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| 1 | IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice显示文摘Strigolactones (SL ) ,一组类胡萝卜素导出 terpenoid 内酯,是压制射击由禁止腋的芽的长出分叉的 root-to-shoot 植物激素。矮子 53 (D53 ) ,表明小径的 SL 的关键抑压者,被推测调整 SL 反应的下游的 transcriptional 网络。然而, D53 指向的下游的抄写因素还都没被报导。这里,我们报导那理想的植物体系结构 1 (IPA1 ) ,在米饭的植物体系结构的一个关键管理者,在调整 tiller 数字和导致 SL 的基因表示作为 D53 的一个直接下游的部件工作。我们证明 D53 在 vivo 并且在 vitro 与 IPA1 交往并且压制 IPA1 的 transcriptional 激活活动。我们进一步证明 IPA1 能直接绑在 D53 倡导者并且在导致 SL 的 D53 表示的反馈规定起一个关键作用。这些调查结果表明 IPA1 是可能的与 D53 行动到的长推测的抄写因素之一调停在米饭的调整 SL 的 tiller 发展。 | Xiaoguang Song Zefu Lu Hong Yu Gaoneng Shao Jinsong Xiong Xiangbing Meng Yanhui Jing Guifu Liu Guosheng Xiong Jingbo Duan Xue-Feng Yao Chun-Ming Liu Hongqing Li Yonghong Wang Jiayang Li | 2017 | Cell Research2017，27，9： | 48 |
| 2 | MONOCULM 3,an Ortholog of WUSCHEL in Rice,Is Required for Tiller Bud Formation显示文摘WUSCHEL(WUS)plays an essential role for the maintenance of meristem activity in dicots,but its function is still elusive in monocots.We isolated a new monoculm mutant,monoculm 3(moc3),in which a point mutation causes the premature termination of rice O.sativa WUS(Os WUS).Morphological observation revealed that the formation of tiller buds was disrupted in moc3.MOC3 was localized in the nuclear and could interact with TOPLESS-RELATED PROTEINS(TPRs).The expression of MOC3 was induced by cytokinins and defection of MOC3 affected the expression of several two-component cytokinin response regulators,Os RRs and ORRs.Our results suggest that MOC3 is required for the formation of axillary buds and has a complex relationship with cytokinins. | Zefu Lu Gaoneng Shao Jinsong Xiong Yongqing Jiao Jing Wang Guifu Liu Xiangbing Meng Yan Liang Guosheng Xiong Yonghong Wang Jiayang Li | 2015 | Journal of Genetics and Genomics2015，42，2： | 17 |
| 3 | Tiller Bud Formation Regulators MOC1 and MOC3 Cooperatively Promote Tiller Bud Outgrowth by Activating F0N1 Expression in Rice显示文摘Tillering in rice is one of the most important agronomic traits.Rice tiller development can be divided into two main processes: the formation of the axillary bud and its subsequent outgrowth.Several genes critical for bud formation in rice have been identified by genetic studies;however,their molecular functions and relationships are still largely unknown.Here,we report that MONOCULM 1 (MOC1) and MONOCULM 3/ TILLERS ABSENT 1/STERILE AND REDUCED TILLERING 1 (MOC3/TAB1/SRT1),two vital regulators for tiller formation in rice,physically interact to regulate tiller bud outgrowth through upregulating the expression of FLORAL ORGAN NUMBER 1 (FON1),the homolog of CLAVATA1 in rice.We found that M0C3 is able to directly bind the promoter ofFONI and subsequently activate FON1 expression.MOC1 functions as a coactivator of MOC3,whereas it could not directly bind the FON1 promoter,and further activated FON1 expression in the presence of MOC3.Accordingly,FON1 is highly expressed at axillary meristems and shows remarkably decreased expression levels in mod and moc3 mutants.Loss-of-function mutants of FON1 exhibit normal bud formation but defective bud outgrowth and reduced tiller number.Collectively,these results shed light on a joint transcriptional regulatory mechanim by MOC1 and MOC3,and establish a new framework for the control of tiller bud formation and outgrowth. | Gaoneng Shao Zefu Lu Jinsong Xiong Bing Wang Yanhui Jing Xiangbing Meng Guifu Liu Haiyan Ma Yan Liang Fan Chen Yonghong Wang Jiayang Li Hong Yu | 2019 | Molecular Plant2019，12，8： | 15 |
| 4 | OsBRXL4 Regulates Shoot Gravitropism and Rice Tiller Angle through Affecting LAZY1 Nuclear Localization显示文摘Rice tiller angle is a key agronomic trait that contributes to ideal plant architecture and grain production.LAZY1 (LA1) was previously shown to control tiller angle via affecting shoot gravitropism,but the underlying molecular mechanism remains largely unknown.In this study,we identified an LA1-interacting protein named Brevis Radix Like 4 (OsBRXL4).We showed that the interaction between OsBRXL4 and LA1 occurs at the plasma membrane and that their interaction determines nuclear localization of LA1.We found that nuclear localization of LA1 is essential for its function,which is different from AtLA1,its Arabidopsis ortho.log.Overexpression of OsBRXL4 leads to a prostrate growth phenotype,whereas OsBRXLs RNAi plants,in which the expression levels of OsBRXLI,OsBRXL4,and OsBRXL5 were decreased,display a compact phenotype.Further genetic analysis also supported that OsBRXL4 controls rice tiller angle by affecting nuclear localization of LA1.Consistently,we demonstrated that OsBRXL4 regulates the shoot gravitropism through affecting polar auxin transport as did LA1.Taken together,our study not only identifies OsBRXL4 as a regulatory component of rice tiller angle but also provides new insights into genetic regulation of rice plant architecture. | Zhen Li Yan Liang Yundong Yuan Lei Wang Xiangbing Meng Guosheng Xiong Jie Zhou Yueyue Cai Ningpei Han Lekai Hua Guifu Liu Jiayang Li Yonghong Wang | 2019 | Molecular Plant2019，12，8： | 12 |
| 5 | Robust genome editing of CRISPR-Cas9 at NAG PAMs in rice显示文摘Dear Editor,The CRISPR-Cas9(clustered regularly interspaced short palindromic repeats/Cas9)system has been widely used for a variety of applications,including targeted gene knockout,gene insertion,gene replacement and base editing.Despite its wide use,the genome editing using CRISPR-Cas9 is performed almost exclusively at sites containing canonical NGG protospacer adjacent motifs(PAMs).To overcome the PAM constraint of the CRISPR-Cas9 system,many attempts have been made to develop various Cas9 orthologs | Xiangbing Meng Xixun Hu Qing Liu Xiaoguang Song Caixia Gao Jiayang Li Kejian Wang | 2018 | Science China(Life Sciences)2018，61，1： | 11 |
| 6 | ζ-Carotene Isomerase Suppresses Tillering in Rice through the Coordinated Biosynthesis of Strigolactone and Abscisic Acid显示文摘Rice tillering is an important agronomic trait affecting grain yield.Here,we identified a high-tillering mutant tillering20(t20),which could be restored to the wild type by treatment with the strigolactone(SL)analog rac-GR24.T20 encodes a chloroplast ζ-carotene isomerase(Z-ISO),which is involved in the biosynthesis of ca-rotenoids and their metabolites,SL and abscisic acid(ABA).The t20 mutant has reduced SL and ABA,raising the question of how SL and ABA biosynthesis is coordinated,and whether they have overlapping functions in tillering.We discovered that rac-GR24 stimulated T20 expression and enhanced all-trans-p-carotene biosynthesis.Importantly,rac-GR24 also stimulated expression of Oryza sativa 9-CIS-EPOXY-CAROTENOID DIOXYGENASE 1(OsNCED1)through induction of Oryza sativa HOMEOBOX12(0sHOX12),promoting ABA biosynthesis in shoot base.On the other hand,ABA treatment significantly repressed SL biosynthesis and the ABA biosynthetic mutants displayed elevated SL biosynthesis.ABA treatment reduced the number of basal tillers in both t20 and wild-type plants.Furthermore,while ABA-deficient mu-tants aba1 and aba2 had the same number of basal tillers as wild type,they had more unproductive upper tillers at maturity.This work demonstrates complex interactions in the biosynthesis of carotenoid,SLs and ABA,and reveals a role for ABA in the regulation of rice tillering. | Xue Liu Qingliang Hu Jijun Yan Kai Sun Yan Liang Meiru Jia Xiangbing Meng Shuang Fang Yiqin Wang Yanhui Jing Guifu Liu Dianxing Wu Chengcai Chu Steven M.Smith Jinfang Chu Yonghong Wang Jiayang Li Bing Wang | 2020 | Molecular Plant2020，13，12： | 11 |
| 7 | FED:a web tool for foreign element detection of genome-edited organism显示文摘Dear Editor,Genome editing,especially the newly developed CRISPR technology,is now widely implemented for diverse medical and agricultural applications(Puchta,2018).However,for genome editing,the DNA cassettes encoding the editing components are usually assembled and delivered into the cells of organisms(Cong et al.,2013). | Qing Liu Xiaozhen Jiao Xiangbing Meng Chun Wang Cao Xu Zhixi Tian Chuanxiao Xie Genying Li Jiayang Li Hong Yu Kejian Wang | 2021 | Science China(Life Sciences)2021，64，1： | 6 |
| 8 | Effects of silver powder particle size on the microstructure and properties of Ag-Yb_2O_3 electrical contact materials prepared by spark plasma sintering显示文摘Ag-Yb2O3 electrical contact materials were fabricated by spark plasma sintering(SPS).The effects of silver powder particle size on the microstructure and properties of the samples were investigated.The surface morphologies of the sintered samples were examined by optical microscope(OM),and the fracture morphologies were observed by scanning electron microscopy(SEM).The physical and mechanical properties such as density,electrical resistivity,microhardness,and tensile strength were also tested.The results show that the silver powder particle size has evident effects on the sintered materials.Comparing with coarse silver powder(5 μm),homogeneous and fine microstructure was obtained by fine silver powder(≤0.5 μm).At the same time,the electrical conductivity,microhardness,and tensile strength of the sintered samples with fine silver powder were higher than those of the samples with coarse silver powder.However,silver powder particle size has little influence on the relative densities,which of all samples(both by fine and coarse silver powders) is more than 95%.The fracture characteristics are ductile. | CHEN Xiaohua,JIA Chengchang,and LIU Xiangbing School of Materials Science and Engineering,University of Science and Technology Beijing,Beijing 100083,China | 2010 | Rare Metals2010，29，4： | 6 |
| 9 | Inhibition of adipogenic differentiation by myostatin is alleviated by arginine supplementation in porcine-muscle-derived mesenchymal stem cells显示文摘Porcine mesenchymal stem cells in postnatal muscle have been demonstrated to differentiate into adipocytes.This increases adipocyte number and lipid accumulation,and is thought to be the origin of intramuscular fat.In this study,the effects of myostatin and arginine on adipogenic differentiation in mesenchymal stem cells derived from porcine muscle (pMDSCs) were investigated in vitro.Intracellular triglyceride levels were reduced by exogenous myostatin and increased by arginine supplementation or myostatin antibody (P<0.01).The inhibition of lipid accumulation by myostatin in pMDSCs was alleviated by arginine supplementation (P<0.01).Expression patterns of adipogenic transcription factors showed that exogenous myostatin suppressed PPARγ2 and aP2 expression (P<0.01),while supplemental arginine or myostatin antibody promoted ADD1 expression (P<0.01).Furthermore,compared with the addition of either myostatin protein or antibody alone,ADD1 and PPARδ expression were promoted by the combination of arginine and myostatin (P<0.01),and arginine combined with myostatin antibody promoted the expression of ADD1,PPAR,C/EBP,PPAR 2 and LPL in pMDSCs (P<0.05).These results suggest that myostatin inhibits adipogenesis in pMDSCs,and that this can be alleviated by arginine supplementation,at least in part,through promoting ADD1 and PPAR expression. | LEI HuLong YU Bing YANG XueRong LIU ZeHui HUANG ZhiQing MAO XiangBing TIAN Gang HE Jun HAN GuoQuan CHEN Hong MAO Qian CHEN DaiWen | 2011 | Science China(Life Sciences)2011，54，10： | 4 |
| 10 | Expanding the scope of genome editing with SpG and SpRY variants in rice显示文摘Dear Editor,The clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9(CRISPR/Cas9)system,since it was excavated,has been rapidly developed and sparked a revolution in the genome editing field.In principle,CRISPR/Cas9 system relies on the recognition of specific loci on the genome,which is titled the protospacer adjacent motif(PAM).However,the canonical Streptococcus pyogenes Cas9(SpCas9)nuclease only recognizes NGG or NAG PAMs,rendering an inherent obstacle in amplifying the application of CRISPR/Cas9 technology. | Jun Ren Xiangbing Meng Fengyue Hu Qing Liu Yuexuan Cao Huiying Li Changjie Yan Jiayang Li Kejian Wang Hong Yu Chun Wang | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 11 | Improving the efficiency of prime editing with epegRNAs and high-temperature treatment in rice显示文摘Dear Editor,Prime editing(PE)systems are important genome-editing tools developed for mediating arbitrary small DNA insertions,deletions and all 12 base-to-base conversions using a CRISPR-nCas9 fusion of an engineered M-MLV and PE guide RNAs(peg RNAs)(Anzalone et al.,2019). | Jinpeng Zou Xiangbing Meng Qing Liu Meiqi Shang Kejian Wang Jiayang Li Hong Yu Chun Wang | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 12 | Enhancing rice grain production by manipulating the naturally evolved cis-regulatory element-containing inverted repeat sequence of OsREM20显示文摘Grain number per panicle(GNP)is an important agronomic trait that contributes to rice grain yield.Despite its importance in rice breeding,the molecular mechanism underlying GNP regulation remains largely unknown.In this study,we identified a previously unrecognized regulatory gene that controls GNP in rice,Oryza sativa REPRODUCTIVE MERISTEM 20(OsREM20),which encodes a B3 domain transcription factor.Through genetic analysis and transgenic validation we found that genetic variation in the CArG box-containing inverted repeat(IR)sequence of the OsREM20 promoter alters its expression level and contributes to GNP variation among rice varieties.Furthermore,we revealed that the IR sequence regulates OsREM20 expression by affecting the direct binding of OsMADS34 to the CArG box within the IR sequence.Interestingly,the divergent pOsREM20IR and pOsREM20ΔIR alleles were found to originate from different Oryza rufipogon accessions,and were independently inherited into the japonica and indica subspecies,respectively,during domestication.Importantly,we demonstrated that IR sequence variations in the OsREM20 promoter can be utilized for germplasm improvement through either genome editing or traditional breeding.Taken together,our study characterizes novel genetic variations responsible for GNP diversity in rice,reveals the underlying molecular mechanism in the regulation of agronomically important gene expression,and provides a promising strategy for improving rice production by manipulating the cis-regulatory element-containing IR sequence. | Xiaowei Wu Yan Liang Hengbin Gao Jiyao Wang Yan Zhao Lekai Hua Yundong Yuan Ahong Wang Xiaohui Zhang Jiafan Liu Jie Zhou Xiangbing Meng Dahan Zhang Shaoyang Lin Xuehui Huang Bin Han Jiayang Li Yonghong Wang | 2021 | Molecular Plant2021，14，6： | 3 |
| 13 | Control Effect of Several Replacement Plants on Invasive Weed Eupatorium adenophorum Spreng显示文摘To select the suitable plant species controlling Eupatorium adenophorum in hilly area,ecological adaptability,competitiveness and control efficacy of many replacement plants with economic value in Guizhou Province of China were studied.The results showed that the coverage of Paspalum wetsfeteini and Dolichos lablab were 100% and 93%,which increased by 3.70 and 3.44 times compared with Lolium perenne,respectively;their relative crowding coefficient with E.adenophorum were 7.09 and 22.78,which increased by 2.43 and 7.80 times compared with L perenne,respectively.Using excavation method,the control efficacies of replacement plants were 99.3 % and 96.9%,respectively,while the control efficacy of replacement plants using mowing method was lower than 66.4%.The overwintering rate of P.wetsfeteini in the following year was 95% ;its coverage was still 100% and its control efficacy against E.adenophorum remained over 99%.D.lablab was difficult to survive the winter in the north region beyond 26.2°N,so it could only be applied as annual replacement plant.The coverage of Setaria anceps,Cajanus cajan and other test plants were less than 90%,with poor control efficacy against E.adenophorum. | Lu Xiangyang Wang Qiuxia Zhang Jinhua Zuo Xiangbing Liu Bin | 2013 | Plant Diseases and Pests2013，4，2： | 3 |
| 14 | OsMPK4 promotes phosphorylation and degradation of IPA1 in response to salt stress to confer salt tolerance in rice显示文摘Salt stress adversely affects plant growth,development,and crop yield.Rice(Oryza sativa L.)is one of the most salt-sensitive cereal crops,especially at the early seedling stage.Mitogen-activated protein kinase(MAPK/MPK)cascades have been shown to play critical roles in salt response in Arabidopsis.However,the roles of the MPK cascade signaling in rice salt response and substrates of Os MPK remain largely unknown.Here,we report that the salt-induced Os MPK4-Ideal Plant Architecture 1(IPA1)signaling pathway regulates the salt tolerance in rice.Under salt stress,Os MPK4 could interact with IPA1 and phosphorylate IPA1 at Thr180,leading to degradation of IPA1.Genetic evidence shows that IPA1 is a negative regulator of salt tolerance in rice,whereas Os MPK4 promotes salt response in an IPA1-dependent manner.Taken together,our results uncover an Os MPK4-IPA1 signal cascade that modulates the salt stress response in rice and sheds new light on the breeding of salt-tolerant rice varieties. | Meiru Jia Nan Luo Xiangbing Meng Xiaoguang Song Yanhui Jing Liquan Kou Guifu Liu Xiahe Huang Yingchun Wang Jiayang Li Bing Wang Hong Yu | 2022 | Journal of Genetics and Genomics2022，49，8： | 2 |
| 15 | Zebra chip disease incidence on potato is influenced by timing of potato psyllid infestation, but not by the host plants on which they were reared显示文摘斑马薄片(ZC ) 症候群是到土豆工业的土豆和主要威胁的新兴的疾病。土豆 psyllid, Bactericerca cockerelli (Sulc ) 被相信是 ZC 病原体的向量,它现在是思维是 Candidatus Liberibacter,一个细菌。为了推进,理解在土豆 psyllid 群袭和 ZC 疾病表示之间的关系,在不同生长阶段(在萌芽以后的 4 , 6 和 10 个星期)的健康土豆植物独立暴露于独立在四 solanaceous 主人植物上被饲养的土豆 psyllids (土豆,西红柿,茄子或钟辣椒)为超过 1 年。在叶子和健康、大批出没于 psyllid 的植物的澡盆 ers 的 ZC 症状,叶率和全部的非结构的糖类累积被监视并且记录。典型 ZC 症状在叶子和不管他们在上被扶养的主人植物暴露于土豆 psyllids 的所有植物的澡盆 ers 被观察。这被重要减小也在网里伴随光合的率。没有到土豆 psyllids (uninfested 控制) 的暴露的将关入笼中的土豆植物没在叶子并且在收获澡盆 ers 显示出任何 ZC 症状。叶子损坏和 ZC 表示在 4 个星期与在以后的生长阶段大批出没于的植物相比在萌芽以后暴露于土豆 psyllids 的土豆植物是很严重的。从大批出没于 psyllid 的植物有的土豆的 Tubers 在健康植物比那些减少糖(葡萄糖) 和淀粉的底层显著地高级,显示那土豆 psyllid 群袭在叶子或澡盆 ers 防碍糖类新陈代谢,导致 ZC 表示。 | Feng Gao John Jifon Xiangbing Yang Tong-Xian Liu | 2009 | Insect Science2009，16，5： | 2 |
| 16 | SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization显示文摘Dear Editor, Centromeres are critical for the faithful inheritanee of genetic information during cell division and maintenance of centromere identity is vital for genome integrity. The identity of centromeres is epigenetically determined by centromere-specific histone H3 varia nt, which is termed CENP-A in mammals. Un like canon ical histones that are incorporated into chromatin during S phase in a replication-dependent manner, CENP-A is incorporated into centromeric chromatin during G1 phase in mammals. | Hang Fu Nan Liu Qiang Dong Chunxiao Ma Jing Yang Jun Xiong Zhuqiang Zhang Xiangbing Qi Chang Huang Bing Zhu | 2019 | Cell Research2019，29，3： | 1 |
| 17 | Grinding of nanostructural ceramic coat- ings: damage evaluation 显示文摘 | Xiangbing Liu Bi Zhang | 2003 | Intemational Journal of Machine Tools & Manufacture2003，43，： | 1 |
| 18 | Generation amount prediction and material flow analysis of electronic waste:a case study in Beijing,China显示文摘 | LIU Xiangbing MASARU T YASUHIRO M | 2006 | Waste Management & Research2006，，24： | 1 |
| 19 | An engineered platform for reconstituting functional multisubunit SCF E3 ligase in vitro显示文摘Multisubunit SKP1/Cullin1/F-box(SCF)E3 ligases play essential roles in regulating the stability of crucial regulatory factors and controlling growth and development in eukaryotes.Detecting E3 ligase activity in vitro is important forexploring the molecular mechanism of protein ubiquitination.However,in vitro ubiquitination assay systems for multisubunit E3 ligases remain difficult to achieve,especially in plants,mainly owing to difficulties in achieving active components of multisubunit E3 ligases with high purity and characterizing specific E2 and E3 pairs.In this study,we characterized components of the rice ScFDiwARF3(SCFDs)E3 ligase,screened the coordinated E2,and reconstituted active ScFD3 E3 ligase in vitro.We further engineered SCFD3 E3 ligase using a fused SKP1-Cullin1-RBX1(eSCR)protein and found that both the wild-type SCFD3 E3 ligase and the engineered SCFD3 E3 ligase catalyzed ubiquitination of the substrate D53,which is the key transcriptional repressor in strigolactone signaling.Finally,we replaced D3 with other F-box proteins from rice and humans and reconstituted active escF E3 ligases,including escFaID2,escFBxL1s,and escFcDC4 E3 ligases.Our work reconstitutes functional SCF E3 ligases in vitro and generates an engineered system with interchangeable F-box proteins,providing a powerful platform for studying the mechanisms of multisubunit SCF E3 ligases in eukaryotes. | Huihui Liu Simiao Liu Hong Yu Xiahe Huang Yingchun Wang Liang Jiang Xiangbing Meng Guifu Liu Mingjiang Chen Yanhui Jing Feifei Yui Bing Wang Jiayang Li | 2022 | Molecular Plant2022，15，8： | 1 |
| 20 | The fusion protein of HSP65 with tandem repeats of β-hCG acting as a potent tumor vaccine in suppressing hepatocarcinoma显示文摘 | Hu Xiangbing Zhang Yankai Lin Ming Lu Yong Zhang Yu Zhang Huiyong Chen Yingying Hou Jing Xing Yun Jin Liang Cao Rongyue Liu Jingjing | 2009 | International Immunopharmacology2009，，： | 1 |
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