|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Investigation and assessment on mountain tunnels and geotechnical damage after the Wenchuan earthquake显示文摘On May 12, 2008, a strong earthquake with a magnitude of 8.0 (Ms) struck Wenchuan town, in the eastern Sichuan area of west China. Following the earthquake on May 18, the Southwest Jiaotong University organized a damage survey team and dispatched it to the affected area for the investigation into the damage and collection of information and data. This paper outlines the findings of this investigation on the earthquake disaster to mountain tunnels and geotechnical engineering. The systematic investigation, involving geological conditions, design documents, construction and maintenance records of the tunnels, has been conducted and the degree of damage to investigated tunnels has been assessed according to the width and length of cracks, the stability of the slope above the tunnel, and the condition of the groundwater inrush. The results show that the major damage of the mountain tunnels was mainly concentrated in the tunnel portals due to widespread landslides and rockfalls, and the inner part of investigated tunnels suffered moderate damages mainly due to fault displacements. It is hoped that the information shared herein could enhance the outstanding of seismic behavior of mountain tunnels and improve seismic design and construction procedures. | WANG ZhengZheng GAO Bo JIANG YuanJun YUAN Song | 2009 | Science China(Technological Sciences)2009，52，2： | 84 |
| 2 | Double-Edge Intelligent Integrated Satellite Terrestrial Networks显示文摘The efficient integration of satellite and terrestrial networks has become an important component for 6 G wireless architectures to provide highly reliable and secure connectivity over a wide geographical area.As the satellite and cellular networks are developed separately these years,the integrated network should synergize the communication,storage,computation capabilities of both sides towards an intelligent system more than mere consideration of coexistence.This has motivated us to develop double-edge intelligent integrated satellite and terrestrial networks(DILIGENT).Leveraging the boost development of multi-access edge computing(MEC)technology and artificial intelligence(AI),the framework is entitled with the systematic learning and adaptive network management of satellite and cellular networks.In this article,we provide a brief review of the state-of-art contributions from the perspective of academic research and standardization.Then we present the overall design of the proposed DILIGENT architecture,where the advantages are discussed and summarized.Strategies of task offloading,content caching and distribution are presented.Numerical results show that the proposed network architecture outperforms the existing integrated networks. | Jiaxin Zhang Xing Zhang Peng Wang Liangjingrong Liu Yuanjun Wang | 2020 | China Communications2020，17，9： | 9 |
| 3 | DEVELOPMENT OF THE ENERGY MANAGEMENT STRATEGY FOR PARALLEL HYBRID ELECTRIC URBAN BUSES显示文摘A novel parallel hybrid electrical urban bus (PHEUB) configuration consisting of an extra one-way clutch and an automatic mechanical transmission (AMT) is taken as the study subject. An energy management strategy combining a logic threshold approach and an instantaneous optimization algorithm is proposed for the investigated PHEUB. The objective of the energy management strategy is to achieve acceptable vehicle performance and drivability requirements while simultaneously maximizing the engine fuel consumption and maintaining the battery state of charge in its operation range at all times. Under the environment of Matlab/Simulink, a computer simulation model for the PHEUB is constructed by using the model building method combining theoretical analysis and bench test data. Simulation and experiment results for China Typical Bus Driving Schedule at Urban District (CTBDS_UD) are obtained, and the results indicate that the proposed control strategy not only controls the hybrid system efficiently but also improves the fuel economy significantly. | HUANG Yuanjun YIN Chengliang ZHANG Jianwu | 2008 | Chinese Journal of Mechanical Engineering2008，21，4： | 7 |
| 4 | Metal-organic frameworks-derived nitrogen-doped carbon supported nanostructured PtNi catalyst for enhanced hydrosilylation of 1-octene显示文摘Here,we successfully developed nano structured PtNi particles supported on n itroge rrdoped carbon(NC),which were obtai ned by carbon izati on of metal-organic frameworks under different temperatures,forming the nano-PtNi/NC-600,nano-PtNi/NC-800,nano-PtNi/NC-900 and nano-PtNi/NC-1000 catalysts.For hydrosilylation of 1-octene,we found that the nano-PtNi/NC-1000 catalyst exhibits higher activity for anti-Markovnikov hydrosilylation of 1-octene than those of nano-PtNi/NC-600,nano-PtNi/NC-800,nano-PtNi/NC-900 catalysts.Experiments have verified that benefiting from obvious charge transfer from nano-PtNi particles to NC support carbonized at 1,000℃,the nano-PtNi/NC-1000 catalyst achieved almost complete conversion and produce exclusive adduct for anti-Markovnikov hydrosilylation of 1-octene.Importantly,the nano-PtNi/NC-1000 catalyst exhibited good reusability for the hydrosilylation reaction.This work provides a new path to optimize electronic structure of catalysts by support modification to enhance electron transfer between metal active species and supports for highly catalytic performance. | Junfeng Wen Yuanjun Chen Shufang Ji Jian Zhang Dingsheng Wang and Yadong Li | 2019 | Nano Research2019，12，10： | 6 |
| 5 | Spatial distribution of water-active soil layer along the south-north transect in the Loess Plateau of China显示文摘Soil water is an important composition of water recycle in the soil-plant-atmosphere continuum.However, intense water exchange between soil-plant and soil-atmosphere interfaces only occurs in a certain layer of the soil profile. For deep insight into water active layer(WAL, defined as the soil layer with a coefficient of variation in soil water content >10% in a given time domain) in the Loess Plateau of China,we measured soil water content(SWC) in the 0.0–5.0 m soil profile from 86 sampling sites along an approximately 860-km long south-north transect during the period 2013–2016. Moreover, a dataset contained four climatic factors(mean annual precipitation, mean annual evaporation, annual mean temperature and mean annual dryness index) and five local factors(altitude, slope gradient, land use, clay content and soil organic carbon) of each sampling site was obtained. In this study, three WAL indices(WALT(the thickness of WAL), WAL-CV(the mean coefficient of variation in SWC within WAL) and WALSWC(the mean SWC within WAL)) were used to evaluate the characteristics of WAL. The results showed that with increasing latitude, WAL-T and WAL-CV increased firstly and then decreased. WAL-SWC showed an opposite distribution pattern along the south-north transect compared with WAL-T and WAL-CV.Average WAL-T of the transect was 2.0 m, suggesting intense soil water exchange in the 0.0–2.0 m soil layer in the study area. Soil water exchange was deeper and more intense in the middle region than in the southern and northern regions, with the values of WAL-CV and WAL-T being 27.3% and 4.3 m in the middle region,respectively. Both climatic(10.1%) and local(4.9%) factors influenced the indices of WAL, with climatic factors having a more dominant effect. Compared with multiple linear regressions, pedotransfer functions(PTFs) from arti?cial neural network can better estimate the WAL indices. PTFs developed by artificial neural network respectively explained 86%, 81% and 64% of the total variations in WAL-T, WAL-SWC and WAL-CV. Knowledge of WAL is crucial for understanding the regional water budget and evaluating the stable soil water reserve, regional water characteristics and eco-hydrological processes in the Loess Plateau of China. | ZHAO Chunlei SHAO Ming'an JIA Xiaoxu HUANG Laiming ZHU Yuanjun | 2019 | Journal of Arid Land2019，11，2： | 6 |
| 6 | Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene显示文摘Telomerase expression and telomere maintenance are critical for long-term cell proliferation and survival,and they play important roles in development,aging,and cancer.Cumulating evidence has indicated that regulation of the rate-limiting subunit of human telomerase reverse transcriptase gene(hTERT)is a complex process in normal cells and many cancer cells.In addition to a number of transcriptional activators and repressors,the chromatin environment and epigenetic status of the endogenous hTERT locus are also pivotal for its regulation in normal human somatic cells and in tumorigenesis. | Jiyue Zhu Yuanjun Zhao Shuwen Wang | 2010 | Protein & Cell2010，1，1： | 5 |
| 7 | A Study of the Crustal Stability in the Yangtze Three Gorges Area显示文摘The Three Gorges Dam on the Yangtze River is situated on the intact rock mass composed of diorite granite at the southern termination of the Huangling block which, as a sub plate with a double layer structure (crystalline basement and sedimentary cover) in the Chinese inland, keeps a constant but slow uplift as a whole since its formation in the Indoncisia movement. Tectonic deformation within the block is not significant, with the exception of a slight southeastward tilt. The block is confined by many active structures, of which the sub longitudinal Yuanan and Xiannvshan ( Mount Fairy ) deep fault zones are the main strongly seismogenic zones. The Yuan’an fault zone represents a regional boundary among West Henan, West Hubei and West Hunan mountainous regions as well as the Nanyang, Jianghan and Dongting Lake basins, with a total length of more than 1,000 km. Two M 6 5 earthquakes (in Changde and Nanyang) occurred in the fault zone in historic time and the distance between the two epicenters is about 500 km. The Mount Fairy fault zone extends northward along the Xiangxi River and ends at the Qingfeng fault. It runs a total length of more than 220 km. southward across Yuyang Pass and then its trace is unknown. The fault zone has a tectonic condition for occurrences of M 6.0 earthquakes. The possible seismic risk for the dam may come from these two strong seismogenic zones. Thus the seismic intensity to influence the dam is estimated to be Ⅵ~Ⅶ and the horizontal peak acceleration to be 0 1~0 15 g. | Li Ping 1, Li Yuanjun 2 (1 Institute of Geology, China Seismological Bureau, Beijing 100029) (2 College of Civil Construction Engineering, Wuhan University, Wuhan 430072) | 2003 | 工程科学(英文版)2003，1，1： | 4 |
| 8 | Effect of size and crystalline phase of TiO2 nanotubes on cell behaviors: A high throughput study using gradient TiO2 nanotubes显示文摘The research of TiO2 nanotubes(TNTs)in the field of biomedicine has been increasingly active.However,given the diversity of the nanoscale dimension and controversial reports,our understanding of the structure-property relationships of TNTs is not yet complete.In this paper,gradient TNTs with a wide diameter range of 20-350 nm were achieved by bipolar electrochemistry and utilized for a thorough high-throughput study of the effect of nanotube dimension and crystalline phase on protein adsorption and cell behaviors.Results indicated that protein adsorption escalated with nanotube dimension whereas cell proliferation and differentiation are preferred on small diameter(<70 nm)nanotubes.Large diameter anatase nanotubes had higher adsorption of serum proteins than as-prepared ones.But only as-prepared small diameter nanotubes presented slightly higher cell proliferation than corresponding annealed nanotubes whereas there was no discernible difference between as-prepared and annealed nanotubes on cell differentiation for the entire gradient.Those findings replenish previous research about how cell responses to TNTs with a wide diameter range and provide scientific guidance for the optimal design of biomedical materials. | Yanran Li Si Wang Yuanjun Dong Ping Mu Yun Yang Xiangyang Liu Changjian Lin Qiaoling Huang | 2020 | Bioactive Materials2020，5，4： | 3 |
| 9 | Zephyranthes-like Co2NiSe4 arrays grown on 3D porous carbon frame-work as electrodes for advanced supercapacitors and sodium-ion batteries显示文摘Developing suitable electrode materials for electrochemical energy storage devices by biomorph assisted design has become a fascinating topic due to the fantastic properties derived from bio-architectures.Herein,zephyranthes-like Co_(2)NiSe_(4)arrays grown on butterfly wings derived three-dimensional(3D)carbon framework(Z-Co_(2)NiSe_(4)/BWC)is fabricated via hydrothermal assembly and further conversion method.Benefiting from its unique structure and multi-components,the obtained Z-Co_(2)NiSe_(4)/BWC electrode for supercapacitor delivers an excellent specific capacitance of 2,280 F·g^(-1)at 1 A·g^(-1).Impressively,the constructed asymmetric supercapacitor using Co_(2)NiSe_(4)/BWC as positive electrode and activated butterfly wings carbon as negative electrode acquires a high energy density of 42.9 Wh·kg^(-1)at a power density of 800 W·kg^(-1)with robust stability of 94.6%capacitance retention at 10 A·g^(-1)after 5,000 cycles.Moreover,the Z-Co_(2)NiSe_(4)/BWC as anode for sodium-ion batteries exhibits a high specific capacity of 568 mAh·g^(-1)at 0.1 A·g^(-1)and high cycling stability(maintaining 80.1%of the second cycle after 100 cycles).The outstanding electrochemical performances are ascribed to that the synergistic effect of bimetallic selenides and N-doped carbon improves electrochemical activities and conductivity.One-dimensional(1D)nanoneedles grown on 3D porous framework increase the exposure of redox-active sites,endow adequate transmission channels of electrons/ions,and guarantee stability of the electrode during charge/discharge processes.This study will shed light on the avenue towards extending such nanohybrids to excellent energy storage applications. | Yanchun Xue Xingmei Guo Mengrong Wu Jiale Chen Mengting Duan Jing Shi Junhao Zhang Fu Cao Yuanjun Liu Qinghong Kong | 2021 | Nano Research2021，14，10： | 3 |
| 10 | Effects of growth temperature on μc-Si:H films prepared by plasma assistant magnetron sputtering显示文摘Hydrogenated microcrystalline silicon thin films (μc-Si:H) were deposited by plasma assistant magnetron sputtering in Ar-H 2 gas mixture. The effects of growth temperature from 150 to 450 C on properties of deposited Si films were investigated at two different hydrogen diluted gases with [H 2 ]/([Ar]+[H 2 ]) of 10% and 50% at 3 Pa. The crystallinity of Si films examined by Raman scattering exhibited higher degrada- tion by lowering growth temperature from 250 to 150 C in low hydrogen diluted gas of 10% than that in high hydrogen diluted gas of 50%. The IR absorption band around 845 and 890 cm 1 as well as calculated concentration of bonded hydrogen showed more obvious decrease of samples deposited in low hydrogen diluted gas of 10% than that in high hydrogen diluted gas of 50%. The optical band gasps of both groups of samples measured by ultraviolet-visible optical absorption were decreased with increasing temperature in both gas conditions. | Su, Yuanjun Dond, Chuang Zhu, Ming Xu, Jun Fan, Penghui | 2012 | Rare Metals2012，31，2： | 3 |
| 11 | Structural properties of GaN(0001) epitaxial layers revealed by high resolution X-ray diffraction显示文摘High-resolution X-ray diffraction has been used to analyze GaN(0001) epitaxial layers on sapphire substrates. Several structural properties of GaN, including the lattice constants, strains, and dislocation densities are revealed by the technique of X-ray dffraction (XRD). Lattice constants calculated from the omega/2theta scan are c=0.5185 nm and a=0.3157 nm. Also, the in-plane strain is -1.003%, while out of the plane, the epitaxial film is almost relaxed. Several methods are used to deduce the mosaicity and dislocation density of GaN, showing that the edge type dislocations are the overwhelming majority. | XIE ZiLi 1,2,3, ZHOU YuanJun 1 , SONG LiHong 1,2 , LIU Bin 1 , HUA XueMei 1,2 , Xiu XiangQian 1 , ZHANG Rong 1,2,3 & ZHENG YouDou 1,2,3 1 JiangSu Provincial Key Laboratory of Advanced Photonic and Electronic Materials and Department of Physics, Nanjing University, Nanjing 210093, China 2 Nanjing National Laboratory of Microstructures, Nanjing 210093, China 3 NJU-Yangzhou Institute of Opto-electronics, Yangzhou, 225001, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 3 |
| 12 | Influence of sintering schedule on the electrical properties of Mn(NO_3)_2-doped Ba_(0.92)Ca_(0.08)TiO_3 PTCR ceramics显示文摘The relationship of electrical properties of Mn-doped Ba0.92Ca0.08TiO3 PTCR (positive temperature coefficient resistance) ceramics with two sintering schedules was discussed. Using TEM (transmission electron microscope) combined with EDS (energy dispersive X-ray spectrometer), the Mn ions distributed at grain boundaries were analyzed. The results show that the PTCR effect of Mn-doped PTCR ceramics is more dependent on the sintering schedule than those of Mn free.The phenomenon may be caused by the valence states variance of Mn ions segregated at the grain boundaries. | CAOMinghe YUANJun CAOMingli ZHOUDongxiang | 2004 | Rare Metals2004，23，3： | 2 |
| 13 | Photoelectrical performance of nanocrystalline TiO_2 film electrode sensitized by Ru(Ⅱ)-bipyridine complexes显示文摘Two kinds of Ru(Ⅱ)-bipyridine complexes, cis-di(thiocyanate)bis(2,2′-bipyridyl-4,4′-dicarboxylate) ruthenium(Ⅱ) and cis-di(thiocyanate)bis(2,2′-bipyridyl-3,3′-dicarboxylate) ruthenium(Ⅱ), were utilized as the sensitizers to the nanocrystalline TiO-2 film electrodes. Study shows that the two dyes have quite different sensitization properties due to the strong steric effect of carboxyl groups. In addition, the pretreatment to nanocrystalline TiO-2 film electrodes with TiCl-4 was investigated, which is an effective way to improve the photoelectric conversion performances of sensitized TiO-2 electrodes. | YANG Rong, WANG Weibo, XIAO Xurui *, HOU Yuanjun, ZHANG Baowen and GAO Yi Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing 100101, China. * Corresponding author | 1998 | Chinese Science Bulletin1998，43，6： | 2 |
| 14 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 15 | Intrinsic Peroxidase-like Activity of Porous CuO Micro-/nanostructures with Clean Surface显示文摘Porous CuO micro-/nanostructures with clean surface,prepared through Cu_(2)(OH)_(2)CO_(3) precursor followed by calcination in air,were proven to be an effective peroxidase mimic.They can quickly catalyze oxidation of the peroxidase substrate 3,3',5,5'-tetramethylbenzidine(TMB)in the presence of H_(2)O_(2),producing a blue color.The obtained porous CuO micro-/nanostructure have potential application in wastewater treatment.The apparent steady-state kinetic parameter was studied with TMB as the substrate.In addition,the potential application of the porous CuO in wastewater treatment was demonstrated with phenol-containing water as an example.Such investigation not only confirms the intrinsic peroxidase-like activity of micro-/nanostructured CuO,but also suggests its potential application in wastewater treatment. | Yuanjun Liu Guoxing Zhu Chunlin Bao Aihua Yuan Xiaoping Shen | 2014 | Chinese Journal of Chemistry2014，32，2： | 2 |
| 16 | Biochemical properties of skin collagens isolated from black carp ( Mylopharyngodon piceus )显示文摘 | Yuanjun Jia Haibo Wang Haiyin Wang Yunyan Li Min Wang Jian Zhou | 2012 | Food Science and Biotechnology2012，，6： | 2 |
| 17 | Transcriptome sequencing analysis for the identification of stable lncRNAs associated with bovine Staphylococcus aureus mastitis显示文摘Background:Staphylococcus aureus(S.aureus)mastitis is one of the most difficult diseases to treat in lactating dairy cows worldwide.S.aureus with different lineages leads to different host immune responses.Long non-coding RNAs(lncRNAs)are reported to be widely involved in the progress of inflammation.However,no research has identified stable lncRNAs among different S.aureus strain infections.In addition,folic acid(FA)can effectively reduce inflammation,and whether the inflammatory response caused by S.aureus can be reduced by FA remains to be explored.Methods:lncRNA transcripts were identified from Holstein mammary gland tissues infected with different concentrations of S.aureus(in vivo)and mammary alveolar cells(Mac-T cells,in vitro)challenged with different S.aureus strains.Differentially expressed(DE)lncRNAs were evaluated,and stable DE lncRNAs were identified in vivo and in vitro.On the basis of the gene sequence conservation and function conservation across species,key lncRNAs with the function of potentially immune regulation were retained for further analysis.The function of FA on inflammation induced by S.aureus challenge was also investigated.Then,the association analysis between these keys lncRNA transcripts and hematological parameters(HPs)was carried out.Lastly,the knockdown and overexpression of the important lncRNA were performed to validate the gene function on the regulation of cell immune response.Results:Linear regression analysis showed a significant correlation between the expression levels of lncRNA shared by mammary tissue and Mac-T cells(P<0.001,R^(2)=0.3517).lncRNAs PRANCR and TNK2-AS1 could be regarded as stable markers associated with bovine S.aureus mastitis.Several HPs could be influenced by SNPs around lncRNAs PRANCR and TNK2-AS1.The results of gene function validation showed PRANCR regulates the mRNA expression of SELPLG and ITGB2 within the S.aureus infection pathway and the Mac-T cells apoptosis.In addition,FA regulated the expression change of DE lncRNA involved in toxin metabolism and inflammation to fight against S.aureus infection.Conclusions:The remarkable association between SNPs around these two lncRNAs and partial HP indicates the potentially important role of PRANCR and TNK2-AS1 in immune regulation.Stable DE lncRNAs PRANCR and TNK2-AS1 can be regarded as potential targets for the prevention of bovine S.aureus mastitis.FA supplementation can reduce the negative effect of S.aureus challenge by regulating the expression of lncRNAs. | Siyuan Mi Yongjie Tang Gerile Dari Yuanjun Shi Jinning Zhang Hailiang Zhang Xueqin Liu Yibing Liu Usman Tahir Ying Yu | 2022 | Journal of Animal Science and Biotechnology2022，13，2： | 2 |
| 18 | The impact of carbon emission trading policy on firms’green innovation in China显示文摘This study aims to examine the green innovation effect of the carbon emissions pilot policy in China.First,using the difference-in-differences method and regressions of instrumental variables using the data from Chinese listed firms,we verify that the policy promotes green innovation among regulated firms and is more pronounced among state-owned enterprises,firms in the eastern region,and those with lower financing constraints.Furthermore,this positive effect spreads downstream relative to the regulated firms through input–output linkages,but reduces green innovation to upstream firms.Accordingly,such diffusion of innovation is achieved through the price mechanism.The results necessitate the introduction of various derivatives to mobilize the market to reduce the speculative volatility of carbon prices.In addition,relevant supporting policies must be established to encourage corporate innovation to reduce the crowding-out effect owing to emission reduction and the nonmarket factors. | Hongxin Yu Yaohui Jiang Zhaowen Zhang Wen-Long Shang Chunjia Han Yuanjun Zhao | 2022 | Financial Innovation2022，8，1： | 2 |
| 19 | Task Autonomy of a Flexible Endoscopic System for Laser-Assisted Surgery显示文摘Laser beam string has ben widely studied forthe automation ofsurgery.Currently fexible instruments for laser surgery areoperated entirely by surgeons,which keeps the automation of endoluminal surgery at the initial level.This paper introducesthe design of a new workflow that enables the task autonomy of laser-assisted surgery in constrained environments such as thegastrointestinal(GI)tract with a flexible continuum robotic system.Unlike current,laser steering systems driven bypiezoelectric require the use of high voltage and are risky.This paper describes a tendon-driven 2mm diameter flexiblemanipulator integrated with an endoscope toster thelaser beamBy separating its motionfrom the total endoscopic systemthe designed flexible manipulator can automatically manipulate the laser beam.After the surgical site is searched by thesurgeon with a master/slave control,a population-based model-free control method is applied for the fexible manipulatortoachieve accurate laser beam steering while overcoming the noise from the visual feedback and disturbances from environmentduring operation.Simulations and experiments are performed with the system and control methods to demonstrate theproposed framework in a simulated constrained environment. | Hangjie Mo Xiaojian Li Bo Ouyang Ge Fang Yuanjun Jia | 2022 | Cyborg and Bionic Systems2022，，1： | 2 |
| 20 | PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma显示文摘Altered energy metabolism of cancer cells shapes the immune cell response in the tumor microenvironment that faclitates tumorprogression.Herein,we reported the novel of tumor cell-expressed Piwi Like RNA-Mediated Gene Silencing 1(PWL1)in mediatingthe crosstlk of fatty acid metabolism and immune response of human hepatocellular carcinoma(HCC).PlWIL1 expression in HCCwas increased compared to normal hepatic tissues and was positively correlated with the proliferation rate of HCC cell ines.PIWL1overexpression accelerated in vitro proliferation and in vivo growth of HCC tumors,while PIWL1 knockdown showed opositeeffects.PIWL1 increased oxygen consumption and energy production via fatty acid metabolism without altering aerobic glycolysis.lnhibition of fatty acid metablism abolished PWIL1-induced HCC prolferation and growth.RNA-seq analysis revealed that immunesystem regulation might be involved,which was echoed by the experimental observation that PIWL1-overexpressing HCC cellsattracted myeloid-derived suppressor cells(MDSCs)into the tumor microenvironment.MDSCs depletion reduced the prolferationand growth of PlWIL1-overexpressing HCC tumors.Complement C3,whose secretion was induced by PIWL1 in HCC cells,mediatesthe interaction of HCC cells with MDSCs by activated p38 MAPK signaling in MDSCs,which in turn initiated expression of immunosuppressive cytokine L10.Neutralizing lL10 secretion reduced the immunosuppressive activity of MDSCs in the microenvironment of PIWL1-overexpressing HCC.Taken together,our study unraveled the critical role of PIWL1 in initiating theinteraction of cancer cell metabolism and immune cell response in HCC.Tumor cell-expressed PlIWL1 may be a potential target forthe devellopment of novel HCC treatment. | Ning Wang Hor-Yue Tan Yuanjun Lu Yau-Tuen Chan Di Wang Wei Guo Yu Xu Cheng Zhang Feiyu Chen Guoyi Tang Yibin Feng | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员