanjun Lv Zhuang Cui Yan Luo Yuanyuan Liu Guang Li Changping Li Jun Ma | 2014 | Journal of Cancer Research and Clinical Oncology2014，，2： | 1 |
| 16 | The flow behavior in as-extruded AZ31 magnesium alloy under impact loading显示文摘As-extruded AZ31 magnesium alloy samples were compressed at ambient temperature and strain rates of 1000-3000 s^(−1).The fracture surfaces of cracked samples,the evolution of microstructures and macrotextures were detected.The received flow curves exhibit an abnormal behavior at strain rates above 1500 s^(−1).A strain constitutive model based on strain equivalent principle was applied to analyze the flow curves of the damaged samples.The results indicate that the abnormal flow behaviors of the fractured samples are related to the increasing area of crack surfaces,and kinetic energy during dynamic crack nucleation and propagation.The initiation of the micro-crack also causes obvious flow softening in the cracked samples.The shapes of flow stresses of the intact samples are affected by twinning.©2018 Published by Elsevier B.V.on behalf of Chongqing University. | Biwu Zhu Xiao Liu Chao Xie Wenhui Liu Changping Tang Liwei Lu | 2018 | Journal of Magnesium and Alloys2018，6，2： | 1 |
| 17 | Mobious isotropic suhmanifolds in Sn显示文摘 | Liu Huili Wang Changping Zhao Guosogn | 2001 | Tohoku Math2001，53，： | 1 |
| 18 | Gabor-based kernel PCA with fractional power polynomial models for face recognition显示文摘 | LIU CHANGPING | 2004 | IEEE Transactions on Pattern Analysis and Machine Intelligence2004，26，5： | 1 |
| 19 | Feature combination using boosting显示文摘 | Yin Xucheng Liu Changping Han Zhi | 2005 | Pattern Recognition2005，26，14： | 1 |
| 20 | 5-11 Conceptual Design of Sub-critical Reactor of CADS Project显示文摘China Initiative Accelerator Driven System (CIADS) proposed by the Chinese Academy of Sciences which is one of the twelve Major National Scientific and Technological Infrastructures has been approved by National Development and Reform Commission of China, and supposed to be the first principle prototype ADS experimental facility in the world. | Gu Long Li Jinyang Wang Dawei Fan Qing Qin Changping Liu Lu Zhu Yanlei Yu Rui Chai Yilin | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
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