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| 1 | Typical basin-fill sequences and basin migration in Yanshan, North China ——Response to Mesozoic tectonic transition显示文摘Basin-fill sequences of Mesozoic typical basins in the Yanshan area, North China may be divided into four phases, reflecting lithosphere tectonic evolution from flexure (T3), flexure with weak rifting (J1+2), tectonic transition (J3), and rifting (K). Except the first phase, the other three phases all start with lava and volcaniclastic rocks, and end with thick coarse clastic rocks and/or conglomerates, showing cyclic basin development rather than simple cyclic rift mechanism and disciplinary basin-stress change from extension to compression in each phase. Prototype basin analysis, based on basin-fill sequences, paleocurrent distribution and depositional systems, shows that single basin-strike and structural-line direction controlling basin development had evidently changed from east-west to northeast in Late Jurassic in the Yanshan area, although basin group still occurred in east-west zonal distribution. Till Early Cretaceous, main structural-line strike controlling basins just turned to northeast by north in the studied area. | LI Zhong, LIU Shaofeng, ZHANG Jinfang & WANG Qingchen1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. China University of Geosciences, Beijing 100083, ChinaCorrespondence should be addressed to Li Zhong (email: lizhongd@mail.igcas.ac.cn) | 2004 | Science China Earth Sciences2004，47，2： | 15 |
| 2 | ζ-Carotene Isomerase Suppresses Tillering in Rice through the Coordinated Biosynthesis of Strigolactone and Abscisic Acid显示文摘Rice tillering is an important agronomic trait affecting grain yield.Here,we identified a high-tillering mutant tillering20(t20),which could be restored to the wild type by treatment with the strigolactone(SL)analog rac-GR24.T20 encodes a chloroplast ζ-carotene isomerase(Z-ISO),which is involved in the biosynthesis of ca-rotenoids and their metabolites,SL and abscisic acid(ABA).The t20 mutant has reduced SL and ABA,raising the question of how SL and ABA biosynthesis is coordinated,and whether they have overlapping functions in tillering.We discovered that rac-GR24 stimulated T20 expression and enhanced all-trans-p-carotene biosynthesis.Importantly,rac-GR24 also stimulated expression of Oryza sativa 9-CIS-EPOXY-CAROTENOID DIOXYGENASE 1(OsNCED1)through induction of Oryza sativa HOMEOBOX12(0sHOX12),promoting ABA biosynthesis in shoot base.On the other hand,ABA treatment significantly repressed SL biosynthesis and the ABA biosynthetic mutants displayed elevated SL biosynthesis.ABA treatment reduced the number of basal tillers in both t20 and wild-type plants.Furthermore,while ABA-deficient mu-tants aba1 and aba2 had the same number of basal tillers as wild type,they had more unproductive upper tillers at maturity.This work demonstrates complex interactions in the biosynthesis of carotenoid,SLs and ABA,and reveals a role for ABA in the regulation of rice tillering. | Xue Liu Qingliang Hu Jijun Yan Kai Sun Yan Liang Meiru Jia Xiangbing Meng Shuang Fang Yiqin Wang Yanhui Jing Guifu Liu Dianxing Wu Chengcai Chu Steven M.Smith Jinfang Chu Yonghong Wang Jiayang Li Bing Wang | 2020 | Molecular Plant2020，13，12： | 11 |
| 3 | Anti-loosening performance of coatings on fasteners subjected to dynamic shear load显示文摘This paper investigates the self-loosening of threaded fasteners subjected to dynamic shear load. Three kinds of typical coatings, PTFE, MoS_2, and TiN applied to bolts and nuts, are tested in this investigation. The study experimentally examines the loosening mechanisms of fasteners and assesses the anti-loosening performance of the three tested coatings based on their tightening characteristics, loosening curves, and the damage of thread surface. Additionally, the anti-loosening performance of the three coatings is compared under different load forms. The results indicate that the PTFE and MoS_2 coatings have significant anti-loosening effect, whereas the anti-loosening performance of Ti N coating is not satisfactory. It is also found that an appropriate increase of the initial tightening torque can significantly improve the anti-loosening effect. In addition, the microscopic analyses of PTFE and MoS2 coating reveal that a reduced initial tightening torque leads to fretting wear on the thread contact surfaces of fasteners, thereby aggravating the damage. | Junbo ZHOU Jianhua LIU Huajiang OUYANG Zhenbing CAI Jinfang PENG Minhao ZHU | 2018 | Friction2018，6，1： | 10 |
| 4 | Expression Patterns of ABA and GA Metabolism Genes and Hormone Levels during Rice Seed Development and Imbibition: A Comparison of Dormant and Non-Dormant Rice Cultivars显示文摘Seed dormancy is an important agronomic trait in cereals. Using deep dormant(N22), medium dormant(ZH11), and non-dormant(G46B)rice cultivars, we correlated seed dormancy phenotypes with abscisic acid(ABA) and gibberellin(GA) metabolism gene expression profiles and phytohormone levels during seed development and imbibition. A time course analysis of ABA and GA content during seed development showed that N22 had a high ABA level at early and middle seed developmental stages, while at late developmental stage it declined to the level of ZH11; however, its ABA/GA ratio maintained at a high level throughout seed development. By contrast, G46 B had the lowest ABA content during seed development though at early developmental stage its ABA level was close to that of ZH11, and its ABA/GA ratio peaked at late developmental stage that was at the same level of ZH11. Compared with N22 and G46 B, ZH11 had an even and medium ABA level during seed development and its ABA/GA ratio peaked at the middle developmental stage. Moreover, the seed development time-point having high ABA/GA ratio also had relatively high transcript levels for key genes in ABA and GA metabolism pathways across three cultivars. These indicated that the embryo-imposed dormancy has been induced before the late developmental stage and is determined by ABA/GA ratio. A similar analysis during seed imbibition showed that ABA was synthesized in different degrees for the three cultivars. In addition, water uptake assay for intact mature seeds suggested that water could permeate through husk barrier into seed embryo for all three cultivars; however, all three cultivars showed distinct colors by vanillin-staining indicative of the existence | Yang Liu Jun Fang Fan Xu Jinfang Chu Cunyu Yan Michael R.Schlappi Youping Wang Chengcai Chu | 2014 | Journal of Genetics and Genomics2014，41，6： | 7 |
| 5 | NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis显示文摘Cerebral ischemia is a major cause of mortality and long-term morbidity worldwide.NDRG4 has been shown to protect against cerebral ischemia,although the underlying mechanisms remain largely unclear.Here we found that NDRG4 expression was decreased in the brain tissues of ischemia/reperfusion(IR)rats,indicating increased apoptosis rates among cerebral cells.NDRG4 restoration via an adenovirus significantly attenuated cerebral infarct sizes and impairments in IR rats.Furthermore,adenovirus-mediated NDRG4 inhibited cell apoptosis in the brains of IR rats and regulated the expression of Bcl-2,Bax,caspase-3,and c-Fos.Moreover,we found that NDRG4 increased expression of BDNF,which is strongly related to cerebral ischemia and cellular apoptosis.Altogether,our findings demonstrate that NDRG4 protects cerebral IR injury by inhibiting cell apoptosis and regulates cerebral cell apoptosis by increasing BDNF expression.These results suggest that NDRG4 may be a therapeutic target for IR treatment. | Lan Wen Lei Liu Linyan Tong Jinfang Li Keming Zhang Qinbin Zhang Changqing Li | 2019 | Genes & Diseases2019，6，4： | 6 |
| 6 | Characteristic analysis of wind field and sea wave field over the NW Pacific Ocean显示文摘According to ship observation data over the NW Pacific Ocean during 1950 - 1995. taking 5°×5° grid, the characteristics and variation rule of wind, wave and swell are analyzed. This area is typical monsoon area. In the period of monsoon, the directions of wind, sea wave and swell are roughly consistent. Sea wave of northeasterly is always prevailing in equatorial zone. The monsoon in winter is stronger than in summer, correspondingly, average wave height is higher, and the frequencies of high sea and heavy swell are also bigger. Both of North Indian Ocean and adjacent sea area is also monsoon area, but characteristic is opposite. This paper provides specific data of wind field and wave field and variaton for ship navigation, operation and scientific experiment in the NW Pacific Ocean. | Jinfang Liu(刘金芳) Xiaowei Tang(唐晓卫) Danhua He(何丹华) | 2001 | 海洋预报2001，18，z1： | 5 |
| 7 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 8 | Preparation and tribological properties of Sol-Gel TiO_2-ZrO_2 composite thin films显示文摘High oriented TiO2-ZrO2 composite thin films on Si (100) and glass sheet were suc-cessfully prepared by sol-gel process followed by dip-coating the ethanol solution of zirconiumoxychloride and titanium tetrachloride. The sol-gel process, microstructure, morphology and tri-bological properties of TiO2 -ZrO2 films were investigated using TGA, DSC, XPS, XRD, AFM anddynamic-static tribometer. The results show that the TiO2-ZrO2films are dense, homogeneous andat a complete tetragonal phase with an excellent antiwear and friction reduction performance. Un-der 0.5N applied load, the friction coefficient is 0.14-0.20 and the antiwear life is more than 5000sliding cycles for both TiO2-ZrO2/ AISI 52100 steel and TiO2-ZrO2/ Si3N4. SEM observation sug-gests that wear mechanism of TiO2 -ZrO2 composite film under low load was fatigue wear, andunder high load was adhesive wear. The TiO2 -ZrO2 films show potential applications as coatingsfor antiwear and friction reduction under the harsh condition. | CHEN Yunxia ZHOU Jinfang LIU Weimin State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical, Physics, Chinese Academy of Sciences, Lanzhou 730000, China | 2001 | Science China Mathematics2001，44，S1： | 3 |
| 9 | A systematic review on food lead concentration and dietary lead exposure in China显示文摘 | Jin Yingliang Liu Pei Wu Yongning Min Jie Wang Cannan Sun Jinfang Zhang Yafei | 2014 | Chinese Medical Journal2014，，15： | 3 |
| 10 | Ginseng saponin Rbl enhances hematopoietic function and dendritic cells differentiation显示文摘 | Li Zhang Hui Feng Yibo He Jinfang Zhao Yimin Chen Yonglin Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 3 |
| 11 | Self-Stabilized Precipitation Polymerization and Its Application显示文摘An efective,value-added use of the large amounts of olefnic compounds produced in the processing of petroleum,aside from ethylene and propylene,has been a long outstanding challenge.Here,we developed a novel heterogeneous polymerization method,beyond emulsion/dispersion/suspension,termed self-stabilized precipitation(2SP)polymerization,which involves the nucleation and growth of nanoparticles(NPs)of a well-defned size without the use of any stabilizers and multifunctional monomers(crosslinker).Tis technique leads to two revolutionary advances:(1)the generation of functional copolymer particles from single olefnic monomer or complex olefnic mixtures(including C4/C5/C9 fractions)in large quantities,which open a new way to transform huge amount of unused olefnic compounds in C4/C5/C9 fractions into valuable copolymers,and(2)the resultant polymeric NPs possess a self-limiting size and narrow size distribution,therefore being one of the most simple,efcient,and green strategies to produce uniform,size-tunable,and functional polymeric nanoparticles.More importantly,the separation of the NPs from the reaction medium is simple and the supernatant liquid can be reused;hence this new synthetic strategy has great potential for industrial production. | Zhenjie Liu Dong Chen Jinfang Zhang Haodong Liao Yanzhao Chen Yingfa Sun Jianyuan Deng Wantai Yang | 2018 | Research2018，，1： | 3 |
| 12 | MIT1, encoding a 15-cis-ζ-carotene isomerase, regulates tiller number and stature in rice显示文摘Lateral branching is an important determinant of shoot architecture and crop yield. The plant hormone strigolactone (SL) inhibits lateral bud outgrowth in various plant species. Deficiencies in SL biosynthesis and signal transduction result in excessive outgrowth of lateral buds (Stirnberg et al., 2002;Sorefan et al., 2003). | Lihua Liu Mengmeng Ren Peng Peng Yan Chun Lu Li Jinfeng Zhao Jingjing Fang Lixiang Peng Jijun Yan Jinfang Chu Yiqin Wang Shoujiang Yuan Xueyong Li | 2021 | Journal of Genetics and Genomics2021，48，1： | 3 |
| 13 | Cdhl regulates craniofacial development via APC- dependent ubiquitination and activation of Goosecoid显示文摘 | Rui Shao Jia Liu Guang Yan Jinfang Zhang Yujiao Han Jianfeng Guo Zhan Xu Zhu Yuan Jiankang Liu Marcos Malumbres Lixin Wan Wenyi Wei Weiguo Zou | 2016 | Cell Research2016，26，6： | 2 |
| 14 | Litter Decomposition of Emergent Plants along an Elevation Gradient in Wetlands of Yunnan Plateau,China显示文摘The decomposition of plant litter is a key process in the flows of energy and nutrients in ecosystems. However, the response of litter decomposition to global climate warming in plateau wetlands remains largely unknown. In this study, we conducted a one-year litter decomposition experiment along an elevation gradient from 1891 m to 3260 m on the Yunnan Plateau of Southwest China, using different litter types to determine the influences of climate change, litter quality and microenvironment on the decomposition rate. The results showed that the average decomposition rate(K) increased from 0.608 to 1.152, and the temperature sensitivity of litter mass losses was approximately 4.98%/℃ along the declining elevation gradient. Based on a correlation analysis, N concentrations and C︰N ratios in the litter were the best predictors of the decomposition rate, with significantly positive and negative correlations, respectively. Additionally, the cumulative effects of decomposition were clearly observed in the mixtures of Scirpus tabernaemontani and Zizania caduciflora. Moreover, the litter decomposition rate in the water was higher than that in the sediment, especially in high-elevation areas where the microenvironment was significantly affected by temperature. These results suggest that future climate warming will have significant impacts on plateau wetlands, which have important functions in biogeochemical cycling in cold highland ecosystems. | LIU Guodong SUN Jinfang TIAN Kun YUAN Xingzhong AN Subang WANG Hang | 2017 | Chinese Geographical Science2017，27，5： | 2 |
| 15 | Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘Whether glucose is predomi nantly metabolized via oxidative phosphorylati on or glycolysis differs between quiesce nt versus proliferating cells,iincluding tumor cells.However,how glucose metabolism is coordinated with cell cycle in mammalian cells remains elusive.Here,we report that mammalian cells predominantly utilize the tricarboxylic acid(TCA)cycle in G1 phase,but prefer glycolysis in S phase.Mechanistically,coupling cell cycle with metabolism is largely achieved by timely destruction of IDH1/2,key TCA cycle enzymes,in a Skp2-dependent manner.As such,depleting SKP2 abolishes cell cycle-dependent fluctuation of IDH1 protein abundance,leading to reduced glycolysis in S phase.Furthermore,elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.Therefore,our study reveals a mechanistic link between two cancer hallmarks,aberrant cell cycle and addiction to glycolysis,and provides the underlying mechanism for the coupling of metabolic fluctuation with periodic cell cycle in mammalian cells. | Jing Liu Yunhua Peng Le Shi Lixin Wan Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wang Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfic John M.Asara William G.Kaelin Jr. Jjankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 2 |
| 16 | Recent Development in Numerical Simulation of Enhanced Geothermal Reservoirs显示文摘This paper briefly introduces the current state in computer modelling of geothermal reservoir system and then focuses on our research efforts in high performance simulation of enhanced geothermal reservoir system. A novel supercomputer simulation tool has been developing towards simulating the highly non-linear coupled geomechanical-fluid flow-thermal systems involving heterogeneously fractured geomaterials at different spatial and temporal scales. It is applied here to simulate and visualise the enhanced geothermal system(EGS),such as(1) visualisation of the microseismic events to monitor and determine where/how the underground rupture proceeds during a hydraulic stimulation,to generate the mesh using the recorded data for determining the domain of the ruptured zone and to evaluate the material parameters(i.e.,the permeability) for the further numerical analysis and evaluation of the enhanced geothermal reservoir;(2) converting the available fractured rock image/fracture data as well as the reservoir geological geometry to suitable meshes/grids and further simulating the fluid flow in the complicated fractures involving the detailed description of fracture dimension and geometry by the lattice Boltzmann method and/or finite element method;(3) interacting fault system simulation to determine the relevant complicated rupture process for evaluating the geological setting and the in-situ reservoir properties;(4) coupled thermo-fluid flow analysis of a geothermal reservoir system for an optimised geothermal reservoir design and management. A few of application examples are presented to show its usefulness in simulating the enhanced geothermal reservoir system. | Huilin Xing Yan Liu Jinfang Gao Shaojie Chen | 2015 | Journal of Earth Science2015，26，1： | 2 |
| 17 | Evaluating Logical Expressions by Membrane Systems显示文摘Boolean and relational operations, which are defined for solving mathematically logical problems,are always required in computing models. Membrane computing is a kind of distributed parallel computing model.In this paper, we design different membranes for implementing primary Boolean and relational operations respectively. And based on these membranes, a membrane system can be constructed by a present algorithm for evaluating a logical expression. Some examples are given to illustrate how to perform the Boolean, relational operations and evaluate the logical expression correctly in these membrane systems. | GUO Ping JI Jinfang CHEN Haizhu LIU Ran | 2014 | Chinese Journal of Electronics2014，23，2： | 1 |
| 18 | HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation显示文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s. | Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun | 2023 | Cellular & Molecular Immunology2023，20，4： | 1 |
| 19 | Analysis ofenergy-efficient connected target coverage algorithmsfor industrial wireless sensor networks显示文摘 | Han Guangjie Liu Li Jiang Jinfang | 2015 | IEEE Transactionson Industrial Informatics2015，1551，： | 1 |
| 20 | HSPT0 inhibits high glucose - induced Smad3 activation and attenuates epithelial - to - mesen- chymal transition of peritoneal mesothelial cells显示文摘 | Jun Liu Jinfang Bao Jing Hao | 2014 | Mol Med Rep2014，10，2： | 1 |
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